RXRG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RXRG_HUMAN
• UniProt AC: P48443
• Protein Name: Retinoic acid receptor RXR-gamma
• Gene Name: RXRG
• Organism: Homo sapiens (Human).
• Sequence Length: 463
• Subcellular Localization: Nucleus .
• Protein Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)..
• Protein Sequence: MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Methylation	GNYSHFMKFPAGYGG CCCCCCCCCCCCCCC	47.45	23644510
15	Phosphorylation	FMKFPAGYGGSPGHT CCCCCCCCCCCCCCC	22.03	24275569
18	Phosphorylation	FPAGYGGSPGHTGST CCCCCCCCCCCCCCC	24.28	24275569
22	Phosphorylation	YGGSPGHTGSTSMSP CCCCCCCCCCCCCCH	38.45	24275569
25	Phosphorylation	SPGHTGSTSMSPSAA CCCCCCCCCCCHHHH	29.78	24275569
34	Phosphorylation	MSPSAALSTGKPMDS CCHHHHHHCCCCCCC	30.32	24275569
151	Phosphorylation	DRSSGKHYGVYSCEG CCCCCCEEEEEECCC	16.27	-
154	Phosphorylation	SGKHYGVYSCEGCKG CCCEEEEEECCCCCC	11.84	28152594
155	Phosphorylation	GKHYGVYSCEGCKGF CCEEEEEECCCCCCH	11.86	28152594
222	Phosphorylation	RSRERAESEAECATS HHHHHHHHHHHHHHC	40.91	25002506
294	Phosphorylation	IPHFSDLTLEDQVIL CCCHHCCCHHHHEEE	32.85	-
398	Phosphorylation	ETLREKVYATLEAYT HHHHHHHHHHHHHHH	12.63	-
404	Phosphorylation	VYATLEAYTKQKYPE HHHHHHHHHHCCCCC	12.70	-
418	Ubiquitination	EQPGRFAKLLLRLPA CCCCHHHHHHHHHHH	36.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RXRG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RXRG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RXRG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPARA_HUMAN	PPARA	physical	16169070
CENPR_HUMAN	ITGB3BP	physical	11713274
SRF_HUMAN	SRF	physical	11641790
CEBPZ_HUMAN	CEBPZ	physical	20211142
KCC2B_HUMAN	CAMK2B	physical	15604093
MAP4_HUMAN	MAP4	physical	15604093
NR1H2_HUMAN	NR1H2	physical	25416956
NR1H3_HUMAN	NR1H3	physical	25416956
NR1H2_HUMAN	NR1H2	physical	28514442
RXRA_HUMAN	RXRA	physical	28514442
NR2F6_HUMAN	NR2F6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.