| UniProt ID | NR1H3_HUMAN | |
|---|---|---|
| UniProt AC | Q13133 | |
| Protein Name | Oxysterols receptor LXR-alpha | |
| Gene Name | NR1H3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 447 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. [PubMed: 19481530] | |
| Protein Sequence | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | O-linked_Glycosylation | EEARMPHSAGGTAGV CHHCCCCCCCCCCCC | 23.80 | 19933273 | |
| 191 | Phosphorylation | EEQAHATSLPPRASS HHHHHHHCCCCCCCC | 39.40 | 24719451 | |
| 197 | Phosphorylation | TSLPPRASSPPQILP HCCCCCCCCCCCCCC | 44.66 | 26657352 | |
| 198 | Phosphorylation | SLPPRASSPPQILPQ CCCCCCCCCCCCCCC | 39.35 | 18250151 | |
| 207 | Phosphorylation | PQILPQLSPEQLGMI CCCCCCCCHHHHHHH | 22.57 | 25850435 | |
| 246 | Phosphorylation | PMAPDPHSREARQQR CCCCCCCCHHHHHHH | 36.88 | 30631047 | |
| 292 | Phosphorylation | DQIALLKTSAIEVML HHHHHHHCHHHHHHH | 24.30 | 22210691 | |
| 303 | Phosphorylation | EVMLLETSRRYNPGS HHHHHHHHHHCCCCC | 12.84 | 22210691 | |
| 306 | Phosphorylation | LLETSRRYNPGSESI HHHHHHHCCCCCCCE | 25.30 | - | |
| 310 | Phosphorylation | SRRYNPGSESITFLK HHHCCCCCCCEEEEE | 29.45 | - | |
| 312 | Phosphorylation | RYNPGSESITFLKDF HCCCCCCCEEEEECC | 28.73 | - | |
| 314 | Phosphorylation | NPGSESITFLKDFSY CCCCCCEEEEECCCC | 31.99 | 22210691 | |
| 320 | Phosphorylation | ITFLKDFSYNREDFA EEEEECCCCCHHHHH | 31.47 | 24719451 | |
| 328 | Sumoylation | YNREDFAKAGLQVEF CCHHHHHHCCCCEEE | 42.87 | - | |
| 328 | Sumoylation | YNREDFAKAGLQVEF CCHHHHHHCCCCEEE | 42.87 | - | |
| 413 | Phosphorylation | RMLMKLVSLRTLSSV HHHHHHHHHHHHHHC | 23.67 | 24719451 | |
| 434 | Ubiquitination | ALRLQDKKLPPLLSE HHHCCCCCCCCHHHH | 74.62 | - | |
| 434 | Sumoylation | ALRLQDKKLPPLLSE HHHCCCCCCCCHHHH | 74.62 | - | |
| 434 | Sumoylation | ALRLQDKKLPPLLSE HHHCCCCCCCCHHHH | 74.62 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NR1H3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NR1H3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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