RXRB_HUMAN - dbPTM
RXRB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RXRB_HUMAN
UniProt AC P28702
Protein Name Retinoic acid receptor RXR-beta
Gene Name RXRB
Organism Homo sapiens (Human).
Sequence Length 533
Subcellular Localization Nucleus .
Protein Description Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)..
Protein Sequence MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Methylation--MSWAARPPFLPQR
--CCCCCCCCCCCCC		31.51115384989
25MethylationQCGPVGVRKEMHCGV
CCCCCCCCCCCCCCC		24.2424129315
26AcetylationCGPVGVRKEMHCGVA
CCCCCCCCCCCCCCC		57.9126051181
60PhosphorylationVAGGEQQTPEPEPGE
HHCCCCCCCCCCCCC		29.3428555341
180SumoylationSGPPEDVKPPVLGVR
CCCHHHCCCCCCCCC		56.79-
202UbiquitinationPGGPGAGKRLCAICG
CCCCCCCCEEEEECC		41.48-
202AcetylationPGGPGAGKRLCAICG
CCCCCCCCEEEEECC		41.4826051181
217PhosphorylationDRSSGKHYGVYSCEG
CCCCCCEEEEEECCC		16.27-
220PhosphorylationSGKHYGVYSCEGCKG
CCCEEEEEECCCCCC		11.8428152594
221PhosphorylationGKHYGVYSCEGCKGF
CCEEEEEECCCCCCH		11.8628152594
235UbiquitinationFFKRTIRKDLTYSCR
HHHHHHCCCCCEECC		53.92-
303MethylationPEEMPVDRILEAELA
CCCCCHHHHHHHHHH		35.31115493035
315PhosphorylationELAVEQKSDQGVEGP
HHHHHCCCCCCCCCC		34.5630377224
325PhosphorylationGVEGPGGTGGSGSSP
CCCCCCCCCCCCCCC		44.2628450419
328PhosphorylationGPGGTGGSGSSPNDP
CCCCCCCCCCCCCCH		36.5328450419
330PhosphorylationGGTGGSGSSPNDPVT
CCCCCCCCCCCCHHH		44.3028450419
331PhosphorylationGTGGSGSSPNDPVTN
CCCCCCCCCCCHHHH		31.1128450419
337PhosphorylationSSPNDPVTNICQAAD
CCCCCHHHHHHHHHH		25.0128450419
345UbiquitinationNICQAADKQLFTLVE
HHHHHHHHHHHHHHH		44.14-
427UbiquitinationVLTELVSKMRDMRMD
HHHHHHHHHHHHCCC		30.40-
435UbiquitinationMRDMRMDKTELGCLR
HHHHCCCHHHHHHEH		34.26-
452UbiquitinationILFNPDAKGLSNPSE
HHHCCCCCCCCCHHH		68.7021890473
456UbiquitinationPDAKGLSNPSEVEVL
CCCCCCCCHHHHHHH		49.5121890473
456UbiquitinationPDAKGLSNPSEVEVL
CCCCCCCCHHHHHHH		49.5121890473
466UbiquitinationEVEVLREKVYASLET
HHHHHHHHHHHHHHH		33.83-
476UbiquitinationASLETYCKQKYPEQQ
HHHHHHHHHHCHHHC		39.14-
478UbiquitinationLETYCKQKYPEQQGR
HHHHHHHHCHHHCCH		48.55-
488UbiquitinationEQQGRFAKLLLRLPA
HHCCHHHHHHHHHHH		36.6321890473
492UbiquitinationRFAKLLLRLPALRSI
HHHHHHHHHHHHHHH		38.3021890473
492UbiquitinationRFAKLLLRLPALRSI
HHHHHHHHHHHHHHH		38.3021890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RXRB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RXRB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RXRB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPOP_HUMANSPOPphysical
16189514
NR1H2_HUMANNR1H2physical
10187832
NRIP1_HUMANNRIP1physical
9626662
TF2H1_HUMANGTF2H1physical
15625236
NR1H3_HUMANNR1H3physical
15604093
NR1H2_HUMANNR1H2physical
15604093
MAP4_HUMANMAP4physical
15604093
PPARG_HUMANPPARGphysical
15604093
ZDH12_HUMANZDHHC12physical
21988832
VDR_HUMANVDRphysical
21988832
SPOP_HUMANSPOPphysical
21988832
CAC1B_HUMANCACNA1Bphysical
20195357
PTMS_HUMANPTMSphysical
20195357
NR1H3_HUMANNR1H3physical
25416956
NCOA1_HUMANNCOA1physical
15604093
ARBK1_HUMANADRBK1physical
26496610
CCNK_HUMANCCNKphysical
26496610
MRCKB_HUMANCDC42BPBphysical
26496610
C2CD5_HUMANC2CD5physical
26496610
RPC6_HUMANPOLR3Fphysical
26496610
AFF4_HUMANAFF4physical
26496610
FABD_HUMANMCATphysical
26496610
WAP53_HUMANWRAP53physical
26496610
RT10_HUMANMRPS10physical
26496610
TXLNA_HUMANTXLNAphysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00459Acitretin
DB00210Adapalene
DB00523Alitretinoin
DB00307Bexarotene
DB00799Tazarotene
DB00755Tretinoin
Regulatory Network of RXRB_HUMAN

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Related Literatures of Post-Translational Modification

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