RPC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPC6_HUMAN
• UniProt AC: Q9H1D9
• Protein Name: DNA-directed RNA polymerase III subunit RPC6
• Gene Name: POLR3F
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Nucleus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA). [PubMed: 21358628]
• Protein Sequence: MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEVKVKVQ ------CCEEEEEEC	30.23	22814378
5	Sumoylation	---MAEVKVKVQPPD ---CCEEEEEECCCC	28.04	28112733
7	Sumoylation	-MAEVKVKVQPPDAD -CCEEEEEECCCCCC	29.45	-
7	Sumoylation	-MAEVKVKVQPPDAD -CCEEEEEECCCCCC	29.45	28112733
59	Phosphorylation	VAINRLLSMGQLDLL HHHHHHHHHCHHHHH	26.01	24719451
60	Sulfoxidation	AINRLLSMGQLDLLR HHHHHHHHCHHHHHH	3.91	21406390
79	Phosphorylation	LLYRIKDSQNAGKMK CEEEEECCCCCCCCC	21.97	-
93	Ubiquitination	KGSDNQEKLVYQIIE CCCCCHHHHHHHHHH	33.23	-
96	Phosphorylation	DNQEKLVYQIIEDAG CCHHHHHHHHHHHHC	12.39	27642862
114	Phosphorylation	IWSRDIRYKSNLPLT CCCCCCCCCCCCCHH	21.07	28152594
116	Phosphorylation	SRDIRYKSNLPLTEI CCCCCCCCCCCHHHH	34.36	28152594
128	Ubiquitination	TEINKILKNLESKKL HHHHHHHHHHHHHHH	64.06	-
140	Acetylation	KKLIKAVKSVAASKK HHHHHHHHHHHHCCC	44.03	24888495
146	Acetylation	VKSVAASKKKVYMLY HHHHHHCCCEEEEEE	52.46	24888503
150	Phosphorylation	AASKKKVYMLYNLQP HHCCCEEEEEEECCC	7.12	22817900
191	Ubiquitination	CFKFLQSKAETARES HHHHHHHHHHHHHHH	36.96	-
199	Ubiquitination	AETARESKQNPMIQR HHHHHHHCCCCCHHC	49.71	-
208	Phosphorylation	NPMIQRNSSFASSHE CCCHHCCCCCCCHHH	29.08	29083192
209	Phosphorylation	PMIQRNSSFASSHEV CCHHCCCCCCCHHHH	28.51	29083192
212	Phosphorylation	QRNSSFASSHEVWKY HCCCCCCCHHHHHHH	30.16	29083192
213	Phosphorylation	RNSSFASSHEVWKYI CCCCCCCHHHHHHHH	21.90	29083192
219	Phosphorylation	SSHEVWKYICELGIS CHHHHHHHHHHHCCC	8.62	22210691
226	Phosphorylation	YICELGISKVELSME HHHHHCCCEEEECHH	28.93	22210691
256	Ubiquitination	EMTIIAAKEGTVGSV EEEEEEECCCCCCEE	47.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPC6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPC6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPC6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF3C4_HUMAN	GTF3C4	physical	10523658
WDR89_HUMAN	WDR89	physical	16169070
PRP4B_HUMAN	PRPF4B	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
STC2_HUMAN	STC2	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
TBP_HUMAN	TBP	physical	9171375
RPC7_HUMAN	POLR3G	physical	22939629
RRP12_HUMAN	RRP12	physical	22939629
UB2G2_HUMAN	UBE2G2	physical	21988832
SUV92_HUMAN	SUV39H2	physical	23455924
RPC4_HUMAN	POLR3D	physical	26344197
RPC7_HUMAN	POLR3G	physical	26344197
RPC8_HUMAN	POLR3H	physical	26344197
RPC10_HUMAN	POLR3K	physical	26344197
SMCA4_HUMAN	SMARCA4	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.