| UniProt ID | TBP_HUMAN | |
|---|---|---|
| UniProt AC | P20226 | |
| Protein Name | TATA-box-binding protein | |
| Gene Name | TBP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 339 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. [PubMed: 2374612] | |
| Protein Sequence | MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 114 | O-linked_Glycosylation | SQQATQGTSGQAPQL HCHHHCCCCCCCCCE | 21.62 | 31866147 | |
| 181 | Ubiquitination | LGCKLDLKTIALRAR CCCCCCHHHHHHHHH | 37.24 | 21890473 | |
| 181 | Sumoylation | LGCKLDLKTIALRAR CCCCCCHHHHHHHHH | 37.24 | - | |
| 181 | Acetylation | LGCKLDLKTIALRAR CCCCCCHHHHHHHHH | 37.24 | 25953088 | |
| 181 | Ubiquitination | LGCKLDLKTIALRAR CCCCCCHHHHHHHHH | 37.24 | 21890473 | |
| 181 | Sumoylation | LGCKLDLKTIALRAR CCCCCCHHHHHHHHH | 37.24 | - | |
| 182 | Phosphorylation | GCKLDLKTIALRARN CCCCCHHHHHHHHHC | 20.84 | - | |
| 225 | Acetylation | KMVCTGAKSEEQSRL CEEECCCCCHHHHHH | 60.80 | 26051181 | |
| 225 | Ubiquitination | KMVCTGAKSEEQSRL CEEECCCCCHHHHHH | 60.80 | - | |
| 230 | Phosphorylation | GAKSEEQSRLAARKY CCCCHHHHHHHHHHH | 32.32 | - | |
| 237 | Phosphorylation | SRLAARKYARVVQKL HHHHHHHHHHHHHHH | 8.29 | - | |
| 243 | Ubiquitination | KYARVVQKLGFPAKF HHHHHHHHHCCCHHH | 38.68 | 21890473 | |
| 243 | Ubiquitination | KYARVVQKLGFPAKF HHHHHHHHHCCCHHH | 38.68 | 21890473 | |
| 249 | Ubiquitination | QKLGFPAKFLDFKIQ HHHCCCHHHHCEEEE | 46.85 | 21890473 | |
| 249 | Ubiquitination | QKLGFPAKFLDFKIQ HHHCCCHHHHCEEEE | 46.85 | 21890473 | |
| 261 | Phosphorylation | KIQNMVGSCDVKFPI EEECCCCCCCEECEE | 8.85 | - | |
| 265 | Ubiquitination | MVGSCDVKFPIRLEG CCCCCCEECEEEEEE | 31.97 | - | |
| 307 | Phosphorylation | IVLLIFVSGKVVLTG EEEEEEECCEEEEEC | 23.34 | - | |
| 322 | Phosphorylation | AKVRAEIYEAFENIY HHHHHHHHHHHHHHH | 7.84 | 29496907 | |
| 329 | Phosphorylation | YEAFENIYPILKGFR HHHHHHHHHHHHCCC | 8.87 | 17360941 | |
| 333 | Ubiquitination | ENIYPILKGFRKTT- HHHHHHHHCCCCCC- | 57.64 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBP_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 607136 | Spinocerebellar ataxia 17 (SCA17) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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