ZNF76_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF76_HUMAN
• UniProt AC: P36508
• Protein Name: Zinc finger protein 76
• Gene Name: ZNF76
• Organism: Homo sapiens (Human).
• Sequence Length: 570
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MESLGLHTVTLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYIHQVTVQKEALSFEDGQPVQLEDGSMAYIHRTPREGYDPSTLEAVQLEDGSTAYIHHPVAVPSESTILAVQTEVGLEDLAAEDDEGFSADAVVALEQYASKVLHDSQIPRNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPRIAYLSEVKEERDDIPAQVAMVTEEDGAPQVALITQDGAQQVSLSPEDLQALGSAISMVTQHGSTTLTIPSPDADLATSGTHTVTMVSADGTQTQPVTIITSGAVVAEDSSVASLRHQQVALLATANGTHIAVQLEEQQTLEEAINVATAAMQQGAVTLETTVSESGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Sumoylation	AYVQQAVKGEKLLEG EHHHHHHCCCCCCCC	65.45	28112733
183	Ubiquitination	YTTAHHLKVHERAHT EECCHHHHHHHHCCC	36.87	-
204	Ubiquitination	CDFPSCGKAFATGYG CCCCCCCCHHHCCCC	44.66	-
208	Phosphorylation	SCGKAFATGYGLKSH CCCCHHHCCCCCHHH	25.20	-
210	Phosphorylation	GKAFATGYGLKSHVR CCHHHCCCCCHHHCE	18.22	22817900
213	Sumoylation	FATGYGLKSHVRTHT HHCCCCCHHHCEECC	33.87	-
213	Ubiquitination	FATGYGLKSHVRTHT HHCCCCCHHHCEECC	33.87	-
213	Sumoylation	FATGYGLKSHVRTHT HHCCCCCHHHCEECC	33.87	-
214	Phosphorylation	ATGYGLKSHVRTHTG HCCCCCHHHCEECCC	32.05	-
218	Phosphorylation	GLKSHVRTHTGEKPY CCHHHCEECCCCCCC	23.77	28348404
220	Phosphorylation	KSHVRTHTGEKPYKC HHHCEECCCCCCCCC	46.56	26055452
223	Ubiquitination	VRTHTGEKPYKCPEE CEECCCCCCCCCCHH	55.80	-
237	Acetylation	ELCSKAFKTSGDLQK HHHHHHHHCCCCHHH	46.79	30593897
244	Ubiquitination	KTSGDLQKHVRTHTG HCCCCHHHHHHHCCC	51.90	-
250	Phosphorylation	QKHVRTHTGERPFQC HHHHHHCCCCCCCCC	39.87	21712546
265	Phosphorylation	PFEGCGRSFTTSNIR CCCCCCCCEECCCEE	16.54	28555341
267	Phosphorylation	EGCGRSFTTSNIRKV CCCCCCEECCCEEEE	30.48	24719451
268	Phosphorylation	GCGRSFTTSNIRKVH CCCCCEECCCEEEEE	20.12	24719451
269	Phosphorylation	CGRSFTTSNIRKVHV CCCCEECCCEEEEEE	27.48	24719451
280	Phosphorylation	KVHVRTHTGERPYTC EEEEEECCCCCCCCC	39.87	25159151
294	Methylation	CPEPHCGRGFTSATN CCCCCCCCCCCCCCC	42.31	115920641
298	Phosphorylation	HCGRGFTSATNYKNH CCCCCCCCCCCCCCC	30.73	-
300	Phosphorylation	GRGFTSATNYKNHVR CCCCCCCCCCCCCEE	38.56	-
303	Sumoylation	FTSATNYKNHVRIHT CCCCCCCCCCEEEEC	42.52	-
303	Ubiquitination	FTSATNYKNHVRIHT CCCCCCCCCCEEEEC	42.52	-
303	Sumoylation	FTSATNYKNHVRIHT CCCCCCCCCCEEEEC	42.52	-
310	Phosphorylation	KNHVRIHTGEKPYVC CCCEEEECCCCCEEE	44.67	28111955
313	Acetylation	VRIHTGEKPYVCTVP EEEECCCCCEEEECC	42.89	26051181
315	Phosphorylation	IHTGEKPYVCTVPGC EECCCCCEEEECCCC	21.16	-
358	Phosphorylation	GKTYRQTSTLAMHKR CCEEEECCCEEEEEH	17.06	22817900
359	Phosphorylation	KTYRQTSTLAMHKRS CEEEECCCEEEEEHH	23.17	22817900
396	Phosphorylation	AASAAEESPPPKRPR HHHHHHHCCCCCCCC	33.92	24719451
408	Phosphorylation	RPRIAYLSEVKEERD CCCEEEEHHHHHHCC	27.89	29083192
411	Ubiquitination	IAYLSEVKEERDDIP EEEEHHHHHHCCCCC	50.21	-
411	Sumoylation	IAYLSEVKEERDDIP EEEEHHHHHHCCCCC	50.21	-
411	Sumoylation	IAYLSEVKEERDDIP EEEEHHHHHHCCCCC	50.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF76_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF76_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF76_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_HUMAN	TBP	physical	15280358
PIAS1_HUMAN	PIAS1	physical	15280358
TBP_HUMAN	TBP	physical	16337145
GRHL1_HUMAN	GRHL1	physical	28514442
ZBTB1_HUMAN	ZBTB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.