GRHL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRHL1_HUMAN
• UniProt AC: Q9NZI5
• Protein Name: Grainyhead-like protein 1 homolog {ECO:0000312|HGNC:HGNC:17923}
• Gene Name: GRHL1 {ECO:0000312|HGNC:HGNC:17923}
• Organism: Homo sapiens (Human).
• Sequence Length: 618
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. [PubMed: 12175488]
• Protein Sequence: MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPTERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFANLQRGTHVLPIASEELEGEGSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTQEYDNKR ------CCCCCCCCC	30.06	28348404
5	Phosphorylation	---MTQEYDNKRPVL ---CCCCCCCCCCEE	18.26	27642862
25	Phosphorylation	ALYPQRRSYTSEDEA CCCCCCCCCCCHHHH	34.64	25159151
26	Phosphorylation	LYPQRRSYTSEDEAW CCCCCCCCCCHHHHH	16.69	29083192
27	Phosphorylation	YPQRRSYTSEDEAWK CCCCCCCCCHHHHHH	27.21	29083192
28	Phosphorylation	PQRRSYTSEDEAWKS CCCCCCCCHHHHHHH	34.51	25159151
35	Phosphorylation	SEDEAWKSFLENPLT CHHHHHHHHHHCHHH	25.10	25159151
50	Phosphorylation	AATKAMMSINGDEDS HHHHHHHHCCCCHHH	10.38	-
57	Phosphorylation	SINGDEDSAAALGLL HCCCCHHHHHHHHHH	20.12	28348404
65	Phosphorylation	AAALGLLYDYYKVPR HHHHHHHHHHHHCCH	13.62	-
67	Phosphorylation	ALGLLYDYYKVPRER HHHHHHHHHHCCHHH	7.51	-
68	Phosphorylation	LGLLYDYYKVPRERR HHHHHHHHHCCHHHC	11.56	-
76	Phosphorylation	KVPRERRSSTAKPEV HCCHHHCCCCCCCCC	37.96	25394399
77	Phosphorylation	VPRERRSSTAKPEVE CCHHHCCCCCCCCCC	30.49	25394399
78	Phosphorylation	PRERRSSTAKPEVEH CHHHCCCCCCCCCCC	39.69	29496963
95	Phosphorylation	PDHSKRNSIPIVTEQ CCCCCCCCCCEECCC	33.50	25849741
196	Phosphorylation	NLNTDQFSSGAQAPN CCCCHHCCCCCCCCC	23.41	27251275
197	Phosphorylation	LNTDQFSSGAQAPNA CCCHHCCCCCCCCCC	39.16	27251275
208	Phosphorylation	APNAQRRTPDSTFSE CCCCCCCCCCCCHHH	33.37	12175488
211	Phosphorylation	AQRRTPDSTFSETFK CCCCCCCCCHHHHHH	32.33	23312004
212	Phosphorylation	QRRTPDSTFSETFKE CCCCCCCCHHHHHHH	38.26	23312004
214	Phosphorylation	RTPDSTFSETFKEGV CCCCCCHHHHHHHHH	35.50	27251275
216	Phosphorylation	PDSTFSETFKEGVQE CCCCHHHHHHHHHHE	38.52	27251275
228	Phosphorylation	VQEVFFPSDLSLRMP HHEEECCCCCCCCCC	46.13	28348404
231	Phosphorylation	VFFPSDLSLRMPGMN EECCCCCCCCCCCCC	20.94	24719451
414	Phosphorylation	NKPVHRAYCQIKVFC CCCCEEEEEEEEEEE	5.71	22817900
442	Phosphorylation	KQSKRKVSDVKVPLL HHHCCCCCCCCCCCC	39.46	-
493	Phosphorylation	THVLPIASEELEGEG CEEEEECCCCCCCCC	32.12	27251275
501	Phosphorylation	EELEGEGSVLKRGPY CCCCCCCCEECCCCC	21.70	24719451
534	Phosphorylation	EPKRVLLYVRKESEE CCCEEEEEEECCCHH	8.27	20049867
539	Phosphorylation	LLYVRKESEEVFDAL EEEEECCCHHHHHHH	41.93	27251275
564	Phosphorylation	MEAISDKYDVPHDKI HHHHHHCCCCCHHHH	27.45	22817900
573	Acetylation	VPHDKIGKIFKKCKK CCHHHHHHHHHHHCC	48.74	7978765
576	Acetylation	DKIGKIFKKCKKGIL HHHHHHHHHHCCCEE	61.81	7978775
594	Phosphorylation	DDNIVKHYSNEDTFQ CCCEEECCCCCCEEE	13.89	-
611	Phosphorylation	IEEAGGSYKLTLTEI EEECCCEEEEEEEEC	17.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRHL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRHL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRHL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GRHL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.