K1143_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1143_HUMAN
• UniProt AC: Q96AT1
• Protein Name: Uncharacterized protein KIAA1143
• Gene Name: KIAA1143
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Protein Sequence: MSKRNQVSYVRPAEPAFLARFKERVGYREGPTVETKRIQPQPPDEDGDHSDKEDEQPQVVVLKKGDLSVEEVMKIKAEIKAAKADEEPTPADGRIIYRKPVKHPSDEKYSGLTASSKKKKPNEDEVNQDSVKKNSQKQIKNSSLLSFDNEDENE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKRNQVSY ------CCCCCCCCC	40.08	26074081
4	Methylation	----MSKRNQVSYVR ----CCCCCCCCCCC	31.35	115481029
8	Phosphorylation	MSKRNQVSYVRPAEP CCCCCCCCCCCCCCH	14.24	21945579
9	Phosphorylation	SKRNQVSYVRPAEPA CCCCCCCCCCCCCHH	11.13	21945579
11	Methylation	RNQVSYVRPAEPAFL CCCCCCCCCCCHHHH	19.24	115481013
20	Methylation	AEPAFLARFKERVGY CCHHHHHHHHHHHCC	45.37	115481021
32	Phosphorylation	VGYREGPTVETKRIQ HCCCCCCCEEEEECC	41.66	26074081
35	Phosphorylation	REGPTVETKRIQPQP CCCCCEEEEECCCCC	22.68	26074081
36	Acetylation	EGPTVETKRIQPQPP CCCCEEEEECCCCCC	33.72	23749302
36	Ubiquitination	EGPTVETKRIQPQPP CCCCEEEEECCCCCC	33.72	-
50	Phosphorylation	PDEDGDHSDKEDEQP CCCCCCCCCCCCCCC	55.93	29255136
68	Phosphorylation	VLKKGDLSVEEVMKI EEECCCCCHHHHHHH	32.02	21815630
73	Sulfoxidation	DLSVEEVMKIKAEIK CCCHHHHHHHHHHHH	4.14	21406390
105	Phosphorylation	RKPVKHPSDEKYSGL ECCCCCCCCCCCCCC	59.11	26055452
108	Acetylation	VKHPSDEKYSGLTAS CCCCCCCCCCCCCCC	50.10	19608861
109	Phosphorylation	KHPSDEKYSGLTASS CCCCCCCCCCCCCCC	13.11	28796482
110	Phosphorylation	HPSDEKYSGLTASSK CCCCCCCCCCCCCCC	38.09	28796482
113	Phosphorylation	DEKYSGLTASSKKKK CCCCCCCCCCCCCCC	28.19	22199227
115	Phosphorylation	KYSGLTASSKKKKPN CCCCCCCCCCCCCCC	37.14	25159151
116	Phosphorylation	YSGLTASSKKKKPNE CCCCCCCCCCCCCCC	46.13	23401153
117	Acetylation	SGLTASSKKKKPNED CCCCCCCCCCCCCCC	67.14	25953088
119	Acetylation	LTASSKKKKPNEDEV CCCCCCCCCCCCCCC	76.75	30584283
120	Acetylation	TASSKKKKPNEDEVN CCCCCCCCCCCCCCC	63.05	30584289
130	Phosphorylation	EDEVNQDSVKKNSQK CCCCCHHHHHHHHHH	26.52	25159151
133	Acetylation	VNQDSVKKNSQKQIK CCHHHHHHHHHHHHH	60.73	30584295
135	Phosphorylation	QDSVKKNSQKQIKNS HHHHHHHHHHHHHHH	47.86	26074081
142	Phosphorylation	SQKQIKNSSLLSFDN HHHHHHHHHCCCCCC	19.84	30266825
143	Phosphorylation	QKQIKNSSLLSFDNE HHHHHHHHCCCCCCC	42.60	30266825
146	Phosphorylation	IKNSSLLSFDNEDEN HHHHHCCCCCCCCCC	35.53	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1143_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1143_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1143_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CEP76_HUMAN	CEP76	physical	25416956
CEP76_HUMAN	CEP76	physical	21516116
AQR_HUMAN	AQR	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
ECD_HUMAN	ECD	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
EAPP_HUMAN	EAPP	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
ZNHI2_HUMAN	ZNHIT2	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
AAR2_HUMAN	AAR2	physical	28514442
BTBD9_HUMAN	BTBD9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-108, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-146, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-146, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-146, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-130, AND MASSSPECTROMETRY.
PubMed: 17287340

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-146, AND MASSSPECTROMETRY.
PubMed: 17081983