CCD12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD12_HUMAN
• UniProt AC: Q8WUD4
• Protein Name: Coiled-coil domain-containing protein 12
• Gene Name: CCDC12
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Protein Sequence: MEATTAGVGRLEEEALRRKERLKALREKTGRKDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAATEQKTCDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEATTAGV -------CCCCCCCC	7.74	22814378
53	Acetylation	EEEEEGEKHRELRLR HHHHHHHHHHHHHHH	59.84	-
62	Phosphorylation	RELRLRNYVPEDEDL HHHHHHHCCCCCHHH	15.79	28674419
78	Acetylation	KRRVPQAKPVAVEEK HCCCCCCCCCCHHHH	34.47	23749302
85	Sumoylation	KPVAVEEKVKEQLEA CCCCHHHHHHHHHHH	45.13	-
85	Sumoylation	KPVAVEEKVKEQLEA CCCCHHHHHHHHHHH	45.13	-
94	Sumoylation	KEQLEAAKPEPVIEE HHHHHHCCCCCCEEH	57.89	-
94	Ubiquitination	KEQLEAAKPEPVIEE HHHHHHCCCCCCEEH	57.89	-
94	Sumoylation	KEQLEAAKPEPVIEE HHHHHHCCCCCCEEH	57.89	28112733
111	Ubiquitination	LANLAPRKPDWDLKR HHHCCCCCCCCCHHH	46.39	-
129	Acetylation	KKLEKLKKRTQRAIA HHHHHHHHHHHHHHH	71.73	7226449
144	Ubiquitination	ELIRERLKGQEDSLA HHHHHHHCCCCCHHH	65.84	-
149	Phosphorylation	RLKGQEDSLASAVDA HHCCCCCHHHHHHHH	25.69	23401153
152	Phosphorylation	GQEDSLASAVDAATE CCCCHHHHHHHHHHH	33.83	30266825
158	Phosphorylation	ASAVDAATEQKTCDS HHHHHHHHHHHCCCC	40.44	30266825
162	Phosphorylation	DAATEQKTCDSD--- HHHHHHHCCCCC---	22.65	30266825
165	Phosphorylation	TEQKTCDSD------ HHHHCCCCC------	47.57	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRNL1_HUMAN	CRNKL1	physical	22365833
CHM4C_HUMAN	CHMP4C	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-165, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-165, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.
PubMed: 18669648