DHX35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX35_HUMAN
• UniProt AC: Q9H5Z1
• Protein Name: Probable ATP-dependent RNA helicase DHX35
• Gene Name: DHX35
• Organism: Homo sapiens (Human).
• Sequence Length: 703
• Protein Description: May be involved in pre-mRNA splicing..
• Protein Sequence: MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Acetylation	AAPVGPVKFWRPGTE CCCCCCCEEECCCCC	42.20	25953088
9	Ubiquitination	AAPVGPVKFWRPGTE CCCCCCCEEECCCCC	42.20	-
19	Ubiquitination	RPGTEGPGVSISEER CCCCCCCCCCCCHHH	36.34	22817900
41	Ubiquitination	GTTVVYNPYAALSIE CCEEEECCCCCCCHH	11.49	21987572
53	Ubiquitination	SIEQQRQKLPVFKLR CHHHHHCCCCHHHHH	57.88	-
106	Phosphorylation	EGRVVGVTQPRRVAA ECEEEEECCCCCEEE	27.25	-
143	Ubiquitination	IRFDDCTDQLATRIK EEECCCCHHHHHHHH	48.07	22817900
147	Phosphorylation	DCTDQLATRIKFLTD CCCHHHHHHHHHHHC	41.33	26074081
150	Ubiquitination	DQLATRIKFLTDGML HHHHHHHHHHHCCHH	30.91	-
153	Phosphorylation	ATRIKFLTDGMLVRE HHHHHHHHCCHHHHH	33.37	26074081
168	Phosphorylation	MMVDPLLTKYSVIML HCCCHHHHCCEEEEC	35.30	26074081
169	Ubiquitination	MVDPLLTKYSVIMLD CCCHHHHCCEEEECC	35.18	-
170	Phosphorylation	VDPLLTKYSVIMLDE CCHHHHCCEEEECCC	11.70	26074081
171	Phosphorylation	DPLLTKYSVIMLDEA CHHHHCCEEEECCCH	13.51	26074081
194	Ubiquitination	IAIGLLKKIQKKRGD HHHHHHHHHHHHCCC	50.79	-
203	Ubiquitination	QKKRGDLRLIVASAT HHHCCCEEEEEEEEE	27.40	24816145
215	Ubiquitination	SATLDADKFRDFFNQ EEECCHHHHHHHHHC	43.98	-
249	Phosphorylation	TFPVDIFYLQSPVPD EEEEEEEEECCCCCC	12.26	-
252	Phosphorylation	VDIFYLQSPVPDYIK EEEEEECCCCCCHHH	25.85	-
257	Phosphorylation	LQSPVPDYIKSTVET ECCCCCCHHHHHHHE	12.27	-
258	Ubiquitination	QSPVPDYIKSTVETV CCCCCCHHHHHHHEE	3.56	21963094
280	Ubiquitination	GDGDVLAFLTGQEEV CCCCEEEEEECCHHH	5.69	21987572
316	Phosphorylation	HLRVLPMYAGLPSFE HHCHHHHHCCCCCHH	8.79	25072903
321	Phosphorylation	PMYAGLPSFEQMKVF HHHCCCCCHHHHHHH	46.59	25072903
326	Ubiquitination	LPSFEQMKVFERVSR CCCHHHHHHHHHHHH	43.39	-
356	Phosphorylation	ITISGIVYVIDCGFV EEEECEEEEEECCCE	6.97	-
382	Ubiquitination	ECLVVVPVSQASANQ EEEEEEECCHHHHCC	4.47	21963094
404	Ubiquitination	SRSGKCYRLYTEEAF CCCCCCEEEECHHHH	30.59	21987572
413	Ubiquitination	YTEEAFDKLPQSTVP ECHHHHHCCCCCCCH	56.46	21906983
435	Ubiquitination	APVILQLKALGIDNV HHHHHHHHHCCCCCE	28.71	21987572
442	Ubiquitination	KALGIDNVLRFHFMS HHCCCCCEEEEEECC	3.44	24816145
464	Phosphorylation	VQALELLYALGGLDK HHHHHHHHHCCCCCC	16.65	22468782
476	Phosphorylation	LDKDCRLTEPLGMRI CCCCCCCCCCCCCEE	19.06	-
491	Sulfoxidation	AEFPLNPMFAKMLLE EECCCCHHHHHHHHH	5.06	21406390
506	Ubiquitination	SGNFGCSQEILSIAA CCCCCCCHHHHHHHH	45.91	22817900
532	Ubiquitination	PNQKSHAIRVHRKFA CCCCCCEEEEEEEEE	3.86	29967540
537	Ubiquitination	HAIRVHRKFAVEEGD CEEEEEEEEEECCCC	23.85	22817900
560	Ubiquitination	EAFIKHNKDSKWCQE HHHHHCCCCCHHHHH	64.20	29967540
563	Ubiquitination	IKHNKDSKWCQEHFL HHCCCCCHHHHHHHC	63.22	29967540
566	Ubiquitination	NKDSKWCQEHFLNYK CCCCHHHHHHHCCHH	46.19	24816145
571	Ubiquitination	WCQEHFLNYKGLVRA HHHHHHCCHHHHHHH	35.21	24816145
573	Ubiquitination	QEHFLNYKGLVRAAT HHHHCCHHHHHHHHH	44.70	-
591	Ubiquitination	QLKKLLVKFQVPRKS HHHHHHHHCCCCCCC	30.01	29967540
597	Ubiquitination	VKFQVPRKSSEGDPD HHCCCCCCCCCCCCH	52.87	24816145
627	Phosphorylation	RFHSTGAYRTIRDDH HCCCCCCCCEECCCC	15.05	-
648	Ubiquitination	ASVLYAEKPPRWVIY CCEEECCCCCCEEEE	52.75	-
655	Phosphorylation	KPPRWVIYNEVIQTS CCCCEEEEEHHHHCC	8.82	25907765
661	Phosphorylation	IYNEVIQTSKYYMRD EEEHHHHCCCCCCCC	18.96	25907765
662	Phosphorylation	YNEVIQTSKYYMRDV EEHHHHCCCCCCCCC	11.41	25907765
664	Phosphorylation	EVIQTSKYYMRDVTA HHHHCCCCCCCCCHH	11.40	29759185
670	Phosphorylation	KYYMRDVTAIESAWL CCCCCCCHHHHHHHH	26.63	29759185
692	Phosphorylation	YQQGTHLSLKAKRAK HHCCCCEEHHHHHHC	21.88	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX35_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DHX35_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.