| UniProt ID | PAXB1_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5B6 | |
| Protein Name | PAX3- and PAX7-binding protein 1 | |
| Gene Name | PAXBP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 917 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).. | |
| Protein Sequence | MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | NVRKRNDSEEEERER CCCCCCCCHHHHHHH | 28355574 | ||
| 38 | Phosphorylation | PLLPPPGTGEEAGPG CCCCCCCCCCCCCCC | 20873877 | ||
| 55 | Phosphorylation | DRAPGGESLLGPGPS CCCCCCCCCCCCCCC | 25850435 | ||
| 62 | Phosphorylation | SLLGPGPSPPSALTP CCCCCCCCCCCCCCC | 26055452 | ||
| 65 | Phosphorylation | GPGPSPPSALTPGLG CCCCCCCCCCCCCCC | 25850435 | ||
| 68 | Phosphorylation | PSPPSALTPGLGAEA CCCCCCCCCCCCCCC | 25850435 | ||
| 108 | Phosphorylation | VPRASLLSFQDEEEE CCHHHHHCCCCCHHH | 25159151 | ||
| 121 | Methylation | EENEEVFKVKKSSYS HHCHHHEEECHHHHH | - | ||
| 123 | Methylation | NEEVFKVKKSSYSKK CHHHEEECHHHHHHH | - | ||
| 149 | Sumoylation | DLEKSKIKTELNSSA HHHHHHCCHHHCCCC | - | ||
| 149 | Sumoylation | DLEKSKIKTELNSSA HHHHHHCCHHHCCCC | 25114211 | ||
| 150 | Phosphorylation | LEKSKIKTELNSSAE HHHHHCCHHHCCCCC | 21712546 | ||
| 154 | Phosphorylation | KIKTELNSSAESEQP HCCHHHCCCCCCCCC | 25159151 | ||
| 155 | Phosphorylation | IKTELNSSAESEQPL CCHHHCCCCCCCCCC | 25159151 | ||
| 158 | Phosphorylation | ELNSSAESEQPLDKT HHCCCCCCCCCCCCC | 25159151 | ||
| 164 | Acetylation | ESEQPLDKTGHVKDT CCCCCCCCCCCCCCC | 23236377 | ||
| 171 | Phosphorylation | KTGHVKDTNQEDGVI CCCCCCCCCCCCCEE | 21955146 | ||
| 180 | Phosphorylation | QEDGVIISEHGEDEM CCCCEEEECCCCCCC | 30576142 | ||
| 191 | Phosphorylation | EDEMDMESEKEEEKP CCCCCCHHHCHHCCC | 21955146 | ||
| 193 | Acetylation | EMDMESEKEEEKPKT CCCCHHHCHHCCCCC | 7339679 | ||
| 197 | Sumoylation | ESEKEEEKPKTGGAF HHHCHHCCCCCCCHH | - | ||
| 197 | Sumoylation | ESEKEEEKPKTGGAF HHHCHHCCCCCCCHH | - | ||
| 210 | Phosphorylation | AFSNALSSLNVLRPG HHHHHHHHCCCCCCC | 28555341 | ||
| 242 | Phosphorylation | ARELGDFTPHDNEPG HHHHCCCCCCCCCCC | 26657352 | ||
| 250 | Acetylation | PHDNEPGKGRLVRED CCCCCCCCCCCCCCC | 25953088 | ||
| 262 | Phosphorylation | REDENDASDDEDDDE CCCCCCCCCCCCCHH | 20201521 | ||
| 276 | Phosphorylation | EKRRIVFSVKEKSQR HHHHHEEEECCHHHH | 23312004 | ||
| 278 | Acetylation | RRIVFSVKEKSQRQK HHHEEEECCHHHHHH | 23749302 | ||
| 295 | Phosphorylation | EEIGIEGSDDDALVT HHHCCCCCCCCCEEC | 30266825 | ||
| 302 | Phosphorylation | SDDDALVTGEQDEEL CCCCCEECCCCCHHH | 28176443 | ||
| 377 | Acetylation | TDNTVPFKTPSNEMT CCCCCCCCCCCCCCC | 25953088 | ||
| 378 | Phosphorylation | DNTVPFKTPSNEMTP CCCCCCCCCCCCCCC | 20068231 | ||
| 380 | Phosphorylation | TVPFKTPSNEMTPVT CCCCCCCCCCCCCCH | 20068231 | ||
| 383 | Sulfoxidation | FKTPSNEMTPVTIDL CCCCCCCCCCCHHHH | 21406390 | ||
| 384 | Phosphorylation | KTPSNEMTPVTIDLV CCCCCCCCCCHHHHH | 27732954 | ||
| 387 | Phosphorylation | SNEMTPVTIDLVKKQ CCCCCCCHHHHHHHH | 20068231 | ||
| 401 | O-linked_Glycosylation | QLKDRLDSMKELHKT HHHHHHHHHHHHHHH | 30379171 | ||
| 433 | Phosphorylation | AIERLEGSSGGIGER HHHHHHCCCCCHHHH | 20860994 | ||
| 434 | Phosphorylation | IERLEGSSGGIGERY HHHHHCCCCCHHHHH | 26699800 | ||
| 441 | Phosphorylation | SGGIGERYKFLQEMR CCCHHHHHHHHHHHH | 26699800 | ||
| 442 | Ubiquitination | GGIGERYKFLQEMRG CCHHHHHHHHHHHHH | - | ||
| 476 | Phosphorylation | ESAIHQLYKQRASRL HHHHHHHHHHHHHHH | - | ||
| 492 | Acetylation | QRRQDDIKDESSEFS HHHHHHCCCCCHHCH | 26051181 | ||
| 492 | Sumoylation | QRRQDDIKDESSEFS HHHHHHCCCCCHHCH | - | ||
| 492 | Sumoylation | QRRQDDIKDESSEFS HHHHHHCCCCCHHCH | - | ||
| 495 | Phosphorylation | QDDIKDESSEFSSHS HHHCCCCCHHCHHHC | 20873877 | ||
| 496 | Phosphorylation | DDIKDESSEFSSHSN HHCCCCCHHCHHHCC | 20873877 | ||
| 507 | Sulfoxidation | SHSNKALMAPNLDSF HHCCCCEECCCHHHC | 21406390 | ||
| 513 | Phosphorylation | LMAPNLDSFGRDRAL EECCCHHHCCCHHHH | 28555341 | ||
| 521 | Phosphorylation | FGRDRALYQEHAKRR CCCHHHHHHHHHHHH | 27642862 | ||
| 546 | Phosphorylation | RRQAREQTGKMADHL HHHHHHHHHCHHHHH | 22468782 | ||
| 557 | Phosphorylation | ADHLEGLSSDDEETS HHHHCCCCCCCCCCC | 20201521 | ||
| 558 | Phosphorylation | DHLEGLSSDDEETST HHHCCCCCCCCCCCC | 20201521 | ||
| 563 | Phosphorylation | LSSDDEETSTDITNF CCCCCCCCCCCCCCC | 21955146 | ||
| 564 | Phosphorylation | SSDDEETSTDITNFN CCCCCCCCCCCCCCC | 30278072 | ||
| 565 | Phosphorylation | SDDEETSTDITNFNL CCCCCCCCCCCCCCH | 25022875 | ||
| 568 | Phosphorylation | EETSTDITNFNLEKD CCCCCCCCCCCHHHH | 23403867 | ||
| 624 | Ubiquitination | YIGLCLPKLFNPLIR CHHHHHHHHHCHHHH | - | ||
| 682 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 682 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 682 | Ubiquitination | LLPTIVEKVILPKLT HHHHHHHHCHHHCCE | 21890473 | ||
| 718 | Phosphorylation | TLKLINGYPSVVNAE EEEECCCCCCCCCCC | 23403867 | ||
| 720 | Phosphorylation | KLINGYPSVVNAENK EECCCCCCCCCCCCC | 23403867 | ||
| 729 | Phosphorylation | VNAENKNTQVYLKAL CCCCCCCHHHHHHHH | 22461510 | ||
| 732 | Phosphorylation | ENKNTQVYLKALLLR CCCCHHHHHHHHHHH | 23612710 | ||
| 807 | Phosphorylation | IDGLLNRYILMAFQN HHHHHHHHHHHHHHC | 26270265 | ||
| 815 | Phosphorylation | ILMAFQNSEYGDDSI HHHHHHCCCCCCHHH | 26270265 | ||
| 817 | Phosphorylation | MAFQNSEYGDDSIKK HHHHCCCCCCHHHHH | 26270265 | ||
| 834 | Acetylation | NVINCFPKQWFMNLK HHHHHCCHHHHHHCC | 26051181 | ||
| 855 | Phosphorylation | QLENFCRYLVHLADT HHHHHHHHHHHHHHH | 20068231 | ||
| 875 | Acetylation | IGCSDVEKRNARENI CCCCHHHHHHHHHHH | 26051181 | ||
| 887 | Acetylation | ENIKQIVKLLASVRA HHHHHHHHHHHHHHH | 25953088 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAXB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAXB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAXB1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PAXB1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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