AQR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AQR_HUMAN
• UniProt AC: O60306
• Protein Name: RNA helicase aquarius {ECO:0000303|PubMed:25599396}
• Gene Name: AQR
• Organism: Homo sapiens (Human).
• Sequence Length: 1485
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Localizes to speckle-like regions of the nucleoplasm.
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 11991638]
• Protein Sequence: MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWEIFKKKPDHFPFFFKHILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQLARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSNLVRREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDTRESLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVEDPALQIPPFRITFPVRSGKGKKRKDADVEDEDTEEAKTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYISKVKNKGSTLPDVTEVSTFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTTRKNGERPSHEVQIIKNMPQMANFVYNMYMHLIQTTHHYHQTLLQLPPAMVEEGEEVQNQETELETEEEAMTVQADIIPSPTDTSCRQETPAFQTDTTPSETGATSTPEAIPALSETTPTVVGAVSAPAEANTPQDATSAPEETK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MAAPAQPKKIVAPTV CCCCCCCCCEECCCH	42.95	-
9	Ubiquitination	AAPAQPKKIVAPTVS CCCCCCCCEECCCHH	49.44	-
14	Phosphorylation	PKKIVAPTVSQINAE CCCEECCCHHHHCHH	24.05	28450419
16	Phosphorylation	KIVAPTVSQINAEFV CEECCCHHHHCHHHH	28.02	28464451
24	Phosphorylation	QINAEFVTQLACKYW HHCHHHHHHHHHHHH	24.16	27251275
44	Ubiquitination	KKSPFDIKVIEDIYE CCCCCCEEEECHHHH	38.72	-
50	Phosphorylation	IKVIEDIYEKEIVKS EEEECHHHHHHHHHH	33.02	-
52	Ubiquitination	VIEDIYEKEIVKSRF EECHHHHHHHHHHHH	35.45	-
52	Acetylation	VIEDIYEKEIVKSRF EECHHHHHHHHHHHH	35.45	26051181
56	Acetylation	IYEKEIVKSRFAIRK HHHHHHHHHHHHHHH	41.39	26051181
188	Ubiquitination	ARLELELKKTPKLRK HHHHHHHCCCHHHHH	45.27	-
195	Acetylation	KKTPKLRKFWNLIKK CCCHHHHHHHHHHHH	66.23	25953088
201	Acetylation	RKFWNLIKKNDEKMD HHHHHHHHHCCCCCC	49.00	25953088
201	Ubiquitination	RKFWNLIKKNDEKMD HHHHHHHHHCCCCCC	49.00	21890473
201	Ubiquitination	RKFWNLIKKNDEKMD HHHHHHHHHCCCCCC	49.00	21890473
223	Phosphorylation	YQERRFLSQLIQKFI HHHHHHHHHHHHHHH	21.89	20068231
235	Phosphorylation	KFISVLKSVPLSEPV HHHHHHHCCCCCCCC	25.47	20068231
235	O-linked_Glycosylation	KFISVLKSVPLSEPV HHHHHHHCCCCCCCC	25.47	23301498
239	Phosphorylation	VLKSVPLSEPVTMDK HHHCCCCCCCCCCCH	33.51	20068231
243	O-linked_Glycosylation	VPLSEPVTMDKVHYC CCCCCCCCCCHHHHH	30.30	23301498
243	Phosphorylation	VPLSEPVTMDKVHYC CCCCCCCCCCHHHHH	30.30	20068231
244	Sulfoxidation	PLSEPVTMDKVHYCE CCCCCCCCCHHHHHH	4.83	21406390
246	Ubiquitination	SEPVTMDKVHYCERF CCCCCCCHHHHHHHH	21.79	-
246	2-Hydroxyisobutyrylation	SEPVTMDKVHYCERF CCCCCCCHHHHHHHH	21.79	-
284	Phosphorylation	SHLLVHCYLSNLVRR HHHHHHHHHHHHHHH	9.78	-
286	Phosphorylation	LLVHCYLSNLVRREE HHHHHHHHHHHHHHC	11.14	-
308	Phosphorylation	LLDMLKFYTGFEIND HHHHHHHHHCCEECC	12.36	26552605
309	Phosphorylation	LDMLKFYTGFEINDQ HHHHHHHHCCEECCC	38.23	26552605
317	Phosphorylation	GFEINDQTGNALTEN CCEECCCCCCCCCCC	34.95	26552605
322	Phosphorylation	DQTGNALTENEMTTI CCCCCCCCCCCCCEE	34.06	26552605
327	Phosphorylation	ALTENEMTTIHYDRI CCCCCCCCEEEHHHH	19.20	26552605
328	Phosphorylation	LTENEMTTIHYDRIT CCCCCCCEEEHHHHH	12.40	26552605
331	Phosphorylation	NEMTTIHYDRITSLQ CCCCEEEHHHHHHHH	11.76	26552605
335	Phosphorylation	TIHYDRITSLQRAAF EEEHHHHHHHHHHHH	25.03	20068231
396	Phosphorylation	TLPKNEDTTFDKEFL CCCCCCCCCCCHHHH	24.16	20860994
409	Phosphorylation	FLLELLVSRHERRIS HHHHHHHHHHHHHHH	28.08	24719451
416	Phosphorylation	SRHERRISQIQQLNQ HHHHHHHHHHHHHHC	21.30	23663014
427	Phosphorylation	QLNQMPLYPTEKIIW HHHCCCCCCCCCEEC	11.39	23663014
429	Phosphorylation	NQMPLYPTEKIIWDE HCCCCCCCCCEECCC	36.03	23663014
493	Ubiquitination	EDSVSRMKPWQSEYG HHHHHHCCCCHHHCC	41.83	-
499	Phosphorylation	MKPWQSEYGGVVFGG CCCCHHHCCCEEECH	25.15	-
576	Acetylation	PTKPYGTKFDRRRPF CCCCCCCCCCCCCCH	40.69	23236377
591	Phosphorylation	IEQVGLVYVRGCEIQ HHHHEEEEEECCEEE	6.89	29449344
604	Acetylation	IQGMLDDKGRVIEDG EECEECCCCCCCCCC	48.56	25953088
604	Ubiquitination	IQGMLDDKGRVIEDG EECEECCCCCCCCCC	48.56	-
622	Phosphorylation	RPNLRGESRTFRVFL CCCCCCCCEEEEEEE	39.17	24719451
667	Acetylation	KPKENNFKAVLETIR CCCCCCHHHHHHHHH	39.44	26051181
667	Ubiquitination	KPKENNFKAVLETIR CCCCCCHHHHHHHHH	39.44	-
672	Phosphorylation	NFKAVLETIRNLMNT CHHHHHHHHHHHCCC	22.52	20068231
771	Phosphorylation	ADVEDEDTEEAKTLI CCCCCCCCHHHHHEE	33.41	21815630
775	Ubiquitination	DEDTEEAKTLIVEPH CCCCHHHHHEEECCC	47.33	-
776	Phosphorylation	EDTEEAKTLIVEPHV CCCHHHHHEEECCCC	28.85	-
799	Phosphorylation	YNQPKRNTIQFTHTQ CCCCCCCEEEECHHH	21.86	25867546
803	Phosphorylation	KRNTIQFTHTQIEAI CCCEEEECHHHHHHH	13.98	25867546
805	Phosphorylation	NTIQFTHTQIEAIRA CEEEECHHHHHHHHC	28.34	25867546
819	Phosphorylation	AGMQPGLTMVVGPPG CCCCCCCEEEECCCC	17.52	25867546
827	Phosphorylation	MVVGPPGTGKTDVAV EEECCCCCCCHHHHH	41.08	25867546
841	Phosphorylation	VQIISNIYHNFPEQR HHHHHHHHHHCCCCC	8.58	-
867	Sulfoxidation	NQLFEKIMALDIDER HHHHHHHHCCCCCHH	4.48	21406390
888	Phosphorylation	HGEEELETEKDFSRY CCHHHHCCHHCHHHH	62.04	25690035
890	Ubiquitination	EEELETEKDFSRYGR HHHHCCHHCHHHHHH	72.06	-
934	Phosphorylation	YTCETAGYFFLYQVM HHHHHHHHHHHHHHH	6.68	-
942	Phosphorylation	FFLYQVMSRWEEYIS HHHHHHHHHHHHHHH	35.07	-
957	Phosphorylation	KVKNKGSTLPDVTEV HHHCCCCCCCCCCCC	51.48	25627689
1025	Acetylation	RSGLDRSKYLLVKEA HCCCCHHHHHHHHHH	40.59	26051181
1030	Acetylation	RSKYLLVKEAKIIAM HHHHHHHHHHHHHHH	52.50	26051181
1033	Ubiquitination	YLLVKEAKIIAMTCT HHHHHHHHHHHHHCH	35.42	-
1045	Acetylation	TCTHAALKRHDLVKL HCHHHHHHHCCHHHH	42.85	23749302
1045	Malonylation	TCTHAALKRHDLVKL HCHHHHHHHCCHHHH	42.85	26320211
1051	Malonylation	LKRHDLVKLGFKYDN HHHCCHHHHCCCCCC	50.63	26320211
1051	Acetylation	LKRHDLVKLGFKYDN HHHCCHHHHCCCCCC	50.63	19608861
1111	Acetylation	IKNMAFQKYSNMEQS HHHHHHHHHCCHHHH	44.16	26051181
1111	Ubiquitination	IKNMAFQKYSNMEQS HHHHHHHHHCCHHHH	44.16	2190698
1112	Ubiquitination	KNMAFQKYSNMEQSL HHHHHHHHCCHHHHH	8.42	21890473
1234	Acetylation	LTTYNGQKHLIRDII EEECCCCEEHHHHHH	41.60	26051181
1256	Ubiquitination	PLIGRPNKVTTVDRF CCCCCCCCCCEEECC	43.57	-
1274	Phosphorylation	QNDYILLSLVRTRAV CCCEEEEHHHHHHHC	22.75	24719451
1412	Phosphorylation	ETEEEAMTVQADIIP CCHHHHHHHEEEECC	19.26	26074081
1420	Phosphorylation	VQADIIPSPTDTSCR HEEEECCCCCCCCCC	29.98	26074081
1422	Phosphorylation	ADIIPSPTDTSCRQE EEECCCCCCCCCCCC	57.13	26074081
1424	Phosphorylation	IIPSPTDTSCRQETP ECCCCCCCCCCCCCC	32.00	26074081
1425	Phosphorylation	IPSPTDTSCRQETPA CCCCCCCCCCCCCCC	15.31	26074081
1430	Phosphorylation	DTSCRQETPAFQTDT CCCCCCCCCCCCCCC	16.16	26074081
1435	Phosphorylation	QETPAFQTDTTPSET CCCCCCCCCCCCCCC	28.94	26074081
1437	Phosphorylation	TPAFQTDTTPSETGA CCCCCCCCCCCCCCC	43.95	26074081
1438	Phosphorylation	PAFQTDTTPSETGAT CCCCCCCCCCCCCCC	27.85	26074081
1440	Phosphorylation	FQTDTTPSETGATST CCCCCCCCCCCCCCC	45.78	26074081
1442	Phosphorylation	TDTTPSETGATSTPE CCCCCCCCCCCCCCC	36.13	26074081
1445	Phosphorylation	TPSETGATSTPEAIP CCCCCCCCCCCCHHH	34.18	26074081
1446	Phosphorylation	PSETGATSTPEAIPA CCCCCCCCCCCHHHC	41.24	26074081
1447	Phosphorylation	SETGATSTPEAIPAL CCCCCCCCCCHHHCC	22.31	26074081
1457	Phosphorylation	AIPALSETTPTVVGA HHHCCCCCCCCEEEE	34.40	26074081
1458	Phosphorylation	IPALSETTPTVVGAV HHCCCCCCCCEEEEE	16.95	26074081
1460	Phosphorylation	ALSETTPTVVGAVSA CCCCCCCCEEEEEEC	26.23	26074081
1466	Phosphorylation	PTVVGAVSAPAEANT CCEEEEEECCCCCCC	28.18	26074081
1473	Phosphorylation	SAPAEANTPQDATSA ECCCCCCCCCCCCCC	29.40	26074081
1478	Phosphorylation	ANTPQDATSAPEETK CCCCCCCCCCCCCCC	33.44	26074081
1479	Phosphorylation	NTPQDATSAPEETK- CCCCCCCCCCCCCC-	43.47	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AQR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AQR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AQR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PQBP1_HUMAN	PQBP1	physical	22365833
RBM22_HUMAN	RBM22	physical	22365833
WDR83_HUMAN	WDR83	physical	22365833
ZN830_HUMAN	ZNF830	physical	22365833
RBM4_HUMAN	RBM4	physical	22365833
MEP50_HUMAN	WDR77	physical	22365833
PP4R1_HUMAN	PPP4R1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-576 AND LYS-1051, AND MASSSPECTROMETRY.
PubMed: 19608861