dbPTM

T2EB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	T2EB_HUMAN
UniProt AC	P29084
Protein Name	Transcription initiation factor IIE subunit beta
Gene Name	GTF2E2
Organism	Homo sapiens (Human).
Sequence Length	291
Subcellular Localization	Nucleus .
Protein Description	Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase..
Protein Sequence	MDPSLLRERELFKKRALSTPVVEKRSASSESSSSSSKKKKTKVEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLDEILDETQHLDIGLKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNVRDKKALLRLLDQHDQRGLGGILLEDIEEALPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITSSK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPSLLRE -------CCHHHHHH	18.04	22814378
4	Phosphorylation	----MDPSLLREREL ----CCHHHHHHHHH	35.45	22673903
18	Phosphorylation	LFKKRALSTPVVEKR HHHHHCCCCCCCCCC	29.67	25159151
19	Phosphorylation	FKKRALSTPVVEKRS HHHHCCCCCCCCCCC	22.43	25159151
24	Acetylation	LSTPVVEKRSASSES CCCCCCCCCCCCCCC	39.79	23749302
26	Phosphorylation	TPVVEKRSASSESSS CCCCCCCCCCCCCCC	43.50	-
28	Phosphorylation	VVEKRSASSESSSSS CCCCCCCCCCCCCCC	35.57	28985074
29	Phosphorylation	VEKRSASSESSSSSS CCCCCCCCCCCCCCC	41.01	20068231
31	Phosphorylation	KRSASSESSSSSSKK CCCCCCCCCCCCCCC	37.15	29052541
32	Phosphorylation	RSASSESSSSSSKKK CCCCCCCCCCCCCCC	30.13	29052541
33	Phosphorylation	SASSESSSSSSKKKK CCCCCCCCCCCCCCC	43.44	29052541
34	Phosphorylation	ASSESSSSSSKKKKT CCCCCCCCCCCCCCC	40.35	29052541
35	Phosphorylation	SSESSSSSSKKKKTK CCCCCCCCCCCCCCC	48.39	29052541
36	Phosphorylation	SESSSSSSKKKKTKV CCCCCCCCCCCCCCC	50.90	29052541
48	Phosphorylation	TKVEHGGSSGSKQNS CCCCCCCCCCCCCCC	35.80	22210691
51	Phosphorylation	EHGGSSGSKQNSDHS CCCCCCCCCCCCCCC	32.77	29214152
52	Acetylation	HGGSSGSKQNSDHSN CCCCCCCCCCCCCCC	57.96	9285713
55	Phosphorylation	SSGSKQNSDHSNGSF CCCCCCCCCCCCCEE	33.92	21406692
58	Phosphorylation	SKQNSDHSNGSFNLK CCCCCCCCCCEEEEE	48.12	28450419
61	Phosphorylation	NSDHSNGSFNLKALS CCCCCCCEEEEEEEC	18.40	28450419
68	Phosphorylation	SFNLKALSGSSGYKF EEEEEEECCCCCCHH	41.30	27251275
70	Phosphorylation	NLKALSGSSGYKFGV EEEEECCCCCCHHHH	19.74	27251275
71	Phosphorylation	LKALSGSSGYKFGVL EEEECCCCCCHHHHH	50.06	28674419
74	Acetylation	LSGSSGYKFGVLAKI ECCCCCCHHHHHHHH	38.88	25953088
86	Ubiquitination	AKIVNYMKTRHQRGD HHHHHHHHHHHCCCC	31.86	29967540
87	Phosphorylation	KIVNYMKTRHQRGDT HHHHHHHHHHCCCCC	19.49	-
114	Ubiquitination	QHLDIGLKQKQWLMT CCCCCCHHHHHHHHH	50.68	21963094
116	Acetylation	LDIGLKQKQWLMTEA CCCCHHHHHHHHHHH	41.68	11924027
116	Ubiquitination	LDIGLKQKQWLMTEA CCCCHHHHHHHHHHH	41.68	22817900
121	Phosphorylation	KQKQWLMTEALVNNP HHHHHHHHHHHHHCC	18.88	21406692
129	Acetylation	EALVNNPKIEVIDGK HHHHHCCCEEEECCC	54.33	11924037
137	Phosphorylation	IEVIDGKYAFKPKYN EEEECCCCCCCCCCC	23.85	22817900
180	Ubiquitination	EALPNSQKAVKALGD HHCCCCHHHHHHHCC	55.77	32015554
183	Ubiquitination	PNSQKAVKALGDQIL CCCHHHHHHHCCEEE	42.63	-
197	2-Hydroxyisobutyrylation	LFVNRPDKKKILFFN EEECCCCCCEEEEEC	59.66	-
198	Acetylation	FVNRPDKKKILFFND EECCCCCCEEEEECC	53.04	7822997
206	Acetylation	KILFFNDKSCQFSVD EEEEECCCCCCCCCC	54.99	7823007
218	Ubiquitination	SVDEEFQKLWRSVTV CCCHHHHHHHHHCCC	56.17	29967540
224	Phosphorylation	QKLWRSVTVDSMDEE HHHHHHCCCCCCCHH	21.60	26852163
227	Phosphorylation	WRSVTVDSMDEEKIE HHHCCCCCCCHHHHH	24.64	21815630
236	Phosphorylation	DEEKIEEYLKRQGIS CHHHHHHHHHHCCCC	12.53	26852163
238	Ubiquitination	EKIEEYLKRQGISSM HHHHHHHHHCCCCHH	41.60	24816145
238	Methylation	EKIEEYLKRQGISSM HHHHHHHHHCCCCHH	41.60	-
245	Sulfoxidation	KRQGISSMQESGPKK HHCCCCHHHHHCCCC	4.01	21406390
248	Phosphorylation	GISSMQESGPKKVAP CCCHHHHHCCCCCCC	43.43	28985074
251	Ubiquitination	SMQESGPKKVAPIQR HHHHHCCCCCCCCCC	64.50	24816145
264	Phosphorylation	QRRKKPASQKKRRFK CCCCCCHHHHHHHHH	51.57	-
267	Ubiquitination	KKPASQKKRRFKTHN CCCHHHHHHHHHHHH	40.96	24816145
271	Ubiquitination	SQKKRRFKTHNEHLA HHHHHHHHHHHHHHH	47.25	29967540
272	Phosphorylation	QKKRRFKTHNEHLAG HHHHHHHHHHHHHHH	27.50	28555341
282	Ubiquitination	EHLAGVLKDYSDITS HHHHHHHHCHHHHHC	52.82	29967540
284	Phosphorylation	LAGVLKDYSDITSSK HHHHHHCHHHHHCCC	13.47	28796482
285	Phosphorylation	AGVLKDYSDITSSK- HHHHHCHHHHHCCC-	32.44	28796482
285	O-linked_Glycosylation	AGVLKDYSDITSSK- HHHHHCHHHHHCCC-	32.44	28510447
288	Phosphorylation	LKDYSDITSSK---- HHCHHHHHCCC----	31.75	29759185
289	Phosphorylation	KDYSDITSSK----- HCHHHHHCCC-----	36.14	28796482
290	Phosphorylation	DYSDITSSK------ CHHHHHCCC------	33.46	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of T2EB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of T2EB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of T2EB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2B_HUMAN	GTF2B	physical	12665589
T2EA_HUMAN	GTF2E1	physical	12665589
RPB1_HUMAN	POLR2A	physical	12665589
TF2AA_HUMAN	GTF2A1	physical	11509574
SND1_HUMAN	SND1	physical	7651391
T2EB_HUMAN	GTF2E2	physical	9677423
TPR_HUMAN	TPR	physical	17643375
ROA1_HUMAN	HNRNPA1	physical	17643375
MTA2_HUMAN	MTA2	physical	17643375
HS90B_HUMAN	HSP90AB1	physical	17643375
EXOC4_HUMAN	EXOC4	physical	17643375
DYN2_HUMAN	DNM2	physical	17643375
UBR5_HUMAN	UBR5	physical	17643375
A4_HUMAN	APP	physical	21832049
CRCM_HUMAN	MCC	physical	21988832
PBDC1_HUMAN	PBDC1	physical	22863883
SC24D_HUMAN	SEC24D	physical	22863883
EF1G_HUMAN	EEF1G	physical	26344197
KLF5_HUMAN	KLF5	physical	9089417
T2EA_HUMAN	GTF2E1	physical	28514442
EIF2A_HUMAN	EIF2A	physical	28514442
SBDS_HUMAN	SBDS	physical	28514442
MS18B_HUMAN	OIP5	physical	28514442
UBCP1_HUMAN	UBLCP1	physical	28514442
FA49B_HUMAN	FAM49B	physical	28514442
MS18A_HUMAN	MIS18A	physical	28514442
DNJC2_HUMAN	DNAJC2	physical	28514442
PHP14_HUMAN	PHPT1	physical	28514442
SLK_HUMAN	SLK	physical	28514442
SYNC_HUMAN	NARS	physical	28514442
TPP2_HUMAN	TPP2	physical	28514442
HDGR2_HUMAN	HDGFRP2	physical	28514442
PDC10_HUMAN	PDCD10	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
NAA15_HUMAN	NAA15	physical	28514442
VRK1_HUMAN	VRK1	physical	28514442
TOM34_HUMAN	TOMM34	physical	28514442
UBE2T_HUMAN	UBE2T	physical	28514442
HIBCH_HUMAN	HIBCH	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
RBM12_HUMAN	RBM12	physical	28514442
LYPA1_HUMAN	LYPLA1	physical	28514442
SYFB_HUMAN	FARSB	physical	28514442
MCTS1_HUMAN	MCTS1	physical	28514442
STX7_HUMAN	STX7	physical	28514442
FEN1_HUMAN	FEN1	physical	28514442
BLVRB_HUMAN	BLVRB	physical	28514442
KAD4_HUMAN	AK4	physical	28514442
DUS3_HUMAN	DUSP3	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
LRC40_HUMAN	LRRC40	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
ERF1_HUMAN	ETF1	physical	28514442
MDC1_HUMAN	MDC1	physical	28514442
CAF17_HUMAN	IBA57	physical	28514442
HMGN5_HUMAN	HMGN5	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
PP1R8_HUMAN	PPP1R8	physical	28514442
FACE1_HUMAN	ZMPSTE24	physical	28514442
EFTS_HUMAN	TSFM	physical	28514442
TLN1_HUMAN	TLN1	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
NHRF2_HUMAN	SLC9A3R2	physical	28514442
UGPA_HUMAN	UGP2	physical	28514442
SLD5_HUMAN	GINS4	physical	28514442
TACC3_HUMAN	TACC3	physical	28514442
PSF1_HUMAN	GINS1	physical	28514442
EIF3J_HUMAN	EIF3J	physical	28514442
WDHD1_HUMAN	WDHD1	physical	28514442
CMTR1_HUMAN	CMTR1	physical	28514442
PYM1_HUMAN	WIBG	physical	28514442
PSF3_HUMAN	GINS3	physical	28514442
CSTF3_HUMAN	CSTF3	physical	28514442
THIK_HUMAN	ACAA1	physical	28514442
EFHD2_HUMAN	EFHD2	physical	28514442
PUR8_HUMAN	ADSL	physical	28514442
MESD_HUMAN	MESDC2	physical	28514442
SNX5_HUMAN	SNX5	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
GUAA_HUMAN	GMPS	physical	28514442
ZRAB2_HUMAN	ZRANB2	physical	28514442
UBA6_HUMAN	UBA6	physical	28514442
CHRD1_HUMAN	CHORDC1	physical	28514442
RRP44_HUMAN	DIS3	physical	28514442
PPME1_HUMAN	PPME1	physical	28514442
SPRY4_HUMAN	SPRYD4	physical	28514442
TOP1_HUMAN	TOP1	physical	28514442
SYYC_HUMAN	YARS	physical	28514442
PACN2_HUMAN	PACSIN2	physical	28514442
IF2P_HUMAN	EIF5B	physical	28514442
CSTF1_HUMAN	CSTF1	physical	28514442
CAB39_HUMAN	CAB39	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
DBNL_HUMAN	DBNL	physical	28514442
BRE1A_HUMAN	RNF20	physical	28514442
ES1_HUMAN	C21orf33	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of T2EB_HUMAN

Related Literatures of Post-Translational Modification