dbPTM

TPP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPP2_HUMAN
UniProt AC	P29144
Protein Name	Tripeptidyl-peptidase 2
Gene Name	TPP2
Organism	Homo sapiens (Human).
Sequence Length	1249
Subcellular Localization	Cytoplasm . Nucleus . Translocates to the nucleus in responce to gamma-irradiation.
Protein Description	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity)..
Protein Sequence	MATAATEEPFPFHGLLPKKETGAASFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIVDIIDTTGSGDVNTATEVEPKDGEIVGLSGRVLKIPASWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPVHRVALAEACRKQEEFDVANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGEVWRACIDSNEDGDLSKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNIIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALILSGLKANNIDYTVHSVRRALENTAVKADNIEVFAQGHGIIQVDKAYDYLVQNTSFANKLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISLQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFIEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLTEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKNWVQTLRPVSAKTKPLGSRDVLPNNRQLYEMVLTYNFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLERLKDLPFIVSHRLSNTLSLDIHENHSFALLGKKKSSNLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSSDIYNELKETYPNYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHTQAQDGAISTDAEGKEEEGESPLDSLAETFWETTKWTDLFDNKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATAATEEP ------CCCCCCCCC	19.76	-
3	Phosphorylation	-----MATAATEEPF -----CCCCCCCCCC	28.78	25867546
6	Phosphorylation	--MATAATEEPFPFH --CCCCCCCCCCCCC	38.12	25867546
19	Ubiquitination	FHGLLPKKETGAASF CCCCCCCCCCCCCEE	59.58	-
21	Phosphorylation	GLLPKKETGAASFLC CCCCCCCCCCCEEEE	40.79	21406692
25	Phosphorylation	KKETGAASFLCRYPE CCCCCCCEEEEECCC	20.44	21406692
28	Glutathionylation	TGAASFLCRYPEYDG CCCCEEEEECCCCCC	3.55	22555962
61	Ubiquitination	MQVTTDGKPKIVDII CEEECCCCCCEEEEE	46.04	21906983
93	Phosphorylation	DGEIVGLSGRVLKIP CCCEEEEECCEEEEC	20.72	21712546
109	Ubiquitination	SWTNPSGKYHIGIKN CCCCCCCCEEEEEEC	37.68	-
118	Phosphorylation	HIGIKNGYDFYPKAL EEEEECCCCCCHHHH	16.57	25839225
123	Acetylation	NGYDFYPKALKERIQ CCCCCCHHHHHHHHH	55.78	26051181
136	Acetylation	IQKERKEKIWDPVHR HHHHHHHHCCCHHHH	52.73	25953088
136	Methylation	IQKERKEKIWDPVHR HHHHHHHHCCCHHHH	52.73	72608713
136	Ubiquitination	IQKERKEKIWDPVHR HHHHHHHHCCCHHHH	52.73	-
152	Ubiquitination	ALAEACRKQEEFDVA HHHHHHHHHCCCCCC	63.04	-
168	Ubiquitination	NGSSQANKLIKEELQ CCCHHHHHHHHHHHH	55.39	-
171	Ubiquitination	SQANKLIKEELQSQV HHHHHHHHHHHHHHH	56.42	-
186	Acetylation	ELLNSFEKKYSDPGP HHHHHHHHHCCCCCC	55.81	25953088
186	Ubiquitination	ELLNSFEKKYSDPGP HHHHHHHHHCCCCCC	55.81	-
187	Acetylation	LLNSFEKKYSDPGPV HHHHHHHHCCCCCCE	42.67	25038526
195	Phosphorylation	YSDPGPVYDCLVWHD CCCCCCEEEEEEECC	12.22	28064214
220	Ubiquitination	NEDGDLSKSTVLRNY CCCCCCCHHHHHHCH	58.40	-
221	Phosphorylation	EDGDLSKSTVLRNYK CCCCCCHHHHHHCHH	22.00	20068231
222	Phosphorylation	DGDLSKSTVLRNYKE CCCCCHHHHHHCHHH	27.57	24719451
227	Phosphorylation	KSTVLRNYKEAQEYG HHHHHHCHHHHHHHC	12.08	20068231
293	Phosphorylation	APGAQILSIKIGDTR CCCCEEEEEEECCEE	24.38	24719451
304	Sulfoxidation	GDTRLSTMETGTGLI CCEEECCCHHCHHHH	3.79	21406390
321	Ubiquitination	MIEVINHKCDLVNYS HHHHHHCCCCCCCCC	25.59	-
397	Phosphorylation	DMMVAEYSLREKLPA CCEEEEECHHHCCCC	16.68	24719451
401	Acetylation	AEYSLREKLPANQYT EEECHHHCCCCCCCC	54.02	25953088
401	Malonylation	AEYSLREKLPANQYT EEECHHHCCCCCCCC	54.02	26320211
401	Ubiquitination	AEYSLREKLPANQYT EEECHHHCCCCCCCC	54.02	-
442	Phosphorylation	PNWTLRGTQLMNGTS CCEEEECEEECCCCC	16.46	23532336
448	Phosphorylation	GTQLMNGTSMSSPNA CEEECCCCCCCCCCC	19.09	23532336
449	Phosphorylation	TQLMNGTSMSSPNAC EEECCCCCCCCCCCH	20.33	27251275
451	Phosphorylation	LMNGTSMSSPNACGG ECCCCCCCCCCCHHH	42.27	27251275
452	Phosphorylation	MNGTSMSSPNACGGI CCCCCCCCCCCHHHH	17.33	27251275
485	Phosphorylation	VRRALENTAVKADNI HHHHHHHCCCCCCCE	24.37	20068231
610	Phosphorylation	GLREGLHYTEVCGYD HHHCCCCEEEECCCC	15.05	17360941
614	Glutathionylation	GLHYTEVCGYDIASP CCCEEEECCCCCCCC	3.21	22555962
642	Phosphorylation	IAAKVNESSHYDLAF EEEECCCCCCCEEEE	19.74	28152594
643	Phosphorylation	AAKVNESSHYDLAFT EEECCCCCCCEEEEE	21.64	28152594
645	Phosphorylation	KVNESSHYDLAFTDV ECCCCCCCEEEEEEC	18.01	28152594
655	Acetylation	AFTDVHFKPGQIRRH EEEECCCCCCCEEEE	33.10	25038526
655	Ubiquitination	AFTDVHFKPGQIRRH EEEECCCCCCCEEEE	33.10	-
697	Acetylation	LHAVQLVKQRAYRSH HHHHHHHHHHHHHCC	42.53	25953088
697	Ubiquitination	LHAVQLVKQRAYRSH HHHHHHHHHHHHHCC	42.53	-
708	Acetylation	YRSHEFYKFCSLPEK HHCCCHHHHCCCCCC	45.26	23749302
708	Malonylation	YRSHEFYKFCSLPEK HHCCCHHHHCCCCCC	45.26	26320211
708	Ubiquitination	YRSHEFYKFCSLPEK HHCCCHHHHCCCCCC	45.26	19608861
715	Acetylation	KFCSLPEKGTLTEAF HHCCCCCCCCCCCCE	56.08	25953088
715	Ubiquitination	KFCSLPEKGTLTEAF HHCCCCCCCCCCCCE	56.08	-
717	Phosphorylation	CSLPEKGTLTEAFPV CCCCCCCCCCCCEEC	41.39	28258704
719	Phosphorylation	LPEKGTLTEAFPVLG CCCCCCCCCCEECCC	25.71	28258704
748	Phosphorylation	LSDVNIDYTISFHGI CCCCCCCEEEEECEE	11.37	23879269
749	Phosphorylation	SDVNIDYTISFHGIV CCCCCCEEEEECEEE	13.34	23879269
751	Phosphorylation	VNIDYTISFHGIVCT CCCCEEEEECEEEEE	11.91	23879269
767	Phosphorylation	PQLNIHASEGINRFD CCCEEEECCCCCCCC	23.38	23879269
791	Acetylation	LAPCITLKNWVQTLR HHHHEEEHHHHHHHC	39.86	25953088
791	Ubiquitination	LAPCITLKNWVQTLR HHHHEEEHHHHHHHC	39.86	-
796	Phosphorylation	TLKNWVQTLRPVSAK EEHHHHHHHCCCCCC	18.34	28348404
801	Phosphorylation	VQTLRPVSAKTKPLG HHHHCCCCCCCCCCC	27.08	28348404
869	Phosphorylation	QNKRQMGSGDAYPHQ CCCCCCCCCCCCCCE	28.32	-
878	Phosphorylation	DAYPHQYSLKLEKGD CCCCCEEEEEECCCC	16.68	24719451
880	Acetylation	YPHQYSLKLEKGDYT CCCEEEEEECCCCEE	48.97	23236377
883	Acetylation	QYSLKLEKGDYTIRL EEEEEECCCCEEEEE	68.47	23954790
883	Malonylation	QYSLKLEKGDYTIRL EEEEEECCCCEEEEE	68.47	26320211
883	Ubiquitination	QYSLKLEKGDYTIRL EEEEEECCCCEEEEE	68.47	-
886	Phosphorylation	LKLEKGDYTIRLQIR EEECCCCEEEEEEEE	16.85	24505115
887	Phosphorylation	KLEKGDYTIRLQIRH EECCCCEEEEEEEEH	12.36	24719451
898	Phosphorylation	QIRHEQISDLERLKD EEEHHHCCCHHHHCC	35.52	-
904	Acetylation	ISDLERLKDLPFIVS CCCHHHHCCCCEEEE	64.54	26051181
904	Malonylation	ISDLERLKDLPFIVS CCCHHHHCCCCEEEE	64.54	26320211
904	Ubiquitination	ISDLERLKDLPFIVS CCCHHHHCCCCEEEE	64.54	-
911	Phosphorylation	KDLPFIVSHRLSNTL CCCCEEEEEECCCCC	9.70	-
915	Phosphorylation	FIVSHRLSNTLSLDI EEEEEECCCCCEEEE	27.94	24275569
917	Phosphorylation	VSHRLSNTLSLDIHE EEEECCCCCEEEEEC	17.85	24275569
936	Phosphorylation	ALLGKKKSSNLTLPP EECCCCCCCCCCCCC	33.08	21406692
937	Phosphorylation	LLGKKKSSNLTLPPK ECCCCCCCCCCCCCC	44.75	21406692
940	Phosphorylation	KKKSSNLTLPPKYNQ CCCCCCCCCCCCCCC	41.28	21406692
945	Phosphorylation	NLTLPPKYNQPFFVT CCCCCCCCCCCEEEE	25.46	23286773
952	Phosphorylation	YNQPFFVTSLPDDKI CCCCEEEEECCCCCC	21.27	23286773
953	Phosphorylation	NQPFFVTSLPDDKIP CCCEEEEECCCCCCC	32.38	29978859
958	Acetylation	VTSLPDDKIPKGAGP EEECCCCCCCCCCCC	69.18	25038526
958	Ubiquitination	VTSLPDDKIPKGAGP EEECCCCCCCCCCCC	69.18	-
961	Acetylation	LPDDKIPKGAGPGCY CCCCCCCCCCCCCCE	65.94	26051181
968	Phosphorylation	KGAGPGCYLAGSLTL CCCCCCCEEECEEEE	12.90	28258704
972	Phosphorylation	PGCYLAGSLTLSKTE CCCEEECEEEECHHH	16.75	28258704
974	Phosphorylation	CYLAGSLTLSKTELG CEEECEEEECHHHCC	30.59	24719451
976	Phosphorylation	LAGSLTLSKTELGKK EECEEEECHHHCCCC	32.09	23286773
983	Malonylation	SKTELGKKADVIPVH CHHHCCCCCCEEEEE	48.28	26320211
998	Phosphorylation	YYLIPPPTKTKNGSK EEECCCCCCCCCCCC	58.06	20860994
999	Acetylation	YLIPPPTKTKNGSKD EECCCCCCCCCCCCC	64.37	25953088
1005	Ubiquitination	TKTKNGSKDKEKDSE CCCCCCCCCCCCCCH	74.37	17370265
1013	Ubiquitination	DKEKDSEKEKDLKEE CCCCCCHHHHHHHHH	74.21	17370265
1018	Ubiquitination	SEKEKDLKEEFTEAL CHHHHHHHHHHHHHH	66.39	-
1029	Ubiquitination	TEALRDLKIQWMTKL HHHHHHHHHHHHHCC	36.82	-
1038	Phosphorylation	QWMTKLDSSDIYNEL HHHHCCCHHHHHHHH	40.10	28348404
1039	Phosphorylation	WMTKLDSSDIYNELK HHHCCCHHHHHHHHH	27.91	25159151
1042	Phosphorylation	KLDSSDIYNELKETY CCCHHHHHHHHHHHC	13.94	-
1046	Ubiquitination	SDIYNELKETYPNYL HHHHHHHHHHCCCHH	41.66	-
1048	Phosphorylation	IYNELKETYPNYLPL HHHHHHHHCCCHHHH	42.57	25072903
1049	Phosphorylation	YNELKETYPNYLPLY HHHHHHHCCCHHHHH	7.20	25072903
1052	Phosphorylation	LKETYPNYLPLYVAR HHHHCCCHHHHHHHH	12.75	25072903
1056	Phosphorylation	YPNYLPLYVARLHQL CCCHHHHHHHHHHHH	7.07	23917254
1067	Ubiquitination	LHQLDAEKERMKRLN HHHHHHHHHHHHHHH	52.95	-
1117	2-Hydroxyisobutyrylation	KNDMDKQKSTLVDAL CCCHHHHHHHHHHHH	51.66	-
1127	Ubiquitination	LVDALCRKGCALADH HHHHHHHHCCHHHHH	58.29	-
1180	Ubiquitination	WTDLFDNKVLTFAYK HHHCCCCCHHHHHHH	40.23	21890473
1183	Phosphorylation	LFDNKVLTFAYKHAL CCCCCHHHHHHHHHH	14.81	-
1186	Phosphorylation	NKVLTFAYKHALVNK CCHHHHHHHHHHHHH	10.10	-
1187	Acetylation	KVLTFAYKHALVNKM CHHHHHHHHHHHHHH	20.97	25953088
1187	Ubiquitination	KVLTFAYKHALVNKM CHHHHHHHHHHHHHH	20.97	21890473
1193	Ubiquitination	YKHALVNKMYGRGLK HHHHHHHHHHHHCCH	26.48	-
1200	Acetylation	KMYGRGLKFATKLVE HHHHHCCHHHHHHHH	35.46	25953088
1200	Ubiquitination	KMYGRGLKFATKLVE HHHHHCCHHHHHHHH	35.46	-
1204	Acetylation	RGLKFATKLVEEKPT HCCHHHHHHHHCCCC	47.29	23749302
1204	Ubiquitination	RGLKFATKLVEEKPT HCCHHHHHHHHCCCC	47.29	-
1209	Acetylation	ATKLVEEKPTKENWK HHHHHHCCCCHHHHH	44.47	25953088
1209	Ubiquitination	ATKLVEEKPTKENWK HHHHHHCCCCHHHHH	44.47	-
1212	Ubiquitination	LVEEKPTKENWKNCI HHHCCCCHHHHHHHH	58.54	-
1216	Ubiquitination	KPTKENWKNCIQLMK CCCHHHHHHHHHHHH	54.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TPP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLOD2_HUMAN	PLOD2	physical	22863883
TRI47_HUMAN	TRIM47	physical	22863883
PP16A_HUMAN	PPP1R16A	physical	25416956
ADAM8_HUMAN	ADAM8	physical	26344197
HXK2_HUMAN	HK2	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPP2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-708, AND MASS SPECTROMETRY.	19608861 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1005 AND LYS-1013, ANDMASS SPECTROMETRY.	17370265 [Abstract]