| UniProt ID | ADAM8_HUMAN | |
|---|---|---|
| UniProt AC | P78325 | |
| Protein Name | Disintegrin and metalloproteinase domain-containing protein 8 | |
| Gene Name | ADAM8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 824 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Possible involvement in extravasation of leukocytes.. | |
| Protein Sequence | MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | RVRRALPSHLGLHPE HHHHHCCHHHCCCHH | 31.99 | 24670416 | |
| 67 | N-linked_Glycosylation | VLGATGHNFTLHLRK EEECCCCCEEEEEEC | 32.70 | UniProtKB CARBOHYD | |
| 91 | N-linked_Glycosylation | TETYTAANGSEVTEQ EEEEECCCCCCCCCC | 52.65 | UniProtKB CARBOHYD | |
| 299 | Phosphorylation | TGVDFTGTTVGFARV EEECCCCCCEEEEHH | 18.43 | 46159131 | |
| 436 | N-linked_Glycosylation | DCRNRCCNSTTCQLA HHCCCCCCCCCCHHH | 46.12 | UniProtKB CARBOHYD | |
| 612 | N-linked_Glycosylation | LHVYRSSNCSAQCHN EEEEECCCCCCCCCC | 25.63 | UniProtKB CARBOHYD | |
| 683 | Phosphorylation | IVYRKARSRILSRNV HHHHHHHHHHHHCCC | 28.65 | 28634120 | |
| 687 | Phosphorylation | KARSRILSRNVAPKT HHHHHHHHCCCCCCC | 21.31 | 24702127 | |
| 755 | Phosphorylation | PPPAPPVTVSSPPFP CCCCCCEEECCCCCC | 22.05 | 28102081 | |
| 757 | Phosphorylation | PAPPVTVSSPPFPVP CCCCEEECCCCCCCC | 27.97 | 30108239 | |
| 758 | Phosphorylation | APPVTVSSPPFPVPV CCCEEECCCCCCCCE | 32.05 | 26657352 | |
| 766 | Phosphorylation | PPFPVPVYTRQAPKQ CCCCCCEECCCCCCC | 7.08 | 29978859 | |
| 767 | Phosphorylation | PFPVPVYTRQAPKQV CCCCCEECCCCCCCC | 19.28 | 27259358 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ADAM8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADAM8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADAM8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ADAM8_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D03517 | Cipemastat (USAN/INN); Trocade (TN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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