PP16A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP16A_HUMAN
• UniProt AC: Q96I34
• Protein Name: Protein phosphatase 1 regulatory subunit 16A
• Gene Name: PPP1R16A
• Organism: Homo sapiens (Human).
• Sequence Length: 528
• Subcellular Localization: Cell membrane; Lipid-anchor.
• Protein Description: Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates..
• Protein Sequence: MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	MPMVGRMSTQERLKH CCCCCCCCHHHHHHH	26.10	29449344
19	Phosphorylation	PMVGRMSTQERLKHA CCCCCCCHHHHHHHH	25.71	29449344
60	Phosphorylation	RPRKEAASQGLLKQV CCHHHHHHCCHHHHH	31.65	25849741
139	O-linked_Glycosylation	ACDSECWTPLHAAAT CCCCCCCCHHHHHHH	27.86	29351928
199	Phosphorylation	DRGITQDSIEAARAV HCCCCHHHHHHHHHC	16.71	27251275
257	Phosphorylation	LLLEHRASLSAKDQD HHHHHHHHCCCCCCC	23.86	23312004
295	Phosphorylation	GADLNAKSLMDETPL CCCCCHHHCCCCCCC	26.90	29083192
300	Phosphorylation	AKSLMDETPLDVCGD HHHCCCCCCCCCCCC	25.53	29083192
333	Phosphorylation	RAQSRQRSLLRRRTS HHHHHHHHHHHHHHC	24.34	23532336
353	Phosphorylation	GKVVRRVSLTQRTDL CCEEEEEECHHCHHH	24.72	30266825
355	Phosphorylation	VVRRVSLTQRTDLYR EEEEEECHHCHHHHH	14.43	30266825
418	Phosphorylation	HNGRVGGSPVRHLYS CCCCCCCCCCHHHHC	17.81	25159151
424	Phosphorylation	GSPVRHLYSKRLDRS CCCCHHHHCCCCCCC	13.16	27251275
425	Phosphorylation	SPVRHLYSKRLDRSV CCCHHHHCCCCCCCC	20.05	24719451
431	Phosphorylation	YSKRLDRSVSYQLSP HCCCCCCCCEEEECC	18.32	21712546
433	Phosphorylation	KRLDRSVSYQLSPLD CCCCCCCEEEECCCC	14.38	25159151
434	Phosphorylation	RLDRSVSYQLSPLDS CCCCCCEEEECCCCC	16.00	25159151
437	Phosphorylation	RSVSYQLSPLDSTTP CCCEEEECCCCCCCC	14.11	25159151
441	Phosphorylation	YQLSPLDSTTPHTLV EEECCCCCCCCCEEE	41.69	23186163
442	Phosphorylation	QLSPLDSTTPHTLVH EECCCCCCCCCEEEC	43.97	23186163
443	Phosphorylation	LSPLDSTTPHTLVHD ECCCCCCCCCEEECC	19.61	23186163
446	Phosphorylation	LDSTTPHTLVHDKAH CCCCCCCEEECCCCH	31.51	23186163
451	Acetylation	PHTLVHDKAHHTLAD CCEEECCCCHHHHHH	34.44	7467743
460	Ubiquitination	HHTLADLKRQRAAAK HHHHHHHHHHHHHHH	47.21	29967540
460	Acetylation	HHTLADLKRQRAAAK HHHHHHHHHHHHHHH	47.21	7467753
478	Phosphorylation	PPPEGPESPETAEPG CCCCCCCCCCCCCCC	31.04	26657352
481	Phosphorylation	EGPESPETAEPGLPG CCCCCCCCCCCCCCC	39.44	28102081
490	Phosphorylation	EPGLPGDTVTPQPDC CCCCCCCCCCCCCCC	31.99	28102081
492	Phosphorylation	GLPGDTVTPQPDCGF CCCCCCCCCCCCCCC	20.49	23312004
511	Phosphorylation	DPPLLKLTAPAVEAP CCCCEECCCCCCCCC	29.07	-
524	S-palmitoylation	APVERRPCCLLM--- CCCCCCCCEECC---	2.12	-
525	Methylation	PVERRPCCLLM---- CCCCCCCEECC----	3.47	-
525	Farnesylation	PVERRPCCLLM---- CCCCCCCEECC----	3.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
340	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
341	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
353	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP16A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP16A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAD24_HUMAN	CDH24	physical	16169070
DDX27_HUMAN	DDX27	physical	16169070
FSD1_HUMAN	FSD1	physical	16169070
I23O1_HUMAN	IDO1	physical	16169070
PBDC1_HUMAN	PBDC1	physical	16169070
PAPS1_HUMAN	PAPSS1	physical	16169070
PHP14_HUMAN	PHPT1	physical	16169070
RGMA_HUMAN	RGMA	physical	16169070
PUF60_HUMAN	PUF60	physical	16169070
TRXR1_HUMAN	TXNRD1	physical	16169070
TRIP6_HUMAN	TRIP6	physical	19060904
PP16A_HUMAN	PPP1R16A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.