I23O1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I23O1_HUMAN
• UniProt AC: P14902
• Protein Name: Indoleamine 2,3-dioxygenase 1
• Gene Name: IDO1
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. [PubMed: 17671174 Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses]
• Protein Sequence: MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAHAMENSWTISKEY CCCCCCCCEEECEEE	16.58	27251275
15	Nitration	SWTISKEYHIDEEVG CEEECEEECCCCCCC	14.07	-
153	Phosphorylation	ENMDVLFSFRDGDCS CCEEEEEEECCCCCC	18.40	24719451
176	Phosphorylation	LVEIAAASAIKVIPT HHHHHHHHHHHHHHH	26.29	24719451
332	Phosphorylation	DAGLREAYDACVKAL CHHHHHHHHHHHHHH	10.18	-
341	Phosphorylation	ACVKALVSLRSYHLQ HHHHHHHHHHHHHHH	20.93	24719451
345	Nitration	ALVSLRSYHLQIVTK HHHHHHHHHHHEEEE	10.50	-
353	Nitration	HLQIVTKYILIPASQ HHHEEEEEEEEEHHH	7.50	-
372	Phosphorylation	NKTSEDPSKLEAKGT CCCCCCHHHHHCCCC	63.29	-
390	Phosphorylation	DLMNFLKTVRSTTEK HHHHHHHHHHHHHHH	24.25	-
398	Phosphorylation	VRSTTEKSLLKEG-- HHHHHHHHHHHCC--	32.47	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of I23O1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I23O1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I23O1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.