RGMA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGMA_HUMAN
• UniProt AC: Q96B86
• Protein Name: Repulsive guidance molecule A
• Gene Name: RGMA
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8..
• Protein Sequence: MQPPRERLVVTGRAGWMGMGRGAGRSALGFWPTLAFLLCSFPAATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYDRTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	N-linked_Glycosylation	EDLMSQHNCSKDGPT HHHHHHCCCCCCCCC	24.91	UniProtKB CARBOHYD
128	Phosphorylation	TSQPRLRTLPPAGDS CCCCCCCCCCCCCCC	48.48	-
136	Phosphorylation	LPPAGDSQERSDSPE CCCCCCCCCCCCCCC	55.66	-
159	N-linked_Glycosylation	HKHSATPNYTHCGLF CCCCCCCCCCCCCCC	50.40	UniProtKB CARBOHYD
276	Phosphorylation	HVEIQAKYIGTTIVV EEEEEEEECCCEEEE	13.96	-
350	O-linked_Glycosylation	AAASPAPTAPETFPY HHCCCCCCCCCCCCH	57.88	OGP
354	Phosphorylation	PAPTAPETFPYETAV CCCCCCCCCCHHHHH	28.93	23917254
357	Phosphorylation	TAPETFPYETAVAKC CCCCCCCHHHHHHHH	23.01	23917254
359	Phosphorylation	PETFPYETAVAKCKE CCCCCHHHHHHHHHH	22.16	23917254
389	N-linked_Glycosylation	LLTTGDVNFTLAAYY HHCCCCHHHHHHHHH	29.00	UniProtKB CARBOHYD
424	GPI-anchor	TRDLPGRAAAGLPLA CCCCCCCCCCCCCCC	13.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGMA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGMA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGMA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOB_HUMAN	TCEB2	physical	26496610
NCOR2_HUMAN	NCOR2	physical	26496610
TXNIP_HUMAN	TXNIP	physical	26496610
HIPK2_HUMAN	HIPK2	physical	26496610
PPHLN_HUMAN	PPHLN1	physical	26496610
SMAG2_HUMAN	SAMD4B	physical	26496610
BDP1_HUMAN	BDP1	physical	26496610
CLK4_HUMAN	CLK4	physical	26496610
ANO3_HUMAN	ANO3	physical	26496610
NBEL1_HUMAN	NBEAL1	physical	26496610
SPICE_HUMAN	SPICE1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.