NBEL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NBEL1_HUMAN
• UniProt AC: Q6ZS30
• Protein Name: Neurobeachin-like protein 1
• Gene Name: NBEAL1
• Organism: Homo sapiens (Human).
• Sequence Length: 2694
• Protein Sequence: MASRERLFELWMLYCTKKDPDYLKLWLDTFVSSYEQFLDVDFEKLPTRVDDMPPGISLLPDNILQVLRIQLLQCVQKMADGLEEQQQALSILLVKFFIILCRNLSNVEEIGTCSYINYVITMTTLYIQQLKSKKKEKEMADQTCIEEFVIHALAFCESLYDPYRNWRHRISGRILSTVEKSRQKYKPASLTVEFVPFFYQCFQESEHLKESLKCCLLHLFGAIVAGGQRNALQAISPATMEVLMRVLADCDSWEDGDPEEVGRKAELTLKCLTEVVHILLSSNSDQRQVETSTILENYFKLLNSDHSALPNQRRSRQWENRFIALQIKMLNTITAMLDCTDRPVLQAIFLNSNCFEHLIRLLQNCKVFQGQLDCLAISTIQALTAVMNKSPAAKEVFKERIGYTHMLEVLKSLGQPPLELLKELMNMAVEGDHTSVGILGISNVQPLLLLIQWLPELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRIIETLDLHSSLHQTCAENLIAIHGSLGSQSVSSEEIRRLLRLLRVDESESVHPYVTPVTRAILTMARKLSLESALQYFNLSHSMAGISVPPIQKWPGSAFSFSAWFCLDQDQLTLGIANKGGKRKQLYSFFTGSGMGFEAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITVVHMPGKRPFGQSFVYIYDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTTTPPPSQIPDPPFSSPITPHRTSFGGILSSASWGGTIEKSKLITKLISAGTQDSEWGCPTSLEGQLGSVIIFYEPLQPPQVKALYLAGPNCLSPWKCQESDMADLPGNILLYYTAKACKNSICLDLSTNCLHGRLTGNKVVNWDIKDIINCIGGLNVLFPLLEQISHFSEGQIPEEKNESTVPESVTPVEGDWLVWTSTKASESRLERNLVATFILIVKHFIQRHPINQGNLIHSHGVATLGALLQKVPSTLMDVNVLMAVQLLIEQVSLEKNMQLLQQMYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRRVFRKKYGVQFLLDTLRIYYGNGCKYNELSLDDIRTIRTSLYGLIKYFLCKGGSHEEIQSIMGYIAATNEEEQLFGILDVLFSLLRTSPTRGQLFLLLFEPGNADILYALLLNQKYSDRLREIIFKIMEQMLKCTNVYERSKQHIRLREVGYSGLGLLLNEALVNTSLIKNLTHQIINTDPVINFKDLLSVVYISHRAHINVRVAICRKVLQILQFQPDAAHQISQQVGWQDTLVRLFLKAKFENGNTLHKHSRAVLMKDNDKNMSTEDTKKNSDEKTDEEKITSFASANVSSDQWSLEDRHSLDSNTPLFPEDSSVGELSFKSENQEEFWHSNPSHLSLDLSGIDSCEMSDSGSQVPDSLPSTPSPVESTKSFSVHSDRESSITNDMGFSDDFSLLESQERCEEELLQLLTHILNYVMCKGLEKSDDDTWIERGQVFSALSKPGISSELLRPSDEIKLTLLQKMLEWAISENREAKTNPVTAENAFRLVLIIQDFLQSEGLVNSNMWTEKLLEDMMLLFDCLSVCYSESPVWVKLSQIQIQLLLGFIGRGNLQVCAMASAKLNTLLQTKVIENQDEACYILGKLEHVLSQSIKEQTEIYSFLIPLVRTLVSKIYELLFMNLHLPSLPFTNGSSSFFEDFQEYCNSNEWQVYIEKYIVPYMKQYEAHTFYDGHENMALYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKAIQLYLTCERGPWAKRKQNPIHWKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLDLPEEDITARVNVDEKEEQDQKEKLVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHSQIREIHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSLHSPNSYYGSRSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTCMIWQITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQILKEQVSDICIIGEHIVTGSIQGFLSIRDLHSLNLSINPLAMRLPIHCVCVTKEYSHILVGLEDGKLIVVGVGKPAEMRSGQLSRKFWGSSKRLSQISAGETEYNTQDSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LFELWMLYCTKKDPD HHHHHHHHHCCCCCC	5.08	22617229
16	Phosphorylation	ELWMLYCTKKDPDYL HHHHHHHCCCCCCHH	27.80	22617229
171	Phosphorylation	RNWRHRISGRILSTV CCHHHHHHHHHHHHH	23.21	-
176	Phosphorylation	RISGRILSTVEKSRQ HHHHHHHHHHHHHHH	28.21	30266825
177	Phosphorylation	ISGRILSTVEKSRQK HHHHHHHHHHHHHHH	29.28	30266825
180	Ubiquitination	RILSTVEKSRQKYKP HHHHHHHHHHHHCCC	46.75	-
291	Phosphorylation	SDQRQVETSTILENY CCCCCHHHHHHHHHH	32.11	-
292	Phosphorylation	DQRQVETSTILENYF CCCCHHHHHHHHHHH	10.43	-
293	Phosphorylation	QRQVETSTILENYFK CCCHHHHHHHHHHHH	36.68	-
298	Phosphorylation	TSTILENYFKLLNSD HHHHHHHHHHHHCCC	7.85	-
394	Ubiquitination	MNKSPAAKEVFKERI HCCCHHHHHHHHHHH	57.42	29967540
653	Ubiquitination	TKREYATVMLPDHSF ECCCCEEEECCCCCC	2.56	27667366
719	Phosphorylation	IGSAGQRTTTPPPSQ CCCCCCCCCCCCCHH	27.43	27251275
720	Phosphorylation	GSAGQRTTTPPPSQI CCCCCCCCCCCCHHC	39.22	27251275
721	Phosphorylation	SAGQRTTTPPPSQIP CCCCCCCCCCCHHCC	32.93	27251275
725	Phosphorylation	RTTTPPPSQIPDPPF CCCCCCCHHCCCCCC	46.66	27251275
730	Ubiquitination	PPSQIPDPPFSSPIT CCHHCCCCCCCCCCC	26.87	27667366
733	Phosphorylation	QIPDPPFSSPITPHR HCCCCCCCCCCCCCC	40.76	26657352
734	Phosphorylation	IPDPPFSSPITPHRT CCCCCCCCCCCCCCC	22.24	25849741
737	Phosphorylation	PPFSSPITPHRTSFG CCCCCCCCCCCCCCC	19.20	26055452
741	Phosphorylation	SPITPHRTSFGGILS CCCCCCCCCCCCCCC	25.93	28857561
742	Phosphorylation	PITPHRTSFGGILSS CCCCCCCCCCCCCCC	23.11	28857561
748	Phosphorylation	TSFGGILSSASWGGT CCCCCCCCCCCCCCH	23.18	27080861
749	Phosphorylation	SFGGILSSASWGGTI CCCCCCCCCCCCCHH	23.91	27080861
751	Phosphorylation	GGILSSASWGGTIEK CCCCCCCCCCCHHCH	28.35	27080861
900	Phosphorylation	PEEKNESTVPESVTP CCCCCCCCCCCCCCC	33.62	28102081
904	Phosphorylation	NESTVPESVTPVEGD CCCCCCCCCCCCCCC	25.81	28348404
906	Phosphorylation	STVPESVTPVEGDWL CCCCCCCCCCCCCEE	30.78	26657352
1150	Phosphorylation	LLLNQKYSDRLREII HHHCCCCHHHHHHHH	24.24	23898821
1171	Phosphorylation	MLKCTNVYERSKQHI HHHCCCHHHHHHHHE	14.01	27050516
1186	Ubiquitination	RLREVGYSGLGLLLN EHHHCCCCHHHHHHC	22.93	27667366
1200	Phosphorylation	NEALVNTSLIKNLTH CHHHHCCHHHHHHHH	23.93	24719451
1258	Phosphorylation	PDAAHQISQQVGWQD CCHHHHHHHHHCCHH	14.16	24043423
1266	Phosphorylation	QQVGWQDTLVRLFLK HHHCCHHHHHHHHHH	16.44	24043423
1299	Phosphorylation	KDNDKNMSTEDTKKN CCCCCCCCHHHHHCC	37.73	18077418
1325	Phosphorylation	SFASANVSSDQWSLE HHHHCCCCCCCCCCC	28.18	27251275
1326	Phosphorylation	FASANVSSDQWSLED HHHCCCCCCCCCCCH	29.55	24719451
1330	Phosphorylation	NVSSDQWSLEDRHSL CCCCCCCCCCHHCCC	19.09	28102081
1336	Phosphorylation	WSLEDRHSLDSNTPL CCCCHHCCCCCCCCC	34.46	29255136
1339	Phosphorylation	EDRHSLDSNTPLFPE CHHCCCCCCCCCCCC	48.15	25849741
1341	Phosphorylation	RHSLDSNTPLFPEDS HCCCCCCCCCCCCCC	25.89	29255136
1354	Phosphorylation	DSSVGELSFKSENQE CCCCCCEEECCCCHH	26.73	24719451
1406	Phosphorylation	SPVESTKSFSVHSDR CCCCCCCCEEECCCC	23.89	25849741
1408	Phosphorylation	VESTKSFSVHSDRES CCCCCCEEECCCCCC	26.47	25850435
1411	Phosphorylation	TKSFSVHSDRESSIT CCCEEECCCCCCCCC	35.89	27794612
1415	Phosphorylation	SVHSDRESSITNDMG EECCCCCCCCCCCCC	28.12	22210691
1416	Phosphorylation	VHSDRESSITNDMGF ECCCCCCCCCCCCCC	28.78	22210691
1458	Ubiquitination	VMCKGLEKSDDDTWI HHHCCCCCCCCCCHH	65.31	29967540
1476	Ubiquitination	QVFSALSKPGISSEL CHHHHHCCCCCCHHH	48.38	29967540
1493	Ubiquitination	PSDEIKLTLLQKMLE CCHHHHHHHHHHHHH	22.03	27667366
1515	Phosphorylation	EAKTNPVTAENAFRL CCCCCCCCHHHHHHH	29.52	-
1593	Phosphorylation	LQVCAMASAKLNTLL HHHHHHHHHHHHHHH	16.92	-
1623	Phosphorylation	GKLEHVLSQSIKEQT HHHHHHHHHHHHHHH	22.31	27251275
1625	Phosphorylation	LEHVLSQSIKEQTEI HHHHHHHHHHHHHHH	32.05	27251275
1704	Ubiquitination	YEAHTFYDGHENMAL EEEEEEECCCCCEEE	48.02	27667366
1813	Ubiquitination	NYSRMRLKLVPNYNF CCCCEEEEECCCCCC	36.75	27667366
1838	Phosphorylation	DNLGIQHSQPSSDTL HHCCCCCCCCCCCCC	27.66	21712546
1841	Phosphorylation	GIQHSQPSSDTLLLE CCCCCCCCCCCCHHH	32.96	28192239
1842	Phosphorylation	IQHSQPSSDTLLLEV CCCCCCCCCCCHHHH	41.10	28857561
1842	Ubiquitination	IQHSQPSSDTLLLEV CCCCCCCCCCCHHHH	41.10	27667366
1844	Phosphorylation	HSQPSSDTLLLEVVK CCCCCCCCCHHHHHH	22.66	28857561
1951	Phosphorylation	RRYNLRRSALEIFHV HHHCHHCHHEEEEEE	30.67	24719451
1961	Phosphorylation	EIFHVDQSNYFLNFK EEEEECCCCCCCCCC	29.09	24719451
1963	Phosphorylation	FHVDQSNYFLNFKKE EEECCCCCCCCCCHH	18.07	24719451
1976	Phosphorylation	KEVRNKIYSRLLSLH HHHHHHHHHHHHHCC	6.85	29978859
1977	Phosphorylation	EVRNKIYSRLLSLHS HHHHHHHHHHHHCCC	21.67	24719451
1981	Phosphorylation	KIYSRLLSLHSPNSY HHHHHHHHCCCCCCC	28.73	25907765
1984	Phosphorylation	SRLLSLHSPNSYYGS HHHHHCCCCCCCCCC	30.94	25907765
1987	Phosphorylation	LSLHSPNSYYGSRSP HHCCCCCCCCCCCCH	24.10	25907765
1988	Phosphorylation	SLHSPNSYYGSRSPQ HCCCCCCCCCCCCHH	20.63	25907765
1989	Phosphorylation	LHSPNSYYGSRSPQE CCCCCCCCCCCCHHH	14.40	25907765
1991	Phosphorylation	SPNSYYGSRSPQELF CCCCCCCCCCHHHHH	17.29	25907765
1999	Methylation	RSPQELFKASGLTQK CCHHHHHHHCCCCHH	55.02	115973699
2023	Phosphorylation	DYLIQINTMAGRTYN CEEEEHHHCCCCCHH	15.27	-
2071	Ubiquitination	PIGVVNEKNAKAMRE CCCCCCHHHHHHHHH	57.93	29967540
2079	Ubiquitination	NAKAMREKYENFEDP HHHHHHHHHHCCCCC	47.72	29967540
2116	Phosphorylation	LIRVEPFTTLHIQLQ EEEECCCCEEEEEEE	38.88	24114839
2124	Phosphorylation	TLHIQLQSGRFDCAD EEEEEEECCCCCCCC	40.29	27134283
2190	Ubiquitination	VNDVILPKWAKSAED HHCCHHHHHHHCHHH	57.23	29967540
2200	Phosphorylation	KSAEDFIYKHRKALE HCHHHHHHHHHHHHH	10.75	-
2201	Ubiquitination	SAEDFIYKHRKALES CHHHHHHHHHHHHHH	31.92	29967540
2293	Ubiquitination	SAEEAVQKPTKIDTS CHHHHHCCCCCCCHH	48.32	29967540
2301	Phosphorylation	PTKIDTSTLNLFQHL CCCCCHHHHHHHHHC	23.04	-
2379	Phosphorylation	FTFIKDQTVTNPKTQ EEEEECCCCCCCCCC	39.16	29083192
2381	Phosphorylation	FIKDQTVTNPKTQRS EEECCCCCCCCCCCC	49.55	29083192
2384	Ubiquitination	DQTVTNPKTQRSING CCCCCCCCCCCCCCC	60.40	29967540
2385	Phosphorylation	QTVTNPKTQRSINGS CCCCCCCCCCCCCCC	30.39	29083192
2449	Phosphorylation	DIVTCLATDYCGIHL CHHHHHHCCCCEEEE	17.98	24114839
2509	Phosphorylation	TELDMAVSGSRDGTV CCCCEECCCCCCCEE	22.85	-
2511	Phosphorylation	LDMAVSGSRDGTVII CCEECCCCCCCEEEE	21.49	-
2575	Phosphorylation	KNALHLFSINGKYLG CCEEEEEEECCEECC	22.85	22985185
2664	Phosphorylation	GKPAEMRSGQLSRKF CCCCHHCCCCCCHHH	29.58	23403867
2674	Phosphorylation	LSRKFWGSSKRLSQI CCHHHHCCCCHHHHC	24.23	24719451
2679	Phosphorylation	WGSSKRLSQISAGET HCCCCHHHHCCCCCC	29.51	30266825
2682	Phosphorylation	SKRLSQISAGETEYN CCHHHHCCCCCCCCC	23.68	30266825
2686	Phosphorylation	SQISAGETEYNTQDS HHCCCCCCCCCCCCC	42.74	30266825
2688	Phosphorylation	ISAGETEYNTQDSK- CCCCCCCCCCCCCC-	30.81	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NBEL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NBEL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NBEL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NBEL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.