ANO3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANO3_HUMAN
• UniProt AC: Q9BYT9
• Protein Name: Anoctamin-3
• Gene Name: ANO3
• Organism: Homo sapiens (Human).
• Sequence Length: 981
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Shows an intracellular localization..
• Protein Description: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity..
• Protein Sequence: MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Methylation	ITKETSLKPSRRSLP HCCCCCCCCCCCCHH	40.49	23644510
36	Phosphorylation	SLKPSRRSLPCLAQS CCCCCCCCHHHHHHH	35.24	28857561
110	Acetylation	CLALGKDKDYTDESE HHHHCCCCCCCCHHH	57.00	19812103
166	Phosphorylation	DGKKRIDYILVYRKT CCCCCEEEEEEEECC	8.19	23403867
170	Phosphorylation	RIDYILVYRKTNIQY CEEEEEEEECCCCCC	11.71	23403867
185	Sumoylation	DKRNTFEKNLRAEGL CCCCCHHHHHHHHCC	58.03	-
185	Sumoylation	DKRNTFEKNLRAEGL CCCCCHHHHHHHHCC	58.03	-
202	Phosphorylation	EKEPAIASPDIMFIK CCCCCCCCCCEEEEE	19.59	50628825
216	Phosphorylation	KIHIPWDTLCKYAER EEECCHHHHHHHHHH	30.13	50628831
243	Phosphorylation	YTDGRSKSMGRMQTY ECCCCCCCHHHHHHH	27.93	22210691
425	N-linked_Glycosylation	FYGLFTMNNSQVSQE HHHHHHCCCHHHHHH	41.78	UniProtKB CARBOHYD
448	N-linked_Glycosylation	MCPLCDKNCSLQRLN ECCCCCCCCCCCCCC	13.83	UniProtKB CARBOHYD
455	N-linked_Glycosylation	NCSLQRLNDSCIYAK CCCCCCCCCCCEEEE	41.14	UniProtKB CARBOHYD
581	Phosphorylation	VVMEQFASFKWNFIK HHHHHHHHCCHHHHH	28.75	24719451
590	Phosphorylation	KWNFIKQYWQFATSA CHHHHHHHHHHHHHH	9.00	24043423
595	Phosphorylation	KQYWQFATSAAAVCI HHHHHHHHHHHHHHH	21.86	24043423
596	Phosphorylation	QYWQFATSAAAVCIN HHHHHHHHHHHHHHH	16.69	24043423
614	Phosphorylation	IMLLNLAYEKIAYLL HHHHHHHHHHHHHHH	22.41	24043423
792	Phosphorylation	IEIRLDAYKFVTQWR HHHHHHHHHHHHCCC	12.48	7322801
866	N-linked_Glycosylation	NCLKGYVNNSLSFFD CCHHHHHCCCCCCCC	24.72	UniProtKB CARBOHYD
884	Phosphorylation	LGMGKSGYCRYRDYR CCCCCCCCCCCCCCC	4.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANO3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANO3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANO3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ANO3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.