dbPTM

SPICE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPICE_HUMAN
UniProt AC	Q8N0Z3
Protein Name	Spindle and centriole-associated protein 1
Gene Name	SPICE1
Organism	Homo sapiens (Human).
Sequence Length	855
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle .
Protein Description	Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis..
Protein Sequence	MSFVRVNRCGPRVGVRKTPKVKKKKTSVKQEWDNTVTDLTVHRATPEDLVRRHEIHKSKNRALVHWELQEKALKRKWRKQKPETLNLEKRRLSIMKEILSDQYQMQDVLEKSDHLIAAAKELFPRRRTGFPNVTVAPDSSQGPIVVNQDPITQSIFNESVIEPQALNDVDGEEEGTVNSQSGESENENELDNSLNSQSNTNTDRFLQQLTEENFELISKLWTDIQQKIATQSQITPPGTPSSALSSGEQRAALNATNAVKRLQTRLQPEESTETLDSSYVVGHVLNSRKQKQLLNKVKRKPNLHALSKPKKNISSGSTTSADLPNRTNSNLDVLKHMIHEVEHEMEEYERWTGREVKGLQSSQGLTGFTLSLVSSLCRLVRYLKESEIQLRKEVETRQQLEQVLGDHRELIDALTAEILRLREENAATQARLQQYMVTTDEQLISLTHAIKNCPVINNRQEIQASESGATGRRVMDSPERPVVNANVSVPLMFREEVAEFPQEELPVKLSQVPDPPDNMNLAKNFPAHIFEPAVLLTPPRQKSNLKFSPLQDVLRRTVQTRPAPRLPPTVEIIEKEQNWEEKTLPIDTDIQNSSEENRLFTQRWRVSHMGEDLENKTQAPFVNLSQPLCNSHSNTQQSRSPTFSEELPVLGDGQQLRTNESLIQRKDIMTRIADLTLQNSAIKAHMNNIIEPRGEQGDGLRELNKQESASDMTSTFPVAQSLTPGSMEERIAELNRQSMEARGKLLQLIEQQKLVGLNLSPPMSPVQLPLRAWTEGAKRTIEVSIPGAEAPESSKCSTVSPVSGINTRRSSGATGNSCSPLNATSGSGRFTPLNPRAKIEKQNEEGWFALSTHVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Acetylation	GPRVGVRKTPKVKKK CCCCCCCCCCCCCCC	67.77	19815131
27	Phosphorylation	KVKKKKTSVKQEWDN CCCCCCCCCCCHHHC	35.88	-
29	Sumoylation	KKKKTSVKQEWDNTV CCCCCCCCCHHHCCC	42.12	-
29	Sumoylation	KKKKTSVKQEWDNTV CCCCCCCCCHHHCCC	42.12	-
29	Ubiquitination	KKKKTSVKQEWDNTV CCCCCCCCCHHHCCC	42.12	29967540
35	Phosphorylation	VKQEWDNTVTDLTVH CCCHHHCCCCHHHCC	23.47	27251275
37	Phosphorylation	QEWDNTVTDLTVHRA CHHHCCCCHHHCCCC	24.21	26471730
40	Phosphorylation	DNTVTDLTVHRATPE HCCCCHHHCCCCCHH	19.64	30108239
43	Ubiquitination	VTDLTVHRATPEDLV CCHHHCCCCCHHHHH	35.50	29967540
45	Phosphorylation	DLTVHRATPEDLVRR HHHCCCCCHHHHHHH	27.45	29255136
71	Ubiquitination	VHWELQEKALKRKWR HHHHHHHHHHHHHHH	46.16	29967540
79	Ubiquitination	ALKRKWRKQKPETLN HHHHHHHHCCCCCCC	62.65	29967540
81	Ubiquitination	KRKWRKQKPETLNLE HHHHHHCCCCCCCHH	48.10	29967540
84	Phosphorylation	WRKQKPETLNLEKRR HHHCCCCCCCHHHHH	29.49	19651622
85	Ubiquitination	RKQKPETLNLEKRRL HHCCCCCCCHHHHHH	7.03	29967540
89	Ubiquitination	PETLNLEKRRLSIMK CCCCCHHHHHHHHHH	46.08	29967540
93	Phosphorylation	NLEKRRLSIMKEILS CHHHHHHHHHHHHHC	20.87	24719451
93	Ubiquitination	NLEKRRLSIMKEILS CHHHHHHHHHHHHHC	20.87	29967540
95	Ubiquitination	EKRRLSIMKEILSDQ HHHHHHHHHHHHCCC	2.61	29967540
100	Phosphorylation	SIMKEILSDQYQMQD HHHHHHHCCCHHHHH	28.47	29978859
103	Ubiquitination	KEILSDQYQMQDVLE HHHHCCCHHHHHHHH	15.79	29967540
111	Ubiquitination	QMQDVLEKSDHLIAA HHHHHHHHCHHHHHH	57.96	29967540
112	Phosphorylation	MQDVLEKSDHLIAAA HHHHHHHCHHHHHHH	22.38	25849741
125	Ubiquitination	AAKELFPRRRTGFPN HHHHHCCCCCCCCCC	33.12	29967540
227	Ubiquitination	LWTDIQQKIATQSQI HHHHHHHHHHHCCCC	20.24	29967540
230	Phosphorylation	DIQQKIATQSQITPP HHHHHHHHCCCCCCC	32.02	29255136
232	Phosphorylation	QQKIATQSQITPPGT HHHHHHCCCCCCCCC	21.13	29255136
235	Phosphorylation	IATQSQITPPGTPSS HHHCCCCCCCCCCHH	18.78	29255136
239	Phosphorylation	SQITPPGTPSSALSS CCCCCCCCCHHHCCH	26.27	29255136
241	Phosphorylation	ITPPGTPSSALSSGE CCCCCCCHHHCCHHH	28.25	28176443
241	Ubiquitination	ITPPGTPSSALSSGE CCCCCCCHHHCCHHH	28.25	29967540
242	Phosphorylation	TPPGTPSSALSSGEQ CCCCCCHHHCCHHHH	34.14	28176443
245	Phosphorylation	GTPSSALSSGEQRAA CCCHHHCCHHHHHHH	35.69	20873877
246	Phosphorylation	TPSSALSSGEQRAAL CCHHHCCHHHHHHHH	47.39	20873877
249	Phosphorylation	SALSSGEQRAALNAT HHCCHHHHHHHHHHH	43.78	32645325
256	Phosphorylation	QRAALNATNAVKRLQ HHHHHHHHHHHHHHH	23.72	25159151
260	Acetylation	LNATNAVKRLQTRLQ HHHHHHHHHHHHHCC	45.01	25953088
260	Ubiquitination	LNATNAVKRLQTRLQ HHHHHHHHHHHHHCC	45.01	27667366
264	Phosphorylation	NAVKRLQTRLQPEES HHHHHHHHHCCCCCC	37.63	28851738
271	Phosphorylation	TRLQPEESTETLDSS HHCCCCCCCCCCCHH	29.86	24719451
272	Phosphorylation	RLQPEESTETLDSSY HCCCCCCCCCCCHHH	35.95	28348404
272	Ubiquitination	RLQPEESTETLDSSY HCCCCCCCCCCCHHH	35.95	27667366
274	Phosphorylation	QPEESTETLDSSYVV CCCCCCCCCCHHHHH	35.63	28348404
274	Ubiquitination	QPEESTETLDSSYVV CCCCCCCCCCHHHHH	35.63	27667366
277	Phosphorylation	ESTETLDSSYVVGHV CCCCCCCHHHHHHHH	27.04	29978859
278	Phosphorylation	STETLDSSYVVGHVL CCCCCCHHHHHHHHC	22.93	28348404
279	Phosphorylation	TETLDSSYVVGHVLN CCCCCHHHHHHHHCC	11.78	29978859
287	Phosphorylation	VVGHVLNSRKQKQLL HHHHHCCHHHHHHHH	36.37	29978859
291	Ubiquitination	VLNSRKQKQLLNKVK HCCHHHHHHHHHHHH	46.04	29967540
300	Ubiquitination	LLNKVKRKPNLHALS HHHHHHCCCCHHHCC	32.32	29967540
305	Ubiquitination	KRKPNLHALSKPKKN HCCCCHHHCCCCCCC	19.39	29967540
307	Phosphorylation	KPNLHALSKPKKNIS CCCHHHCCCCCCCCC	47.93	24719451
311	Ubiquitination	HALSKPKKNISSGST HHCCCCCCCCCCCCC	68.95	29967540
314	Phosphorylation	SKPKKNISSGSTTSA CCCCCCCCCCCCCCC	37.73	23663014
314	Ubiquitination	SKPKKNISSGSTTSA CCCCCCCCCCCCCCC	37.73	29967540
315	Phosphorylation	KPKKNISSGSTTSAD CCCCCCCCCCCCCCC	32.72	23663014
317	Phosphorylation	KKNISSGSTTSADLP CCCCCCCCCCCCCCC	30.38	23401153
318	Phosphorylation	KNISSGSTTSADLPN CCCCCCCCCCCCCCC	28.44	23663014
319	Phosphorylation	NISSGSTTSADLPNR CCCCCCCCCCCCCCC	24.50	28348404
320	Phosphorylation	ISSGSTTSADLPNRT CCCCCCCCCCCCCCC	21.63	23401153
325	Ubiquitination	TTSADLPNRTNSNLD CCCCCCCCCCCCCHH	71.37	29967540
327	Phosphorylation	SADLPNRTNSNLDVL CCCCCCCCCCCHHHH	50.03	30108239
329	Phosphorylation	DLPNRTNSNLDVLKH CCCCCCCCCHHHHHH	37.85	30108239
334	Phosphorylation	TNSNLDVLKHMIHEV CCCCHHHHHHHHHHH	2.92	33259812
335	Ubiquitination	NSNLDVLKHMIHEVE CCCHHHHHHHHHHHH	30.86	29967540
348	Phosphorylation	VEHEMEEYERWTGRE HHHHHHHHHHHCCCC	9.48	-
349	Ubiquitination	EHEMEEYERWTGREV HHHHHHHHHHCCCCC	45.05	29967540
361	Phosphorylation	REVKGLQSSQGLTGF CCCCCCCCCCCCCHH	29.67	23401153
362	Phosphorylation	EVKGLQSSQGLTGFT CCCCCCCCCCCCHHH	18.46	23401153
369	Phosphorylation	SQGLTGFTLSLVSSL CCCCCHHHHHHHHHH	19.44	23401153
371	Phosphorylation	GLTGFTLSLVSSLCR CCCHHHHHHHHHHHH	24.54	23401153
374	Phosphorylation	GFTLSLVSSLCRLVR HHHHHHHHHHHHHHH	23.92	23401153
428	Phosphorylation	LREENAATQARLQQY HHHHHHHHHHHHHHH	21.98	-
451	Ubiquitination	ISLTHAIKNCPVINN HHHHHHHHCCCCCCC	53.96	-
470	Phosphorylation	QASESGATGRRVMDS ECCCCCCCCCCCCCC	34.44	-
472	Methylation	SESGATGRRVMDSPE CCCCCCCCCCCCCCC	24.54	-
477	Phosphorylation	TGRRVMDSPERPVVN CCCCCCCCCCCCCCC	15.57	23898821
488	Phosphorylation	PVVNANVSVPLMFRE CCCCCCCCCEEECHH	20.16	22210691
508	Ubiquitination	PQEELPVKLSQVPDP CHHHCCCCHHCCCCC	40.25	-
523	Ubiquitination	PDNMNLAKNFPAHIF CCCCCHHHHCCCHHC	63.39	29967540
537	Phosphorylation	FEPAVLLTPPRQKSN CCCEEECCCCCCCCC	27.38	30266825
537	Ubiquitination	FEPAVLLTPPRQKSN CCCEEECCCCCCCCC	27.38	29967540
543	Phosphorylation	LTPPRQKSNLKFSPL CCCCCCCCCCCCCCH	38.77	23312004
548	Phosphorylation	QKSNLKFSPLQDVLR CCCCCCCCCHHHHHH	24.10	22617229
551	Phosphorylation	NLKFSPLQDVLRRTV CCCCCCHHHHHHHHH	41.99	32142685
557	Phosphorylation	LQDVLRRTVQTRPAP HHHHHHHHHCCCCCC	15.55	27794612
560	Phosphorylation	VLRRTVQTRPAPRLP HHHHHHCCCCCCCCC	33.99	27794612
575	Ubiquitination	PTVEIIEKEQNWEEK CCEEEEECCCCHHHC	54.94	29967540
582	Ubiquitination	KEQNWEEKTLPIDTD CCCCHHHCCCCCCCC	43.79	29967540
583	Phosphorylation	EQNWEEKTLPIDTDI CCCHHHCCCCCCCCC	40.83	-
589	Ubiquitination	KTLPIDTDIQNSSEE CCCCCCCCCCCCHHH	36.41	29967540
596	Ubiquitination	DIQNSSEENRLFTQR CCCCCHHHHCHHHHH	49.99	29967540
607	Phosphorylation	FTQRWRVSHMGEDLE HHHHHHHHHCCCCCC	10.13	28555341
616	Ubiquitination	MGEDLENKTQAPFVN CCCCCCCCCCCCCCC	32.41	29967540
617	Phosphorylation	GEDLENKTQAPFVNL CCCCCCCCCCCCCCC	41.36	21130716
625	Phosphorylation	QAPFVNLSQPLCNSH CCCCCCCCCCCCCCC	25.25	21130716
630	Ubiquitination	NLSQPLCNSHSNTQQ CCCCCCCCCCCCCCC	50.90	29967540
631	Phosphorylation	LSQPLCNSHSNTQQS CCCCCCCCCCCCCCC	27.56	21130716
633	Phosphorylation	QPLCNSHSNTQQSRS CCCCCCCCCCCCCCC	41.20	21130716
635	Phosphorylation	LCNSHSNTQQSRSPT CCCCCCCCCCCCCCC	30.88	21130716
638	Phosphorylation	SHSNTQQSRSPTFSE CCCCCCCCCCCCCCC	25.55	21130716
640	Phosphorylation	SNTQQSRSPTFSEEL CCCCCCCCCCCCCCC	33.27	19664994
642	Phosphorylation	TQQSRSPTFSEELPV CCCCCCCCCCCCCCC	40.83	30266825
644	Phosphorylation	QSRSPTFSEELPVLG CCCCCCCCCCCCCCC	32.41	30266825
661	Phosphorylation	QQLRTNESLIQRKDI CCCCCCHHHHHHHHH	32.61	28857561
676	Phosphorylation	MTRIADLTLQNSAIK HHHHHHHHHHHHHHH	27.18	28348404
680	Phosphorylation	ADLTLQNSAIKAHMN HHHHHHHHHHHHHHH	20.57	25159151
683	Ubiquitination	TLQNSAIKAHMNNII HHHHHHHHHHHHCCC	31.77	29967540
697	Ubiquitination	IEPRGEQGDGLRELN CCCCCCCCCHHHHHH	27.01	29967540
708	Phosphorylation	RELNKQESASDMTST HHHHHHCCHHHCCCC	30.49	28348404
710	Phosphorylation	LNKQESASDMTSTFP HHHHCCHHHCCCCCC	36.87	28348404
714	Phosphorylation	ESASDMTSTFPVAQS CCHHHCCCCCCHHHC	22.78	22210691
723	Phosphorylation	FPVAQSLTPGSMEER CCHHHCCCCCCHHHH	30.74	20860994
726	Phosphorylation	AQSLTPGSMEERIAE HHCCCCCCHHHHHHH	24.99	22210691
738	Phosphorylation	IAELNRQSMEARGKL HHHHHHHHHHHHHHH	18.49	24719451
744	Ubiquitination	QSMEARGKLLQLIEQ HHHHHHHHHHHHHHH	40.23	22817900
756	Ubiquitination	IEQQKLVGLNLSPPM HHHHHCCCCCCCCCC	21.20	22817900
758	Ubiquitination	QQKLVGLNLSPPMSP HHHCCCCCCCCCCCC	32.32	22817900
760	Phosphorylation	KLVGLNLSPPMSPVQ HCCCCCCCCCCCCCC	26.36	29255136
764	Phosphorylation	LNLSPPMSPVQLPLR CCCCCCCCCCCCCCH	27.91	28355574
774	Phosphorylation	QLPLRAWTEGAKRTI CCCCHHHCCCCCEEE	24.45	32142685
778	Ubiquitination	RAWTEGAKRTIEVSI HHHCCCCCEEEEEEC	62.01	29967540
779	Methylation	AWTEGAKRTIEVSIP HHCCCCCEEEEEECC	40.16	-
792	Ubiquitination	IPGAEAPESSKCSTV CCCCCCCCCCCCCCC	74.76	29967540
794	O-linked_Glycosylation	GAEAPESSKCSTVSP CCCCCCCCCCCCCCC	35.70	30379171
795	Ubiquitination	AEAPESSKCSTVSPV CCCCCCCCCCCCCCC	41.29	-
797	Phosphorylation	APESSKCSTVSPVSG CCCCCCCCCCCCCCC	35.26	30108239
798	Phosphorylation	PESSKCSTVSPVSGI CCCCCCCCCCCCCCC	34.18	19691289
800	Phosphorylation	SSKCSTVSPVSGINT CCCCCCCCCCCCCCC	21.48	25159151
803	Phosphorylation	CSTVSPVSGINTRRS CCCCCCCCCCCCCCC	37.02	30108239
807	Phosphorylation	SPVSGINTRRSSGAT CCCCCCCCCCCCCCC	26.07	30108239
809	Methylation	VSGINTRRSSGATGN CCCCCCCCCCCCCCC	32.89	-
810	Phosphorylation	SGINTRRSSGATGNS CCCCCCCCCCCCCCC	29.81	28450419
811	Phosphorylation	GINTRRSSGATGNSC CCCCCCCCCCCCCCC	30.54	25849741
814	Phosphorylation	TRRSSGATGNSCSPL CCCCCCCCCCCCCCC	40.18	28450419
817	Phosphorylation	SSGATGNSCSPLNAT CCCCCCCCCCCCCCC	19.81	28450419
819	Phosphorylation	GATGNSCSPLNATSG CCCCCCCCCCCCCCC	32.04	23927012
824	Phosphorylation	SCSPLNATSGSGRFT CCCCCCCCCCCCCCC	32.33	23927012
825	Phosphorylation	CSPLNATSGSGRFTP CCCCCCCCCCCCCCC	28.66	23927012
827	Phosphorylation	PLNATSGSGRFTPLN CCCCCCCCCCCCCCC	26.94	23927012
831	Phosphorylation	TSGSGRFTPLNPRAK CCCCCCCCCCCCCCC	26.04	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPICE_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPICE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPICE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
PCM1_HUMAN	PCM1	physical	26638075
IPO5_HUMAN	IPO5	physical	26638075
PTCD3_HUMAN	PTCD3	physical	26638075
PA2G4_HUMAN	PA2G4	physical	26638075
RHG21_HUMAN	ARHGAP21	physical	26638075
ARI1B_HUMAN	ARID1B	physical	26638075
CP131_HUMAN	CEP131	physical	26638075
BAF_HUMAN	BANF1	physical	26638075
BTF3_HUMAN	BTF3	physical	26638075
SKAP_HUMAN	KNSTRN	physical	26638075
MMTA2_HUMAN	C1orf35	physical	26638075
C2CD3_HUMAN	C2CD3	physical	26638075
CAMP1_HUMAN	CAMSAP1	physical	26638075
CAMP2_HUMAN	CAMSAP2	physical	26638075
C2D1A_HUMAN	CC2D1A	physical	26638075
CC138_HUMAN	CCDC138	physical	26638075
CCD66_HUMAN	CCDC66	physical	26638075
CCD77_HUMAN	CCDC77	physical	26638075
CCNB1_HUMAN	CCNB1	physical	26638075
CE120_HUMAN	CEP120	physical	26638075
CP135_HUMAN	CEP135	physical	26638075
CE162_HUMAN	CEP162	physical	26638075
CE350_HUMAN	CEP350	physical	26638075
CEP44_HUMAN	CEP44	physical	26638075
CEP55_HUMAN	CEP55	physical	26638075
CEP72_HUMAN	CEP72	physical	26638075
CEP85_HUMAN	CEP85	physical	26638075
CEP95_HUMAN	CEP95	physical	26638075
CKAP2_HUMAN	CKAP2	physical	26638075
CKP2L_HUMAN	CKAP2L	physical	26638075
KCRB_HUMAN	CKB	physical	26638075
CLAP1_HUMAN	CLASP1	physical	26638075
CSPP1_HUMAN	CSPP1	physical	26638075
DCLK1_HUMAN	DCLK1	physical	26638075
DDX54_HUMAN	DDX54	physical	26638075
DIAP3_HUMAN	DIAPH3	physical	26638075
ECH1_HUMAN	ECH1	physical	26638075
EMAL4_HUMAN	EML4	physical	26638075
F161A_HUMAN	FAM161A	physical	26638075
GARS_HUMAN	GARS	physical	26638075
GPC4_HUMAN	GPC4	physical	26638075
G6PI_HUMAN	GPI	physical	26638075
GTPB1_HUMAN	GTPBP1	physical	26638075
GTSE1_HUMAN	GTSE1	physical	26638075
HAUS1_HUMAN	HAUS1	physical	26638075
HAUS2_HUMAN	HAUS2	physical	26638075
HAUS3_HUMAN	HAUS3	physical	26638075
HAUS4_HUMAN	HAUS4	physical	26638075
HAUS5_HUMAN	HAUS5	physical	26638075
HAUS6_HUMAN	HAUS6	physical	26638075
HAUS7_HUMAN	HAUS7	physical	26638075
HAUS8_HUMAN	HAUS8	physical	26638075
HMGN1_HUMAN	HMGN1	physical	26638075
HMMR_HUMAN	HMMR	physical	26638075
IPO4_HUMAN	IPO4	physical	26638075
IPO7_HUMAN	IPO7	physical	26638075
IPO8_HUMAN	IPO8	physical	26638075
MOONR_HUMAN	KIAA0753	physical	26638075
CFA97_HUMAN	CFAP97	physical	26638075
CE295_HUMAN	CEP295	physical	26638075
KIF14_HUMAN	KIF14	physical	26638075
KIF2A_HUMAN	KIF2A	physical	26638075
KIF7_HUMAN	KIF7	physical	26638075
LRC49_HUMAN	LRRC49	physical	26638075
LTV1_HUMAN	LTV1	physical	26638075
LUZP1_HUMAN	LUZP1	physical	26638075
MAP1S_HUMAN	MAP1S	physical	26638075
MAP7_HUMAN	MAP7	physical	26638075
MA7D1_HUMAN	MAP7D1	physical	26638075
MA7D2_HUMAN	MAP7D2	physical	26638075
MA7D3_HUMAN	MAP7D3	physical	26638075
MAP9_HUMAN	MAP9	physical	26638075
TAU_HUMAN	MAPT	physical	26638075
MCTS1_HUMAN	MCTS1	physical	26638075
MED4_HUMAN	MED4	physical	26638075
MPP9_HUMAN	MPHOSPH9	physical	26638075
MTPN_HUMAN	MTPN	physical	26638075
MTUS1_HUMAN	MTUS1	physical	26638075
NP1L1_HUMAN	NAP1L1	physical	26638075
NP1L4_HUMAN	NAP1L4	physical	26638075
NDC80_HUMAN	NDC80	physical	26638075
NEDD1_HUMAN	NEDD1	physical	26638075
NOL10_HUMAN	NOL10	physical	26638075
NOP58_HUMAN	NOP58	physical	26638075
NSA2_HUMAN	NSA2	physical	26638075
OFD1_HUMAN	OFD1	physical	26638075
PDZ11_HUMAN	PDZD11	physical	26638075
PHIP_HUMAN	PHIP	physical	26638075
PIBF1_HUMAN	PIBF1	physical	26638075
PKHA5_HUMAN	PLEKHA5	physical	26638075
RAB2A_HUMAN	RAB2A	physical	26638075
RAB35_HUMAN	RAB35	physical	26638075
RALY_HUMAN	RALY	physical	26638075
RBM15_HUMAN	RBM15	physical	26638075
RBMX_HUMAN	RBMX	physical	26638075
RFC5_HUMAN	RFC5	physical	26638075
RPF2_HUMAN	RPF2	physical	26638075
FTM_HUMAN	RPGRIP1L	physical	26638075
SAMH1_HUMAN	SAMHD1	physical	26638075
SEBP2_HUMAN	SECISBP2	physical	26638075
SKA1_HUMAN	SKA1	physical	26638075
SKA2_HUMAN	SKA2	physical	26638075
SKA3_HUMAN	SKA3	physical	26638075
SMG7_HUMAN	SMG7	physical	26638075
SPAG5_HUMAN	SPAG5	physical	26638075
SPC24_HUMAN	SPC24	physical	26638075
SRP72_HUMAN	SRP72	physical	26638075
SSRP1_HUMAN	SSRP1	physical	26638075
ADIP_HUMAN	SSX2IP	physical	26638075
SP16H_HUMAN	SUPT16H	physical	26638075
TCHP_HUMAN	TCHP	physical	26638075
TEX9_HUMAN	TEX9	physical	26638075
TOP2A_HUMAN	TOP2A	physical	26638075
TOP2B_HUMAN	TOP2B	physical	26638075
P53_HUMAN	TP53	physical	26638075
TPGS1_HUMAN	TPGS1	physical	26638075
TRA2B_HUMAN	TRA2B	physical	26638075
TRI36_HUMAN	TRIM36	physical	26638075
TRI37_HUMAN	TRIM37	physical	26638075
TROAP_HUMAN	TROAP	physical	26638075
TXLNG_HUMAN	TXLNG	physical	26638075
VP33B_HUMAN	VPS33B	physical	26638075
TBC31_HUMAN	TBC1D31	physical	26638075
WRP73_HUMAN	WRAP73	physical	26638075
ZC21A_HUMAN	ZC2HC1A	physical	26638075
CENPJ_HUMAN	CENPJ	physical	26638075
NH2L1_HUMAN	NHP2L1	physical	26638075
CE295_HUMAN	CEP295	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
CE120_HUMAN	CEP120	physical	28514442
PLBL1_HUMAN	PLBD1	physical	28514442
MS18A_HUMAN	MIS18A	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
ARGI1_HUMAN	ARG1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPICE_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-235; SER-644 ANDSER-760, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760 AND SER-764, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760 AND SER-764, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-235, AND MASSSPECTROMETRY.	19413330 [Abstract]