dbPTM

ZC21A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC21A_HUMAN
UniProt AC	Q96GY0
Protein Name	Zinc finger C2HC domain-containing protein 1A
Gene Name	ZC2HC1A
Organism	Homo sapiens (Human).
Sequence Length	325
Subcellular Localization
Protein Description
Protein Sequence	MEGLEENGGVVQVGELLPCKICGRTFFPVALKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYDPDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSGKVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNLPKFCHECGTKYPVEWAKFCCECGIRRMIL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	KHEEFIATIRAAKGL HHHHHHHHHHHHHCH	13.23	19413330
149	Phosphorylation	KEQAARISNKGKFST HHHHHHHCCCCCCCC	27.25	28102081
175	Acetylation	VYKPPALKKSNSPGT EECCCCCCCCCCCCC	57.15	12435567
177	Phosphorylation	KPPALKKSNSPGTAS CCCCCCCCCCCCCCC	40.74	22199227
179	Phosphorylation	PALKKSNSPGTASSG CCCCCCCCCCCCCCC	31.62	22199227
182	Phosphorylation	KKSNSPGTASSGSSR CCCCCCCCCCCCCCC	27.10	22199227
184	Phosphorylation	SNSPGTASSGSSRLP CCCCCCCCCCCCCCC	34.76	23090842
185	Phosphorylation	NSPGTASSGSSRLPQ CCCCCCCCCCCCCCC	39.98	23090842
187	Phosphorylation	PGTASSGSSRLPQPS CCCCCCCCCCCCCCC	17.77	28985074
188	Phosphorylation	GTASSGSSRLPQPSG CCCCCCCCCCCCCCC	41.17	28102081
194	Phosphorylation	SSRLPQPSGAGKTVV CCCCCCCCCCCCEEE	35.71	23312004
194	O-linked_Glycosylation	SSRLPQPSGAGKTVV CCCCCCCCCCCCEEE	35.71	28510447
209	Phosphorylation	GVPSGKVSSSSSSLG EECCCCCCCCCCHHH	28.17	23312004
210	Phosphorylation	VPSGKVSSSSSSLGN ECCCCCCCCCCHHHH	36.91	23312004
211	Phosphorylation	PSGKVSSSSSSLGNK CCCCCCCCCCHHHHH	27.08	21712546
212	Phosphorylation	SGKVSSSSSSLGNKL CCCCCCCCCHHHHHH	26.37	21712546
213	Phosphorylation	GKVSSSSSSLGNKLQ CCCCCCCCHHHHHHC	31.37	26699800
214	Phosphorylation	KVSSSSSSLGNKLQT CCCCCCCHHHHHHCC	42.09	26699800
221	Phosphorylation	SLGNKLQTLSPSHKG HHHHHHCCCCCCCCC	39.37	30266825
223	Phosphorylation	GNKLQTLSPSHKGIA HHHHCCCCCCCCCCC	27.95	30266825
225	Phosphorylation	KLQTLSPSHKGIAAP HHCCCCCCCCCCCCC	34.16	22617229
243	Phosphorylation	ANVKPRNSTPPSLAR CCCCCCCCCCHHHHC	43.50	30266825
244	Phosphorylation	NVKPRNSTPPSLARN CCCCCCCCCHHHHCC	42.65	30266825
247	Phosphorylation	PRNSTPPSLARNPAP CCCCCCHHHHCCCCC	35.55	25159151
247	O-linked_Glycosylation	PRNSTPPSLARNPAP CCCCCCHHHHCCCCC	35.55	28510447
258	Phosphorylation	NPAPGVLTNKRKTYT CCCCCCCCCCCCCCC	35.97	25159151
260	Malonylation	APGVLTNKRKTYTES CCCCCCCCCCCCCEE	50.46	26320211
263	Phosphorylation	VLTNKRKTYTESYIA CCCCCCCCCCEEEEC	39.44	28555341
264	Phosphorylation	LTNKRKTYTESYIAR CCCCCCCCCEEEECC	16.14	28555341
278	Phosphorylation	RPDGDCASSLNGGNI CCCCCCCHHCCCCCC	41.51	25159151
279	Phosphorylation	PDGDCASSLNGGNIK CCCCCCHHCCCCCCC	13.82	25159151
292	Phosphorylation	IKGIEGHSPGNLPKF CCCCCCCCCCCHHHH	45.41	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC21A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC21A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC21A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049
CAST1_HUMAN	GATSL3	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC21A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-244 AND SER-292, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-244, AND MASSSPECTROMETRY.	16964243 [Abstract]