CAST1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAST1_HUMAN
• UniProt AC: Q8WTX7
• Protein Name: Cytosolic arginine sensor for mTORC1 subunit 1 {ECO:0000312|HGNC:HGNC:34423}
• Gene Name: CASTOR1 {ECO:0000303|PubMed:26972053, ECO:0000312|HGNC:HGNC:34423}
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway..
• Protein Sequence: MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	EHRVRVLSVARPGLW HHHHHHHHHCCCCEE		-
23	Phosphorylation	ARPGLWLYTHPLIKL CCCCEEEECCHHHHH		-
37	Phosphorylation	LLFLPRRSRCKFFSL HHCCCCCCCCCEEEC		17081983
100	Phosphorylation	GVTKIARSVIAPLAE CHHHHHHHHHHHHHH		22210691
117	Phosphorylation	VSVLMLSTYQTDFIL EEEEEEEECCCCEEE		22210691
120	Phosphorylation	LMLSTYQTDFILVRE EEEEECCCCEEEEEH		22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAST1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAST1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAST1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAST1_HUMAN	GATSL3	physical	25416956
CAST2_HUMAN	GATSL2	physical	26186194
MIO_HUMAN	MIOS	physical	26186194
WDR24_HUMAN	WDR24	physical	26186194
ZC21A_HUMAN	ZC2HC1A	physical	26186194
WDR59_HUMAN	WDR59	physical	26186194
MIO_HUMAN	MIOS	physical	26972053
CAST1_HUMAN	GATSL3	physical	26972053
CAST2_HUMAN	GATSL2	physical	26972053
WDR24_HUMAN	WDR24	physical	26972053
ZC21A_HUMAN	ZC2HC1A	physical	28514442
CAST2_HUMAN	GATSL2	physical	28514442
WDR24_HUMAN	WDR24	physical	28514442
MIO_HUMAN	MIOS	physical	28514442
WDR59_HUMAN	WDR59	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.