WDR24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR24_HUMAN
• UniProt AC: Q96S15
• Protein Name: GATOR complex protein WDR24 {ECO:0000305}
• Gene Name: WDR24 {ECO:0000312|HGNC:HGNC:20852}
• Organism: Homo sapiens (Human).
• Sequence Length: 920
• Subcellular Localization: Lysosome membrane .
• Protein Description: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. [PubMed: 23723238]
• Protein Sequence: MGKKRTTSGEGRERQRLPARRFRTTSPAALRADSVDGGSLLAPLLGLTDRAFSDCPDLADGAMEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGEATEAGPREWAMAGCVPILPVLSCRILRLHHSFAHGPMQDAESTANDARESWGCPLYPLGLCSGPQAGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MGKKRTTSGE -----CCCCCCCCCC	37.47	-
3 (in isoform 2)	Ubiquitination	-	37.47	-
47	Phosphorylation	LLAPLLGLTDRAFSD HHHHHHCCCCCHHCC	4.55	24719451
67	Phosphorylation	DGAMEKMSRVTTALG HHHHHHHHHHHHHHC	34.37	24043423
70	Phosphorylation	MEKMSRVTTALGGSV HHHHHHHHHHHCCCE	12.77	30257219
71	Phosphorylation	EKMSRVTTALGGSVL HHHHHHHHHHCCCEE	19.61	30257219
76	Phosphorylation	VTTALGGSVLTGRTM HHHHHCCCEECCCEE	16.50	28857561
79	Phosphorylation	ALGGSVLTGRTMHCH HHCCCEECCCEEEEE	23.59	-
109	Phosphorylation	QVVVAGRSIFKIYAI HHHHCCCCEEEEEEE	31.31	24719451
120	Ubiquitination	IYAIEEEQFVEKLNL EEEECHHHHHHHHCC	51.47	32015554
153 (in isoform 2)	Ubiquitination	-	9.81	-
153	Ubiquitination	QMDENLLATAATNGV HCCCCHHHHHHHCCE	9.81	-
233 (in isoform 2)	Ubiquitination	-	7.82	-
233	Ubiquitination	TEAGPREWAMAGCVP CCCCHHHHHHCCCEE	7.82	-
356	Ubiquitination	DRGWLATGGRDKMVK HCCEECCCCCCCEEE	24.43	32015554
363	Ubiquitination	GGRDKMVKVWDMTTH CCCCCEEEEECCCCC	33.82	-
368	Phosphorylation	MVKVWDMTTHRAKEM EEEEECCCCCHHCCC	19.58	-
369	Phosphorylation	VKVWDMTTHRAKEMH EEEECCCCCHHCCCH	11.61	-
380	Ubiquitination	KEMHCVQTIASVARV CCCHHHHHHHHHHCC	9.71	32015554
380	Methylation	KEMHCVQTIASVARV CCCHHHHHHHHHHCC	9.71	-
409	Phosphorylation	MMVDHNIYVWDVRRP EECCCCEEEEECCCC	10.78	24248375
435	Ubiquitination	DVTTGIAWRHPHDPS CCCCCCCCCCCCCHH	9.37	-
435 (in isoform 2)	Ubiquitination	-	9.37	-
448	Phosphorylation	PSFLLSGSKDSSLCQ HHHHCCCCCCCHHHH	29.88	24260401
451	Phosphorylation	LLSGSKDSSLCQHLF HCCCCCCCHHHHHHH	29.01	28857561
452	Phosphorylation	LSGSKDSSLCQHLFR CCCCCCCHHHHHHHC	43.21	28857561
458	Phosphorylation	SSLCQHLFRDASQPV CHHHHHHHCCCCCCH	6.61	-
464	Phosphorylation	LFRDASQPVERANPE HHCCCCCCHHHCCCC	27.69	-
470	Phosphorylation	QPVERANPEGLCYGL CCHHHCCCCCCCHHH	35.73	24719451
473 (in isoform 2)	Ubiquitination	-	1.62	-
484	Phosphorylation	LFGDLAFAAKESLVA HHHHHHHHHHHHHHH	16.41	24719451
488	Ubiquitination	LAFAAKESLVAAESG HHHHHHHHHHHHHCC	27.69	32015554
494	Phosphorylation	ESLVAAESGRKPYTG HHHHHHHCCCCCCCC	38.89	28555341
496	Phosphorylation	LVAAESGRKPYTGDR HHHHHCCCCCCCCCC	46.16	24719451
503	Phosphorylation	RKPYTGDRRHPIFFK CCCCCCCCCCCCEEE	39.90	-
510	Methylation	RRHPIFFKRKLDPAE CCCCCEEECCCCCCC	37.56	115978697
524	Phosphorylation	EPFAGLASSALSVFE CCCCCHHHHHEEEEE	22.61	22210691
525	Phosphorylation	PFAGLASSALSVFET CCCCHHHHHEEEEEC	27.85	22210691
545	Phosphorylation	GMRWFVDTAERYALA CCEEEEEHHHHHHHC	25.72	22210691
565	Ubiquitination	ELCDHNAKVARELGR HHHHHHHHHHHHHCC	41.57	-
581	Phosphorylation	QVAQTWTMLRIIYCS HHHHHHHHHHHHHCC	1.46	24719451
586	Phosphorylation	WTMLRIIYCSPGLVP HHHHHHHHCCCCCCC	5.63	23403867
588	Phosphorylation	MLRIIYCSPGLVPTA HHHHHHCCCCCCCCC	12.67	23403867
594	Phosphorylation	CSPGLVPTANLNHSV CCCCCCCCCCCCCCC	22.24	30278072
598	Phosphorylation	LVPTANLNHSVGKGG CCCCCCCCCCCCCCC	25.79	-
600	Phosphorylation	PTANLNHSVGKGGSC CCCCCCCCCCCCCCC	31.34	30278072
603	Ubiquitination	NLNHSVGKGGSCGLP CCCCCCCCCCCCCCC	58.92	-
606	Phosphorylation	HSVGKGGSCGLPLMN CCCCCCCCCCCCCCC	17.43	26074081
614	Phosphorylation	CGLPLMNSFNLKDMA CCCCCCCCCCHHHCC	11.10	30278072
626	Phosphorylation	DMAPGLGSETRLDRS HCCCCCCCCCCCCCC	40.62	25159151
628	Phosphorylation	APGLGSETRLDRSKG CCCCCCCCCCCCCCC	37.92	30108239
633	Phosphorylation	SETRLDRSKGDARSD CCCCCCCCCCCCCCC	40.43	25159151
711	Phosphorylation	LRHEIVDTPPGPEHL CCCCCCCCCCCCHHH	22.08	23401153
724	Phosphorylation	HLQDKADSPHVSGSE HHHCCCCCCCCCCCC	23.05	27422710
728	Phosphorylation	KADSPHVSGSEADVA CCCCCCCCCCCCCHH	33.30	28857561
730	Phosphorylation	DSPHVSGSEADVASL CCCCCCCCCCCHHHH	23.31	27251275
736	Phosphorylation	GSEADVASLAPVDSS CCCCCHHHHCCCCCC	25.55	27080861
742	Phosphorylation	ASLAPVDSSFSLLSV HHHCCCCCCCCHHHH	33.25	21712546
743	Phosphorylation	SLAPVDSSFSLLSVS HHCCCCCCCCHHHHH	17.87	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIO_HUMAN	MIOS	physical	23723238
WDR59_HUMAN	WDR59	physical	23723238
SEH1_HUMAN	SEH1L	physical	23723238
SEC13_HUMAN	SEC13	physical	23723238
DEPD5_HUMAN	DEPDC5	physical	23723238
NPRL3_HUMAN	NPRL3	physical	23723238
NPRL2_HUMAN	NPRL2	physical	23723238
RRAGB_HUMAN	RRAGB	physical	23723238
RRAGC_HUMAN	RRAGC	physical	23723238
FAF1_HUMAN	FAF1	physical	26389662
AIPL1_HUMAN	AIPL1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, AND MASSSPECTROMETRY.
PubMed: 19690332