DEPD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEPD5_HUMAN
• UniProt AC: O75140
• Protein Name: GATOR complex protein DEPDC5 {ECO:0000305}
• Gene Name: DEPDC5 {ECO:0000312|HGNC:HGNC:18423}
• Organism: Homo sapiens (Human).
• Sequence Length: 1603
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm, perinuclear region . Lysosome membrane . Localization to lysosomes is amino acid-independent.
• Protein Description: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway..
• Protein Sequence: MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	HKKGFGGSDDELVVN ECCCCCCCCCCEEEC	42.12	24247654
57	Phosphorylation	PLLLQVKSLKEDLQK HHHHHHHHHHHHHHH	45.90	24719451
66	Phosphorylation	KEDLQKETISVDQTV HHHHHHCCCCCCHHH	26.11	-
155	Phosphorylation	NEKVMCGYISEDTRV CCEEEEEECCCCCEE	9.06	21214269
157	Phosphorylation	KVMCGYISEDTRVVF EEEEEECCCCCEEEE	22.42	28509920
241	Phosphorylation	FPEINRASIRQDHKG CCCCCHHHHCCCCCC	18.31	23879269
273	Phosphorylation	EWTSLLVTIKKLFIQ HHHHHHHHHHHHHHH	27.35	-
299	Phosphorylation	GFPQGDNSTSAQGNY CCCCCCCCCCCCCCH	28.60	28270605
300	Phosphorylation	FPQGDNSTSAQGNYL CCCCCCCCCCCCCHH	34.04	28270605
301	Phosphorylation	PQGDNSTSAQGNYLE CCCCCCCCCCCCHHH	20.58	28270605
306	Phosphorylation	STSAQGNYLEAINLS CCCCCCCHHHHEEEE	16.85	28270605
313	Phosphorylation	YLEAINLSFNVFDKH HHHHEEEEEEEECHH	15.41	28270605
411	Methylation	NHSFYTSKSQLFCNS CCCCCCCCHHHCCCC	34.13	-
432	Phosphorylation	LAGKKPASEKAKNGR ECCCCCCCHHHHCCC	48.43	-
441	Phosphorylation	KAKNGRDTSLGSPKE HHHCCCCCCCCCCCC	25.21	28450419
442	Phosphorylation	AKNGRDTSLGSPKES HHCCCCCCCCCCCCC	34.71	28450419
445	Phosphorylation	GRDTSLGSPKESENA CCCCCCCCCCCCCCC	37.78	29255136
449	Phosphorylation	SLGSPKESENALPIQ CCCCCCCCCCCCCCE	42.13	28464451
469	Phosphorylation	YDAQVFRLPGPSRAQ CCCEEEECCCCCHHH	3.80	33259812
483	Phosphorylation	QCLTTCRSVRERESH HHHHHHHHHHHHHCC	27.89	24247654
489	Phosphorylation	RSVRERESHSRKSAS HHHHHHHCCCCCCCC	32.74	-
491	Phosphorylation	VRERESHSRKSASSC HHHHHCCCCCCCCCC	51.16	-
494	Phosphorylation	RESHSRKSASSCDVS HHCCCCCCCCCCCCC	32.07	25159151
496	Phosphorylation	SHSRKSASSCDVSSS CCCCCCCCCCCCCCC	38.29	25159151
497	Phosphorylation	HSRKSASSCDVSSSP CCCCCCCCCCCCCCC	17.66	25159151
501	Phosphorylation	SASSCDVSSSPSLPS CCCCCCCCCCCCCCC	16.31	22617229
502	Phosphorylation	ASSCDVSSSPSLPSR CCCCCCCCCCCCCCC	46.23	25159151
503	Phosphorylation	SSCDVSSSPSLPSRT CCCCCCCCCCCCCCC	15.82	25159151
505	Phosphorylation	CDVSSSPSLPSRTLP CCCCCCCCCCCCCCC	55.66	25366275
508	Phosphorylation	SSSPSLPSRTLPTEE CCCCCCCCCCCCCHH	43.10	29396449
513	O-linked_Glycosylation	LPSRTLPTEEVRSQA CCCCCCCCHHHHHHC	48.14	28657654
518	Phosphorylation	LPTEEVRSQASDDSS CCCHHHHHHCCCCCC	34.96	25159151
521	Phosphorylation	EEVRSQASDDSSLGK HHHHHHCCCCCCCCC	34.02	25159151
524	Phosphorylation	RSQASDDSSLGKSAN HHHCCCCCCCCCCCE	32.24	25159151
525	Phosphorylation	SQASDDSSLGKSANI HHCCCCCCCCCCCEE	48.40	25159151
546	Phosphorylation	HLHQYEVSSSLGYTS CCCEEECCCCCCCCC	11.41	28348404
547	Phosphorylation	LHQYEVSSSLGYTST CCEEECCCCCCCCCH	34.46	28348404
548	Phosphorylation	HQYEVSSSLGYTSTR CEEECCCCCCCCCHH	20.50	28348404
551	Phosphorylation	EVSSSLGYTSTRDVL ECCCCCCCCCHHHHH	11.65	32645325
569	Phosphorylation	MEPPQRDSSAPGRFH CCCCCCCCCCCCCEE	30.50	28348404
570	Phosphorylation	EPPQRDSSAPGRFHV CCCCCCCCCCCCEEE	42.65	28348404
579	Phosphorylation	PGRFHVGSAESMLHV CCCEEECCCCHHEEC	27.98	29255136
582	Phosphorylation	FHVGSAESMLHVRPG EEECCCCHHEECCCC	26.76	23927012
591	Phosphorylation	LHVRPGGYTPQRALI EECCCCCCCCCHHHC	22.59	23927012
592	Phosphorylation	HVRPGGYTPQRALIN ECCCCCCCCCHHHCC	19.07	23927012
604	Phosphorylation	LINPFAPSRMPMKLT HCCCCCCCCCCCEEC	37.47	25954137
646	Phosphorylation	NMAELQGSGQRDPTH CHHHHCCCCCCCCCC	20.84	29083192
663	Phosphorylation	AELLELAYHEAAGRH HHHHHHHHHHHCCCC	16.90	27642862
671	Phosphorylation	HEAAGRHSNSRQPGD HHHCCCCCCCCCCCC	34.83	25954137
673	Phosphorylation	AAGRHSNSRQPGDGM HCCCCCCCCCCCCCC	34.99	25954137
681	Phosphorylation	RQPGDGMSFLNFSGT CCCCCCCCCCCCCCC	31.92	25954137
699	Phosphorylation	SVGLLSNSGAGMNPR EEEHHCCCCCCCCCC	27.01	25954137
749	Phosphorylation	VDWKSLTTPACLPLT CCHHHCCCCCCEECC	37.53	-
759	Phosphorylation	CLPLTTDYFPDRQGL CEECCCCCCCCCCCC	49.66	-
811	Phosphorylation	CQRLMQGYQIIVQPK HHHHHCCCEEEECCC	66.39	24043423
819	Phosphorylation	QIIVQPKTQKPNPAV EEEECCCCCCCCCCC	35.55	23403867
822	Phosphorylation	VQPKTQKPNPAVPPP ECCCCCCCCCCCCCC	34.25	24719451
831	Phosphorylation	PAVPPPLSSSPLYSR CCCCCCCCCCCCCCC	2.84	25159151
832	Phosphorylation	AVPPPLSSSPLYSRG CCCCCCCCCCCCCCC	5.86	23401153
833	Phosphorylation	VPPPLSSSPLYSRGL CCCCCCCCCCCCCCC	28.96	26657352
836	Phosphorylation	PLSSSPLYSRGLVSR CCCCCCCCCCCCCCC	38.61	28450419
837	Phosphorylation	LSSSPLYSRGLVSRN CCCCCCCCCCCCCCC	57.83	28450419
872	Ubiquitination	LKDKMITVTRYLPKY ECCCEEEEEEECCCC	21.30	21890473
920	Phosphorylation	LEEYKWNYLDQYICS HHHHCCHHHHHHHHC	18.44	-
924	Phosphorylation	KWNYLDQYICSAGSE CCHHHHHHHHCCCCC	5.85	-
960 (in isoform 7)	Ubiquitination	-	10.34	21890473
1003 (in isoform 8)	Phosphorylation	-	3.39	28555341
1012 (in isoform 8)	Phosphorylation	-	8.63	23401153
1016 (in isoform 8)	Phosphorylation	-	33.64	28450419
1018 (in isoform 8)	Phosphorylation	-	49.40	28450419
1021	Phosphorylation	GLQMTGPISTHSLES CCCCCCCCCCCCCCC	18.71	32142685
1028	Phosphorylation	ISTHSLESTAPPVGK CCCCCCCCCCCCCCC	28.52	-
1066	Phosphorylation	AAVHGGKSSAQSAES HHHHCCCCHHCHHCC	24.15	28985074
1071	Phosphorylation	GKSSAQSAESSSVAM CCCHHCHHCCCCCCC	14.40	32142685
1072 (in isoform 1)	Phosphorylation	-	23.47	28555341
1081	Phosphorylation	SSVAMTPTYMDSPRK CCCCCCCCCCCCCCC	24.02	24719451
1081 (in isoform 1)	Phosphorylation	-	24.02	23401153
1081 (in isoform 4)	Phosphorylation	-	24.02	28555341
1085	Phosphorylation	MTPTYMDSPRKDGAF CCCCCCCCCCCCCCC	28.21	25627689
1085 (in isoform 1)	Phosphorylation	-	28.21	28450419
1087 (in isoform 1)	Phosphorylation	-	16.78	28450419
1090	Phosphorylation	MDSPRKDGAFFMEFV CCCCCCCCCCHHHHH	6.06	32142685
1090 (in isoform 4)	Phosphorylation	-	6.06	23401153
1094 (in isoform 4)	Phosphorylation	-	30.08	28450419
1096 (in isoform 4)	Phosphorylation	-	16.82	28450419
1099	Phosphorylation	FFMEFVRSPRTASSA CHHHHHCCCCCCCCC	36.01	32142685
1102	Phosphorylation	EFVRSPRTASSAFYP HHHCCCCCCCCCCCC	24.80	24043423
1104	Phosphorylation	VRSPRTASSAFYPQV HCCCCCCCCCCCCCC	61.66	24043423
1105	Phosphorylation	RSPRTASSAFYPQVS CCCCCCCCCCCCCCC	37.24	24043423
1108	Phosphorylation	RTASSAFYPQVSVDQ CCCCCCCCCCCCCCC	33.16	24043423
1112	Phosphorylation	SAFYPQVSVDQTATP CCCCCCCCCCCCCCC	35.95	24043423
1116	Phosphorylation	PQVSVDQTATPMLDG CCCCCCCCCCCCCCC	44.01	24043423
1118	Phosphorylation	VSVDQTATPMLDGTS CCCCCCCCCCCCCCE	28.82	24043423
1124	Phosphorylation	ATPMLDGTSLGICTG CCCCCCCCEEEEECC	24.11	24043423
1125	Phosphorylation	TPMLDGTSLGICTGQ CCCCCCCEEEEECCC	32.93	24043423
1130	Phosphorylation	GTSLGICTGQSMDRG CCEEEEECCCCCCCC	33.56	24043423
1133	Phosphorylation	LGICTGQSMDRGNSQ EEEECCCCCCCCCCC	42.44	24043423
1328	Phosphorylation	ASYASRHSSFSRSFG CHHHHCCCCCCCCCC	36.77	26699800
1329	Phosphorylation	SYASRHSSFSRSFGG HHHHCCCCCCCCCCC	7.41	26699800
1474	Ubiquitination	DRMHLFQEAIAHRFG HHHHHHHHHHHHHHC	3.71	21890473
1474	Ubiquitination	DRMHLFQEAIAHRFG HHHHHHHHHHHHHHC	3.71	21890473
1487	Ubiquitination	FGFVQDKYSASAFNF HCCCCCCCCCCCCCC	39.03	21890473
1496	Ubiquitination	ASAFNFPAENKPQYI CCCCCCCCCCCCCEE	44.30	21890473
1499	Phosphorylation	FNFPAENKPQYIHVT CCCCCCCCCCEEEEE	28.05	24719451
1502	Phosphorylation	PAENKPQYIHVTGTV CCCCCCCEEEEEEEE	31.31	24043423
1506	Phosphorylation	KPQYIHVTGTVFLQL CCCEEEEEEEEEEEC	27.80	24043423
1508	Phosphorylation	QYIHVTGTVFLQLPY CEEEEEEEEEEECCC	6.60	24043423
1515	Phosphorylation	TVFLQLPYSKRKFSG EEEEECCCCCCCCCC	12.50	18083107
1516	Phosphorylation	VFLQLPYSKRKFSGQ EEEECCCCCCCCCCC	15.80	24043423
1530	Phosphorylation	QQRRRRNSTSSTNQN CHHHHCCCCCCCHHH	22.67	23401153
1531	Phosphorylation	QRRRRNSTSSTNQNM HHHHCCCCCCCHHHH	19.49	23401153
1532	Phosphorylation	RRRRNSTSSTNQNMF HHHCCCCCCCHHHHC	47.30	30108239
1533	Phosphorylation	RRRNSTSSTNQNMFC HHCCCCCCCHHHHCC	40.57	30108239
1534	Phosphorylation	RRNSTSSTNQNMFCE HCCCCCCCHHHHCCE	52.11	30576142
1543	Ubiquitination	QNMFCEERVGYNWAY HHHCCEEHHCCCHHH	56.22	21890473
1543 (in isoform 1)	Ubiquitination	-	56.22	21890473
1546	Phosphorylation	FCEERVGYNWAYNTM CCEEHHCCCHHHHCH	38.00	18083107
1550	Phosphorylation	RVGYNWAYNTMLTKT HHCCCHHHHCHHCCH	4.84	18083107
1552	Ubiquitination	GYNWAYNTMLTKTWR CCCHHHHCHHCCHHH	23.75	21890473
1552 (in isoform 4)	Ubiquitination	-	23.75	21890473
1565	Ubiquitination	WRSSATGDEKFADRL HHCCCCCCHHHHHHH	53.30	21890473
1574	Ubiquitination	KFADRLLKDFTDFCI HHHHHHHHHHHHHHC		21890473
1574	Ubiquitination	KFADRLLKDFTDFCI HHHHHHHHHHHHHHC		21890473
1574	Ubiquitination	KFADRLLKDFTDFCI HHHHHHHHHHHHHHC		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL22	Q53GT1	PMID:29769719:32296023

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEPD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEPD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRAGC_HUMAN	RRAGC	physical	23723238
RRAGA_HUMAN	RRAGA	physical	23723238
NPRL3_HUMAN	NPRL3	physical	23723238
RRAGB_HUMAN	RRAGB	physical	23723238
SZT2_HUMAN	SZT2	physical	28514442
CL066_HUMAN	C12orf66	physical	28514442
ITFG2_HUMAN	ITFG2	physical	28514442
KPTN_HUMAN	KPTN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 604364: Epilepsy, familial focal, with variable foci (FFEVF)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.