KPTN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPTN_HUMAN
• UniProt AC: Q9Y664
• Protein Name: KICSTOR complex protein kaptin {ECO:0000305|PubMed:10099934}
• Gene Name: KPTN {ECO:0000312|HGNC:HGNC:6404}
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Subcellular Localization: Lysosome membrane . Cell projection, lamellipodium . Cell projection, stereocilium . Localization to lysosomes is amino acid-independent (PubMed:28199306). Colocalizes with F-actin (PubMed:24239382).
• Protein Description: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose..
• Protein Sequence: MMGEAAVAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNFPGTSRRLSALGCQSGYVRVAHVDQRSREVLQMWSVLQDGPISRVIVFSLSAAKETKDRPLQDEYSVLVASMLEPAVVYRDLLNRGLEDQLLLPGSDQFDSVLCSLVTDVDLDGRPEVLVATYGQELLCYKYRGPESGLPEAQHGFHLLWQRSFSSPLLAMAHVDLTGDGLQELAVVSLKGVHILQHSLIQASELVLTRLRHQVEQRRRRLQGLEDGAGAGPAENAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMGEAAVA -------CCCCCHHH	7.60	22814378
23	Phosphorylation	EDSFTRFSSQSNVYG CCCCCCCCCCCCCCE	24.95	21406692
24	Phosphorylation	DSFTRFSSQSNVYGL CCCCCCCCCCCCCEE	34.61	21406692
25	Ubiquitination	SFTRFSSQSNVYGLA CCCCCCCCCCCCEEC	37.51	-
26	Phosphorylation	FTRFSSQSNVYGLAG CCCCCCCCCCCEECC	30.15	21406692
29	Phosphorylation	FSSQSNVYGLAGGAG CCCCCCCCEECCCCC	15.63	21406692
38	Methylation	LAGGAGGRGELLAAT ECCCCCCHHHHHHHH	34.20	82955125
47	Ubiquitination	ELLAATLKGKVLGFR HHHHHHHCCCEECCC	52.94	-
49	Ubiquitination	LAATLKGKVLGFRYQ HHHHHCCCEECCCHH	32.47	-
67	Ubiquitination	QKIRPVAKELQFNYI HHHHHHHHHCCCCCC	60.22	-
88	Ubiquitination	VSIDTFNKSPPKRGL EEEECCCCCCCCCCE	61.21	-
100	Phosphorylation	RGLVVGITFIKDSGD CCEEEEEEEEECCCC	17.24	-
223	Phosphorylation	LSALGCQSGYVRVAH HHHCCCCCCEEEEEE	35.85	-
257	Phosphorylation	ISRVIVFSLSAAKET CCEEEEEEECCCCCC	15.55	26270265
259	Phosphorylation	RVIVFSLSAAKETKD EEEEEEECCCCCCCC	25.61	26270265
265	Ubiquitination	LSAAKETKDRPLQDE ECCCCCCCCCCCCCH	53.48	-
287	Phosphorylation	MLEPAVVYRDLLNRG HCCHHHHHHHHHHCC	7.57	-
361	Phosphorylation	FHLLWQRSFSSPLLA HEEEEEECCCCCEEE	17.87	-
363	Phosphorylation	LLWQRSFSSPLLAMA EEEEECCCCCEEEEE	32.09	-
364	Phosphorylation	LWQRSFSSPLLAMAH EEEECCCCCEEEEEC	19.98	-
375	Phosphorylation	AMAHVDLTGDGLQEL EEECEECCCCCHHHE	28.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPTN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPTN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPTN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB25_HUMAN	RAB25	physical	17353931
ITFG2_HUMAN	ITFG2	physical	17353931
TSN7_HUMAN	TSPAN7	physical	17353931
AUP1_HUMAN	AUP1	physical	17353931
A4_HUMAN	APP	physical	21832049
ELP1_HUMAN	IKBKAP	physical	26186194
NFRKB_HUMAN	NFRKB	physical	26186194
DCAM_HUMAN	AMD1	physical	26186194
CL066_HUMAN	C12orf66	physical	26186194
IF4G3_HUMAN	EIF4G3	physical	26186194
ELP2_HUMAN	ELP2	physical	26186194
KLC1_HUMAN	KLC1	physical	26186194
KLC2_HUMAN	KLC2	physical	26186194
KLC4_HUMAN	KLC4	physical	26186194
KINH_HUMAN	KIF5B	physical	26186194
KIF5C_HUMAN	KIF5C	physical	26186194
S14L1_HUMAN	SEC14L1	physical	26186194
ITFG2_HUMAN	ITFG2	physical	26186194
RNH2A_HUMAN	RNASEH2A	physical	26186194
TES_HUMAN	TES	physical	26186194
UBP19_HUMAN	USP19	physical	26186194
SZT2_HUMAN	SZT2	physical	26186194
KLH15_HUMAN	KLHL15	physical	26186194
ELP3_HUMAN	ELP3	physical	26186194
GTSE1_HUMAN	GTSE1	physical	26186194
TMCO4_HUMAN	TMCO4	physical	26186194
COX16_HUMAN	COX16	physical	26186194
MAVS_HUMAN	MAVS	physical	26186194
DPH1_HUMAN	DPH1	physical	26186194
FMN2_HUMAN	FMN2	physical	26186194
ITFG2_HUMAN	ITFG2	physical	28514442
SZT2_HUMAN	SZT2	physical	28514442
CL066_HUMAN	C12orf66	physical	28514442
TMCO4_HUMAN	TMCO4	physical	28514442
S14L1_HUMAN	SEC14L1	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442
KLC4_HUMAN	KLC4	physical	28514442
TES_HUMAN	TES	physical	28514442
RNH2A_HUMAN	RNASEH2A	physical	28514442
ELP3_HUMAN	ELP3	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
KLC1_HUMAN	KLC1	physical	28514442
GTSE1_HUMAN	GTSE1	physical	28514442
MAVS_HUMAN	MAVS	physical	28514442
FMN2_HUMAN	FMN2	physical	28514442
IF4G3_HUMAN	EIF4G3	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
KINH_HUMAN	KIF5B	physical	28514442
ELP2_HUMAN	ELP2	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.