NFRKB_HUMAN - dbPTM
NFRKB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NFRKB_HUMAN
UniProt AC Q6P4R8
Protein Name Nuclear factor related to kappa-B-binding protein
Gene Name NFRKB
Organism Homo sapiens (Human).
Sequence Length 1299
Subcellular Localization Nucleus .
Protein Description Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex..
Protein Sequence MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MDSLDHMLTD
-----CCCHHHHCCC		47.7823663014
7 (in isoform 2)Phosphorylation-4.2624043423
8 (in isoform 2)Phosphorylation-4.3924043423
9PhosphorylationDSLDHMLTDPLELGP
CCHHHHCCCCCCCCC		28.1723663014
13 (in isoform 2)Phosphorylation-58.0024043423
16 (in isoform 2)Phosphorylation-31.3824043423
22 (in isoform 2)Phosphorylation-23.4024043423
36 (in isoform 2)Phosphorylation-7.4724043423
109UbiquitinationNPLHIAQKLFRDGHF
CHHHHHHHHHHCCCC		40.34-
122UbiquitinationHFNPEVVKYRQLCFK
CCCHHHHHHHHHHCH		39.63-
122 (in isoform 2)Ubiquitination-39.63-
130PhosphorylationYRQLCFKSQYKRYLN
HHHHHCHHHHHHHHH		20.6320860994
135 (in isoform 2)Ubiquitination-13.19-
148AcetylationQYFHRLLKQILASRS
HHHHHHHHHHHHCHH		39.6320167786
148UbiquitinationQYFHRLLKQILASRS
HHHHHHHHHHHHCHH		39.632189047
148 (in isoform 1)Ubiquitination-39.6321890473
148 (in isoform 3)Ubiquitination-39.6321890473
155PhosphorylationKQILASRSDLLEMAR
HHHHHCHHHHHHHHH		30.07-
161 (in isoform 2)Ubiquitination-8.3821890473
164PhosphorylationLLEMARRSGPALPFR
HHHHHHHHCCCCCCC		43.5028555341
176PhosphorylationPFRQKRPSPSRTPEE
CCCCCCCCCCCCHHH		39.2723927012
178PhosphorylationRQKRPSPSRTPEERE
CCCCCCCCCCHHHHH		53.8023403867
180PhosphorylationKRPSPSRTPEEREWR
CCCCCCCCHHHHHHH		39.1123403867
188PhosphorylationPEEREWRTQQRYLKV
HHHHHHHHHHHHHHH		30.08-
189 (in isoform 2)Phosphorylation-19.7224719451
191 (in isoform 2)Phosphorylation-29.00-
194UbiquitinationRTQQRYLKVLREVKE
HHHHHHHHHHHHHHH		30.23-
206PhosphorylationVKEECGDTALSSDEE
HHHHHCCCCCCCCHH		18.1220873877
207 (in isoform 2)Ubiquitination-15.36-
209PhosphorylationECGDTALSSDEEDLS
HHCCCCCCCCHHHHH		33.0229116813
210PhosphorylationCGDTALSSDEEDLSS
HCCCCCCCCHHHHHH		50.3029116813
216PhosphorylationSSDEEDLSSWLPSSP
CCCHHHHHHHCCCCC		31.6128102081
217PhosphorylationSDEEDLSSWLPSSPA
CCHHHHHHHCCCCCC		39.6728102081
221PhosphorylationDLSSWLPSSPARSPS
HHHHHCCCCCCCCCC		46.9420873877
222PhosphorylationLSSWLPSSPARSPSP
HHHHCCCCCCCCCCC		22.1920873877
226PhosphorylationLPSSPARSPSPAVPL
CCCCCCCCCCCCCCE		31.6629255136
228PhosphorylationSSPARSPSPAVPLRV
CCCCCCCCCCCCEEE		27.0829255136
251 (in isoform 2)Phosphorylation-53.4224719451
253 (in isoform 2)Phosphorylation-20.9024719451
269UbiquitinationKKHHEKRKHQPDHPD
HHHHHHHCCCCCCCC		58.63-
298PhosphorylationVNAGRKGSLAALYDL
HHCCCCCHHHHHHHH		20.1922617229
303PhosphorylationKGSLAALYDLAVLKK
CCHHHHHHHHHHHHH		12.2723403867
310UbiquitinationYDLAVLKKKVKEKEE
HHHHHHHHHHHHHHH		59.65-
321 (in isoform 2)Ubiquitination-69.48-
323 (in isoform 2)Phosphorylation-6.9924719451
325PhosphorylationKKKKKIKTIKSEAED
HHHHHHHHHHHHHHH		36.7928060719
327SumoylationKKKIKTIKSEAEDLA
HHHHHHHHHHHHHHH		47.6928112733
328PhosphorylationKKIKTIKSEAEDLAE
HHHHHHHHHHHHHHC		37.8820873877
328 (in isoform 2)Phosphorylation-37.8827642862
338PhosphorylationEDLAEPLSSTEGVAP
HHHHCCCCCCCCCCC		46.0230108239
339PhosphorylationDLAEPLSSTEGVAPL
HHHCCCCCCCCCCCH		37.8530108239
340PhosphorylationLAEPLSSTEGVAPLS
HHCCCCCCCCCCCHH		33.1230108239
347PhosphorylationTEGVAPLSQAPSPLA
CCCCCCHHHCCCCCC		24.2028176443
351PhosphorylationAPLSQAPSPLAIPAI
CCHHHCCCCCCCCCC		35.2525159151
372 (in isoform 2)Phosphorylation-2.4227251275
376PhosphorylationCLGINEISSSFFSLL
CCCHHHHCHHHHHHH		17.4716565220
376 (in isoform 2)Phosphorylation-17.4724719451
446PhosphorylationRAVPSSFSPFVEFKE
CCCCCCCCCCCHHHH		21.2628348404
459UbiquitinationKEKTQQWKLLGQSQD
HHHHHHHHHHCCCCC		29.51-
469SumoylationGQSQDNEKELAALFQ
CCCCCCHHHHHHHHH		65.3728112733
488SumoylationTKDQAFCKQENEDSS
HCCHHHHHHCCCCCC		54.94-
488SumoylationTKDQAFCKQENEDSS
HCCHHHHHHCCCCCC		54.9425114211
494PhosphorylationCKQENEDSSDATTPV
HHHCCCCCCCCCCCC		24.7629255136
495PhosphorylationKQENEDSSDATTPVP
HHCCCCCCCCCCCCC		43.5229255136
498PhosphorylationNEDSSDATTPVPRVR
CCCCCCCCCCCCCEE		36.3023927012
499PhosphorylationEDSSDATTPVPRVRT
CCCCCCCCCCCCEEC		24.8225159151
519 (in isoform 2)Phosphorylation-37.4527251275
524 (in isoform 2)Phosphorylation-29.6824719451
527PhosphorylationVFQEQERYRYSQPHK
HHHHHHHHHCCCCCC		17.1028060719
529PhosphorylationQEQERYRYSQPHKAF
HHHHHHHCCCCCCEE		11.6128060719
530PhosphorylationEQERYRYSQPHKAFT
HHHHHHCCCCCCEEE		28.3928060719
556UbiquitinationPVKGVFDKETSLNKA
CCCCCCCCCCCHHHH		51.97-
558PhosphorylationKGVFDKETSLNKARE
CCCCCCCCCHHHHHH		44.2328509920
559PhosphorylationGVFDKETSLNKAREH
CCCCCCCCHHHHHHH		30.9128509920
567PhosphorylationLNKAREHSLLRSDRP
HHHHHHHHHHCCCCC		25.0924719451
576PhosphorylationLRSDRPAYVTILSLV
HCCCCCHHHHHHHHH		10.78-
578PhosphorylationSDRPAYVTILSLVRD
CCCCHHHHHHHHHHH		11.97-
581PhosphorylationPAYVTILSLVRDAAA
CHHHHHHHHHHHHHH		22.4424719451
581 (in isoform 2)Ubiquitination-22.44-
634UbiquitinationLDRLHYEKDPCVKYD
HHHCCCCCCCCEEEE		60.86-
655PhosphorylationIYLHRDRSEEEFERI
EEECCCCCHHHHHHH		54.3624719451
671AcetylationQAQAAAAKARKALQQ
HHHHHHHHHHHHHHC		43.9525953088
680 (in isoform 2)Phosphorylation-50.4724719451
736PhosphorylationALPAIPISPPPVSAV
CCCCCCCCCCCCCCC		26.4628348404
746O-linked_GlycosylationPVSAVNKSGPSTVSE
CCCCCCCCCCCCCCC		51.2130059200
746PhosphorylationPVSAVNKSGPSTVSE
CCCCCCCCCCCCCCC		51.2122199227
749O-linked_GlycosylationAVNKSGPSTVSEPAK
CCCCCCCCCCCCCCC		44.9930059200
750O-linked_GlycosylationVNKSGPSTVSEPAKS
CCCCCCCCCCCCCCC		31.0532574038
750O-linked_GlycosylationVNKSGPSTVSEPAKS
CCCCCCCCCCCCCCC		31.0520068230
752O-linked_GlycosylationKSGPSTVSEPAKSSS
CCCCCCCCCCCCCCC		37.6430059200
757PhosphorylationTVSEPAKSSSGVLLV
CCCCCCCCCCCEEEE		31.6630108239
758PhosphorylationVSEPAKSSSGVLLVS
CCCCCCCCCCEEEEE		30.3330108239
759PhosphorylationSEPAKSSSGVLLVSS
CCCCCCCCCEEEEEC		39.7630108239
765PhosphorylationSSGVLLVSSPTMPHL
CCCEEEEECCCCCCC		30.4828450419
766PhosphorylationSGVLLVSSPTMPHLG
CCEEEEECCCCCCCC		19.5328450419
768PhosphorylationVLLVSSPTMPHLGTM
EEEEECCCCCCCCCC		45.3328450419
774PhosphorylationPTMPHLGTMLSPASS
CCCCCCCCCCCCCCC		22.6928450419
775 (in isoform 2)O-linked_Glycosylation-3.11-
777PhosphorylationPHLGTMLSPASSQTA
CCCCCCCCCCCCCCC		13.9628450419
780PhosphorylationGTMLSPASSQTAPSS
CCCCCCCCCCCCCCH		26.7730108239
781PhosphorylationTMLSPASSQTAPSSQ
CCCCCCCCCCCCCHH		33.3930108239
783PhosphorylationLSPASSQTAPSSQAA
CCCCCCCCCCCHHHH		42.3522199227
786PhosphorylationASSQTAPSSQAAARV
CCCCCCCCHHHHHHH		32.3926074081
787PhosphorylationSSQTAPSSQAAARVV
CCCCCCCHHHHHHHH		23.8426074081
790 (in isoform 2)Phosphorylation-6.5324719451
793 (in isoform 2)Phosphorylation-4.43-
795O-linked_GlycosylationQAAARVVSHSGSAGL
HHHHHHHHCCCCCCC		14.7430059200
799PhosphorylationRVVSHSGSAGLSQVR
HHHHCCCCCCCCEEE		23.3717525332
802 (in isoform 2)Phosphorylation-3.0227251275
803O-linked_GlycosylationHSGSAGLSQVRVVAQ
CCCCCCCCEEEEEEC		26.2230059200
803PhosphorylationHSGSAGLSQVRVVAQ
CCCCCCCCEEEEEEC		26.2217525332
805 (in isoform 2)Phosphorylation-4.51-
812PhosphorylationVRVVAQPSLPAVPQQ
EEEEECCCCCCCCCC		34.6022210691
824 (in isoform 2)Phosphorylation-20.4724719451
841O-linked_GlycosylationPQIRVPATATQTKVV
CCEECCCCCCCCEEE		24.9432574038
841O-linked_GlycosylationPQIRVPATATQTKVV
CCEECCCCCCCCEEE		24.9420068230
841PhosphorylationPQIRVPATATQTKVV
CCEECCCCCCCCEEE		24.9422210691
843O-linked_GlycosylationIRVPATATQTKVVPQ
EECCCCCCCCEEECC		32.2030059200
845O-linked_GlycosylationVPATATQTKVVPQTV
CCCCCCCCEEECCEE		22.8130059200
851PhosphorylationQTKVVPQTVMATVPV
CCEEECCEEEEECCE		13.2325072903
855PhosphorylationVPQTVMATVPVKAQT
ECCEEEEECCEEEEE		13.7725072903
866O-linked_GlycosylationKAQTTAATVQRPGPG
EEEECEEEECCCCCC		18.08-
866 (in isoform 2)O-linked_Glycosylation-18.08-
880PhosphorylationGQTGLTVTSLPATAS
CCCCEEEEECCCCCC		21.2226074081
881O-linked_GlycosylationQTGLTVTSLPATASP
CCCEEEEECCCCCCC		28.1930059200
881PhosphorylationQTGLTVTSLPATASP
CCCEEEEECCCCCCC		28.1926074081
885PhosphorylationTVTSLPATASPVSKP
EEEECCCCCCCCCCC		26.2326074081
887PhosphorylationTSLPATASPVSKPAT
EECCCCCCCCCCCCC		22.8325850435
890PhosphorylationPATASPVSKPATSSP
CCCCCCCCCCCCCCC		35.9826074081
894PhosphorylationSPVSKPATSSPGTSA
CCCCCCCCCCCCCCC		37.9625159151
895PhosphorylationPVSKPATSSPGTSAP
CCCCCCCCCCCCCCC		36.3225627689
896PhosphorylationVSKPATSSPGTSAPS
CCCCCCCCCCCCCCC		24.0125627689
899PhosphorylationPATSSPGTSAPSAST
CCCCCCCCCCCCCCH		25.7125627689
900PhosphorylationATSSPGTSAPSASTA
CCCCCCCCCCCCCHH		44.0625627689
903PhosphorylationSPGTSAPSASTAAVI
CCCCCCCCCCHHHHH		34.2727732954
905PhosphorylationGTSAPSASTAAVIQN
CCCCCCCCHHHHHHC		23.9427732954
906PhosphorylationTSAPSASTAAVIQNV
CCCCCCCHHHHHHCC		20.5327732954
931UbiquitinationITGQLGVKPQTGNSI
EECCCCCCCCCCCCC		29.61-
950AcetylationTNFRIQGKDVLRLPP
ECEEECCEECEECCC		28.4327452117
950UbiquitinationTNFRIQGKDVLRLPP
ECEEECCEECEECCC		28.43-
956 (in isoform 2)Ubiquitination-21.94-
965UbiquitinationSSITTDAKGQTVLRI
CCCCCCCCCCEEEEE		55.12-
968PhosphorylationTTDAKGQTVLRITPD
CCCCCCCEEEEECHH		30.1224719451
975 (in isoform 2)Ubiquitination-30.73-
979PhosphorylationITPDMMATLAKSQVT
ECHHHHHHHHHCCCE		14.8922210691
982UbiquitinationDMMATLAKSQVTTVK
HHHHHHHHCCCEEEE		44.53-
983PhosphorylationMMATLAKSQVTTVKL
HHHHHHHCCCEEEEE		25.0322210691
989UbiquitinationKSQVTTVKLTQDLFG
HCCCEEEEEEEHHHC		43.66-
1004UbiquitinationTGGNTTGKGISATLH
CCCCCCCCCEEEEEE		51.48-
1007 (in isoform 2)Ubiquitination-24.70-
1022PhosphorylationNPVHAADSPAKASSA
CCCCCCCCCCCCCCC		23.2525159151
1027O-linked_GlycosylationADSPAKASSASAPSS
CCCCCCCCCCCCCCC		26.2330059200
1027PhosphorylationADSPAKASSASAPSS
CCCCCCCCCCCCCCC		26.2326074081
1028PhosphorylationDSPAKASSASAPSST
CCCCCCCCCCCCCCC		30.9726074081
1029 (in isoform 2)Ubiquitination-13.76-
1030O-linked_GlycosylationPAKASSASAPSSTPT
CCCCCCCCCCCCCCC		42.5330059200
1030PhosphorylationPAKASSASAPSSTPT
CCCCCCCCCCCCCCC		42.5323312004
1033PhosphorylationASSASAPSSTPTGTT
CCCCCCCCCCCCCCE		46.7020068231
1034PhosphorylationSSASAPSSTPTGTTV
CCCCCCCCCCCCCEE		37.0320068231
1035PhosphorylationSASAPSSTPTGTTVV
CCCCCCCCCCCCEEE		29.2520068231
1037PhosphorylationSAPSSTPTGTTVVKV
CCCCCCCCCCEEEEE		47.4520068231
1039PhosphorylationPSSTPTGTTVVKVTP
CCCCCCCCEEEEECC		20.9220068231
1040PhosphorylationSSTPTGTTVVKVTPD
CCCCCCCEEEEECCC		25.3325002506
1043AcetylationPTGTTVVKVTPDLKP
CCCCEEEEECCCCCC		35.7326051181
1047 (in isoform 2)Phosphorylation-58.9427251275
1049AcetylationVKVTPDLKPTEASSS
EEECCCCCCCCCCCH		58.2223954790
1049UbiquitinationVKVTPDLKPTEASSS
EEECCCCCCCCCCCH		58.22-
1060 (in isoform 2)Phosphorylation-3.78-
1067O-linked_GlycosylationLMPALGVSVADQKGK
HHHHHCCEEECCCCC		15.1330059200
1072AcetylationGVSVADQKGKSTVAS
CCEEECCCCCCCCCC		69.7025953088
1074 (in isoform 2)Ubiquitination-50.41-
1076PhosphorylationADQKGKSTVASSEAK
ECCCCCCCCCCCCCC		24.47-
1080O-linked_GlycosylationGKSTVASSEAKPAAT
CCCCCCCCCCCCCCE		31.6630059200
1083SumoylationTVASSEAKPAATIRI
CCCCCCCCCCCEEEE		31.01-
1083AcetylationTVASSEAKPAATIRI
CCCCCCCCCCCEEEE		31.0123749302
1083SumoylationTVASSEAKPAATIRI
CCCCCCCCCCCEEEE		31.01-
1083UbiquitinationTVASSEAKPAATIRI
CCCCCCCCCCCEEEE		31.01-
1087PhosphorylationSEAKPAATIRIVQGL
CCCCCCCEEEEEEEC		16.94-
1097SulfoxidationIVQGLGVMPPKAGQT
EEEECCCCCCCCCCE		4.4521406390
1116O-linked_GlycosylationTHAKQGASVASGSGT
EECCCCCCCCCCCCE		25.6630059200
1130O-linked_GlycosylationTVHTSAVSLPSMNAA
EEECCCCCCCCCCHH		33.9930059200
1141O-linked_GlycosylationMNAAVSKTVAVASGA
CCHHHCCEEEHHCCC		13.2430059200
1150O-linked_GlycosylationAVASGAASTPISIST
EHHCCCCCCCEEEEC		33.8930059200
1151O-linked_GlycosylationVASGAASTPISISTG
HHCCCCCCCEEEECC		21.6630059200
1154O-linked_GlycosylationGAASTPISISTGAPT
CCCCCCEEEECCCCC		16.2230059200
1156O-linked_GlycosylationASTPISISTGAPTVR
CCCCEEEECCCCCEE		17.6330059200
1161O-linked_GlycosylationSISTGAPTVRQVPVS
EEECCCCCEEECCCE		27.9930059200
1168O-linked_GlycosylationTVRQVPVSTTVVSTS
CEEECCCEEEEEECC		16.5830059200
1168PhosphorylationTVRQVPVSTTVVSTS
CEEECCCEEEEEECC		16.5822210691
1170O-linked_GlycosylationRQVPVSTTVVSTSQA
EECCCEEEEEECCCC		16.0530059200
1173O-linked_GlycosylationPVSTTVVSTSQAGKL
CCEEEEEECCCCCCC		20.2930059200
1173PhosphorylationPVSTTVVSTSQAGKL
CCEEEEEECCCCCCC		20.2922210691
1174O-linked_GlycosylationVSTTVVSTSQAGKLP
CEEEEEECCCCCCCC		17.1630059200
1175O-linked_GlycosylationSTTVVSTSQAGKLPT
EEEEEECCCCCCCCC		15.5530059200
1179AcetylationVSTSQAGKLPTRITV
EECCCCCCCCCEEEE		55.0725953088
1185PhosphorylationGKLPTRITVPLSVIS
CCCCCEEEEEHHHCC		16.8720860994
1189O-linked_GlycosylationTRITVPLSVISQPMK
CEEEEEHHHCCCCCC		16.0130059200
1189PhosphorylationTRITVPLSVISQPMK
CEEEEEHHHCCCCCC		16.0120860994
1192PhosphorylationTVPLSVISQPMKGKS
EEEHHHCCCCCCCCC		26.5220068231
1196AcetylationSVISQPMKGKSVVTA
HHCCCCCCCCCEEEC		70.6225953088
1196MethylationSVISQPMKGKSVVTA
HHCCCCCCCCCEEEC		70.62115973947
1198MethylationISQPMKGKSVVTAPI
CCCCCCCCCEEECCE		34.26115973955
1198UbiquitinationISQPMKGKSVVTAPI
CCCCCCCCCEEECCE		34.26-
1199PhosphorylationSQPMKGKSVVTAPII
CCCCCCCCEEECCEE		30.4128258704
1202PhosphorylationMKGKSVVTAPIIKGN
CCCCCEEECCEECCC		25.2619413330
1207UbiquitinationVVTAPIIKGNLGANL
EEECCEECCCCCCCC		42.33-
1215PhosphorylationGNLGANLSGLGRNII
CCCCCCCCCCCCCEE		31.6020068231
1223 (in isoform 2)Ubiquitination-2.63-
1224PhosphorylationLGRNIILTTMPAGTK
CCCCEEEEECCCCCE		15.6121406692
1225O-linked_GlycosylationGRNIILTTMPAGTKL
CCCEEEEECCCCCEE		20.0830059200
1225PhosphorylationGRNIILTTMPAGTKL
CCCEEEEECCCCCEE		20.0821406692
1230PhosphorylationLTTMPAGTKLIAGNK
EEECCCCCEEECCCC		25.4521406692
1232 (in isoform 2)Ubiquitination-3.05-
1237AcetylationTKLIAGNKPVSFLTA
CEEECCCCCCCHHHH		45.9719608861
1237UbiquitinationTKLIAGNKPVSFLTA
CEEECCCCCCCHHHH		45.9719608861
1255 (in isoform 2)Phosphorylation-36.5821406692
1262AcetylationQATQVRIQTVPASHL
CCCEEEEEEECHHHH		26.3619608861
1262 (in isoform 2)Acetylation-26.36-
1262 (in isoform 2)Ubiquitination-26.36-
1263O-linked_GlycosylationATQVRIQTVPASHLQ
CCEEEEEEECHHHHC		26.5330059200
1267O-linked_GlycosylationRIQTVPASHLQQGTA
EEEEECHHHHCCCCC		20.7530059200
1273O-linked_GlycosylationASHLQQGTASGSSKA
HHHHCCCCCCCCCCE		17.2029406981
1273O-linked_GlycosylationASHLQQGTASGSSKA
HHHHCCCCCCCCCCE		17.2020068230
1275O-linked_GlycosylationHLQQGTASGSSKAVS
HHCCCCCCCCCCEEE		38.7630059200
1278O-linked_GlycosylationQGTASGSSKAVSTVV
CCCCCCCCCEEEEEE		28.3230059200
1279AcetylationGTASGSSKAVSTVVV
CCCCCCCCEEEEEEE		55.2826051181
1282PhosphorylationSGSSKAVSTVVVTTA
CCCCCEEEEEEEECC		21.9723403867
1283PhosphorylationGSSKAVSTVVVTTAP
CCCCEEEEEEEECCC		15.6623403867
1287O-linked_GlycosylationAVSTVVVTTAPSPKQ
EEEEEEEECCCCCCC		12.9630059200
1287PhosphorylationAVSTVVVTTAPSPKQ
EEEEEEEECCCCCCC		12.9630266825
1288PhosphorylationVSTVVVTTAPSPKQA
EEEEEEECCCCCCCC		25.5930266825
1291PhosphorylationVVVTTAPSPKQAPEQ
EEEECCCCCCCCCCC		42.1229255136
1298 (in isoform 2)O-linked_Glycosylation-53.90-
1316 (in isoform 2)Phosphorylation-24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NFRKB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NFRKB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NFRKB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RUVB1_HUMANRUVBL1physical
17721549
RUVB2_HUMANRUVBL2physical
17721549
ACL6A_HUMANACTL6Aphysical
17721549
IN80C_HUMANINO80Cphysical
17721549
TYY1_HUMANYY1physical
17721549
INO80_HUMANINO80physical
17721549
TFPT_HUMANTFPTphysical
17721549
ARP5_HUMANACTR5physical
17721549
ARP8_HUMANACTR8physical
17721549
IN80B_HUMANINO80Bphysical
17721549
IN80E_HUMANINO80Ephysical
17721549
UCHL5_HUMANUCHL5physical
17721549
IN80D_HUMANINO80Dphysical
17721549
MCRS1_HUMANMCRS1physical
17721549
RUVB1_HUMANRUVBL1physical
22939629
TRDMT_HUMANTRDMT1physical
21988832
IPO7_HUMANIPO7physical
22863883
XPOT_HUMANXPOTphysical
22863883
UCHL5_HUMANUCHL5physical
25416956
UCHL5_HUMANUCHL5physical
25194926
INO80_HUMANINO80physical
25194926
ARP5_HUMANACTR5physical
26344197
INO80_HUMANINO80physical
26344197
IN80E_HUMANINO80Ephysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NFRKB_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1237, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228; SER-298 ANDSER-1291, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; THR-1035; SER-1199;THR-1202 AND SER-1291, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-1291, ANDMASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-228, ANDMASS SPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-799 AND SER-803, ANDMASS SPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, AND MASSSPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, AND MASSSPECTROMETRY.

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