IN80E_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IN80E_HUMAN
• UniProt AC: Q8NBZ0
• Protein Name: INO80 complex subunit E
• Gene Name: INO80E
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Nucleus .
• Protein Description: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair..
• Protein Sequence: MNGPADGEVDYKKKYRNLKRKLKFLIYEHECFQEELRKAQRKLLKVSRDKSFLLDRLLQYENVDEDSSDSDATASSDNSETEGTPKLSDTPAPKRKRSPPLGGAPSPSSLSLPPSTGFPLQASGVPSPYLSSLASSRYPPFPSDYLALQLPEPSPLRPKREKRPRLPRKLKMAVGPPDCPVGGPLTFPGRGSGAGVGTTLTPLPPPKMPPPTILSTVPRQMFSDAGSGDDALDGDDDLVIDIPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PADGEVDYKKKYRNL CCCCCCCHHHHHHHH	29.86	21403953
50	2-Hydroxyisobutyrylation	LLKVSRDKSFLLDRL HHHHHHCHHHHHHHH	41.83	-
51	Phosphorylation	LKVSRDKSFLLDRLL HHHHHCHHHHHHHHH	25.97	21712546
67	Phosphorylation	YENVDEDSSDSDATA CCCCCCCCCCCCCCC	33.72	-
88	Phosphorylation	TEGTPKLSDTPAPKR CCCCCCCCCCCCCCC	45.63	29396449
90	Phosphorylation	GTPKLSDTPAPKRKR CCCCCCCCCCCCCCC	20.27	29255136
98	Phosphorylation	PAPKRKRSPPLGGAP CCCCCCCCCCCCCCC	33.63	28464451
106	Phosphorylation	PPLGGAPSPSSLSLP CCCCCCCCCHHCCCC	36.56	28464451
108	Phosphorylation	LGGAPSPSSLSLPPS CCCCCCCHHCCCCCC	48.53	27174698
109	Phosphorylation	GGAPSPSSLSLPPST CCCCCCHHCCCCCCC	25.92	27174698
111	Phosphorylation	APSPSSLSLPPSTGF CCCCHHCCCCCCCCC	40.55	27174698
115	Phosphorylation	SSLSLPPSTGFPLQA HHCCCCCCCCCCCCC	38.94	27174698
116	Phosphorylation	SLSLPPSTGFPLQAS HCCCCCCCCCCCCCC	48.92	27174698
123	Phosphorylation	TGFPLQASGVPSPYL CCCCCCCCCCCCHHH	27.62	30177828
127	Phosphorylation	LQASGVPSPYLSSLA CCCCCCCCHHHHHHH	24.62	26055452
129	Phosphorylation	ASGVPSPYLSSLASS CCCCCCHHHHHHHHH	24.45	24144214
131	Phosphorylation	GVPSPYLSSLASSRY CCCCHHHHHHHHHCC	19.91	24144214
132	Phosphorylation	VPSPYLSSLASSRYP CCCHHHHHHHHHCCC	25.92	24144214
135	Phosphorylation	PYLSSLASSRYPPFP HHHHHHHHHCCCCCC	22.20	24144214
136	Phosphorylation	YLSSLASSRYPPFPS HHHHHHHHCCCCCCC	30.17	24144214
143	Phosphorylation	SRYPPFPSDYLALQL HCCCCCCCCCEEECC	38.99	25884760
145	Phosphorylation	YPPFPSDYLALQLPE CCCCCCCCEEECCCC	9.75	24732914
154	Phosphorylation	ALQLPEPSPLRPKRE EECCCCCCCCCCCCC	34.60	25159151
159	Sumoylation	EPSPLRPKREKRPRL CCCCCCCCCCCCCCC	67.75	28112733
171	Sumoylation	PRLPRKLKMAVGPPD CCCCCHHHCCCCCCC	28.05	28112733
192	Phosphorylation	LTFPGRGSGAGVGTT CCCCCCCCCCCCCCC	24.90	28674419
199	Phosphorylation	SGAGVGTTLTPLPPP CCCCCCCCCCCCCCC	23.78	30576142
201	Phosphorylation	AGVGTTLTPLPPPKM CCCCCCCCCCCCCCC	22.23	21815630
212	Phosphorylation	PPKMPPPTILSTVPR CCCCCCCCEECCCCH	40.08	28555341
215	Phosphorylation	MPPPTILSTVPRQMF CCCCCEECCCCHHHH	24.41	28555341
223	Phosphorylation	TVPRQMFSDAGSGDD CCCHHHHCCCCCCCC	22.62	28102081
227	Phosphorylation	QMFSDAGSGDDALDG HHHCCCCCCCCCCCC	40.55	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
154	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IN80E_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IN80E_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INO80_HUMAN	INO80	physical	17721549
NFRKB_HUMAN	NFRKB	physical	17721549
TFE2_HUMAN	TCF3	physical	17721549
ARP5_HUMAN	ACTR5	physical	17721549
ARP8_HUMAN	ACTR8	physical	17721549
IN80B_HUMAN	INO80B	physical	17721549
TYY1_HUMAN	YY1	physical	17721549
UCHL5_HUMAN	UCHL5	physical	17721549
IN80D_HUMAN	INO80D	physical	17721549
MCRS1_HUMAN	MCRS1	physical	17721549
RUVB1_HUMAN	RUVBL1	physical	17721549
RUVB2_HUMAN	RUVBL2	physical	17721549
ACL6A_HUMAN	ACTL6A	physical	17721549
IN80C_HUMAN	INO80C	physical	17721549
TFPT_HUMAN	TFPT	physical	17721549
ARP5_HUMAN	ACTR5	physical	18922472
ARP8_HUMAN	ACTR8	physical	18922472
ACL6A_HUMAN	ACTL6A	physical	18922472
UCHL5_HUMAN	UCHL5	physical	18922472
IN80B_HUMAN	INO80B	physical	18922472
IN80C_HUMAN	INO80C	physical	18922472
INO80_HUMAN	INO80	physical	18922472
MCRS1_HUMAN	MCRS1	physical	18922472
NFRKB_HUMAN	NFRKB	physical	18922472
TFPT_HUMAN	TFPT	physical	18922472
RUVB1_HUMAN	RUVBL1	physical	18922472
RUVB2_HUMAN	RUVBL2	physical	18922472
TYY1_HUMAN	YY1	physical	18922472
HEN1_HUMAN	NHLH1	physical	21988832
ARP5_HUMAN	ACTR5	physical	26344197
INO80_HUMAN	INO80	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.