HEN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEN1_HUMAN
• UniProt AC: Q02575
• Protein Name: Helix-loop-helix protein 1
• Gene Name: NHLH1
• Organism: Homo sapiens (Human).
• Sequence Length: 133
• Subcellular Localization: Nucleus .
• Protein Description: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system..
• Protein Sequence: MMLNSDTMELDLPPTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	RRRRRRATAKYRTAH HHHHHHHHHHHHHHH	23.13	-
76	Phosphorylation	RRRATAKYRTAHATR HHHHHHHHHHHHHCH	15.67	-
78	Phosphorylation	RATAKYRTAHATRER HHHHHHHHHHHCHHH	21.50	-
104	Phosphorylation	ELRKLLPTLPPDKKL HHHHHHCCCCCCCCC	52.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBTN2_HUMAN	LMO2	physical	12878195
TFE2_HUMAN	TCF3	physical	12878195
LMO3_XENLA	xlmo1	physical	10603358
PSME2_HUMAN	PSME2	physical	21988832
PIM1_HUMAN	PIM1	physical	25416956
CENPP_HUMAN	CENPP	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.