dbPTM

RBTN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBTN2_HUMAN
UniProt AC	P25791
Protein Name	Rhombotin-2
Gene Name	LMO2
Organism	Homo sapiens (Human).
Sequence Length	158
Subcellular Localization	Nucleus .
Protein Description	Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state..
Protein Sequence	MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 3)	Phosphorylation	-	10.60	-
28 (in isoform 3)	Phosphorylation	-	4.34	24247654
64 (in isoform 3)	Phosphorylation	-	8.79	28450419
68 (in isoform 3)	Phosphorylation	-	12.51	28450419
71 (in isoform 3)	Phosphorylation	-	5.44	28450419
72 (in isoform 3)	Phosphorylation	-	9.20	28450419
73	Phosphorylation	EVGRRLYYKLGRKLC HHHHHHHHHHCHHHH	12.34	22817900
74	Ubiquitination	VGRRLYYKLGRKLCR HHHHHHHHHCHHHHH	30.79	21890473
74 (in isoform 1)	Ubiquitination	-	30.79	21890473
84	Phosphorylation	RKLCRRDYLRLFGQD HHHHHHHHHHHHCCC	7.60	22817900
104	Phosphorylation	CDKRIRAYEMTMRVK CHHHHHHHEEEEECC	9.08	22817900
143	Ubiquitination	LLINSDIVCEQDIYE EEECCCEEECHHHHH	3.36	21890473
143 (in isoform 3)	Ubiquitination	-	3.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:31801865

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RBTN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBTN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM5A_HUMAN	KDM5A	physical	9129143
RBTN2_HUMAN	LMO2	physical	7731680
MARE2_HUMAN	MAPRE2	physical	16189514
STAT1_HUMAN	STAT1	physical	16189514
MARE3_HUMAN	MAPRE3	physical	16189514
DAZP2_HUMAN	DAZAP2	physical	16189514
EHMT2_HUMAN	EHMT2	physical	16189514
TAL1_HUMAN	TAL1	physical	8078932
AFAD_HUMAN	MLLT4	physical	12067721
ISL1_HUMAN	ISL1	physical	9452425
TAL1_HUMAN	TAL1	physical	7568177
GATA1_HUMAN	GATA1	physical	7568177
GATA2_HUMAN	GATA2	physical	7568177
TAL1_HUMAN	TAL1	physical	7957052
RB_HUMAN	RB1	physical	10866689
TF65_HUMAN	RELA	physical	21988832
STIP1_HUMAN	STIP1	physical	21988832
CNDH2_HUMAN	NCAPH2	physical	21988832
TLX3_HUMAN	TLX3	physical	21988832
MAGA8_HUMAN	MAGEA8	physical	25416956
HNRPM_HUMAN	HNRNPM	physical	25416956
PDE9A_HUMAN	PDE9A	physical	25416956
KGP1_HUMAN	PRKG1	physical	25416956
REL_HUMAN	REL	physical	25416956
ROCK1_HUMAN	ROCK1	physical	25416956
SKP1_HUMAN	SKP1	physical	25416956
SOX5_HUMAN	SOX5	physical	25416956
STAT1_HUMAN	STAT1	physical	25416956
STAT3_HUMAN	STAT3	physical	25416956
TRIP6_HUMAN	TRIP6	physical	25416956
TUFT1_HUMAN	TUFT1	physical	25416956
UBC9_HUMAN	UBE2I	physical	25416956
ZNF24_HUMAN	ZNF24	physical	25416956
AIMP2_HUMAN	AIMP2	physical	25416956
GO45_HUMAN	BLZF1	physical	25416956
LDB1_HUMAN	LDB1	physical	25416956
ABI2_HUMAN	ABI2	physical	25416956
CACO2_HUMAN	CALCOCO2	physical	25416956
N42L2_HUMAN	N4BP2L2	physical	25416956
NC2A_HUMAN	DRAP1	physical	25416956
MARE2_HUMAN	MAPRE2	physical	25416956
IKZF3_HUMAN	IKZF3	physical	25416956
MARE1_HUMAN	MAPRE1	physical	25416956
MARE3_HUMAN	MAPRE3	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
NUP62_HUMAN	NUP62	physical	25416956
KANK2_HUMAN	KANK2	physical	25416956
TFPT_HUMAN	TFPT	physical	25416956
HOOK1_HUMAN	HOOK1	physical	25416956
MBIP1_HUMAN	MBIP	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
BANP_HUMAN	BANP	physical	25416956
ZF64A_HUMAN	ZFP64	physical	25416956
ZF64B_HUMAN	ZFP64	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
NIF3L_HUMAN	NIF3L1	physical	25416956
RINT1_HUMAN	RINT1	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
DBF4B_HUMAN	DBF4B	physical	25416956
T22D4_HUMAN	TSC22D4	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
IFT43_HUMAN	IFT43	physical	25416956
MR1L1_HUMAN	MRFAP1L1	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
CLHC1_HUMAN	CLHC1	physical	25416956
SAXO1_HUMAN	FAM154A	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
NUTM1_HUMAN	NUTM1	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
HNRPM_HUMAN	HNRNPM	physical	21516116
GORAB_HUMAN	GORAB	physical	28514442
RECQ5_HUMAN	RECQL5	physical	28514442
MEX3D_HUMAN	MEX3D	physical	28514442
LDB1_HUMAN	LDB1	physical	28514442
MN1_HUMAN	MN1	physical	28514442
RNF31_HUMAN	RNF31	physical	28514442
HOIL1_HUMAN	RBCK1	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
SSBP3_HUMAN	SSBP3	physical	28514442
SSBP2_HUMAN	SSBP2	physical	28514442
ARMC5_HUMAN	ARMC5	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
ISL2_HUMAN	ISL2	physical	28514442
AHNK2_HUMAN	AHNAK2	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
ZMYM1_HUMAN	ZMYM1	physical	28514442
RPB7_HUMAN	POLR2G	physical	28514442
RPR1B_HUMAN	RPRD1B	physical	28514442
SSBP4_HUMAN	SSBP4	physical	28514442
CPSM_HUMAN	CPS1	physical	28514442
GPN3_HUMAN	GPN3	physical	28514442
SHRPN_HUMAN	SHARPIN	physical	28514442
RPB3_HUMAN	POLR2C	physical	28514442
RPB4_HUMAN	POLR2D	physical	28514442
LIMD1_HUMAN	LIMD1	physical	28514442
RPB11_HUMAN	POLR2J	physical	28514442
RPRD2_HUMAN	RPRD2	physical	28514442
MSH3_HUMAN	MSH3	physical	28514442
RPB2_HUMAN	POLR2B	physical	28514442
TRI33_HUMAN	TRIM33	physical	28514442
MARE2_HUMAN	MAPRE2	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
CCZ1B_HUMAN	CCZ1	physical	28514442
CCZ1_HUMAN	CCZ1	physical	28514442
MBIP1_HUMAN	MBIP	physical	28514442
RPAB1_HUMAN	POLR2E	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
ABHD8_HUMAN	ABHD8	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
MED20_HUMAN	MED20	physical	28514442
MED14_HUMAN	MED14	physical	28514442
BACD3_HUMAN	KCTD10	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
MED17_HUMAN	MED17	physical	28514442
RPAB2_HUMAN	POLR2F	physical	28514442
RPB9_HUMAN	POLR2I	physical	28514442
KBTB6_HUMAN	KBTBD6	physical	28514442
MEX3C_HUMAN	MEX3C	physical	28514442
KLH23_HUMAN	KLHL23	physical	28514442
I2BP2_HUMAN	IRF2BP2	physical	28514442
GPN1_HUMAN	GPN1	physical	28514442
CSTF1_HUMAN	CSTF1	physical	28514442
MED24_HUMAN	MED24	physical	28514442
APBB1_HUMAN	APBB1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBTN2_HUMAN

Related Literatures of Post-Translational Modification