MEX3D_HUMAN - dbPTM
MEX3D_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MEX3D_HUMAN
UniProt AC Q86XN8
Protein Name RNA-binding protein MEX3D
Gene Name MEX3D
Organism Homo sapiens (Human).
Sequence Length 651
Subcellular Localization Cytoplasm. Nucleus. Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway..
Protein Description RNA binding protein, may be involved in post-transcriptional regulatory mechanisms..
Protein Sequence MPSSLGQPDGGGGGGGGGGGVGAAGEDPGPGPAPPPEGAQEAAPAPRPPPEPDDAAAALRLALDQLSALGLGGAGDTDEEGAAGDGAAAAGGADGGAAPEPVPPDGPEAGAPPTLAPAVAPGSLPLLDPNASPPPPPPPRPSPPDVFAGFAPHPAALGPPTLLADQMSVIGSRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREILSAAEHFSIIRATRSKAGGLPGAAQGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEIEAHITLRTGAFTDAGPDSDFHANGTDVCLDLLGAAASLWAKTPNQGRRPPTATAGLRGDTALGAPSAPEAFYAGSRGGPSVPDPGPASPYSGSGNGGFAFGAEGPGAPVGTAAPDDCDFGFDFDFLALDLTVPAAATIWAPFERAAPLPAFSGCSTVNGAPGPPAAGARRSSGAGTPRHSPTLPEPGGLRLELPLSRRGAPDPVGALSWRPPQGPVSFPGGAAFSTATSLPSSPAAAACAPLDSGASENSRKPPSASSAPALARECVVCAEGEVMAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
155UbiquitinationAGFAPHPAALGPPTL
CCCCCCHHHHCCCCE		16.5727667366
176 (in isoform 3)Phosphorylation-23.0424719451
176PhosphorylationVIGSRKKSVNMTECV
HHCCCCCCCCCEEEE		23.0427050516
180PhosphorylationRKKSVNMTECVPVPS
CCCCCCCEEEEECCC		22.4928634298
208UbiquitinationKIKALRAKTNTYIKT
EEEEEEECCCCEECC		35.5527667366
209PhosphorylationIKALRAKTNTYIKTP
EEEEEECCCCEECCC		31.6328152594
211PhosphorylationALRAKTNTYIKTPVR
EEEECCCCEECCCCC		31.6828152594
212PhosphorylationLRAKTNTYIKTPVRG
EEECCCCEECCCCCC		11.5128152594
214UbiquitinationAKTNTYIKTPVRGEE
ECCCCEECCCCCCCC		36.04-
215PhosphorylationKTNTYIKTPVRGEEP
CCCCEECCCCCCCCC		19.9125159151
256UbiquitinationIIRATRSKAGGLPGA
HHHHHHHHCCCCCCC		48.00-
282PhosphorylationTIQVRVPYRVVGLVV
EEEEECCEEEEEEEE		17.1222210691
292UbiquitinationVGLVVGPKGATIKRI
EEEEECCCCHHHHHH		56.0732142685
309PhosphorylationRTHTYIVTPGRDKEP
CCCEEEECCCCCCCC		15.5128555341
314UbiquitinationIVTPGRDKEPVFAVT
EECCCCCCCCEEEEE		63.66-
385PhosphorylationNQGRRPPTATAGLRG
CCCCCCCCCCCCCCC		39.0525954137
394PhosphorylationTAGLRGDTALGAPSA
CCCCCCCCCCCCCCC		26.9725954137
406 (in isoform 3)Phosphorylation-19.6627642862
406PhosphorylationPSAPEAFYAGSRGGP
CCCCHHHHCCCCCCC		19.6625954137
422PhosphorylationVPDPGPASPYSGSGN
CCCCCCCCCCCCCCC		27.7526074081
424PhosphorylationDPGPASPYSGSGNGG
CCCCCCCCCCCCCCC		24.1426074081
486O-linked_GlycosylationAAPLPAFSGCSTVNG
CCCCCCCCCCCCCCC		40.7831492838
505 (in isoform 3)Phosphorylation-27.8027251275
505 (in isoform 2)Phosphorylation-27.8021406692
505PhosphorylationPAAGARRSSGAGTPR
CCCCCCCCCCCCCCC		27.8023898821
506 (in isoform 3)Phosphorylation-30.7424719451
506PhosphorylationAAGARRSSGAGTPRH
CCCCCCCCCCCCCCC		30.7430278072
506 (in isoform 2)Phosphorylation-30.7421406692
510PhosphorylationRRSSGAGTPRHSPTL
CCCCCCCCCCCCCCC		19.3330278072
510 (in isoform 3)Phosphorylation-19.3324719451
514 (in isoform 2)Phosphorylation-22.3621406692
514 (in isoform 3)Phosphorylation-22.3624719451
514PhosphorylationGAGTPRHSPTLPEPG
CCCCCCCCCCCCCCC		22.3629255136
516PhosphorylationGTPRHSPTLPEPGGL
CCCCCCCCCCCCCCE		58.9430266825
516 (in isoform 2)Phosphorylation-58.9421406692
524MethylationLPEPGGLRLELPLSR
CCCCCCEEEEEECCC		29.4154558815
530PhosphorylationLRLELPLSRRGAPDP
EEEEEECCCCCCCCC		20.2829496963
542PhosphorylationPDPVGALSWRPPQGP
CCCCCCCCCCCCCCC		22.0924719451
559PhosphorylationFPGGAAFSTATSLPS
CCCCCCCCCCCCCCC		16.6522210691
560PhosphorylationPGGAAFSTATSLPSS
CCCCCCCCCCCCCCC		27.7427251275
562PhosphorylationGAAFSTATSLPSSPA
CCCCCCCCCCCCCCC		30.7722210691
563PhosphorylationAAFSTATSLPSSPAA
CCCCCCCCCCCCCCH		35.5027251275
566PhosphorylationSTATSLPSSPAAAAC
CCCCCCCCCCCHHHH		55.0027251275
566 (in isoform 3)Phosphorylation-55.0027251275
567PhosphorylationTATSLPSSPAAAACA
CCCCCCCCCCHHHHC		19.3327251275
567 (in isoform 3)Phosphorylation-19.3327251275
578PhosphorylationAACAPLDSGASENSR
HHHCCCCCCCCCCCC		43.8922210691
586UbiquitinationGASENSRKPPSASSA
CCCCCCCCCCCCCCH		62.19-
589PhosphorylationENSRKPPSASSAPAL
CCCCCCCCCCCHHHH		49.6721406692
591PhosphorylationSRKPPSASSAPALAR
CCCCCCCCCHHHHHH		31.2221406692
592PhosphorylationRKPPSASSAPALARE
CCCCCCCCHHHHHHH		37.6821406692
592 (in isoform 2)Phosphorylation-37.6821406692
631UbiquitinationCAVRICGKSEPECPA
HHHHHCCCCCCCCCC		47.43-
632 (in isoform 3)Phosphorylation-43.6025278378
632 (in isoform 2)Phosphorylation-43.6025278378
632PhosphorylationAVRICGKSEPECPAC
HHHHCCCCCCCCCCC		43.60-
641 (in isoform 3)Phosphorylation-19.7025278378
641 (in isoform 2)Phosphorylation-19.7025278378
641PhosphorylationPECPACRTPATQAIH
CCCCCCCCCCCEEEE		19.7027251275
644 (in isoform 3)Phosphorylation-21.5325278378
644 (in isoform 2)Phosphorylation-21.5325278378
651PhosphorylationTQAIHIFS-------
CEEEEECC-------		38.4127134283
651 (in isoform 3)Phosphorylation-38.41-
651 (in isoform 2)Phosphorylation-38.4124247654
653 (in isoform 3)Phosphorylation--
658 (in isoform 2)Phosphorylation--
660 (in isoform 3)Phosphorylation--
664 (in isoform 2)Phosphorylation--
666 (in isoform 3)Phosphorylation--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MEX3D_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MEX3D_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MEX3D_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AGO2_HUMANAGO2physical
17267406
AGO1_HUMANAGO1physical
17267406
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MEX3D_HUMAN

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Related Literatures of Post-Translational Modification

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