GORAB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GORAB_HUMAN
• UniProt AC: Q5T7V8
• Protein Name: RAB6-interacting golgin
• Gene Name: GORAB
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Cytoplasm . Golgi apparatus .
• Protein Sequence: MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVSPKVDDQCGNSSSIPFLSPNCPNQEGNDISAALAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSWAAVLAV ------CCHHHHHHH	25.97	-
92	Phosphorylation	LLPEQLLSAPKQRVN CCHHHHHCCCHHHCC	51.63	21815630
106	Phosphorylation	NVQKPPFSSPTLPSH CCCCCCCCCCCCCCC	40.98	25850435
107	Phosphorylation	VQKPPFSSPTLPSHF CCCCCCCCCCCCCCE	23.45	25850435
109	Phosphorylation	KPPFSSPTLPSHFTL CCCCCCCCCCCCEEE	53.93	25850435
112	Phosphorylation	FSSPTLPSHFTLTSP CCCCCCCCCEEEECC	34.05	25850435
115	Phosphorylation	PTLPSHFTLTSPVGD CCCCCCEEEECCCCC	24.57	25850435
117	Phosphorylation	LPSHFTLTSPVGDGQ CCCCEEEECCCCCCC	28.11	18669648
118	Phosphorylation	PSHFTLTSPVGDGQP CCCEEEECCCCCCCC	22.24	25159151
140	Phosphorylation	KELGLENSHDGHNNV HHHCCCCCCCCCCCC	17.36	28555341
201	Acetylation	KAIAERSKRTQAETM HHHHHHHHHHHHHHH	66.73	30592249
209	Acetylation	RTQAETMKLKRIQKE HHHHHHHHHHHHHHH	59.27	30592255
256	Phosphorylation	FDRAEAEYIAAKLDI HCHHHHHHHHHHHCH	11.69	27642862
342	Phosphorylation	PFQPAEESVTLEFAK CCCCHHHHHHHHHHH	16.35	28555341
360	Phosphorylation	KCQEQAVSPKVDDQC HHHHHCCCCCCCCCC	23.24	21815630
371	Phosphorylation	DDQCGNSSSIPFLSP CCCCCCCCCCCCCCC	35.97	27251275
372	Phosphorylation	DQCGNSSSIPFLSPN CCCCCCCCCCCCCCC	33.82	27251275
377	Phosphorylation	SSSIPFLSPNCPNQE CCCCCCCCCCCCCCC	17.91	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RCHY1	Q96PM5	PMID:15781263

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GORAB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GORAB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	20598683
ZN363_HUMAN	RCHY1	physical	15781263
A4_HUMAN	APP	physical	21832049
DHB7_HUMAN	HSD17B7	physical	21988832
SCYL1_HUMAN	SCYL1	physical	21988832
HXD9_HUMAN	HOXD9	physical	21988832
NKG7_HUMAN	NKG7	physical	21988832
PTAFR_HUMAN	PTAFR	physical	21988832
ZNF16_HUMAN	ZNF16	physical	21988832
NED4L_HUMAN	NEDD4L	physical	21988832
ZN363_HUMAN	RCHY1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 231070: Geroderma osteodysplasticum (GO)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.