SCYL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCYL1_HUMAN
• UniProt AC: Q96KG9
• Protein Name: N-terminal kinase-like protein
• Gene Name: SCYL1
• Organism: Homo sapiens (Human).
• Sequence Length: 808
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Endoplasmic reticulum-Golgi intermediate compartment . Golgi apparatus, cis-Golgi network . Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-indepe
• Protein Description: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. [PubMed: 18556652 Involved in the maintenance of the Golgi apparatus morphology]
• Protein Sequence: MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	HRGRKKATGSPVSIF CCCCCCCCCCCEEEE		28102081
41	Phosphorylation	GRKKATGSPVSIFVY CCCCCCCCCEEEEEE		25850435
44	Phosphorylation	KATGSPVSIFVYDVK CCCCCCEEEEEEECC		28102081
176	Ubiquitination	NGGGPPRKGIPELEQ CCCCCCCCCCCCHHH		-
249	Malonylation	ELVGANPKVRPNPAR HHHCCCCCCCCCHHH		26320211
292	Ubiquitination	KEPAEKQKFFQELSK CCHHHHHHHHHHHHH		-
299	Ubiquitination	KFFQELSKSLDAFPE HHHHHHHHHHHCCCH		-
332	Phosphorylation	NAGAVVLTPLFKVGK CCCEEEEECHHHHCC		-
339	Ubiquitination	TPLFKVGKFLSAEEY ECHHHHCCCCCHHHH		-
339	Acetylation	TPLFKVGKFLSAEEY ECHHHHCCCCCHHHH		25953088
349	Ubiquitination	SAEEYQQKIIPVVVK CHHHHHHCHHHHHHH		-
430	Ubiquitination	NLNVELMKHFARLQA CCCHHHHHHHHHHHH		-
438	Ubiquitination	HFARLQAKDEQGPIR HHHHHHHCCCCCCCC		-
457	Phosphorylation	VCLGKIGSYLSASTR EEEHHHHHHCCHHHH		23312004
458	Phosphorylation	CLGKIGSYLSASTRH EEHHHHHHCCHHHHH		23312004
460	Phosphorylation	GKIGSYLSASTRHRV HHHHHHCCHHHHHHH		23312004
462	Phosphorylation	IGSYLSASTRHRVLT HHHHCCHHHHHHHHH		28857561
463	Phosphorylation	GSYLSASTRHRVLTS HHHCCHHHHHHHHHH		28857561
469	Phosphorylation	STRHRVLTSAFSRAT HHHHHHHHHHHHHHC		23312004
470	Phosphorylation	TRHRVLTSAFSRATR HHHHHHHHHHHHHCC		23312004
473	Phosphorylation	RVLTSAFSRATRDPF HHHHHHHHHHCCCCC		23312004
536	Ubiquitination	AIRSFLSKLESVSED HHHHHHHHHHHCCCC		-
558	Phosphorylation	EKDVHAASSPGMGGA HHHHHHHCCCCCCHH		28450419
559	Phosphorylation	KDVHAASSPGMGGAA HHHHHHCCCCCCHHH		28450419
568	Phosphorylation	GMGGAAASWAGWAVT CCCHHHHHHHHHHHH		29496963
575	Phosphorylation	SWAGWAVTGVSSLTS HHHHHHHHCHHHHHH		20068231
578	Phosphorylation	GWAVTGVSSLTSKLI HHHHHCHHHHHHHHH		20068231
579	Phosphorylation	WAVTGVSSLTSKLIR HHHHCHHHHHHHHHH		27251275
603 (in isoform 3)	Phosphorylation	-		-
618	Phosphorylation	APTPVPATPTTSGHW CCCCCCCCCCCCCCC		24275569
621	Phosphorylation	PVPATPTTSGHWETQ CCCCCCCCCCCCCCC		24275569
634	Phosphorylation	TQEEDKDTAEDSSTA CCCCCCCCCCCCCCC		-
638	Phosphorylation	DKDTAEDSSTADRWD CCCCCCCCCCCCCCC		25849741
639	Phosphorylation	KDTAEDSSTADRWDD CCCCCCCCCCCCCCC		-
640	Phosphorylation	DTAEDSSTADRWDDE CCCCCCCCCCCCCCC		-
679	Phosphorylation	VSRASQVSNSDHKSS CCCHHHCCCCCCCCC		25849741
681	Phosphorylation	RASQVSNSDHKSSKS CHHHCCCCCCCCCCC		20068231
685	Phosphorylation	VSNSDHKSSKSPESD CCCCCCCCCCCCCCC		28348404
686	Phosphorylation	SNSDHKSSKSPESDW CCCCCCCCCCCCCCH		28348404
688	Phosphorylation	SDHKSSKSPESDWSS CCCCCCCCCCCCHHH		28348404
691	Phosphorylation	KSSKSPESDWSSWEA CCCCCCCCCHHHHHC		28348404
694	Phosphorylation	KSPESDWSSWEAEGS CCCCCCHHHHHCCCC		28348404
695	Phosphorylation	SPESDWSSWEAEGSW CCCCCHHHHHCCCCH		28348404
723	Phosphorylation	PDGTRLASEYNWGGP CCCCCCCCCCCCCCC		28796482
725	Phosphorylation	GTRLASEYNWGGPES CCCCCCCCCCCCCCC		28796482
732	Phosphorylation	YNWGGPESSDKGDPF CCCCCCCCCCCCCCC		28348404
733	Phosphorylation	NWGGPESSDKGDPFA CCCCCCCCCCCCCCC		28348404
735	Ubiquitination	GGPESSDKGDPFATL CCCCCCCCCCCCCEE		-
741	Phosphorylation	DKGDPFATLSARPST CCCCCCCEECCCCCC		21406692
743	Phosphorylation	GDPFATLSARPSTQP CCCCCEECCCCCCCC		26074081
747	Phosphorylation	ATLSARPSTQPRPDS CEECCCCCCCCCCCC		30576142
748	Phosphorylation	TLSARPSTQPRPDSW EECCCCCCCCCCCCC		22199227
754	Phosphorylation	STQPRPDSWGEDNWE CCCCCCCCCCCCCCC		25159151
765	Phosphorylation	DNWEGLETDSRQVKA CCCCCCCCCHHHHHH		22199227
767	Phosphorylation	WEGLETDSRQVKAEL CCCCCCCHHHHHHHH		22199227
801	Acetylation	KVAKGPMKLGARKLD HHHCCCCCCCCCCCC		25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
469	T	Phosphorylation	Kinase	AKT1	P31749	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCYL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCYL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SPT2_HUMAN	SPTY2D1	physical	22939629
CWC27_HUMAN	CWC27	physical	22939629
CRTC3_HUMAN	CRTC3	physical	22863883
SC31A_HUMAN	SEC31A	physical	26186194
CCNF_HUMAN	CCNF	physical	25980818
UBR3_HUMAN	UBR3	physical	28514442
NEK7_HUMAN	NEK7	physical	27173435
P4HA2_HUMAN	P4HA2	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.