UBR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBR3_HUMAN
• UniProt AC: Q6ZT12
• Protein Name: E3 ubiquitin-protein ligase UBR3
• Gene Name: UBR3
• Organism: Homo sapiens (Human).
• Sequence Length: 1888
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A. [PubMed: 27331610]
• Protein Sequence: MAAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLSAERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCKRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADGPSEKDLNKVLQLLEPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTSGLGENACVKKSHEKYLIALKSSGLTYPEDKLVYGVQEPSAGTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKRVKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSVLPDQEMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLTMASQHQNTVLDAEHERSMLEGALTFLVILLSLRLHLGMSDDEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPVFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLENSAEEESDEEASVGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPEVKRDSPASTSSDNLGSLQNSGTAQVFSLVAERRKKFQEIINRSSSEANQVVRPKTSSKWSAPGSAPQLTTAILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEILIQPEIPKYSHGDGITAVERILLKAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASRQKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQASSVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGGVYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVENNPWQRPSNKSIQDLIKEVEELQGRPGAFPSETNLSKEMESVMKDIKNTTQKKYRDYSKTPGSPDNDFLFMYSVARTNLELELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSIDSEYNPWRKLTQLEEMNPQLGYEEQQPEVPILYHDVTSLLLIQILMMPQPLRKDHFTCIVKVLFTLLYTQALAALSVKCSEEDRSAWKHAGALKKSTCDAEKSYEVLLSFVISELFKGKLYHEEGTQECAMVNPIAWSPESMEKCLQDFCLPFLRITSLLQHHLFGEDLPSCQEEEEFSVLASCLGLLPTFYQTEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQESKWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICKERYKVLEQQWISHTFDHINKRWGPHYNGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	AVGGQQPSQPELPAP HHCCCCCCCCCCCCC	54.77	24850871
36	Ubiquitination	AATAAHLKAALSRPD HHHHHHHHHHHCCCC	23.03	29967540
40	Phosphorylation	AHLKAALSRPDNRAG HHHHHHHCCCCCHHC	36.72	27251275
60	Phosphorylation	ALLERVLSAERPLAA HHHHHHHCCCCHHHH	25.81	24719451
206	Phosphorylation	PKDLLMMSEFVLPRF CHHHHHHCHHHHHHH	17.58	23403867
235	Ubiquitination	PAADGPSEKDLNKVL CCCCCCCHHHHHHHH	54.44	22817900
236	Ubiquitination	AADGPSEKDLNKVLQ CCCCCCHHHHHHHHH	72.37	21906983
236 (in isoform 1)	Ubiquitination	-	72.37	21890473
236 (in isoform 4)	Ubiquitination	-	72.37	21890473
239	Ubiquitination	GPSEKDLNKVLQLLE CCCHHHHHHHHHHHH	42.39	22817900
239 (in isoform 3)	Ubiquitination	-	42.39	21906983
240	Ubiquitination	PSEKDLNKVLQLLEP CCHHHHHHHHHHHHH	52.17	22817900
277	Ubiquitination	LTNQQNYKDLTSGLG HHCCCCHHHHHCCCC	54.53	-
290	Ubiquitination	LGENACVKKSHEKYL CCCCCCCCHHHHHEE	48.74	29967540
301	Ubiquitination	EKYLIALKSSGLTYP HHEEEEEHHCCCCCC	33.29	29967540
314	Ubiquitination	YPEDKLVYGVQEPSA CCCHHEEEEECCCCC	23.24	27667366
320	Phosphorylation	VYGVQEPSAGTSSLA EEEECCCCCCCCHHH	38.28	-
323	Phosphorylation	VQEPSAGTSSLAVQG ECCCCCCCCHHHHEE	18.17	-
324	Phosphorylation	QEPSAGTSSLAVQGF CCCCCCCCHHHHEEE	23.57	27251275
325	Phosphorylation	EPSAGTSSLAVQGFI CCCCCCCHHHHEEEC	21.86	27251275
335	Phosphorylation	VQGFIGATGTLGQVD HEEECCCCCCCCCCC	26.03	27251275
337	Phosphorylation	GFIGATGTLGQVDSS EECCCCCCCCCCCCC	24.30	27251275
343	Phosphorylation	GTLGQVDSSDEDDQD CCCCCCCCCCCCCCC	40.61	27251275
344	Phosphorylation	TLGQVDSSDEDDQDG CCCCCCCCCCCCCCC	40.32	27251275
361	Ubiquitination	GLGKRKRVKLSSGTK CCCCCCEEECCCCCC	9.08	27667366
362	Ubiquitination	LGKRKRVKLSSGTKD CCCCCEEECCCCCCC	46.84	27667366
371	Phosphorylation	SSGTKDQSIMDVLKH CCCCCCHHHHHHHHC	29.98	28857561
377	Ubiquitination	QSIMDVLKHKSFLEE HHHHHHHHCHHHHHH	49.16	29967540
411	Phosphorylation	NMLPDQEYKVAFTKT HCCCCCCCCHHEEHH	12.72	-
429	Phosphorylation	HYAFIMKTLKKSHES HHHHHHHHHHHHCCC	26.82	24719451
433	Phosphorylation	IMKTLKKSHESDTMS HHHHHHHHCCCCCCC	30.79	24719451
461	Phosphorylation	EELARQVTEECQLLD HHHHHHHHHHHHHHH	20.09	24043423
472	Phosphorylation	QLLDIMVTVLLYMME HHHHHHHHHHHHHHH	6.51	24043423
476	Phosphorylation	IMVTVLLYMMESCLI HHHHHHHHHHHHHHH	7.11	24043423
480	Phosphorylation	VLLYMMESCLIKSEL HHHHHHHHHHHCHHH	9.05	24043423
554 (in isoform 2)	Ubiquitination	-	50.87	21906983
731	Phosphorylation	DPDYFISSVFERFKV CCCHHHHHHHHHHHH	26.47	24719451
890	Ubiquitination	DRYTAFLKQSGKFPG HHHHHHHHHHCCCCC	35.64	32142685
912	Phosphorylation	KRTSLHPSYKGLMRL CCCCCCCCHHHHHHH	28.82	-
913	Phosphorylation	RTSLHPSYKGLMRLL CCCCCCCHHHHHHHH	17.33	-
991	Phosphorylation	FPGSNLVSNMRHFIN CCCCCHHHHHHHHHH	28.24	-
1008	Ubiquitination	RVRVPETAPEVKRDS EEECCCCCCCCCCCC	9.15	21890473
1012	Ubiquitination	PETAPEVKRDSPAST CCCCCCCCCCCCCCC	49.15	33845483
1015	Phosphorylation	APEVKRDSPASTSSD CCCCCCCCCCCCCCC	26.80	21712546
1018	Phosphorylation	VKRDSPASTSSDNLG CCCCCCCCCCCCCCH	32.00	21712546
1019	Phosphorylation	KRDSPASTSSDNLGS CCCCCCCCCCCCCHH	34.06	27251275
1020	Phosphorylation	RDSPASTSSDNLGSL CCCCCCCCCCCCHHH	32.95	27251275
1021	Phosphorylation	DSPASTSSDNLGSLQ CCCCCCCCCCCHHHC	30.52	27251275
1026	Phosphorylation	TSSDNLGSLQNSGTA CCCCCCHHHCCCHHH	29.92	26657352
1044	Ubiquitination	SLVAERRKKFQEIIN HHHHHHHHHHHHHHH	65.25	21890473
1045	Ubiquitination	LVAERRKKFQEIINR HHHHHHHHHHHHHHC	50.93	27667366
1045 (in isoform 1)	Ubiquitination	-	50.93	21890473
1045 (in isoform 4)	Ubiquitination	-	50.93	21890473
1053	Phosphorylation	FQEIINRSSSEANQV HHHHHHCCCCCCCCC	33.46	28857561
1054	Phosphorylation	QEIINRSSSEANQVV HHHHHCCCCCCCCCC	29.03	28857561
1055	Phosphorylation	EIINRSSSEANQVVR HHHHCCCCCCCCCCC	41.81	28857561
1055	Ubiquitination	EIINRSSSEANQVVR HHHHCCCCCCCCCCC	41.81	21890473
1056	Ubiquitination	IINRSSSEANQVVRP HHHCCCCCCCCCCCC	54.29	21890473
1064	Ubiquitination	ANQVVRPKTSSKWSA CCCCCCCCCCCCCCC	50.94	29967540
1065	Phosphorylation	NQVVRPKTSSKWSAP CCCCCCCCCCCCCCC	40.70	20873877
1066	Phosphorylation	QVVRPKTSSKWSAPG CCCCCCCCCCCCCCC	35.73	20873877
1067	Phosphorylation	VVRPKTSSKWSAPGS CCCCCCCCCCCCCCC	43.29	20873877
1070	Phosphorylation	PKTSSKWSAPGSAPQ CCCCCCCCCCCCCCH	28.46	20873877
1074	Phosphorylation	SKWSAPGSAPQLTTA CCCCCCCCCCHHHHH	35.40	20873877
1079	Phosphorylation	PGSAPQLTTAILEIK CCCCCHHHHHHHHHH	14.66	20873877
1080	Phosphorylation	GSAPQLTTAILEIKE CCCCHHHHHHHHHHH	21.94	20873877
1101	Phosphorylation	IKLHHKLSGKQNSYY HHHHHHHCCCCCCCC	49.07	29391485
1104	Ubiquitination	HHKLSGKQNSYYPPW HHHHCCCCCCCCCCC	47.85	21890473
1140	Ubiquitination	TAVERILLKAASQSR HHHHHHHHHHHHHHH	3.10	21890473
1141	Methylation	AVERILLKAASQSRM HHHHHHHHHHHHHHH	38.16	44508513
1141	Ubiquitination	AVERILLKAASQSRM HHHHHHHHHHHHHHH	38.16	27667366
1141 (in isoform 1)	Ubiquitination	-	38.16	21890473
1141 (in isoform 4)	Ubiquitination	-	38.16	21890473
1144	Phosphorylation	RILLKAASQSRMNKR HHHHHHHHHHHHHHH	33.28	29449344
1146	Phosphorylation	LLKAASQSRMNKRII HHHHHHHHHHHHHHH	30.88	29449344
1151	Ubiquitination	SQSRMNKRIIEEICR HHHHHHHHHHHHHHH	30.07	21890473
1152	Ubiquitination	QSRMNKRIIEEICRK HHHHHHHHHHHHHHH	5.06	21890473
1159	Ubiquitination	IIEEICRKVTPPVPP HHHHHHHHCCCCCCC	46.15	29967540
1161	Phosphorylation	EEICRKVTPPVPPKK HHHHHHCCCCCCCHH	25.55	22985185
1168	Acetylation	TPPVPPKKVTAAEKK CCCCCCHHCCHHHHH	51.06	91283
1170	Phosphorylation	PVPPKKVTAAEKKTL CCCCHHCCHHHHHCC	29.09	22798277
1174	Acetylation	KKVTAAEKKTLDKEE HHCCHHHHHCCCHHH	46.46	91285
1174	Ubiquitination	KKVTAAEKKTLDKEE HHCCHHHHHCCCHHH	46.46	-
1199	Phosphorylation	KLLAEFASRQKSFME HHHHHHHHHCHHHHH	40.33	24173317
1203	Phosphorylation	EFASRQKSFMETAMD HHHHHCHHHHHHCCC	22.84	-
1274	Ubiquitination	RDNVEPKKLPISEEE CCCCCCCCCCCCHHH	70.93	29967540
1284	Phosphorylation	ISEEEQIYPWDTCAA CCHHHCCCCHHHHHH	9.66	-
1355	Ubiquitination	LQGFSVDKGEFTCPL ECCEECCCCCCCCHH	59.18	30230243
1390	Ubiquitination	PWQRPSNKSIQDLIK CCCCCCCHHHHHHHH	53.96	-
1397	Ubiquitination	KSIQDLIKEVEELQG HHHHHHHHHHHHHCC	64.10	29967540
1421	Phosphorylation	NLSKEMESVMKDIKN CCCHHHHHHHHHHHH	26.63	23663014
1424	Methylation	KEMESVMKDIKNTTQ HHHHHHHHHHHHHHH	54.89	-
1472	Phosphorylation	HRGGNLCSGGASTAG ECCCCCCCCCCCCCC	43.35	-
1480	Ubiquitination	GGASTAGKRSCLNQL CCCCCCCHHHHHHHH	38.38	29901268
1565	Phosphorylation	CIVKVLFTLLYTQAL HHHHHHHHHHHHHHH	16.22	-
1588	Ubiquitination	EEDRSAWKHAGALKK HHHHHHHHHHHHHCC	24.24	29967540
1700	Ubiquitination	QTEHPFISASCLDWP CCCCCCCCHHHCCCC	17.95	22817900
1733	Ubiquitination	ERHAEQGKALLIQES HHHHHHCCEEEEECC	35.24	22817900
1733 (in isoform 1)	Ubiquitination	-	35.24	21890473
1736	Ubiquitination	AEQGKALLIQESKWK HHHCCEEEEECCCCC	4.54	22817900
1737	Ubiquitination	EQGKALLIQESKWKL HHCCEEEEECCCCCC	4.43	22817900
1744	Ubiquitination	IQESKWKLPHLLQLP EECCCCCCCHHHCCC	2.91	22817900
1747	Ubiquitination	SKWKLPHLLQLPENY CCCCCCHHHCCCCHH	2.85	22817900
1748	Ubiquitination	KWKLPHLLQLPENYN CCCCCHHHCCCCHHH	4.46	22817900
1762 (in isoform 4)	Ubiquitination	-	21.59	21890473
1771	Ubiquitination	KTCSVCTKVPKDPAV CCCCCCCCCCCCHHH	51.95	29967540
1853	Ubiquitination	DRDLRRGKPLYICKE CCCCCCCCEEEEEHH	30.00	-
1856	Phosphorylation	LRRGKPLYICKERYK CCCCCEEEEEHHHHH	16.89	21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APEX1_HUMAN	APEX1	physical	21933813
UBE2H_HUMAN	UBE2H	physical	21933813

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.