CCNF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNF_HUMAN
• UniProt AC: P41002
• Protein Name: Cyclin-F
• Gene Name: CCNF
• Organism: Homo sapiens (Human).
• Sequence Length: 786
• Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosom
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication..
• Protein Sequence: MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMNLGLVRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	VVHCRCAKCFCYPTK EEEECCCCCEECCCH	31.31	-
17	Phosphorylation	RCAKCFCYPTKRRIR CCCCCEECCCHHHHH	8.16	29759185
20	Acetylation	KCFCYPTKRRIRRRP CCEECCCHHHHHCCC	34.86	25953088
20	Ubiquitination	KCFCYPTKRRIRRRP CCEECCCHHHHHCCC	34.86	-
31	Phosphorylation	RRRPRNLTILSLPED HCCCCCCEEEECCHH	24.34	22210691
34	Phosphorylation	PRNLTILSLPEDVLF CCCCEEEECCHHHHH	37.72	22210691
97	Ubiquitination	LFERAAEKGNFEAAV HHHHHHHCCCHHHHH	55.20	21906983
130	Ubiquitination	RAEVNGLKASRFFSL HHHHCCCHHHHHHHH	45.79	-
183	Ubiquitination	CQLQRTHKASILHCL HHHHHHHHHHHHHHH	43.12	-
264	Ubiquitination	EAQLSLAKACANANQ HHHHHHHHHHHCCHH	49.65	-
404	Ubiquitination	IVSALEGKIRVPTVV HHHHHCCCCCCCCEE	20.26	2190698
414	Ubiquitination	VPTVVDYKEVLLTLV CCCEECHHHHHHHEE	36.56	-
495	Ubiquitination	CVLSLHKKCFHDDAP HHHHHHHHHCCCCCC	31.24	-
503	Ubiquitination	CFHDDAPKDYRQVSL HCCCCCCCCHHHHHH	69.94	-
514	Ubiquitination	QVSLTAVKQRFEDKR HHHHHHHHHHHCCCC	33.04	-
577	Phosphorylation	TKRKRENSLQEDRGS CCCHHHCCCCCCCCC	27.03	-
588	Phosphorylation	DRGSFVTTPTAELSS CCCCCCCCCCHHHCC	17.22	-
590	Phosphorylation	GSFVTTPTAELSSQE CCCCCCCCHHHCCCC	30.58	-
621	Phosphorylation	GYEGDQESEGEKEGD CCCCCCCCCCCCCCC	45.31	-
680	Phosphorylation	LDTQIPATPGPKPLV HCCCCCCCCCCCCCC	24.35	27050516
684	Ubiquitination	IPATPGPKPLVRTSR CCCCCCCCCCCCCCC	57.82	-
709	Phosphorylation	YSSVSTASPTSSVDG CCCCCCCCCCCCCCC	28.88	-
713	Phosphorylation	STASPTSSVDGGLGA CCCCCCCCCCCCCCC	27.06	-
746	Phosphorylation	CHHQARKSCLQCRPP CHHHHHHHHHCCCCC	17.95	24719451
754	Phosphorylation	CLQCRPPSPPESSVP HHCCCCCCCCCCCCC	56.63	23663014
758	Phosphorylation	RPPSPPESSVPQQQV CCCCCCCCCCCHHHH	42.27	23663014
759	Phosphorylation	PPSPPESSVPQQQVK CCCCCCCCCCHHHHC	35.83	23663014
774	Phosphorylation	RINLCIHSEEEDMNL EEEEECCCCCHHCCC	27.13	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	T	Phosphorylation	Kinase	AKT1	P31749	PSP
577	S	Phosphorylation	Kinase	AKT1	P31749	PSP
621	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP110_HUMAN	CCP110	physical	20596027
RIR2_HUMAN	RRM2	physical	22632967
SKP1_HUMAN	SKP1	physical	22632967
CUL1_HUMAN	CUL1	physical	21640084
RBX1_HUMAN	RBX1	physical	21640084
SKP1_HUMAN	SKP1	physical	21640084
CP110_HUMAN	CCP110	physical	23486064
NUSAP_HUMAN	NUSAP1	physical	21963094
CUL1_HUMAN	CUL1	physical	23319600
MYBB_HUMAN	MYBL2	physical	25557911
CDC6_HUMAN	CDC6	physical	26818844
SLBP_HUMAN	SLBP	physical	27773672
SKP1_HUMAN	SKP1	physical	28614300
FZR1_HUMAN	FZR1	physical	27653696
CDC20_HUMAN	CDC20	physical	27653696
AKT1_HUMAN	AKT1	physical	28954236
SKP1_HUMAN	SKP1	physical	28954236
CUL1_HUMAN	CUL1	physical	28954236

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.