dbPTM

NUSAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NUSAP_HUMAN
UniProt AC	Q9BXS6
Protein Name	Nucleolar and spindle-associated protein 1
Gene Name	NUSAP1
Organism	Homo sapiens (Human).
Sequence Length	441
Subcellular Localization	Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anap
Protein Description	Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them..
Protein Sequence	MIIPSLEELDSLKYSDLQNLAKSLGLRANLRATKLLKALKGYIKHEARKGNENQDESQTSASSCDETEIQISNQEEAERQPLGHVTKTRRRCKTVRVDPDSQQNHSEIKISNPTEFQNHEKQESQDLRATAKVPSPPDEHQEAENAVSSGNRDSKVPSEGKKSLYTDESSKPGKNKRTAITTPNFKKLHEAHFKEMESIDQYIERKKKHFEEHNSMNELKQQPINKGGVRTPVPPRGRLSVASTPISQRRSQGRSCGPASQSTLGLKGSLKRSAISAAKTGVRFSAATKDNEHKRSLTKTPARKSAHVTVSGGTPKGEAVLGTHKLKTITGNSAAVITPFKLTTEATQTPVSNKKPVFDLKASLSRPLNYEPHKGKLKPWGQSKENNYLNQHVNRINFYKKTYKQPHLQTKEEQRKKREQERKEKKAKVLGMRRGLILAED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MIIPSLEELDSL ---CCCCCHHHHHHC	37.70	26552605
11	Phosphorylation	PSLEELDSLKYSDLQ CCHHHHHHCCHHHHH	39.11	26552605
33	Phosphorylation	LRANLRATKLLKALK HHHHHHHHHHHHHHH	18.78	-
57	Phosphorylation	GNENQDESQTSASSC CCCCCCHHHCCHHHC	47.23	23663014
59	Phosphorylation	ENQDESQTSASSCDE CCCCHHHCCHHHCCC	35.22	23663014
60	Phosphorylation	NQDESQTSASSCDET CCCHHHCCHHHCCCC	20.65	23663014
62	Phosphorylation	DESQTSASSCDETEI CHHHCCHHHCCCCEE	31.13	23663014
63	Phosphorylation	ESQTSASSCDETEIQ HHHCCHHHCCCCEEE	25.88	23663014
67	Phosphorylation	SASSCDETEIQISNQ CHHHCCCCEEECCCH	25.74	23663014
84	Ubiquitination	AERQPLGHVTKTRRR HHHCCCCCHHHCCCC	31.58	24816145
87	Acetylation	QPLGHVTKTRRRCKT CCCCCHHHCCCCEEE	38.66	25953088
99	Ubiquitination	CKTVRVDPDSQQNHS EEEEEECCCCCCCCC	40.05	24816145
101	Phosphorylation	TVRVDPDSQQNHSEI EEEECCCCCCCCCCC	38.77	25849741
106	Phosphorylation	PDSQQNHSEIKISNP CCCCCCCCCCCCCCC	48.87	25159151
109 (in isoform 4)	Phosphorylation	-	35.71	25849741
109 (in isoform 6)	Phosphorylation	-	35.71	25849741
111	Phosphorylation	NHSEIKISNPTEFQN CCCCCCCCCCHHHCC	31.58	23186163
114	Phosphorylation	EIKISNPTEFQNHEK CCCCCCCHHHCCCCH	54.40	23186163
121	Ubiquitination	TEFQNHEKQESQDLR HHHCCCCHHHCCCHH	52.38	16196087
124	Phosphorylation	QNHEKQESQDLRATA CCCCHHHCCCHHHHC	26.88	17525332
130	Phosphorylation	ESQDLRATAKVPSPP HCCCHHHHCCCCCCC	22.15	24732914
132	Acetylation	QDLRATAKVPSPPDE CCHHHHCCCCCCCHH	50.77	25953088
135	Phosphorylation	RATAKVPSPPDEHQE HHHCCCCCCCHHHHH	52.64	29255136
139	Ubiquitination	KVPSPPDEHQEAENA CCCCCCHHHHHHHHH	53.93	24816145
147	Ubiquitination	HQEAENAVSSGNRDS HHHHHHHHHCCCCCC	7.64	24816145
148	Phosphorylation	QEAENAVSSGNRDSK HHHHHHHHCCCCCCC	30.07	25159151
148	Ubiquitination	QEAENAVSSGNRDSK HHHHHHHHCCCCCCC	30.07	16196087
149	Phosphorylation	EAENAVSSGNRDSKV HHHHHHHCCCCCCCC	33.22	25159151
151	Ubiquitination	ENAVSSGNRDSKVPS HHHHHCCCCCCCCCC	46.67	16196087
153	Ubiquitination	AVSSGNRDSKVPSEG HHHCCCCCCCCCCCC	57.73	24816145
154	Phosphorylation	VSSGNRDSKVPSEGK HHCCCCCCCCCCCCC	32.11	25056879
156	Ubiquitination	SGNRDSKVPSEGKKS CCCCCCCCCCCCCCC	7.94	16196087
158	Phosphorylation	NRDSKVPSEGKKSLY CCCCCCCCCCCCCCC	63.07	26055452
159	Ubiquitination	RDSKVPSEGKKSLYT CCCCCCCCCCCCCCC	69.80	16196087
161	Ubiquitination	SKVPSEGKKSLYTDE CCCCCCCCCCCCCCC	34.83	24816145
162	Ubiquitination	KVPSEGKKSLYTDES CCCCCCCCCCCCCCC	57.46	24816145
164	Ubiquitination	PSEGKKSLYTDESSK CCCCCCCCCCCCCCC	7.98	29967540
165	Phosphorylation	SEGKKSLYTDESSKP CCCCCCCCCCCCCCC	21.16	25884760
165	Ubiquitination	SEGKKSLYTDESSKP CCCCCCCCCCCCCCC	21.16	16196087
166	Phosphorylation	EGKKSLYTDESSKPG CCCCCCCCCCCCCCC	38.29	28555341
167	Ubiquitination	GKKSLYTDESSKPGK CCCCCCCCCCCCCCC	39.98	24816145
168	Ubiquitination	KKSLYTDESSKPGKN CCCCCCCCCCCCCCC	49.46	24816145
169	Phosphorylation	KSLYTDESSKPGKNK CCCCCCCCCCCCCCC	46.61	28985074
170	Phosphorylation	SLYTDESSKPGKNKR CCCCCCCCCCCCCCC	40.60	-
170	Ubiquitination	SLYTDESSKPGKNKR CCCCCCCCCCCCCCC	40.60	16196087
171	Ubiquitination	LYTDESSKPGKNKRT CCCCCCCCCCCCCCC	68.05	16196087
172	Ubiquitination	YTDESSKPGKNKRTA CCCCCCCCCCCCCCE	62.02	29967540
173	Ubiquitination	TDESSKPGKNKRTAI CCCCCCCCCCCCCEE	50.32	16196087
174	Ubiquitination	DESSKPGKNKRTAIT CCCCCCCCCCCCEEE	68.75	16196087
176	Ubiquitination	SSKPGKNKRTAITTP CCCCCCCCCCEEECC	55.39	16196087
177	Ubiquitination	SKPGKNKRTAITTPN CCCCCCCCCEEECCC	38.49	16196087
178	Phosphorylation	KPGKNKRTAITTPNF CCCCCCCCEEECCCH	24.83	30266825
179	Ubiquitination	PGKNKRTAITTPNFK CCCCCCCEEECCCHH	10.93	16196087
180	Ubiquitination	GKNKRTAITTPNFKK CCCCCCEEECCCHHH	4.33	16196087
181	Phosphorylation	KNKRTAITTPNFKKL CCCCCEEECCCHHHH	33.46	30266825
182	Phosphorylation	NKRTAITTPNFKKLH CCCCEEECCCHHHHH	15.32	30266825
186	Acetylation	AITTPNFKKLHEAHF EEECCCHHHHHHHHH	62.15	25953088
186	Methylation	AITTPNFKKLHEAHF EEECCCHHHHHHHHH	62.15	115974413
186	Ubiquitination	AITTPNFKKLHEAHF EEECCCHHHHHHHHH	62.15	29967540
187	Ubiquitination	ITTPNFKKLHEAHFK EECCCHHHHHHHHHH	51.44	29967540
192 (in isoform 7)	Phosphorylation	-	31.18	20068231
198	Phosphorylation	AHFKEMESIDQYIER HHHHHHHHHHHHHHH	30.10	28674419
200 (in isoform 4)	Phosphorylation	-	44.50	20068231
214 (in isoform 3)	Phosphorylation	-	46.35	20068231
215	Phosphorylation	KHFEEHNSMNELKQQ HHHHHHCCHHHHHCC	25.54	20068231
215 (in isoform 2)	Phosphorylation	-	25.54	20068231
231	Phosphorylation	INKGGVRTPVPPRGR CCCCCCCCCCCCCCC	26.65	30266825
233	Ubiquitination	KGGVRTPVPPRGRLS CCCCCCCCCCCCCCE	11.44	24816145
240	Phosphorylation	VPPRGRLSVASTPIS CCCCCCCEEECCCHH	17.80	30266825
243	O-linked_Glycosylation	RGRLSVASTPISQRR CCCCEEECCCHHHCH	32.34	31373491
243	Phosphorylation	RGRLSVASTPISQRR CCCCEEECCCHHHCH	32.34	30266825
243	Ubiquitination	RGRLSVASTPISQRR CCCCEEECCCHHHCH	32.34	33845483
244	Phosphorylation	GRLSVASTPISQRRS CCCEEECCCHHHCHH	18.20	30266825
247	Phosphorylation	SVASTPISQRRSQGR EEECCCHHHCHHCCC	20.88	30266825
251	Phosphorylation	TPISQRRSQGRSCGP CCHHHCHHCCCCCCC	38.89	25159151
252	Ubiquitination	PISQRRSQGRSCGPA CHHHCHHCCCCCCCC	49.89	33845483
255	Phosphorylation	QRRSQGRSCGPASQS HCHHCCCCCCCCCHH	30.19	23927012
255	Ubiquitination	QRRSQGRSCGPASQS HCHHCCCCCCCCCHH	30.19	24816145
260	Phosphorylation	GRSCGPASQSTLGLK CCCCCCCCHHHHCCC	28.00	21815630
262	Phosphorylation	SCGPASQSTLGLKGS CCCCCCHHHHCCCHH	24.09	28152594
263	Phosphorylation	CGPASQSTLGLKGSL CCCCCHHHHCCCHHH	19.74	28152594
263	Ubiquitination	CGPASQSTLGLKGSL CCCCCHHHHCCCHHH	19.74	24816145
264	Ubiquitination	GPASQSTLGLKGSLK CCCCHHHHCCCHHHH	10.28	24816145
265	Ubiquitination	PASQSTLGLKGSLKR CCCHHHHCCCHHHHH	25.98	33845483
266	Ubiquitination	ASQSTLGLKGSLKRS CCHHHHCCCHHHHHH	6.80	33845483
267	Methylation	SQSTLGLKGSLKRSA CHHHHCCCHHHHHHH	44.66	115974421
267	Ubiquitination	SQSTLGLKGSLKRSA CHHHHCCCHHHHHHH	44.66	33845483
269	Phosphorylation	STLGLKGSLKRSAIS HHHCCCHHHHHHHHH	29.18	23401153
270	Ubiquitination	TLGLKGSLKRSAISA HHCCCHHHHHHHHHH	7.92	24816145
271	Methylation	LGLKGSLKRSAISAA HCCCHHHHHHHHHHH	46.10	115974425
273	Phosphorylation	LKGSLKRSAISAAKT CCHHHHHHHHHHHHH	28.50	29396449
276	Phosphorylation	SLKRSAISAAKTGVR HHHHHHHHHHHHCCC	23.14	33259812
277	Ubiquitination	LKRSAISAAKTGVRF HHHHHHHHHHHCCCE	13.58	24816145
278	Ubiquitination	KRSAISAAKTGVRFS HHHHHHHHHHCCCEE	11.80	24816145
279	Acetylation	RSAISAAKTGVRFSA HHHHHHHHHCCCEEE	45.59	25953088
279	Ubiquitination	RSAISAAKTGVRFSA HHHHHHHHHCCCEEE	45.59	24816145
280	Ubiquitination	SAISAAKTGVRFSAA HHHHHHHHCCCEEEC	35.86	29967540
284	Ubiquitination	AAKTGVRFSAATKDN HHHHCCCEEECCCCC	5.60	24816145
285	Phosphorylation	AKTGVRFSAATKDNE HHHCCCEEECCCCCH	13.36	33259812
285	Ubiquitination	AKTGVRFSAATKDNE HHHCCCEEECCCCCH	13.36	24816145
289	Acetylation	VRFSAATKDNEHKRS CCEEECCCCCHHHCC	54.55	23749302
289	Ubiquitination	VRFSAATKDNEHKRS CCEEECCCCCHHHCC	54.55	29967540
292	Ubiquitination	SAATKDNEHKRSLTK EECCCCCHHHCCCCC	62.00	33845483
293	Ubiquitination	AATKDNEHKRSLTKT ECCCCCHHHCCCCCC	36.76	24816145
294	Ubiquitination	ATKDNEHKRSLTKTP CCCCCHHHCCCCCCC	37.19	24816145
296	Phosphorylation	KDNEHKRSLTKTPAR CCCHHHCCCCCCCCC	45.23	25849741
298	Phosphorylation	NEHKRSLTKTPARKS CHHHCCCCCCCCCCC	33.83	33259812
299	Acetylation	EHKRSLTKTPARKSA HHHCCCCCCCCCCCC	58.78	25953088
299	Phosphorylation	EHKRSLTKTPARKSA HHHCCCCCCCCCCCC	58.78	33259812
299	Ubiquitination	EHKRSLTKTPARKSA HHHCCCCCCCCCCCC	58.78	24816145
300	Phosphorylation	HKRSLTKTPARKSAH HHCCCCCCCCCCCCE	19.56	25849741
300	Ubiquitination	HKRSLTKTPARKSAH HHCCCCCCCCCCCCE	19.56	24816145
301	Ubiquitination	KRSLTKTPARKSAHV HCCCCCCCCCCCCEE	31.46	33845483
302	Ubiquitination	RSLTKTPARKSAHVT CCCCCCCCCCCCEEE	36.44	29967540
303	Ubiquitination	SLTKTPARKSAHVTV CCCCCCCCCCCEEEE	34.36	29967540
304	Ubiquitination	LTKTPARKSAHVTVS CCCCCCCCCCEEEEE	54.85	29967540
305	O-linked_Glycosylation	TKTPARKSAHVTVSG CCCCCCCCCEEEEEC	20.32	31373491
305	Phosphorylation	TKTPARKSAHVTVSG CCCCCCCCCEEEEEC	20.32	25159151
307	Ubiquitination	TPARKSAHVTVSGGT CCCCCCCEEEEECCC	23.91	16196087
309	Phosphorylation	ARKSAHVTVSGGTPK CCCCCEEEEECCCCC	10.09	23927012
310	Ubiquitination	RKSAHVTVSGGTPKG CCCCEEEEECCCCCC	4.94	33845483
311	Phosphorylation	KSAHVTVSGGTPKGE CCCEEEEECCCCCCE	23.34	23927012
312	Ubiquitination	SAHVTVSGGTPKGEA CCEEEEECCCCCCEE	39.39	33845483
314	Phosphorylation	HVTVSGGTPKGEAVL EEEEECCCCCCEEEE	25.92	20201521
314	Ubiquitination	HVTVSGGTPKGEAVL EEEEECCCCCCEEEE	25.92	33845483
315	Ubiquitination	VTVSGGTPKGEAVLG EEEECCCCCCEEEEE	46.02	33845483
316	Ubiquitination	TVSGGTPKGEAVLGT EEECCCCCCEEEEEE	70.04	33845483
321	Ubiquitination	TPKGEAVLGTHKLKT CCCCEEEEEEEEEEE	9.38	16196087
322	Ubiquitination	PKGEAVLGTHKLKTI CCCEEEEEEEEEEEE	21.12	16196087
323	Phosphorylation	KGEAVLGTHKLKTIT CCEEEEEEEEEEEEC	16.21	30576142
323	Ubiquitination	KGEAVLGTHKLKTIT CCEEEEEEEEEEEEC	16.21	33845483
324	Ubiquitination	GEAVLGTHKLKTITG CEEEEEEEEEEEECC	31.49	33845483
325	Ubiquitination	EAVLGTHKLKTITGN EEEEEEEEEEEECCC	52.06	33845483
326	Ubiquitination	AVLGTHKLKTITGNS EEEEEEEEEEECCCC	4.61	33845483
327	Ubiquitination	VLGTHKLKTITGNSA EEEEEEEEEECCCCC	42.56	33845483
333	Phosphorylation	LKTITGNSAAVITPF EEEECCCCCEEEECE	20.96	19664995
338	Phosphorylation	GNSAAVITPFKLTTE CCCCEEEECEEEECC	18.97	25159151
339	Ubiquitination	NSAAVITPFKLTTEA CCCEEEECEEEECCC	17.16	33845483
340	Ubiquitination	SAAVITPFKLTTEAT CCEEEECEEEECCCC	8.30	33845483
341	Ubiquitination	AAVITPFKLTTEATQ CEEEECEEEECCCCC	46.24	29967540
343	Phosphorylation	VITPFKLTTEATQTP EEECEEEECCCCCCC	24.15	18669648
344	Phosphorylation	ITPFKLTTEATQTPV EECEEEECCCCCCCC	33.78	30266825
346	Ubiquitination	PFKLTTEATQTPVSN CEEEECCCCCCCCCC	11.69	29967540
347	Phosphorylation	FKLTTEATQTPVSNK EEEECCCCCCCCCCC	27.09	30266825
348	Acetylation	KLTTEATQTPVSNKK EEECCCCCCCCCCCC	51.35	19608861
349	Phosphorylation	LTTEATQTPVSNKKP EECCCCCCCCCCCCC	22.69	23401153
352	Phosphorylation	EATQTPVSNKKPVFD CCCCCCCCCCCCEEE	44.10	23401153
352	Ubiquitination	EATQTPVSNKKPVFD CCCCCCCCCCCCEEE	44.10	33845483
353	Ubiquitination	ATQTPVSNKKPVFDL CCCCCCCCCCCEEEC	57.51	33845483
354	Acetylation	TQTPVSNKKPVFDLK CCCCCCCCCCEEECC	51.45	25953088
354	Ubiquitination	TQTPVSNKKPVFDLK CCCCCCCCCCEEECC	51.45	33845483
355	Ubiquitination	QTPVSNKKPVFDLKA CCCCCCCCCEEECCH	51.14	33845483
359	Ubiquitination	SNKKPVFDLKASLSR CCCCCEEECCHHHCC	47.71	29967540
360	Ubiquitination	NKKPVFDLKASLSRP CCCCEEECCHHHCCC	3.20	29967540
361	Ubiquitination	KKPVFDLKASLSRPL CCCEEECCHHHCCCC	37.46	29967540
363	Phosphorylation	PVFDLKASLSRPLNY CEEECCHHHCCCCCC	25.87	25159151
363	Ubiquitination	PVFDLKASLSRPLNY CEEECCHHHCCCCCC	25.87	29967540
365	Phosphorylation	FDLKASLSRPLNYEP EECCHHHCCCCCCCC	29.38	20068231
365	Ubiquitination	FDLKASLSRPLNYEP EECCHHHCCCCCCCC	29.38	24816145
369	Ubiquitination	ASLSRPLNYEPHKGK HHHCCCCCCCCCCCC	41.63	29967540
370	Phosphorylation	SLSRPLNYEPHKGKL HHCCCCCCCCCCCCC	38.22	27080861
373	Ubiquitination	RPLNYEPHKGKLKPW CCCCCCCCCCCCCCC	39.29	24816145
374	Ubiquitination	PLNYEPHKGKLKPWG CCCCCCCCCCCCCCC	69.34	29967540
375	Ubiquitination	LNYEPHKGKLKPWGQ CCCCCCCCCCCCCCC	37.18	29967540
376	Acetylation	NYEPHKGKLKPWGQS CCCCCCCCCCCCCCC	59.13	25953088
376	Ubiquitination	NYEPHKGKLKPWGQS CCCCCCCCCCCCCCC	59.13	29967540
377	Ubiquitination	YEPHKGKLKPWGQSK CCCCCCCCCCCCCCC	12.57	29967540
378	Ubiquitination	EPHKGKLKPWGQSKE CCCCCCCCCCCCCCC	42.06	29967540
382	Ubiquitination	GKLKPWGQSKENNYL CCCCCCCCCCCCCHH	47.68	29967540
383	Ubiquitination	KLKPWGQSKENNYLN CCCCCCCCCCCCHHH	37.69	29967540
384	Methylation	LKPWGQSKENNYLNQ CCCCCCCCCCCHHHH	57.48	115974429
384	Ubiquitination	LKPWGQSKENNYLNQ CCCCCCCCCCCHHHH	57.48	29967540
388	Phosphorylation	GQSKENNYLNQHVNR CCCCCCCHHHHHHHH	20.72	27642862
388	Ubiquitination	GQSKENNYLNQHVNR CCCCCCCHHHHHHHH	20.72	24816145
389	Ubiquitination	QSKENNYLNQHVNRI CCCCCCHHHHHHHHH	5.59	29967540
394	Ubiquitination	NYLNQHVNRINFYKK CHHHHHHHHHHHHHH	36.67	24816145
395	Ubiquitination	YLNQHVNRINFYKKT HHHHHHHHHHHHHHH	24.92	24816145
396	Acetylation	LNQHVNRINFYKKTY HHHHHHHHHHHHHHH	3.36	19608861
402	Ubiquitination	RINFYKKTYKQPHLQ HHHHHHHHHCCCCCC	31.62	29967540
403	Ubiquitination	INFYKKTYKQPHLQT HHHHHHHHCCCCCCC	19.26	29967540
404	Acetylation	NFYKKTYKQPHLQTK HHHHHHHCCCCCCCH	63.69	25953088
404	Ubiquitination	NFYKKTYKQPHLQTK HHHHHHHCCCCCCCH	63.69	29967540
409	Acetylation	TYKQPHLQTKEEQRK HHCCCCCCCHHHHHH	47.71	19608861
410	Acetylation	YKQPHLQTKEEQRKK HCCCCCCCHHHHHHH	46.94	19608861
411	Acetylation	KQPHLQTKEEQRKKR CCCCCCCHHHHHHHH	46.42	19608861
412	Ubiquitination	QPHLQTKEEQRKKRE CCCCCCHHHHHHHHH	63.85	24816145
413	Ubiquitination	PHLQTKEEQRKKREQ CCCCCHHHHHHHHHH	58.19	24816145
419	Ubiquitination	EEQRKKREQERKEKK HHHHHHHHHHHHHHH	66.72	24816145
426	Ubiquitination	EQERKEKKAKVLGMR HHHHHHHHHHHHHHH	55.31	24816145
427	Ubiquitination	QERKEKKAKVLGMRR HHHHHHHHHHHHHHC	20.46	24816145
428	Ubiquitination	ERKEKKAKVLGMRRG HHHHHHHHHHHHHCC	47.04	24816145
433	Ubiquitination	KAKVLGMRRGLILAE HHHHHHHHCCEEEEC	27.93	24816145
434	Ubiquitination	AKVLGMRRGLILAED HHHHHHHCCEEEECC	35.06	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
124	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
240	S	Phosphorylation	Kinase	AURKA	O14965	GPS
240	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
300	T	Phosphorylation	Kinase	CDK1	P06493	PSP
338	T	Phosphorylation	Kinase	CDK1	P06493	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:17618083

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NUSAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NUSAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBE4B_HUMAN	UBE4B	physical	22863883
CEP70_HUMAN	CEP70	physical	25416956
IMB1_HUMAN	KPNB1	physical	26186194
IPO7_HUMAN	IPO7	physical	26186194
G3PT_HUMAN	GAPDHS	physical	26186194
RBP2_HUMAN	RANBP2	physical	26186194
CYTM_HUMAN	CST6	physical	26186194
NU153_HUMAN	NUP153	physical	26186194
S100P_HUMAN	S100P	physical	26186194
CE030_HUMAN	C5orf30	physical	26186194
GSTA2_HUMAN	GSTA2	physical	26186194
CAF1A_HUMAN	CHAF1A	physical	26344197
CE030_HUMAN	C5orf30	physical	28514442
S100P_HUMAN	S100P	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
GSTA2_HUMAN	GSTA2	physical	28514442
RBP2_HUMAN	RANBP2	physical	28514442
CYTM_HUMAN	CST6	physical	28514442
NU153_HUMAN	NUP153	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NUSAP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-411, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-349 AND SER-352, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; THR-182; SER-240;THR-244; SER-247; THR-314; THR-349 AND SER-352, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; THR-244 ANDSER-247, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-338, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-314, AND MASSSPECTROMETRY.	17924679 [Abstract]