GSTA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTA2_HUMAN
• UniProt AC: P09210
• Protein Name: Glutathione S-transferase A2
• Gene Name: GSTA2
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAKLALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEKPKLHY ------CCCCCCCCC	33.26	-
4	Succinylation	----MAEKPKLHYSN ----CCCCCCCCCCC	37.60	-
4	Succinylation	----MAEKPKLHYSN ----CCCCCCCCCCC	37.60	-
9	Phosphorylation	AEKPKLHYSNIRGRM CCCCCCCCCCCHHHH	17.53	24719451
10	Phosphorylation	EKPKLHYSNIRGRME CCCCCCCCCCHHHHH	18.29	24719451
37	Phosphorylation	FEEKFIKSAEDLDKL HHHHHHHCHHHHHHH	31.88	28192239
49	Phosphorylation	DKLRNDGYLMFQQVP HHHHHCCEEEEEECC	9.61	28258704
74	Phosphorylation	QTRAILNYIASKYNL HHHHHHHHHHHHCCC	8.40	-
77	Phosphorylation	AILNYIASKYNLYGK HHHHHHHHHCCCCCC	26.56	28857561
79	Phosphorylation	LNYIASKYNLYGKDI HHHHHHHCCCCCCCH	14.12	-
82	Phosphorylation	IASKYNLYGKDIKEK HHHHCCCCCCCHHHH	20.63	-
84	Acetylation	SKYNLYGKDIKEKAL HHCCCCCCCHHHHHH	42.60	28641467
112	Phosphorylation	MILLLPFSQPEEQDA HEEEEECCCCHHHHH	42.77	26074081
132	Phosphorylation	QEKTKNRYFPAFEKV HHHHHCCCCHHHHHH	24.25	21253578
142	Phosphorylation	AFEKVLKSHGQDYLV HHHHHHHHCCCCCCC	28.79	20166139
147	Phosphorylation	LKSHGQDYLVGNKLS HHHCCCCCCCCCCCC	8.73	28258704
152	Acetylation	QDYLVGNKLSRADIH CCCCCCCCCCHHHHH	41.74	24885201
154	Phosphorylation	YLVGNKLSRADIHLV CCCCCCCCHHHHHHH	27.34	24275569
172	Phosphorylation	YYVEELDSSLISSFP HHHHHHCHHHHHCHH	39.40	24275569
173	Phosphorylation	YVEELDSSLISSFPL HHHHHCHHHHHCHHH	29.41	24275569
176	Phosphorylation	ELDSSLISSFPLLKA HHCHHHHHCHHHHHH	31.08	24275569
177	Phosphorylation	LDSSLISSFPLLKAL HCHHHHHCHHHHHHH	24.72	24275569
189	Phosphorylation	KALKTRISNLPTVKK HHHHHHHHCCHHHHH	29.08	28857561
193	Phosphorylation	TRISNLPTVKKFLQP HHHHCCHHHHHHCCC	48.39	28857561
195	Acetylation	ISNLPTVKKFLQPGS HHCCHHHHHHCCCCC	40.04	12431279
196	Acetylation	SNLPTVKKFLQPGSP HCCHHHHHHCCCCCC	47.15	12431287
202	Phosphorylation	KKFLQPGSPRKPPMD HHHCCCCCCCCCCCC	28.37	28355574
212	Phosphorylation	KPPMDEKSLEESRKI CCCCCHHHHHHHHHH	38.68	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTA4_HUMAN	GSTA4	physical	25416956
GSTA5_HUMAN	GSTA5	physical	26186194
GSTA3_HUMAN	GSTA3	physical	26186194
GSTA4_HUMAN	GSTA4	physical	26186194
GSTA5_HUMAN	GSTA5	physical	28514442
GSTA3_HUMAN	GSTA3	physical	28514442
GSTA4_HUMAN	GSTA4	physical	28514442
ATG4C_HUMAN	ATG4C	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00993: Azathioprine
• DB01008: Busulfan
• DB00608: Chloroquine
• DB00636: Clofibrate
• DB00903: Ethacrynic acid
• DB00143: Glutathione
• DB00163: Vitamin E