GSTA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTA4_HUMAN
• UniProt AC: O15217
• Protein Name: Glutathione S-transferase A4
• Gene Name: GSTA4
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE)..
• Protein Sequence: MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAARPKLH -------CCCCCCCC	6.25	-
34	Ubiquitination	GVEFDEEFLETKEQL CCCCCHHHHHHHHHH	7.60	21890473
45	Ubiquitination	KEQLYKLQDGNHLLF HHHHHCCCCCCEEEE	53.03	21890473
84	Ubiquitination	DKHNLFGKNLKERTL HHCCCCCCCCHHHHH	52.34	-
127	Ubiquitination	EVVNMAQKAIIRYFP HHHHHHHHHHHHHHH	31.82	21890473
138	Ubiquitination	RYFPVFEKILRGHGQ HHHHHHHHHHCCCCC	35.26	21890473
189	Phosphorylation	QEYTVKLSNIPTIKR HHHHHHHHCCCCHHH	27.31	12646569
193	Phosphorylation	VKLSNIPTIKRFLEP HHHHCCCCHHHHCCC	35.02	12646569
202	Phosphorylation	KRFLEPGSKKKPPPD HHHCCCCCCCCCCCC	52.60	27251275
203	Ubiquitination	RFLEPGSKKKPPPDE HHCCCCCCCCCCCCC	71.39	-
204	Ubiquitination	FLEPGSKKKPPPDEI HCCCCCCCCCCCCCC	72.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
189	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
193	T	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTA4_HUMAN	GSTA4	physical	16189514
GSTA4_HUMAN	GSTA4	physical	25416956
CB050_HUMAN	C2orf50	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione