GSTA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTA3_HUMAN
• UniProt AC: Q16772
• Protein Name: Glutathione S-transferase A3
• Gene Name: GSTA3
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively..
• Protein Sequence: MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAKIALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPLLKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGKPKLHY ------CCCCCCCEE	34.42	-
4	Succinylation	----MAGKPKLHYFN ----CCCCCCCEECC	29.46	-
4	Succinylation	----MAGKPKLHYFN ----CCCCCCCEECC	29.46	-
49	Phosphorylation	GKLRNDGSLMFQQVP HHHCCCCCCCEEECC	21.37	22817900
74	Phosphorylation	QTRAILNYIASKYNL HHHHHHHHHHHHCCC	8.40	-
77	Phosphorylation	AILNYIASKYNLYGK HHHHHHHHHCCCCCC	26.56	28857561
79	Phosphorylation	LNYIASKYNLYGKDI HHHHHHHCCCCCCCH	14.12	-
82	Phosphorylation	IASKYNLYGKDIKER HHHHCCCCCCCHHHH	20.63	-
84	Acetylation	SKYNLYGKDIKERAL HHCCCCCCCHHHHHH	42.60	28641473
87	Acetylation	NLYGKDIKERALIDM CCCCCCHHHHHHHHH	51.81	158581
95	Phosphorylation	ERALIDMYTEGMADL HHHHHHHHHHCCCCH	9.63	22210691
96	Phosphorylation	RALIDMYTEGMADLN HHHHHHHHHCCCCHH	21.30	22210691
125	Ubiquitination	DAKIALIKEKTKSRY CCCHHHHHHHHHHCC	54.75	-
142	Phosphorylation	AFEKVLQSHGQDYLV HHHHHHHHCCCCCCC	25.98	28258704
147	Phosphorylation	LQSHGQDYLVGNKLS HHHCCCCCCCCCCCC	8.73	28258704
152	Acetylation	QDYLVGNKLSRADIS CCCCCCCCCCHHCCH	41.74	24885321
154	Phosphorylation	YLVGNKLSRADISLV CCCCCCCCHHCCHHH	27.34	-
189	Phosphorylation	KALKTRISNLPTVKK HHHHHHHHCCHHHHH	29.08	28857561
193	Phosphorylation	TRISNLPTVKKFLQP HHHHCCHHHHHHCCC	48.39	28857561
195	Acetylation	ISNLPTVKKFLQPGS HHCCHHHHHHCCCCC	40.04	2402337
196	Acetylation	SNLPTVKKFLQPGSP HCCHHHHHHCCCCCC	47.15	12431497
202	Phosphorylation	KKFLQPGSPRKPPAD HHHCCCCCCCCCCCH	28.37	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione