S100P_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S100P_HUMAN
• UniProt AC: P25815
• Protein Name: Protein S100-P
• Gene Name: S100P
• Organism: Homo sapiens (Human).
• Sequence Length: 95
• Subcellular Localization: Nucleus. Cytoplasm. Cell projection, microvillus membrane. Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
• Protein Description: May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE)..
• Protein Sequence: MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTELETAMG ------CCHHHHHHH	49.64	21060948
6	Phosphorylation	--MTELETAMGMIID --CCHHHHHHHHHHH	34.27	25072903
16	Phosphorylation	GMIIDVFSRYSGSEG HHHHHHHHHCCCCCC	30.11	25072903
18	Phosphorylation	IIDVFSRYSGSEGST HHHHHHHCCCCCCCC	19.04	20068231
19	Phosphorylation	IDVFSRYSGSEGSTQ HHHHHHCCCCCCCCE	34.43	20068231
21	Phosphorylation	VFSRYSGSEGSTQTL HHHHCCCCCCCCEEE	32.61	26657352
24	Phosphorylation	RYSGSEGSTQTLTKG HCCCCCCCCEEECHH	17.19	25159151
25	Phosphorylation	YSGSEGSTQTLTKGE CCCCCCCCEEECHHH	36.11	28450419
27	Phosphorylation	GSEGSTQTLTKGELK CCCCCCEEECHHHHH	36.16	28450419
29	Phosphorylation	EGSTQTLTKGELKVL CCCCEEECHHHHHHH	40.15	20068231
30	Ubiquitination	GSTQTLTKGELKVLM CCCEEECHHHHHHHH	54.20	21963094
30	Acetylation	GSTQTLTKGELKVLM CCCEEECHHHHHHHH	54.20	26051181
34	Acetylation	TLTKGELKVLMEKEL EECHHHHHHHHHCCC	29.08	27452117
34	Ubiquitination	TLTKGELKVLMEKEL EECHHHHHHHHHCCC	29.08	22817900
39	Succinylation	ELKVLMEKELPGFLQ HHHHHHHCCCCCHHH	51.06	23954790
39	Acetylation	ELKVLMEKELPGFLQ HHHHHHHCCCCCHHH	51.06	26051181
39	Ubiquitination	ELKVLMEKELPGFLQ HHHHHHHCCCCCHHH	51.06	33845483
49	Ubiquitination	PGFLQSGKDKDAVDK CCHHHCCCCHHHHHH	67.84	29967540
49	Acetylation	PGFLQSGKDKDAVDK CCHHHCCCCHHHHHH	67.84	27452117
49	Succinylation	PGFLQSGKDKDAVDK CCHHHCCCCHHHHHH	67.84	23954790
56	Ubiquitination	KDKDAVDKLLKDLDA CCHHHHHHHHHHHCC	49.47	29967540
91	Ubiquitination	ACHKYFEKAGLK--- HHHHHHHHCCCC---	37.54	33845483
91	Acetylation	ACHKYFEKAGLK--- HHHHHHHHCCCC---	37.54	27178108

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:23344957

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S100P_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S100P_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S100P_HUMAN	S100P	physical	10924150
RAGE_HUMAN	AGER	physical	14617629
EZRI_HUMAN	EZR	physical	12808036
S100Z_HUMAN	S100Z	physical	11747429
S100P_HUMAN	S100P	physical	1633809
S100P_HUMAN	S100P	physical	12507480
SGT1_HUMAN	SUGT1	physical	22939629
CHIP_HUMAN	STUB1	physical	23344957
TFP11_HUMAN	TFIP11	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01003: Cromoglicic acid