UBE4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE4B_HUMAN
• UniProt AC: O95155
• Protein Name: Ubiquitin conjugation factor E4 B {ECO:0000305}
• Gene Name: UBE4B {ECO:0000312|HGNC:HGNC:12500}
• Organism: Homo sapiens (Human).
• Sequence Length: 1302
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase..
• Protein Sequence: MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEELSADE -------CCCCCHHH	40.22	22223895
10	Methylation	ELSADEIRRRRLARL CCCHHHHHHHHHHHH	24.81	115919401
22	Phosphorylation	ARLAGGQTSQPTTPL HHHHCCCCCCCCCCC	32.38	30266825
22 (in isoform 2)	Phosphorylation	-	32.38	-
23	Phosphorylation	RLAGGQTSQPTTPLT HHHCCCCCCCCCCCC	26.69	30266825
23 (in isoform 2)	Phosphorylation	-	26.69	-
26	Phosphorylation	GGQTSQPTTPLTSPQ CCCCCCCCCCCCCCC	33.15	30266825
26 (in isoform 2)	Phosphorylation	-	33.15	-
27	Phosphorylation	GQTSQPTTPLTSPQR CCCCCCCCCCCCCCC	24.00	30266825
27 (in isoform 2)	Phosphorylation	-	24.00	-
30	Phosphorylation	SQPTTPLTSPQRENP CCCCCCCCCCCCCCC	39.29	30266825
31	Phosphorylation	QPTTPLTSPQRENPP CCCCCCCCCCCCCCC	27.07	30266825
31 (in isoform 2)	Phosphorylation	-	27.07	-
45	Phosphorylation	PGPPIAASAPGPSQS CCCCCCCCCCCCCCC	26.44	23186163
50	Phosphorylation	AASAPGPSQSLGLNV CCCCCCCCCCCCCCC	38.01	22210691
52	Phosphorylation	SAPGPSQSLGLNVHN CCCCCCCCCCCCCCC	28.83	30576142
53	Ubiquitination	APGPSQSLGLNVHNM CCCCCCCCCCCCCCC	7.58	27667366
61	Phosphorylation	GLNVHNMTPATSPIG CCCCCCCCCCCCCCC	18.32	30278072
64	Phosphorylation	VHNMTPATSPIGASG CCCCCCCCCCCCCCC	35.92	29496963
65	Phosphorylation	HNMTPATSPIGASGV CCCCCCCCCCCCCCC	19.34	29496963
70	Phosphorylation	ATSPIGASGVAHRSQ CCCCCCCCCCCCCCC	28.70	30576142
76	Phosphorylation	ASGVAHRSQSSEGVS CCCCCCCCCCCCCCC	25.25	23927012
76	Ubiquitination	ASGVAHRSQSSEGVS CCCCCCCCCCCCCCC	25.25	27667366
78	Phosphorylation	GVAHRSQSSEGVSSL CCCCCCCCCCCCCCC	31.44	25159151
79	Phosphorylation	VAHRSQSSEGVSSLS CCCCCCCCCCCCCCC	30.63	30278072
83	Phosphorylation	SQSSEGVSSLSSSPS CCCCCCCCCCCCCCC	36.10	23401153
83 (in isoform 2)	Phosphorylation	-	36.10	-
84	Phosphorylation	QSSEGVSSLSSSPSN CCCCCCCCCCCCCCC	29.84	23927012
84 (in isoform 2)	Phosphorylation	-	29.84	-
86	Phosphorylation	SEGVSSLSSSPSNSL CCCCCCCCCCCCCCH	30.62	29209046
86 (in isoform 2)	Phosphorylation	-	30.62	-
87	Phosphorylation	EGVSSLSSSPSNSLE CCCCCCCCCCCCCHH	52.11	23927012
87 (in isoform 2)	Phosphorylation	-	52.11	-
88	Phosphorylation	GVSSLSSSPSNSLET CCCCCCCCCCCCHHH	29.04	19664994
88 (in isoform 2)	Phosphorylation	-	29.04	-
90	Phosphorylation	SSLSSSPSNSLETQS CCCCCCCCCCHHHHH	40.78	23927012
90 (in isoform 2)	Phosphorylation	-	40.78	-
92	Phosphorylation	LSSSPSNSLETQSQS CCCCCCCCHHHHHHH	31.74	29209046
92 (in isoform 2)	Phosphorylation	-	31.74	-
95	Phosphorylation	SPSNSLETQSQSLSR CCCCCHHHHHHHCHH	38.52	23927012
95 (in isoform 2)	Phosphorylation	-	38.52	-
97	Phosphorylation	SNSLETQSQSLSRSQ CCCHHHHHHHCHHHH	29.20	30278072
99	Phosphorylation	SLETQSQSLSRSQSM CHHHHHHHCHHHHCC	33.29	30278072
99 (in isoform 2)	Phosphorylation	-	33.29	-
101	Phosphorylation	ETQSQSLSRSQSMDI HHHHHHCHHHHCCCC	34.82	23927012
101 (in isoform 2)	Phosphorylation	-	34.82	-
103	Phosphorylation	QSQSLSRSQSMDIDG HHHHCHHHHCCCCCC	24.19	22167270
103 (in isoform 2)	Phosphorylation	-	24.19	-
105	Phosphorylation	QSLSRSQSMDIDGVS HHCHHHHCCCCCCCC	21.48	22167270
105 (in isoform 2)	Phosphorylation	-	21.48	-
112	Phosphorylation	SMDIDGVSCEKSMSQ CCCCCCCCCCCCCCC	23.30	29632367
116	Phosphorylation	DGVSCEKSMSQVDVD CCCCCCCCCCCCCCC	11.02	25159151
118	Phosphorylation	VSCEKSMSQVDVDSG CCCCCCCCCCCCCCC	33.86	30266825
124	Phosphorylation	MSQVDVDSGIENMEV CCCCCCCCCCCCCCC	41.33	30266825
141	Phosphorylation	NDRREKRSLSDKEPS CCHHHHHCCCCCCCC	43.20	23663014
143	Phosphorylation	RREKRSLSDKEPSSG HHHHHCCCCCCCCCC	48.13	23663014
145	Ubiquitination	EKRSLSDKEPSSGPE HHHCCCCCCCCCCCC	69.05	29967540
148	Phosphorylation	SLSDKEPSSGPEVSE CCCCCCCCCCCCCCH	49.36	23663014
149	Phosphorylation	LSDKEPSSGPEVSEE CCCCCCCCCCCCCHH	69.91	23663014
154	Phosphorylation	PSSGPEVSEEQALQL CCCCCCCCHHHHHHH	33.48	23663014
181	Phosphorylation	DRDVIFLSSLSAQFK CCCEEEEECHHHHHH	20.63	24719451
182	Phosphorylation	RDVIFLSSLSAQFKQ CCEEEEECHHHHHHH	28.61	27251275
184	Phosphorylation	VIFLSSLSAQFKQNP EEEEECHHHHHHHCH	23.21	24719451
192	Ubiquitination	AQFKQNPKEVFSDFK HHHHHCHHHHHHHHH	74.24	27667366
197	Ubiquitination	NPKEVFSDFKDLIGQ CHHHHHHHHHHHHHH	43.05	27667366
224	Phosphorylation	RDENPFASLTATSQP CCCCCCCCCCCCCCC	26.99	28176443
224 (in isoform 2)	Phosphorylation	-	26.99	-
226	Phosphorylation	ENPFASLTATSQPIA CCCCCCCCCCCCCHH	25.95	29978859
228	Phosphorylation	PFASLTATSQPIAAA CCCCCCCCCCCHHHH	23.74	29116813
229	Phosphorylation	FASLTATSQPIAAAA CCCCCCCCCCHHHHH	31.34	28450419
238	Phosphorylation	PIAAAARSPDRNLLL CHHHHHCCCCCCEEE	26.82	25463755
238 (in isoform 2)	Phosphorylation	-	26.82	-
247	Phosphorylation	DRNLLLNTGSNPGTS CCCEEECCCCCCCCC	41.79	20068231
249	Phosphorylation	NLLLNTGSNPGTSPM CEEECCCCCCCCCCC	37.50	26074081
253	Phosphorylation	NTGSNPGTSPMFCSV CCCCCCCCCCCCCCH	30.80	26074081
254	Phosphorylation	TGSNPGTSPMFCSVA CCCCCCCCCCCCCHH	21.93	26074081
259	Phosphorylation	GTSPMFCSVASFGAS CCCCCCCCHHHCCCH	14.95	20068231
262	Phosphorylation	PMFCSVASFGASSLS CCCCCHHHCCCHHHH	23.27	20068231
266	Phosphorylation	SVASFGASSLSSLYE CHHHCCCHHHHHHHH	31.99	20068231
267	Phosphorylation	VASFGASSLSSLYES HHHCCCHHHHHHHHC	31.56	20068231
269	Phosphorylation	SFGASSLSSLYESSP HCCCHHHHHHHHCCC	21.90	20068231
270	Phosphorylation	FGASSLSSLYESSPA CCCHHHHHHHHCCCC	40.02	20068231
272	Phosphorylation	ASSLSSLYESSPAPT CHHHHHHHHCCCCCC	18.73	20068231
274	Phosphorylation	SLSSLYESSPAPTPS HHHHHHHCCCCCCCC	28.23	20068231
275	Phosphorylation	LSSLYESSPAPTPSF HHHHHHCCCCCCCCC	17.09	20068231
279	Phosphorylation	YESSPAPTPSFWSSV HHCCCCCCCCCCCCC	33.40	20068231
281	Phosphorylation	SSPAPTPSFWSSVPV CCCCCCCCCCCCCCC	41.65	20068231
284	Phosphorylation	APTPSFWSSVPVMGP CCCCCCCCCCCCCCC	21.32	20068231
285	Phosphorylation	PTPSFWSSVPVMGPS CCCCCCCCCCCCCCC	22.49	20068231
292	Phosphorylation	SVPVMGPSLASPSRA CCCCCCCCCCCHHHH	30.73	20068231
295	Phosphorylation	VMGPSLASPSRAASQ CCCCCCCCHHHHHHH	28.80	20068231
297	Phosphorylation	GPSLASPSRAASQLA CCCCCCHHHHHHHCC	31.86	20068231
307	Phosphorylation	ASQLAVPSTPLSPHS HHHCCCCCCCCCCCC	35.74	28450419
308	Phosphorylation	SQLAVPSTPLSPHSA HHCCCCCCCCCCCCC	23.37	28450419
311	Phosphorylation	AVPSTPLSPHSAASG CCCCCCCCCCCCCCC	23.05	28450419
313	Ubiquitination	PSTPLSPHSAASGTA CCCCCCCCCCCCCCC	27.05	27667366
314	Phosphorylation	STPLSPHSAASGTAA CCCCCCCCCCCCCCC	28.99	28450419
317	Phosphorylation	LSPHSAASGTAAGSQ CCCCCCCCCCCCCCC	36.07	28450419
319	Phosphorylation	PHSAASGTAAGSQPS CCCCCCCCCCCCCCC	15.73	28450419
323	Phosphorylation	ASGTAAGSQPSSPRY CCCCCCCCCCCCCCC	33.90	28450419
326	Phosphorylation	TAAGSQPSSPRYRPY CCCCCCCCCCCCCCE	45.39	28450419
327	Phosphorylation	AAGSQPSSPRYRPYT CCCCCCCCCCCCCEE	21.78	28450419
330	Phosphorylation	SQPSSPRYRPYTVTH CCCCCCCCCCEEECC	21.23	22673903
330	Ubiquitination	SQPSSPRYRPYTVTH CCCCCCCCCCEEECC	21.23	23000965
333	Phosphorylation	SSPRYRPYTVTHPWA CCCCCCCEEECCCCH	12.58	22673903
334	Phosphorylation	SPRYRPYTVTHPWAS CCCCCCEEECCCCHH	22.93	22673903
336	Phosphorylation	RYRPYTVTHPWASSG CCCCEEECCCCHHCC	17.89	22673903
341	Phosphorylation	TVTHPWASSGVSILS EECCCCHHCCCEECC	24.61	22673903
342	Phosphorylation	VTHPWASSGVSILSS ECCCCHHCCCEECCC	35.15	22673903
345	Phosphorylation	PWASSGVSILSSSPS CCHHCCCEECCCCCC	22.72	29523821
348	Phosphorylation	SSGVSILSSSPSPPA HCCCEECCCCCCCCH	27.40	29523821
349	Phosphorylation	SGVSILSSSPSPPAL CCCEECCCCCCCCHH	42.71	29523821
350	Phosphorylation	GVSILSSSPSPPALA CCEECCCCCCCCHHH	26.48	29523821
352	Phosphorylation	SILSSSPSPPALASS EECCCCCCCCHHHCC	45.52	29523821
354	Ubiquitination	LSSSPSPPALASSPQ CCCCCCCCHHHCCCC	44.22	27667366
358	Phosphorylation	PSPPALASSPQAVPA CCCCHHHCCCCCCCC	43.32	29523821
359	Phosphorylation	SPPALASSPQAVPAS CCCHHHCCCCCCCCC	18.54	29523821
361	Ubiquitination	PALASSPQAVPASSS CHHHCCCCCCCCCCC	57.87	23000965
365	Ubiquitination	SSPQAVPASSSRQRP CCCCCCCCCCCCCCC	18.55	21890473
365 (in isoform 3)	Ubiquitination	-	18.55	21890473
373	Phosphorylation	SSSRQRPSSTGPPLP CCCCCCCCCCCCCCC	42.60	23186163
374	Phosphorylation	SSRQRPSSTGPPLPP CCCCCCCCCCCCCCC	39.81	23186163
375	Phosphorylation	SRQRPSSTGPPLPPA CCCCCCCCCCCCCCC	59.03	23186163
377	Ubiquitination	QRPSSTGPPLPPASP CCCCCCCCCCCCCCC	27.61	27667366
383	Phosphorylation	GPPLPPASPSATSRR CCCCCCCCCCCCCCC	25.76	30266825
385	Phosphorylation	PLPPASPSATSRRPS CCCCCCCCCCCCCCC	41.50	30266825
387	Phosphorylation	PPASPSATSRRPSSL CCCCCCCCCCCCCCC	27.40	30266825
388	Phosphorylation	PASPSATSRRPSSLR CCCCCCCCCCCCCCE	26.47	30266825
388	Ubiquitination	PASPSATSRRPSSLR CCCCCCCCCCCCCCE	26.47	33845483
392	Phosphorylation	SATSRRPSSLRISPS CCCCCCCCCCEECCC	39.95	20068231
393	Phosphorylation	ATSRRPSSLRISPSL CCCCCCCCCEECCCC	25.09	20068231
413	Ubiquitination	ASNWDSYSDHFTIET CCCCCCCCCCEEEEE	28.67	29967540
442	Ubiquitination	DRVGIEEKKAPKMCS HHHCCCCCCCCCCCC	41.25	27667366
443	Ubiquitination	RVGIEEKKAPKMCSQ HHCCCCCCCCCCCCH	73.52	-
446	Ubiquitination	IEEKKAPKMCSQPAV CCCCCCCCCCCHHHH	58.35	23000965
449	Phosphorylation	KKAPKMCSQPAVSQL CCCCCCCCHHHHHHH	35.38	30387612
455	Ubiquitination	CSQPAVSQLLSNIRS CCHHHHHHHHHHHHH	39.56	22817900
457	Ubiquitination	QPAVSQLLSNIRSQC HHHHHHHHHHHHHHH	2.60	22817900
457 (in isoform 3)	Ubiquitination	-	2.60	21890473
477	Ubiquitination	LVLQGSLTQPRSLQQ HHHCCCCCCCCCCCC	37.92	23000965
481	Ubiquitination	GSLTQPRSLQQPSFL CCCCCCCCCCCCCCH	36.89	21890473
481	Ubiquitination	GSLTQPRSLQQPSFL CCCCCCCCCCCCCCH	36.89	21890473
481 (in isoform 2)	Ubiquitination	-	36.89	21890473
487	Ubiquitination	RSLQQPSFLVPYMLC CCCCCCCCHHHHHHH	11.52	23000965
493	Ubiquitination	SFLVPYMLCRNLPYG CCHHHHHHHCCCCHH	1.73	27667366
510	Ubiquitination	QELVRTTHQDEEVFK HHHHHHCCCCHHHHH	32.26	23000965
517	Ubiquitination	HQDEEVFKQIFIPIL CCCHHHHHHHHHHHH	47.89	33845483
518	Ubiquitination	QDEEVFKQIFIPILQ CCHHHHHHHHHHHHH	25.10	23000965
522	Ubiquitination	VFKQIFIPILQGLAL HHHHHHHHHHHHHHH	15.53	21890473
541	Ubiquitination	CSLDSDYFKYPLMAL CCCCCCHHHHHHHHH	7.99	23000965
542	Ubiquitination	SLDSDYFKYPLMALG CCCCCHHHHHHHHHH	39.46	29967540
545	Ubiquitination	SDYFKYPLMALGELC CCHHHHHHHHHHHHH	2.59	21890473
549	Ubiquitination	KYPLMALGELCETKF HHHHHHHHHHHHHCC	19.11	21963094
549 (in isoform 3)	Ubiquitination	-	19.11	21890473
555	Acetylation	LGELCETKFGKTHPV HHHHHHHCCCCCCHH	29.81	25953088
556	Ubiquitination	GELCETKFGKTHPVC HHHHHHCCCCCCHHH	18.53	27667366
556 (in isoform 3)	Ubiquitination	-	18.53	21890473
558	Ubiquitination	LCETKFGKTHPVCNL HHHHCCCCCCHHHHH	46.95	-
571	Ubiquitination	NLVASLRLWLPKSLS HHHHHHHHHCCCCCC	7.17	22817900
573	Ubiquitination	VASLRLWLPKSLSPG HHHHHHHCCCCCCCC	4.54	22817900
573 (in isoform 2)	Ubiquitination	-	4.54	21890473
575	Ubiquitination	SLRLWLPKSLSPGCG HHHHHCCCCCCCCCC	62.96	23000965
606	Ubiquitination	VFAEDDVKVVEKYFS EECCCHHHHHHHHHC	47.78	23000965
610	Ubiquitination	DDVKVVEKYFSGPAI CHHHHHHHHHCCCEE	39.73	23000965
610 (in isoform 1)	Ubiquitination	-	39.73	21890473
611	Phosphorylation	DVKVVEKYFSGPAIT HHHHHHHHHCCCEEE	6.89	23879269
612	Ubiquitination	VKVVEKYFSGPAITL HHHHHHHHCCCEEEE	11.44	22817900
614	Ubiquitination	VVEKYFSGPAITLEN HHHHHHCCCEEEECC	13.03	22817900
626	Ubiquitination	LENTRVVSQSLQHYL ECCHHHHHHHHHHHH	15.93	-
626	Ubiquitination	LENTRVVSQSLQHYL ECCHHHHHHHHHHHH	15.93	23000965
635	Ubiquitination	SLQHYLELGRQELFK HHHHHHHHCHHHHHH	6.73	22817900
637	Ubiquitination	QHYLELGRQELFKIL HHHHHHCHHHHHHHH	39.15	22817900
657	Ubiquitination	NGETREAALSYMAAV CCCCHHHHHHHHHHH	7.71	23000965
659	Phosphorylation	ETREAALSYMAAVVN CCHHHHHHHHHHHHH	14.24	23312004
660	Phosphorylation	TREAALSYMAAVVNA CHHHHHHHHHHHHHH	7.51	23312004
661	Ubiquitination	REAALSYMAAVVNAN HHHHHHHHHHHHHHH	1.41	-
661	Ubiquitination	REAALSYMAAVVNAN HHHHHHHHHHHHHHH	1.41	21890473
665	Ubiquitination	LSYMAAVVNANMKKA HHHHHHHHHHHHHHH	4.86	21890473
665	Ubiquitination	LSYMAAVVNANMKKA HHHHHHHHHHHHHHH	4.86	21963094
665 (in isoform 2)	Ubiquitination	-	4.86	21890473
669 (in isoform 2)	Phosphorylation	-	4.35	-
672	Ubiquitination	VNANMKKAQMQTDDR HHHHHHHHHCCCCCC	12.45	21890473
672	Ubiquitination	VNANMKKAQMQTDDR HHHHHHHHHCCCCCC	12.45	27667366
672 (in isoform 2)	Ubiquitination	-	12.45	21890473
674 (in isoform 2)	Phosphorylation	-	5.75	-
676	Phosphorylation	MKKAQMQTDDRLVST HHHHHCCCCCCCCCC	34.23	23312004
700	Ubiquitination	VLQQLSTKIKLETVD HHHHHCCCCCCEECC	34.17	22817900
702	2-Hydroxyisobutyrylation	QQLSTKIKLETVDPT HHHCCCCCCEECCCC	41.65	-
702	Ubiquitination	QQLSTKIKLETVDPT HHHCCCCCCEECCCC	41.65	21906983
702 (in isoform 1)	Ubiquitination	-	41.65	21890473
705	Phosphorylation	STKIKLETVDPTYIF CCCCCCEECCCCEEE	40.42	24719451
706	Ubiquitination	TKIKLETVDPTYIFH CCCCCEECCCCEEEC	6.40	23000965
706 (in isoform 3)	Ubiquitination	-	6.40	21890473
709	Phosphorylation	KLETVDPTYIFHPRC CCEECCCCEEECCCC	25.45	24719451
710	Phosphorylation	LETVDPTYIFHPRCR CEECCCCEEECCCCE	13.64	24719451
713	Ubiquitination	VDPTYIFHPRCRITL CCCCEEECCCCEEEC	10.19	27667366
719	Ubiquitination	FHPRCRITLPNDETR ECCCCEEECCCCCHH	19.46	21890473
719 (in isoform 3)	Ubiquitination	-	19.46	21890473
729	Ubiquitination	NDETRVNATMEDVND CCCHHHCCCHHHHHH	12.88	21963094
736	Ubiquitination	ATMEDVNDWLTELYG CCHHHHHHHHHHHHC	41.43	27667366
744	Ubiquitination	WLTELYGDQPPFSEP HHHHHHCCCCCCCCC	44.23	21890473
744 (in isoform 3)	Ubiquitination	-	44.23	21890473
751	Ubiquitination	DQPPFSEPKFPTECF CCCCCCCCCCCCHHE	42.25	22817900
753	Ubiquitination	PPFSEPKFPTECFFL CCCCCCCCCCHHEEE	15.38	22817900
789	Phosphorylation	AIRELNRTVEDLKNN HHHHHHCHHHHHHCC	27.46	23186163
794	Acetylation	NRTVEDLKNNESQWK HCHHHHHHCCHHHHC	70.78	23236377
794	Malonylation	NRTVEDLKNNESQWK HCHHHHHHCCHHHHC	70.78	26320211
794	Ubiquitination	NRTVEDLKNNESQWK HCHHHHHHCCHHHHC	70.78	21963094
794 (in isoform 1)	Ubiquitination	-	70.78	21890473
798	Phosphorylation	EDLKNNESQWKDSPL HHHHCCHHHHCCCHH	43.39	30266825
800 (in isoform 2)	Phosphorylation	-	18.72	-
801	Sumoylation	KNNESQWKDSPLATR HCCHHHHCCCHHHHH	40.46	-
801	Ubiquitination	KNNESQWKDSPLATR HCCHHHHCCCHHHHH	40.46	27667366
801 (in isoform 1)	Ubiquitination	-	40.46	21890473
803	Phosphorylation	NESQWKDSPLATRHR CHHHHCCCHHHHHHH	20.34	22167270
807	Phosphorylation	WKDSPLATRHREMLK HCCCHHHHHHHHHHH	34.39	30266825
811	Ubiquitination	PLATRHREMLKRCKT HHHHHHHHHHHHHHH	42.62	22817900
811 (in isoform 3)	Ubiquitination	-	42.62	21890473
813	Ubiquitination	ATRHREMLKRCKTQL HHHHHHHHHHHHHHH	2.44	22817900
813 (in isoform 3)	Ubiquitination	-	2.44	21890473
822	Ubiquitination	RCKTQLKKLVRCKAC HHHHHHHHHHHCHHH	61.89	21890473
822	Ubiquitination	RCKTQLKKLVRCKAC HHHHHHHHHHHCHHH	61.89	23000965
822 (in isoform 2)	Ubiquitination	-	61.89	21890473
827	Ubiquitination	LKKLVRCKACADAGL HHHHHHCHHHHCCCC	35.62	-
835	Ubiquitination	ACADAGLLDESFLRR HHHCCCCCCHHHHHH	7.21	21890473
835	Ubiquitination	ACADAGLLDESFLRR HHHCCCCCCHHHHHH	7.21	21963094
835 (in isoform 2)	Ubiquitination	-	7.21	21890473
843	Ubiquitination	DESFLRRCLNFYGLL CHHHHHHHHHHHHHH	2.70	29967540
845	Ubiquitination	SFLRRCLNFYGLLIQ HHHHHHHHHHHHHHH	31.55	21963094
847	Phosphorylation	LRRCLNFYGLLIQLL HHHHHHHHHHHHHHH	13.04	30576142
852	Ubiquitination	NFYGLLIQLLLRILD HHHHHHHHHHHHHHC	26.48	27667366
857	Ubiquitination	LIQLLLRILDPAYPD HHHHHHHHHCCCCCC	5.30	22817900
860	Ubiquitination	LLLRILDPAYPDITL HHHHHHCCCCCCCCC	30.19	21890473
860	Ubiquitination	LLLRILDPAYPDITL HHHHHHCCCCCCCCC	30.19	21890473
860 (in isoform 2)	Ubiquitination	-	30.19	21890473
861	Ubiquitination	LLRILDPAYPDITLP HHHHHCCCCCCCCCC	28.32	21890473
861 (in isoform 3)	Ubiquitination	-	28.32	21890473
863	Ubiquitination	RILDPAYPDITLPLN HHHCCCCCCCCCCCC	28.74	21890473
871	Phosphorylation	DITLPLNSDVPKVFA CCCCCCCCCCCHHHH	47.90	30576142
876	Ubiquitination	LNSDVPKVFAALPEF CCCCCCHHHHHCCCC	3.02	21890473
886	Ubiquitination	ALPEFYVEDVAEFLF HCCCCHHHHHHHHHH	35.07	21890473
892	Ubiquitination	VEDVAEFLFFIVQYS HHHHHHHHHHHHHHC	2.29	27667366
897 (in isoform 2)	Phosphorylation	-	28.33	-
899	Ubiquitination	LFFIVQYSPQALYEP HHHHHHHCHHHHHCC	8.08	21890473
901	Ubiquitination	FIVQYSPQALYEPCT HHHHHCHHHHHCCCH	37.75	21890473
915 (in isoform 2)	Phosphorylation	-	1.21	-
924	Ubiquitination	VMLCNQNYIRNPYLV HHHHCCCCCCCHHHH	7.47	21890473
927	Ubiquitination	CNQNYIRNPYLVAKL HCCCCCCCHHHHHHH	21.73	22817900
927 (in isoform 2)	Ubiquitination	-	21.73	21890473
929	Phosphorylation	QNYIRNPYLVAKLVE CCCCCCHHHHHHHHH	19.84	20068231
929	Ubiquitination	QNYIRNPYLVAKLVE CCCCCCHHHHHHHHH	19.84	27667366
929 (in isoform 2)	Ubiquitination	-	19.84	21890473
944	Ubiquitination	VMFMTNPAVQPRTQK HHHCCCCCCCHHHHH	18.04	21890473
944 (in isoform 3)	Ubiquitination	-	18.04	21890473
947	Ubiquitination	MTNPAVQPRTQKFFE CCCCCCCHHHHHHHH	34.39	22817900
951	Ubiquitination	AVQPRTQKFFEMIEN CCCHHHHHHHHHHHC	51.94	23000965
951 (in isoform 1)	Ubiquitination	-	51.94	21890473
958	Ubiquitination	KFFEMIENHPLSTKL HHHHHHHCCCCCHHH	31.02	21890473
958 (in isoform 3)	Ubiquitination	-	31.02	21890473
960	Ubiquitination	FEMIENHPLSTKLLV HHHHHCCCCCHHHHH	39.32	22817900
964	Ubiquitination	ENHPLSTKLLVPSLM HCCCCCHHHHHHHHH	36.13	21963094
964 (in isoform 1)	Ubiquitination	-	36.13	21890473
968	Ubiquitination	LSTKLLVPSLMKFYT CCHHHHHHHHHHHHC	23.01	22817900
969	Phosphorylation	STKLLVPSLMKFYTD CHHHHHHHHHHHHCC	33.35	20068231
970	Ubiquitination	TKLLVPSLMKFYTDV HHHHHHHHHHHHCCC	3.37	22817900
972	Ubiquitination	LLVPSLMKFYTDVEH HHHHHHHHHHCCCCC	40.28	22817900
972 (in isoform 3)	Ubiquitination	-	40.28	21890473
973	Ubiquitination	LVPSLMKFYTDVEHT HHHHHHHHHCCCCCC	5.03	22817900
977	Ubiquitination	LMKFYTDVEHTGATS HHHHHCCCCCCCCCC	4.47	21890473
977	Ubiquitination	LMKFYTDVEHTGATS HHHHHCCCCCCCCCC	4.47	21890473
977 (in isoform 2)	Ubiquitination	-	4.47	21890473
989	Ubiquitination	ATSEFYDKFTIRYHI CCCHHHHHHHHHHHH	32.78	21890473
989 (in isoform 1)	Ubiquitination	-	32.78	21890473
991	Phosphorylation	SEFYDKFTIRYHIST CHHHHHHHHHHHHHH	15.41	24719451
991	Ubiquitination	SEFYDKFTIRYHIST CHHHHHHHHHHHHHH	15.41	22817900
993	Ubiquitination	FYDKFTIRYHISTIF HHHHHHHHHHHHHHH	17.58	22817900
1002	Ubiquitination	HISTIFKSLWQNIAH HHHHHHHHHHHHHHH	24.88	-
1002	Ubiquitination	HISTIFKSLWQNIAH HHHHHHHHHHHHHHH	24.88	21890473
1008	Ubiquitination	KSLWQNIAHHGTFME HHHHHHHHHHCCHHH	9.00	33845483
1014	Ubiquitination	IAHHGTFMEEFNSGK HHHHCCHHHHHHCHH	4.91	33845483
1015	Ubiquitination	AHHGTFMEEFNSGKQ HHHCCHHHHHHCHHH	56.07	21890473
1018	Ubiquitination	GTFMEEFNSGKQFVR CCHHHHHHCHHHHHH	53.80	21890473
1026	Phosphorylation	SGKQFVRYINMLIND CHHHHHHHHHHHHCC	7.43	18452278
1034	Phosphorylation	INMLINDTTFLLDES HHHHHCCCHHHCHHH	18.24	-
1037	Ubiquitination	LINDTTFLLDESLES HHCCCHHHCHHHHHH	5.75	22817900
1040	Ubiquitination	DTTFLLDESLESLKR CCHHHCHHHHHHHHH	58.13	21890473
1041	Ubiquitination	TTFLLDESLESLKRI CHHHCHHHHHHHHHH	36.78	21890473
1044	Phosphorylation	LLDESLESLKRIHEV HCHHHHHHHHHHHHH	44.47	18452278
1049	Ubiquitination	LESLKRIHEVQEEMK HHHHHHHHHHHHHHC	32.96	27667366
1051	Ubiquitination	SLKRIHEVQEEMKNK HHHHHHHHHHHHCCH	5.55	29967540
1056	Ubiquitination	HEVQEEMKNKEQWDQ HHHHHHHCCHHHHHH	69.05	21906983
1056 (in isoform 1)	Ubiquitination	-	69.05	21890473
1058	Ubiquitination	VQEEMKNKEQWDQLP HHHHHCCHHHHHHCC	45.85	21906983
1058 (in isoform 1)	Ubiquitination	-	45.85	21890473
1060	Ubiquitination	EEMKNKEQWDQLPRD HHHCCHHHHHHCCHH	51.13	21890473
1060	Ubiquitination	EEMKNKEQWDQLPRD HHHCCHHHHHHCCHH	51.13	21890473
1060 (in isoform 2)	Ubiquitination	-	51.13	21890473
1063	Ubiquitination	KNKEQWDQLPRDQQQ CCHHHHHHCCHHHHH	50.86	22817900
1067	Ubiquitination	QWDQLPRDQQQARQS HHHHCCHHHHHHHHH	49.02	29967540
1072	Ubiquitination	PRDQQQARQSQLAQD CHHHHHHHHHHHHHH	32.14	27667366
1074	Ubiquitination	DQQQARQSQLAQDER HHHHHHHHHHHHHHH	22.93	21890473
1074	Ubiquitination	DQQQARQSQLAQDER HHHHHHHHHHHHHHH	22.93	21890473
1074 (in isoform 2)	Ubiquitination	-	22.93	21890473
1076	Ubiquitination	QQARQSQLAQDERVS HHHHHHHHHHHHHHH	5.83	22817900
1081	Ubiquitination	SQLAQDERVSRSYLA HHHHHHHHHHHHHHH	39.75	27667366
1088	Ubiquitination	RVSRSYLALATETVD HHHHHHHHHHHHCHH	6.21	32015554
1088 (in isoform 2)	Ubiquitination	-	6.21	21890473
1101	Ubiquitination	VDMFHILTKQVQKPF HHHHHHHHHHCCCCC	20.87	21890473
1102	Ubiquitination	DMFHILTKQVQKPFL HHHHHHHHHCCCCCC	45.05	22817900
1104	Ubiquitination	FHILTKQVQKPFLRP HHHHHHHCCCCCCCC	9.35	22817900
1106	Malonylation	ILTKQVQKPFLRPEL HHHHHCCCCCCCCCH	38.59	26320211
1106	Ubiquitination	ILTKQVQKPFLRPEL HHHHHCCCCCCCCCH	38.59	21890473
1106 (in isoform 1)	Ubiquitination	-	38.59	21890473
1107	Ubiquitination	LTKQVQKPFLRPELG HHHHCCCCCCCCCHH	19.20	22817900
1109	Ubiquitination	KQVQKPFLRPELGPR HHCCCCCCCCCHHHH	13.98	22817900
1115	Ubiquitination	FLRPELGPRLAAMLN CCCCCHHHHHHHHHC	40.51	21890473
1117	Ubiquitination	RPELGPRLAAMLNFN CCCHHHHHHHHHCCC	3.92	22817900
1124	Ubiquitination	LAAMLNFNLQQLCGP HHHHHCCCHHHHHCC	35.55	21890473
1127	Ubiquitination	MLNFNLQQLCGPKCR HHCCCHHHHHCCCCC	41.72	22817900
1129	Ubiquitination	NFNLQQLCGPKCRDL CCCHHHHHCCCCCCC	8.35	22817900
1132	Ubiquitination	LQQLCGPKCRDLKVE HHHHHCCCCCCCCCC	27.47	-
1136 (in isoform 2)	Phosphorylation	-	3.28	-
1137	Ubiquitination	GPKCRDLKVENPEKY CCCCCCCCCCCHHHH	52.36	33845483
1138	Ubiquitination	PKCRDLKVENPEKYG CCCCCCCCCCHHHHC	12.81	21890473
1140	Ubiquitination	CRDLKVENPEKYGFE CCCCCCCCHHHHCCC	53.68	22817900
1143	Ubiquitination	LKVENPEKYGFEPKK CCCCCHHHHCCCHHH	52.51	33845483
1150	Ubiquitination	KYGFEPKKLLDQLTD HHCCCHHHHHHHHHH	66.07	-
1152	Ubiquitination	GFEPKKLLDQLTDIY CCCHHHHHHHHHHHH	5.61	22817900
1153	Ubiquitination	FEPKKLLDQLTDIYL CCHHHHHHHHHHHHH	52.45	22817900
1157	Ubiquitination	KLLDQLTDIYLQLDC HHHHHHHHHHHHHHH	35.81	21890473
1169	Ubiquitination	LDCARFAKAIADDQR HHHHHHHHHHHCCHH	37.30	27667366
1180	Ubiquitination	DDQRSYSKELFEEVI CCHHHHHHHHHHHHH	50.64	29967540
1188	Ubiquitination	ELFEEVISKMRKAGI HHHHHHHHHHHHCCC	26.10	27667366
1189	Ubiquitination	LFEEVISKMRKAGIK HHHHHHHHHHHCCCC	31.44	22817900
1189 (in isoform 1)	Ubiquitination	-	31.44	21890473
1192	Ubiquitination	EVISKMRKAGIKSTI HHHHHHHHCCCCHHH	47.68	22817900
1196	Ubiquitination	KMRKAGIKSTIAIEK HHHHCCCCHHHHHHH	40.40	29967540
1203	Ubiquitination	KSTIAIEKFKLLAEK CHHHHHHHHHHHHHH	41.51	22817900
1203 (in isoform 1)	Ubiquitination	-	41.51	21890473
1205	Ubiquitination	TIAIEKFKLLAEKVE HHHHHHHHHHHHHHH	54.37	22817900
1210	Ubiquitination	KFKLLAEKVEEIVAK HHHHHHHHHHHHHHH	49.71	29967540
1217	Ubiquitination	KVEEIVAKNARAEID HHHHHHHHHCCCCCC	40.00	27667366
1217 (in isoform 1)	Ubiquitination	-	40.00	21890473
1220	Ubiquitination	EIVAKNARAEIDYSD HHHHHHCCCCCCCCC	41.99	27667366
1240	Ubiquitination	RDPLMDTLMTDPVRL CCCHHHHHCCCCCCC	2.79	21890473
1243	Ubiquitination	LMDTLMTDPVRLPSG HHHHHCCCCCCCCCC	26.23	22817900
1249	Phosphorylation	TDPVRLPSGTIMDRS CCCCCCCCCCCCCHH	53.83	-
1254	Ubiquitination	LPSGTIMDRSIILRH CCCCCCCCHHHHHHH	37.01	21890473
1256	Phosphorylation	SGTIMDRSIILRHLL CCCCCCHHHHHHHHH	15.09	25159151
1256	Ubiquitination	SGTIMDRSIILRHLL CCCCCCHHHHHHHHH	15.09	22817900
1265	Phosphorylation	ILRHLLNSPTDPFNR HHHHHHCCCCCCCCC	29.19	22167270
1267	Phosphorylation	RHLLNSPTDPFNRQT HHHHCCCCCCCCCHH	57.01	22167270
1268	Ubiquitination	HLLNSPTDPFNRQTL HHHCCCCCCCCCHHC	49.53	22817900
1274	Phosphorylation	TDPFNRQTLTESMLE CCCCCCHHCCHHHHC	32.20	25850435
1276	Phosphorylation	PFNRQTLTESMLEPV CCCCHHCCHHHHCCC	29.42	22199227
1278	Phosphorylation	NRQTLTESMLEPVPE CCHHCCHHHHCCCHH	24.35	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P73_HUMAN	TP73	physical	16170377
TERA_HUMAN	VCP	physical	14749733
XPC_HUMAN	XPC	physical	19889839
TERA_HUMAN	VCP	physical	21282470
UB2D3_HUMAN	UBE2D3	physical	20017557
UBE4B_HUMAN	UBE4B	physical	20017557
CBL_HUMAN	CBL	physical	20696396
UB2D3_HUMAN	UBE2D3	physical	20696396
UB2D2_HUMAN	UBE2D2	physical	20696396
MDM2_HUMAN	MDM2	physical	21317885
P53_HUMAN	TP53	physical	21317885
TERA_HUMAN	VCP	physical	18022694
TERA_HUMAN	VCP	physical	20414249
FEZ1_HUMAN	FEZ1	physical	15466860
P63_HUMAN	TP63	physical	18418053
UB2D3_HUMAN	UBE2D3	physical	15466860
UB2D2_HUMAN	UBE2D2	physical	21317885
UBL7_HUMAN	UBL7	physical	22939629
UBP34_HUMAN	USP34	physical	22939629
VP26A_HUMAN	VPS26A	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
VPS36_HUMAN	VPS36	physical	22939629
VPS35_HUMAN	VPS35	physical	22939629
UBQL1_HUMAN	UBQLN1	physical	22939629
VPS4B_HUMAN	VPS4B	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
UFM1_HUMAN	UFM1	physical	22939629
ZRAB2_HUMAN	ZRANB2	physical	22939629
UCHL3_HUMAN	UCHL3	physical	22939629
VIGLN_HUMAN	HDLBP	physical	22939629
VPS29_HUMAN	VPS29	physical	22939629
CDC27_HUMAN	CDC27	physical	22045814
UB2D3_HUMAN	UBE2D3	physical	23550736
MDM2_HUMAN	MDM2	physical	24587254
TRIPC_HUMAN	TRIP12	physical	18627766
RD23A_HUMAN	RAD23A	physical	18234089
FOXK1_HUMAN	FOXK1	physical	26344197
CHIP_HUMAN	STUB1	physical	26344197
UBQL1_HUMAN	UBQLN1	physical	26344197
UB2D2_HUMAN	UBE2D2	physical	25801170
P53_HUMAN	TP53	physical	26673821
UBE4B_HUMAN	UBE4B	physical	29053960

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-88; SER-90 ANDSER-101, AND MASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-88; SER-90;SER-92; THR-95 AND SER-105, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-22; THR-26; SER-31;SER-88; SER-90; SER-101 AND SER-803, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 AND SER-803, AND MASSSPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1265, AND MASSSPECTROMETRY.
PubMed: 18220336

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803 AND SER-1265, ANDMASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.
PubMed: 15302935