FEZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEZ1_HUMAN
• UniProt AC: Q99689
• Protein Name: Fasciculation and elongation protein zeta-1
• Gene Name: FEZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell membrane. Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity)..
• Protein Description: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules..
• Protein Sequence: MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSEDWRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	NFSSEIISFKSMEDL CCCHHHCCCCCHHHH	32.08	24719451
58	Phosphorylation	SEIISFKSMEDLVNE HHHCCCCCHHHHHHH	25.95	26657352
136	Phosphorylation	LNGNCSDTEIHEKEE HCCCCCCCHHHHHHH	22.12	26670566
247	Phosphorylation	EGAIRDFSEELVQQL HHHHHHCHHHHHHHH	34.16	-
298	Phosphorylation	RRKEKGLSLQSSRIE HHHHHCCCCHHHCHH	32.79	20363803
301	Phosphorylation	EKGLSLQSSRIEKGN HHCCCCHHHCHHCCC	27.20	20363803
302	Phosphorylation	KGLSLQSSRIEKGNQ HCCCCHHHCHHCCCC	25.07	22912867
316	Phosphorylation	QMPLKRFSMEGISNI CCCCHHHCHHHHHHH	21.69	22617229
321	Phosphorylation	RFSMEGISNILQSGI HHCHHHHHHHHHHCH	28.77	30301811
341	Phosphorylation	SSGTDKQYLNTVIPY CCCCCHHHHHHCCCC	13.99	-
344	Phosphorylation	TDKQYLNTVIPYEKK CCHHHHHHCCCCCCC	19.74	-
348	Phosphorylation	YLNTVIPYEKKASPP HHHHCCCCCCCCCCC	29.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
58	S	Phosphorylation	Kinase	MARK1	Q9P0L2	PSP
58	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP
58	S	Phosphorylation	Kinase	MARK3	P27448	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	UBE4B	O95155	PMID:15466860

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
26	K	ubiquitylation	Polyubiquitin linkage seems to be mainly through Lys-26.	22354037

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DISC1_HUMAN	DISC1	physical	12874605
ACTG_HUMAN	ACTG1	physical	12874605
NBR1_HUMAN	NBR1	physical	11856312
KPCZ_HUMAN	PRKCZ	physical	9971736
NC2A_HUMAN	DRAP1	physical	16484223
SMRD1_HUMAN	SMARCD1	physical	16484223
SP30L_HUMAN	SAP30L	physical	16484223
BRD1_HUMAN	BRD1	physical	16484223
TLK2_HUMAN	TLK2	physical	16484223
ZN251_HUMAN	ZNF251	physical	16484223
SMC3_HUMAN	SMC3	physical	16484223
CLAP2_HUMAN	CLASP2	physical	16484223
RB3GP_HUMAN	RAB3GAP1	physical	16484223
FEZ1_HUMAN	FEZ1	physical	16484223
KIBRA_HUMAN	WWC1	physical	16484223
RAI14_HUMAN	RAI14	physical	16484223
PDCD7_HUMAN	PDCD7	physical	16484223
SCOC_HUMAN	SCOC	physical	16484223
CP059_HUMAN	C16orf59	physical	16484223
TBC25_HUMAN	TBC1D25	physical	16484223
FEZ2_HUMAN	FEZ2	physical	16484223
HD_HUMAN	HTT	physical	15383276
MIC60_HUMAN	IMMT	physical	15383276
LRIF1_HUMAN	LRIF1	physical	15383276
HAP1_HUMAN	HAP1	physical	15383276
UBE4B_HUMAN	UBE4B	physical	15466860
SCOC_HUMAN	SCOC	physical	28514442
ANK3_HUMAN	ANK3	physical	28514442
DGKD_HUMAN	DGKD	physical	28514442
ZY11A_HUMAN	ZYG11A	physical	28514442
NELFA_HUMAN	NELFA	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442
KLDC2_HUMAN	KLHDC2	physical	28514442
AURKA_HUMAN	AURKA	physical	28514442
HD_HUMAN	HTT	physical	28514442
MRS2_HUMAN	MRS2	physical	28514442
SELN_HUMAN	SEPN1	physical	28514442
LANC2_HUMAN	LANCL2	physical	28514442
IF140_HUMAN	IFT140	physical	28514442
MED25_HUMAN	MED25	physical	28514442
MYO5A_HUMAN	MYO5A	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
CREB1_HUMAN	CREB1	physical	28514442
ZN638_HUMAN	ZNF638	physical	28514442
CYTSA_HUMAN	SPECC1L	physical	28514442
SCPDL_HUMAN	SCCPDH	physical	28514442
PLK1_HUMAN	PLK1	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.