AT12A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT12A_HUMAN
• UniProt AC: P54707
• Protein Name: Potassium-transporting ATPase alpha chain 2
• Gene Name: ATP12A
• Organism: Homo sapiens (Human).
• Sequence Length: 1039
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues..
• Protein Sequence: MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MHQKTPEIYSVE ---CCCCCCCEEEEE	21.42	23663014
9	Phosphorylation	HQKTPEIYSVELSGT CCCCCCEEEEECCCC	12.66	23663014
10	Phosphorylation	QKTPEIYSVELSGTK CCCCCEEEEECCCCC	18.12	23663014
14	Phosphorylation	EIYSVELSGTKDIVK CEEEEECCCCCCEEE	30.80	23663014
16	Phosphorylation	YSVELSGTKDIVKTD EEEECCCCCCEEECC	23.36	23663014
42	Acetylation	KNNCLELKKKNHKEE HHCHHHHHHHHCHHH	52.94	20167786
62	Phosphorylation	HLDDHKLSNRELEEK CCCCCCCCHHHHHHH	38.35	26074081
94	Phosphorylation	LARDGPNSLTPPKQT HHHCCCCCCCCCCCC	36.43	19413330
101	Phosphorylation	SLTPPKQTPEIVKFL CCCCCCCCHHHHHHH	29.08	-
169	Phosphorylation	AYYQEAKSTNIMSSF HHHHHHHHCCHHHHH	33.46	-
170	Phosphorylation	YYQEAKSTNIMSSFN HHHHHHHCCHHHHHH	28.23	-
243	Phosphorylation	ESEPQPRSSEFTHEN CCCCCCCCCCCCCCC	40.68	-
290	Phosphorylation	GHIASLASGVGNEKT HHHHHHHCCCCCCCC	39.03	-
362	Phosphorylation	VTVTLSLTAKRMAKK HHEEHHHHHHHHHHC	27.10	19664994
393	Phosphorylation	SIICSDKTGTLTQNR EEEEECCCCCCCCCC	40.15	26437602
395	Phosphorylation	ICSDKTGTLTQNRMT EEECCCCCCCCCCEE	31.68	26437602
397	Phosphorylation	SDKTGTLTQNRMTVA ECCCCCCCCCCEEEE	24.52	26437602
449	Acetylation	LCNRAEFKPGQENVP HHHCCCCCCCCCCCC	39.48	22368381
459	Acetylation	QENVPIMKKAVIGDA CCCCCCEEEEECCCC	38.00	22368391
467	Phosphorylation	KAVIGDASETALLKF EEECCCCCHHHHHHH	39.97	-
499	Phosphorylation	VAEIPFNSTNKFQLS EEECCCCCCCCEEEE	33.46	25307156
534	Phosphorylation	ERILEKCSTIMINGE HHHHHHCCEEEECCC	31.84	22210691
535	Phosphorylation	RILEKCSTIMINGEE HHHHHCCEEEECCCC	24.84	22210691
605	Phosphorylation	LCFVGLLSMIDPPRS EEEEHHHHCCCCCCC	20.80	-
623	Phosphorylation	DAVTKCRSAGIKVIM HHHHHHHHCCCEEEE	40.07	20068231
627 (in isoform 1)	Ubiquitination	-	25.45	21890473
627	Ubiquitination	KCRSAGIKVIMVTGD HHHHCCCEEEEEECC	25.45	-
632	Phosphorylation	GIKVIMVTGDHPITA CCEEEEEECCCCCCH	21.36	20068231
633 (in isoform 2)	Ubiquitination	-	21.59	21890473
638	Phosphorylation	VTGDHPITAKAIAKS EECCCCCCHHHHHHH	26.93	20068231
640	Ubiquitination	GDHPITAKAIAKSVG CCCCCCHHHHHHHHC	31.51	-
640 (in isoform 1)	Ubiquitination	-	31.51	21890473
646 (in isoform 2)	Ubiquitination	-	6.68	21890473
690	Phosphorylation	MELKDMSSEQLDEIL CCHHCCCHHHHHHHH	23.79	-
713 (in isoform 1)	Ubiquitination	-	36.08	21890473
713	Ubiquitination	ARTSPQQKLIIVEGC EECCCCCCEEEEECC	36.08	-
719 (in isoform 2)	Ubiquitination	-	11.27	21890473
720	S-palmitoylation	KLIIVEGCQRQDAVV CEEEEECCCCCCCEE	1.58	29575903
737	Phosphorylation	TGDGVNDSPALKKAD ECCCCCCCHHHHHCC	13.58	20068231
788 (in isoform 1)	Ubiquitination	-	54.87	21890473
788	Ubiquitination	RLIFDNLKKTIAYSL EEEEHHHHHHHHHHH	54.87	-
794 (in isoform 2)	Ubiquitination	-	22.12	21890473
844	Phosphorylation	LAYEKAESDIMNRKP HHHHHHHHHHHCCCC	36.98	-
856	Acetylation	RKPRHKNKDRLVNQP CCCCCCCHHHHCCCC	49.37	24848915
958	Phosphorylation	IRKTRRNSIFQQGLF HHHHCCCCHHHCCCC	23.98	-
985	Phosphorylation	IIIGLILSYGLGSVT HHHHHHHHHCCCHHH	15.34	-
1038	Phosphorylation	SWWDKNMYY------ CCCCCCCCC------	18.54	-
1039	Phosphorylation	WWDKNMYY------- CCCCCCCC-------	10.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
958	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT12A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT12A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI3_HUMAN	GNAI3	physical	21988832
NPY_HUMAN	NPY	physical	21988832
PPIB_HUMAN	PPIB	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.