KLDC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLDC2_HUMAN
• UniProt AC: Q9Y2U9
• Protein Name: Kelch domain-containing protein 2
• Gene Name: KLHDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Nucleus .
• Protein Description: Represses CREB3-mediated transcription by interfering with CREB3-DNA binding..
• Protein Sequence: MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	VSDGRHMFVWGGYKS EECCCEEEEECCCCC	3.23	21890473
51	Ubiquitination	MFVWGGYKSNQVRGL EEEECCCCCCCCCCC	46.32	-
94	Phosphorylation	VPPSMSGSCAVCVDR CCCCCCCCCEEEECE	7.50	-
117	Ubiquitination	HSRGNTNKFYMLDSR CCCCCCCCEEEECCC	35.51	22817900
117 (in isoform 1)	Ubiquitination	-	35.51	21890473
117 (in isoform 2)	Ubiquitination	-	35.51	21890473
125	Phosphorylation	FYMLDSRSTDRVLQW EEEECCCCCCCEEEE	38.31	22210691
126	Phosphorylation	YMLDSRSTDRVLQWE EEECCCCCCCEEEEE	27.07	22210691
147	Ubiquitination	IPPSSKDKLGVWVYK CCCCCCCCCEEEEEC	51.37	-
210	Phosphorylation	FTWSQPITTGKAPSP EEECCCCCCCCCCCC	35.86	-
213	Ubiquitination	SQPITTGKAPSPRAA CCCCCCCCCCCCCHH	55.84	-
317	Ubiquitination	FNHPYTEKPRLWHTA CCCCCCCCCCCEEEE	27.86	-
362	Ubiquitination	LIFSVQPKSLVRLSL EEEEECCHHHHCCHH	39.05	-
382	Phosphorylation	FKEMLANSWNCLPKH HHHHHHHCCCCCCHH	17.66	29083192
393	Phosphorylation	LPKHLLHSVNQRFGS CCHHHHHHHHHHCCC	23.80	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLDC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLDC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLDC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DD19B_HUMAN	DDX19B	physical	17353931
CUL2_HUMAN	CUL2	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417
CUL5_HUMAN	CUL5	physical	18187417
SELS_HUMAN	VIMP	physical	28514442
RN169_HUMAN	RNF169	physical	28514442
CUL5_HUMAN	CUL5	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
FAIM1_HUMAN	FAIM	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442
KTU_HUMAN	DNAAF2	physical	28514442
ELOC_HUMAN	TCEB1	physical	28514442
PTOV1_HUMAN	PTOV1	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
UBE3D_HUMAN	UBE3D	physical	28514442
RAB2A_HUMAN	RAB2A	physical	28514442
NMD3_HUMAN	NMD3	physical	28514442
RSAD1_HUMAN	RSAD1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
PFD1_HUMAN	PFDN1	physical	28514442
KLH42_HUMAN	KLHL42	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
ELOB_HUMAN	TCEB2	physical	28514442
PFD5_HUMAN	PFDN5	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
PFD2_HUMAN	PFDN2	physical	28514442
CHIP_HUMAN	STUB1	physical	28514442
CCZ1B_HUMAN	CCZ1	physical	28514442
CCZ1_HUMAN	CCZ1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.