UniProt ID | KTU_HUMAN | |
---|---|---|
UniProt AC | Q9NVR5 | |
Protein Name | Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069} | |
Gene Name | DNAAF2 {ECO:0000255|HAMAP-Rule:MF_03069} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 837 | |
Subcellular Localization | Cytoplasm . Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. | |
Protein Description | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.. | |
Protein Sequence | MAKAAASSSLEDLDLSGEEVQRLTSAFQDPEFRRMFSQYAEELTDPENRRRYEAEITALERERGVEVRFVHPEPGHVLRTSLDGARRCFVNVCSNALVGAPSSRPGSGGDRGAAPGSHWSLPYSLAPGREYAGRSSSRYMVYDVVFHPDALALARRHEGFRQMLDATALEAVEKQFGVKLDRRNAKTLKAKYKGTPEAAVLRTPLPGVIPARPDGEPKGPLPDFPYPYQYPAAPGPRAPSPPEAALQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPSPVPHELVITIELPLLRSAEQAALEVTRKLLCLDSRKPDYRLRLSLPYPVDDGRGKAQFNKARRQLVVTLPVVLPAARREPAVAVAAAAPEESADRSGTDGQACASAREGEAGPARSRAEDGGHDTCVAGAAGSGVTTLGDPEVAPPPAAAGEERVPKPGEQDLSRHAGSPPGSVEEPSPGGENSPGGGGSPCLSSRSLAWGSSAGRESARGDSSVETREESEGTGGQRSACAMGGPGTKSGEPLCPPLLCNQDKETLTLLIQVPRIQPQSLQGDLNPLWYKLRFSAQDLVYSFFLQFAPENKLSTTEPVISISSNNAVIELAKSPESHGHWREWYYGVNNDSLEERLFVNEENVNEFLEEVLSSPFKQSMSLTPPLIEVLQVTDNKIQINAKLQECSNSDQLQGKEERVNEESHLTEKEYIEHCNTPTTDSDSSIAVKALQIDSFGLVTCFQQESLDVSQMILGKSQQPESKMQSEFIKEKSATCSNEEKDNLNESVITEEKETDGDHLSSLLNKTTVHNIPGFDSIKETNMQDGSVQVIKDHVTNCAFSFQNSLLYDLD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
24 | O-linked_Glycosylation | GEEVQRLTSAFQDPE HHHHHHHHHHHCCHH | 21.87 | OGP | |
25 | O-linked_Glycosylation | EEVQRLTSAFQDPEF HHHHHHHHHHCCHHH | 31.51 | OGP | |
52 | Phosphorylation | DPENRRRYEAEITAL CHHHHHHHHHHHHHH | 20.06 | - | |
102 | Phosphorylation | NALVGAPSSRPGSGG CCCCCCCCCCCCCCC | 38.14 | 27251275 | |
103 | Phosphorylation | ALVGAPSSRPGSGGD CCCCCCCCCCCCCCC | 41.24 | 27251275 | |
107 | Phosphorylation | APSSRPGSGGDRGAA CCCCCCCCCCCCCCC | 42.14 | 27251275 | |
167 | Phosphorylation | FRQMLDATALEAVEK HHHHHHHHHHHHHHH | 31.29 | - | |
192 | Phosphorylation | AKTLKAKYKGTPEAA CHHHHHHHCCCCCCE | 21.36 | 24719451 | |
195 | Phosphorylation | LKAKYKGTPEAAVLR HHHHHCCCCCCEEEC | 17.50 | 24719451 | |
240 | Phosphorylation | APGPRAPSPPEAALQ CCCCCCCCCCHHHCC | 52.69 | 26657352 | |
268 | Phosphorylation | HHVDLQDYRCSRDSA CCCCHHHHCCCCCCC | 10.68 | - | |
345 | Phosphorylation | ARRQLVVTLPVVLPA HHHHHEEEECEECHH | 20.19 | - | |
446 | Phosphorylation | DLSRHAGSPPGSVEE HHHHHCCCCCCCCCC | 28.80 | 28450419 | |
450 | Phosphorylation | HAGSPPGSVEEPSPG HCCCCCCCCCCCCCC | 31.93 | 28450419 | |
455 | Phosphorylation | PGSVEEPSPGGENSP CCCCCCCCCCCCCCC | 39.18 | 23090842 | |
461 | Phosphorylation | PSPGGENSPGGGGSP CCCCCCCCCCCCCCC | 22.18 | 23927012 | |
467 | Phosphorylation | NSPGGGGSPCLSSRS CCCCCCCCCCCCCCC | 18.73 | 23927012 | |
471 | Phosphorylation | GGGSPCLSSRSLAWG CCCCCCCCCCCCCCC | 30.35 | 23663014 | |
472 | Phosphorylation | GGSPCLSSRSLAWGS CCCCCCCCCCCCCCC | 16.97 | 23663014 | |
485 | Phosphorylation | GSSAGRESARGDSSV CCCCCCHHHCCCCCC | 23.16 | - | |
498 | Phosphorylation | SVETREESEGTGGQR CCCCHHHCCCCCCCC | 36.25 | - | |
501 | Phosphorylation | TREESEGTGGQRSAC CHHHCCCCCCCCCCC | 33.80 | - | |
558 (in isoform 2) | Ubiquitination | - | 22.92 | 21890473 | |
558 | Ubiquitination | DLNPLWYKLRFSAQD CCCHHHHHHHHCHHH | 22.92 | 21890473 | |
558 (in isoform 1) | Ubiquitination | - | 22.92 | 21890473 | |
558 | Ubiquitination | DLNPLWYKLRFSAQD CCCHHHHHHHHCHHH | 22.92 | 21890473 | |
640 | Phosphorylation | EFLEEVLSSPFKQSM HHHHHHHCCCHHHCC | 40.93 | 18691976 | |
641 | Phosphorylation | FLEEVLSSPFKQSMS HHHHHHCCCHHHCCC | 30.14 | 25159151 | |
646 | Phosphorylation | LSSPFKQSMSLTPPL HCCCHHHCCCCCCCE | 15.78 | 23403867 | |
648 | Phosphorylation | SPFKQSMSLTPPLIE CCHHHCCCCCCCEEE | 34.05 | 22199227 | |
650 | Phosphorylation | FKQSMSLTPPLIEVL HHHCCCCCCCEEEEE | 18.63 | 21815630 | |
674 | Phosphorylation | NAKLQECSNSDQLQG HHHHHHCCCCHHHCC | 38.32 | 26074081 | |
676 | Phosphorylation | KLQECSNSDQLQGKE HHHHCCCCHHHCCHH | 15.50 | 26074081 | |
697 | Phosphorylation | SHLTEKEYIEHCNTP CCCCHHHHHHHCCCC | 23.76 | 28450419 | |
703 | Phosphorylation | EYIEHCNTPTTDSDS HHHHHCCCCCCCCCC | 27.66 | 25159151 | |
705 | Phosphorylation | IEHCNTPTTDSDSSI HHHCCCCCCCCCCCH | 40.99 | 28450419 | |
706 | Phosphorylation | EHCNTPTTDSDSSIA HHCCCCCCCCCCCHH | 34.41 | 28450419 | |
708 | Phosphorylation | CNTPTTDSDSSIAVK CCCCCCCCCCCHHHE | 36.98 | 27251275 | |
710 | Phosphorylation | TPTTDSDSSIAVKAL CCCCCCCCCHHHEEE | 27.83 | 27251275 | |
711 | Phosphorylation | PTTDSDSSIAVKALQ CCCCCCCCHHHEEEE | 21.40 | 27251275 | |
731 | Ubiquitination | LVTCFQQESLDVSQM CEEEEECCCCCHHHH | 42.35 | 29967540 | |
744 | Ubiquitination | QMILGKSQQPESKMQ HHHHCCCCCCCHHHH | 67.35 | 29967540 | |
759 | Phosphorylation | SEFIKEKSATCSNEE HHHHHHHHCCCCHHH | 29.87 | 28102081 | |
761 | Phosphorylation | FIKEKSATCSNEEKD HHHHHHCCCCHHHHC | 24.45 | 28102081 | |
763 | Phosphorylation | KEKSATCSNEEKDNL HHHHCCCCHHHHCCC | 42.81 | 28102081 | |
773 | Phosphorylation | EKDNLNESVITEEKE HHCCCCCCCCCCCHH | 20.11 | 25159151 | |
776 | Phosphorylation | NLNESVITEEKETDG CCCCCCCCCCHHCCC | 35.62 | 20068231 | |
779 | Ubiquitination | ESVITEEKETDGDHL CCCCCCCHHCCCHHH | 60.73 | 29967540 | |
781 | Phosphorylation | VITEEKETDGDHLSS CCCCCHHCCCHHHHH | 57.24 | 21712546 | |
787 | Phosphorylation | ETDGDHLSSLLNKTT HCCCHHHHHHHHHCC | 18.60 | 25627689 | |
788 | Phosphorylation | TDGDHLSSLLNKTTV CCCHHHHHHHHHCCC | 43.14 | 24719451 | |
792 | Ubiquitination | HLSSLLNKTTVHNIP HHHHHHHHCCCCCCC | 45.61 | 29967540 | |
793 | Phosphorylation | LSSLLNKTTVHNIPG HHHHHHHCCCCCCCC | 32.74 | 28555341 | |
794 | Phosphorylation | SSLLNKTTVHNIPGF HHHHHHCCCCCCCCC | 22.75 | 28555341 | |
803 | Phosphorylation | HNIPGFDSIKETNMQ CCCCCCCCCCCCCCC | 33.04 | 28555341 | |
809 | Sulfoxidation | DSIKETNMQDGSVQV CCCCCCCCCCCCEEE | 5.12 | 21406390 | |
831 | Phosphorylation | CAFSFQNSLLYDLD- CEEEECCCCCCCCC- | 14.68 | - | |
834 | Phosphorylation | SFQNSLLYDLD---- EECCCCCCCCC---- | 21.54 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KTU_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KTU_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KTU_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
612518 | Ciliary dyskinesia, primary, 10 (CILD10) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...
Phosphorylation | |
Reference | PubMed |
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, AND MASSSPECTROMETRY. |