| UniProt ID | KTU_HUMAN | |
|---|---|---|
| UniProt AC | Q9NVR5 | |
| Protein Name | Protein kintoun {ECO:0000255|HAMAP-Rule:MF_03069} | |
| Gene Name | DNAAF2 {ECO:0000255|HAMAP-Rule:MF_03069} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 837 | |
| Subcellular Localization | Cytoplasm . Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. | |
| Protein Description | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.. | |
| Protein Sequence | MAKAAASSSLEDLDLSGEEVQRLTSAFQDPEFRRMFSQYAEELTDPENRRRYEAEITALERERGVEVRFVHPEPGHVLRTSLDGARRCFVNVCSNALVGAPSSRPGSGGDRGAAPGSHWSLPYSLAPGREYAGRSSSRYMVYDVVFHPDALALARRHEGFRQMLDATALEAVEKQFGVKLDRRNAKTLKAKYKGTPEAAVLRTPLPGVIPARPDGEPKGPLPDFPYPYQYPAAPGPRAPSPPEAALQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPSPVPHELVITIELPLLRSAEQAALEVTRKLLCLDSRKPDYRLRLSLPYPVDDGRGKAQFNKARRQLVVTLPVVLPAARREPAVAVAAAAPEESADRSGTDGQACASAREGEAGPARSRAEDGGHDTCVAGAAGSGVTTLGDPEVAPPPAAAGEERVPKPGEQDLSRHAGSPPGSVEEPSPGGENSPGGGGSPCLSSRSLAWGSSAGRESARGDSSVETREESEGTGGQRSACAMGGPGTKSGEPLCPPLLCNQDKETLTLLIQVPRIQPQSLQGDLNPLWYKLRFSAQDLVYSFFLQFAPENKLSTTEPVISISSNNAVIELAKSPESHGHWREWYYGVNNDSLEERLFVNEENVNEFLEEVLSSPFKQSMSLTPPLIEVLQVTDNKIQINAKLQECSNSDQLQGKEERVNEESHLTEKEYIEHCNTPTTDSDSSIAVKALQIDSFGLVTCFQQESLDVSQMILGKSQQPESKMQSEFIKEKSATCSNEEKDNLNESVITEEKETDGDHLSSLLNKTTVHNIPGFDSIKETNMQDGSVQVIKDHVTNCAFSFQNSLLYDLD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | O-linked_Glycosylation | GEEVQRLTSAFQDPE HHHHHHHHHHHCCHH | 21.87 | OGP | |
| 25 | O-linked_Glycosylation | EEVQRLTSAFQDPEF HHHHHHHHHHCCHHH | 31.51 | OGP | |
| 52 | Phosphorylation | DPENRRRYEAEITAL CHHHHHHHHHHHHHH | 20.06 | - | |
| 102 | Phosphorylation | NALVGAPSSRPGSGG CCCCCCCCCCCCCCC | 38.14 | 27251275 | |
| 103 | Phosphorylation | ALVGAPSSRPGSGGD CCCCCCCCCCCCCCC | 41.24 | 27251275 | |
| 107 | Phosphorylation | APSSRPGSGGDRGAA CCCCCCCCCCCCCCC | 42.14 | 27251275 | |
| 167 | Phosphorylation | FRQMLDATALEAVEK HHHHHHHHHHHHHHH | 31.29 | - | |
| 192 | Phosphorylation | AKTLKAKYKGTPEAA CHHHHHHHCCCCCCE | 21.36 | 24719451 | |
| 195 | Phosphorylation | LKAKYKGTPEAAVLR HHHHHCCCCCCEEEC | 17.50 | 24719451 | |
| 240 | Phosphorylation | APGPRAPSPPEAALQ CCCCCCCCCCHHHCC | 52.69 | 26657352 | |
| 268 | Phosphorylation | HHVDLQDYRCSRDSA CCCCHHHHCCCCCCC | 10.68 | - | |
| 345 | Phosphorylation | ARRQLVVTLPVVLPA HHHHHEEEECEECHH | 20.19 | - | |
| 446 | Phosphorylation | DLSRHAGSPPGSVEE HHHHHCCCCCCCCCC | 28.80 | 28450419 | |
| 450 | Phosphorylation | HAGSPPGSVEEPSPG HCCCCCCCCCCCCCC | 31.93 | 28450419 | |
| 455 | Phosphorylation | PGSVEEPSPGGENSP CCCCCCCCCCCCCCC | 39.18 | 23090842 | |
| 461 | Phosphorylation | PSPGGENSPGGGGSP CCCCCCCCCCCCCCC | 22.18 | 23927012 | |
| 467 | Phosphorylation | NSPGGGGSPCLSSRS CCCCCCCCCCCCCCC | 18.73 | 23927012 | |
| 471 | Phosphorylation | GGGSPCLSSRSLAWG CCCCCCCCCCCCCCC | 30.35 | 23663014 | |
| 472 | Phosphorylation | GGSPCLSSRSLAWGS CCCCCCCCCCCCCCC | 16.97 | 23663014 | |
| 485 | Phosphorylation | GSSAGRESARGDSSV CCCCCCHHHCCCCCC | 23.16 | - | |
| 498 | Phosphorylation | SVETREESEGTGGQR CCCCHHHCCCCCCCC | 36.25 | - | |
| 501 | Phosphorylation | TREESEGTGGQRSAC CHHHCCCCCCCCCCC | 33.80 | - | |
| 558 (in isoform 2) | Ubiquitination | - | 22.92 | 21890473 | |
| 558 | Ubiquitination | DLNPLWYKLRFSAQD CCCHHHHHHHHCHHH | 22.92 | 21890473 | |
| 558 (in isoform 1) | Ubiquitination | - | 22.92 | 21890473 | |
| 558 | Ubiquitination | DLNPLWYKLRFSAQD CCCHHHHHHHHCHHH | 22.92 | 21890473 | |
| 640 | Phosphorylation | EFLEEVLSSPFKQSM HHHHHHHCCCHHHCC | 40.93 | 18691976 | |
| 641 | Phosphorylation | FLEEVLSSPFKQSMS HHHHHHCCCHHHCCC | 30.14 | 25159151 | |
| 646 | Phosphorylation | LSSPFKQSMSLTPPL HCCCHHHCCCCCCCE | 15.78 | 23403867 | |
| 648 | Phosphorylation | SPFKQSMSLTPPLIE CCHHHCCCCCCCEEE | 34.05 | 22199227 | |
| 650 | Phosphorylation | FKQSMSLTPPLIEVL HHHCCCCCCCEEEEE | 18.63 | 21815630 | |
| 674 | Phosphorylation | NAKLQECSNSDQLQG HHHHHHCCCCHHHCC | 38.32 | 26074081 | |
| 676 | Phosphorylation | KLQECSNSDQLQGKE HHHHCCCCHHHCCHH | 15.50 | 26074081 | |
| 697 | Phosphorylation | SHLTEKEYIEHCNTP CCCCHHHHHHHCCCC | 23.76 | 28450419 | |
| 703 | Phosphorylation | EYIEHCNTPTTDSDS HHHHHCCCCCCCCCC | 27.66 | 25159151 | |
| 705 | Phosphorylation | IEHCNTPTTDSDSSI HHHCCCCCCCCCCCH | 40.99 | 28450419 | |
| 706 | Phosphorylation | EHCNTPTTDSDSSIA HHCCCCCCCCCCCHH | 34.41 | 28450419 | |
| 708 | Phosphorylation | CNTPTTDSDSSIAVK CCCCCCCCCCCHHHE | 36.98 | 27251275 | |
| 710 | Phosphorylation | TPTTDSDSSIAVKAL CCCCCCCCCHHHEEE | 27.83 | 27251275 | |
| 711 | Phosphorylation | PTTDSDSSIAVKALQ CCCCCCCCHHHEEEE | 21.40 | 27251275 | |
| 731 | Ubiquitination | LVTCFQQESLDVSQM CEEEEECCCCCHHHH | 42.35 | 29967540 | |
| 744 | Ubiquitination | QMILGKSQQPESKMQ HHHHCCCCCCCHHHH | 67.35 | 29967540 | |
| 759 | Phosphorylation | SEFIKEKSATCSNEE HHHHHHHHCCCCHHH | 29.87 | 28102081 | |
| 761 | Phosphorylation | FIKEKSATCSNEEKD HHHHHHCCCCHHHHC | 24.45 | 28102081 | |
| 763 | Phosphorylation | KEKSATCSNEEKDNL HHHHCCCCHHHHCCC | 42.81 | 28102081 | |
| 773 | Phosphorylation | EKDNLNESVITEEKE HHCCCCCCCCCCCHH | 20.11 | 25159151 | |
| 776 | Phosphorylation | NLNESVITEEKETDG CCCCCCCCCCHHCCC | 35.62 | 20068231 | |
| 779 | Ubiquitination | ESVITEEKETDGDHL CCCCCCCHHCCCHHH | 60.73 | 29967540 | |
| 781 | Phosphorylation | VITEEKETDGDHLSS CCCCCHHCCCHHHHH | 57.24 | 21712546 | |
| 787 | Phosphorylation | ETDGDHLSSLLNKTT HCCCHHHHHHHHHCC | 18.60 | 25627689 | |
| 788 | Phosphorylation | TDGDHLSSLLNKTTV CCCHHHHHHHHHCCC | 43.14 | 24719451 | |
| 792 | Ubiquitination | HLSSLLNKTTVHNIP HHHHHHHHCCCCCCC | 45.61 | 29967540 | |
| 793 | Phosphorylation | LSSLLNKTTVHNIPG HHHHHHHCCCCCCCC | 32.74 | 28555341 | |
| 794 | Phosphorylation | SSLLNKTTVHNIPGF HHHHHHCCCCCCCCC | 22.75 | 28555341 | |
| 803 | Phosphorylation | HNIPGFDSIKETNMQ CCCCCCCCCCCCCCC | 33.04 | 28555341 | |
| 809 | Sulfoxidation | DSIKETNMQDGSVQV CCCCCCCCCCCCEEE | 5.12 | 21406390 | |
| 831 | Phosphorylation | CAFSFQNSLLYDLD- CEEEECCCCCCCCC- | 14.68 | - | |
| 834 | Phosphorylation | SFQNSLLYDLD---- EECCCCCCCCC---- | 21.54 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KTU_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KTU_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KTU_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612518 | Ciliary dyskinesia, primary, 10 (CILD10) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, AND MASSSPECTROMETRY. | |
