| UniProt ID | GPM6B_HUMAN | |
|---|---|---|
| UniProt AC | Q13491 | |
| Protein Name | Neuronal membrane glycoprotein M6-b | |
| Gene Name | GPM6B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 265 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Colocalizes with SERT at the plasma membrane.. |
|
| Protein Description | May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.. | |
| Protein Sequence | MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 39 (in isoform 3) | Phosphorylation | - | 4.01 | 23663014 | |
| 39 (in isoform 4) | Phosphorylation | - | 4.01 | 23663014 | |
| 44 (in isoform 3) | Phosphorylation | - | 1.95 | 25884760 | |
| 44 (in isoform 4) | Phosphorylation | - | 1.95 | 25884760 | |
| 55 (in isoform 3) | Phosphorylation | - | 12.00 | - | |
| 55 (in isoform 4) | Phosphorylation | - | 12.00 | - | |
| 58 (in isoform 4) | Phosphorylation | - | 5.99 | - | |
| 58 (in isoform 3) | Phosphorylation | - | 5.99 | - | |
| 59 (in isoform 4) | Phosphorylation | - | 4.37 | - | |
| 59 (in isoform 3) | Phosphorylation | - | 4.37 | - | |
| 73 | N-linked_Glycosylation | LEQHFSTNASDHALL HHHHCCCCCCHHHHH | 35.93 | UniProtKB CARBOHYD | |
| 177 | N-linked_Glycosylation | VIKSPQTNGTTGVEQ HHCCCCCCCCCCCEE | 40.33 | UniProtKB CARBOHYD | |
| 257 | Phosphorylation | YAVLKFKSREDCCTK CHHHHCCCHHHHCCC | 43.99 | - | |
| 264 | Ubiquitination | SREDCCTKF------ CHHHHCCCC------ | 34.85 | - | |
| 297 (in isoform 4) | Phosphorylation | - | - | ||
| 302 (in isoform 4) | Phosphorylation | - | - | ||
| 318 (in isoform 4) | Phosphorylation | - | 25850435 | ||
| 320 (in isoform 4) | Phosphorylation | - | 25850435 | ||
| 326 (in isoform 4) | Phosphorylation | - | - | ||
| 327 (in isoform 4) | Phosphorylation | - | 25884760 | ||
| 328 (in isoform 4) | Phosphorylation | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPM6B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPM6B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPM6B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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