CAMKV_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAMKV_HUMAN
• UniProt AC: Q8NCB2
• Protein Name: CaM kinase-like vesicle-associated protein
• Gene Name: CAMKV
• Organism: Homo sapiens (Human).
• Sequence Length: 501
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular
• Protein Description: Does not appear to have detectable kinase activity..
• Protein Sequence: MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAARAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTPATDRSATPATDGRATPATEESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAPPSSKGEEAAGYAQESQREEAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	KKNYNQPSEVTDRYD CCCCCCCCCCCCCCC	34.63	22115753
21	Phosphorylation	YNQPSEVTDRYDLGQ CCCCCCCCCCCCHHH	15.65	22115753
48	Acetylation	AKDKTTGKLHTCKKF CCCCCCCCCCCCHHH	34.70	24884183
53	Acetylation	TGKLHTCKKFQKRDG CCCCCCCHHHHHCCC	58.75	24884193
62	Acetylation	FQKRDGRKVRKAAKN HHHCCCHHHHHHHHH	52.50	7266327
65 (in isoform 3)	Ubiquitination	-	56.54	21906983
65 (in isoform 2)	Ubiquitination	-	56.54	21906983
65 (in isoform 1)	Ubiquitination	-	56.54	21906983
65	Ubiquitination	RDGRKVRKAAKNEIG CCCHHHHHHHHHHCC	56.54	2190698
154	Phosphorylation	KLENLVYYNRLKNSK CHHHHEEHHCCCCCE	6.07	21082442
249	Phosphorylation	AGDYEFDSPYWDDIS HCCCCCCCCCHHHHH	25.80	22210691
251	Phosphorylation	DYEFDSPYWDDISQA CCCCCCCCHHHHHHH	25.97	22210691
256	Phosphorylation	SPYWDDISQAAKDLV CCCHHHHHHHHHHHH	22.29	22210691
264	Phosphorylation	QAAKDLVTRLMEVEQ HHHHHHHHHHHHHHH	25.94	22210691
376	Phosphorylation	DAARAAKSDNVAPAD HHHHHHHCCCCCCCC	29.68	24425749
425	Phosphorylation	VTPATDRSATPATDG CCCCCCCCCCCCCCC	39.03	27732954
427	Phosphorylation	PATDRSATPATDGRA CCCCCCCCCCCCCCC	18.07	27732954
430	Phosphorylation	DRSATPATDGRATPA CCCCCCCCCCCCCCC	39.94	24076635
435	Phosphorylation	PATDGRATPATEEST CCCCCCCCCCCCCCC	16.46	27732954
438	O-linked_Glycosylation	DGRATPATEESTVPT CCCCCCCCCCCCCCC	41.30	28657654
438	Phosphorylation	DGRATPATEESTVPT CCCCCCCCCCCCCCC	41.30	24076635
441	O-linked_Glycosylation	ATPATEESTVPTTQS CCCCCCCCCCCCCHH	28.59	28657654
441	Phosphorylation	ATPATEESTVPTTQS CCCCCCCCCCCCCHH	28.59	27732954
442	Phosphorylation	TPATEESTVPTTQSS CCCCCCCCCCCCHHH	33.51	27732954
445	O-linked_Glycosylation	TEESTVPTTQSSAML CCCCCCCCCHHHHHH	32.88	28657654
445	Phosphorylation	TEESTVPTTQSSAML CCCCCCCCCHHHHHH	32.88	27732954
446	Phosphorylation	EESTVPTTQSSAMLA CCCCCCCCHHHHHHH	22.00	27732954
446	O-linked_Glycosylation	EESTVPTTQSSAMLA CCCCCCCCHHHHHHH	22.00	28657654
459	Phosphorylation	LATKAAATPEPAMAQ HHHHHHCCCCCHHCC	24.37	15345747
469	Phosphorylation	PAMAQPDSTAPEGAT CHHCCCCCCCCCCCC	32.90	27732954
470	Phosphorylation	AMAQPDSTAPEGATG HHCCCCCCCCCCCCC	54.32	27732954
476	Phosphorylation	STAPEGATGQAPPSS CCCCCCCCCCCCCCC	40.46	27732954
491	Phosphorylation	KGEEAAGYAQESQRE CHHHHHHHHHHHHHH	10.61	-
495	Phosphorylation	AAGYAQESQREEAS- HHHHHHHHHHHHCC-	23.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAMKV_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAMKV_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAMKV_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBF1_HUMAN	UBTF	physical	28514442
GPC1_HUMAN	GPC1	physical	28514442
BRD2_HUMAN	BRD2	physical	28514442
AFF4_HUMAN	AFF4	physical	28514442
AFF1_HUMAN	AFF1	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
NRX3B_HUMAN	NRXN3	physical	28514442
NRX3A_HUMAN	NRXN3	physical	28514442
SAHH3_HUMAN	AHCYL2	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442
AGRIN_HUMAN	AGRN	physical	28514442
BRD3_HUMAN	BRD3	physical	28514442
GPC3_HUMAN	GPC3	physical	28514442
ENL_HUMAN	MLLT1	physical	28514442
BRD4_HUMAN	BRD4	physical	28514442
RNPS1_HUMAN	RNPS1	physical	28514442
PININ_HUMAN	PNN	physical	28514442
AP3B1_HUMAN	AP3B1	physical	28514442
NOLC1_HUMAN	NOLC1	physical	28514442
AP3M1_HUMAN	AP3M1	physical	28514442
PNISR_HUMAN	PNISR	physical	28514442
ELL_HUMAN	ELL	physical	28514442
PKN2_HUMAN	PKN2	physical	28514442
TGBR3_HUMAN	TGFBR3	physical	28514442
AP3M2_HUMAN	AP3M2	physical	28514442
GPC4_HUMAN	GPC4	physical	28514442
MINT_HUMAN	SPEN	physical	28514442
ZCH18_HUMAN	ZC3H18	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442
TCOF_HUMAN	TCOF1	physical	28514442
TNC18_HUMAN	TNRC18	physical	28514442
CHD9_HUMAN	CHD9	physical	28514442
EAF1_HUMAN	EAF1	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442
NAF1_HUMAN	NAF1	physical	28514442
GPTC8_HUMAN	GPATCH8	physical	28514442
GPC6_HUMAN	GPC6	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
CAPON_HUMAN	NOS1AP	physical	28514442
TR150_HUMAN	THRAP3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.