dbPTM

TNC18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNC18_HUMAN
UniProt AC	O15417
Protein Name	Trinucleotide repeat-containing gene 18 protein
Gene Name	TNRC18
Organism	Homo sapiens (Human).
Sequence Length	2968
Subcellular Localization
Protein Description
Protein Sequence	MDGRDFGPQRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVASGMGPSASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPSYLHLNHLEPPSSGSPLLSQLGQPSIFDTQKGQGPGGDGFYLPTAGAPGSLHSHAPSARTPGGGHSSGAPAKGSSSRDGPAKERAGRGGEPPPLFGKKDPRARGEEASGPRGVVDLTQEARAEGRQDRGPPRLAERLSPFLAESKTKNAALQPSVLTMCNGGAGDVGLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAATPAGVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQIASQARDARAREREAGRPGVLQAPPGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPEADPRPCERAPRGPAGPAAQQAAKLFGLEPGRPPPTGPEHKWKPFELGNFAATQMAVLAAQHHHSRAEEEAAVVAASSSKKAYLDPGAVLPRSAATCGRPVADMHSAAHGSGEASAMQSLIKYSGSFARDAVAVRPGGCGKKSPFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLGPGLVDQERSLSLSNVKGHGRADEDCVDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAPNGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGNASMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERATVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEHRAEMEEKGSKRGLEAAGKAGLATAGPGLLPRKPPGLAAGPAGTYGKAVSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPTSPPPASPPPTPGITRKEEAPENVVEKKDLELEKEAPSPFQALFSDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPIRLSPSKITEPLREGPEEEPLAEREVKAEVEDMDEGPTELPPLESPLPLPAAEAMATPSPAGGCGGGLLEAQALSATGQSCAEPSECPDFVEGPEPRVDSPGRTEPCTAALDLGVQLTPETLVEAKEEPVEVPVAVPVVEAVPEEGLAQVAPSESQPTLEMSDCDVPAGEGQCPSLEPQEAVPVLGSTCFLEEASSDQFLPSLEDPLAGMNALAAAAELPQARPLPSPGAAGAQALEKLEAAESLVLEQSFLHGITLLSEIAELELERRSQEMGGAERALVARPSLESLLAAGSHMLREVLDGPVVDPLKNLRLPRELKPNKKYSWMRKKEERMYAMKSSLEDMDALELDFRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHAPSALSPPRKRGKSGHSSGKLSSKSLLTSDDYELGAGIRKRHKGSEEEHDALIGMGKARGRNQTWDEHEASSDFISQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGLGLSLKSSREGKHKRAAKTRKMEVGFKARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKDEWPAQGPSSSKLTPSLLCSMVAKNSKAAGGPKLTKRGLAAPRTLKPKPATSRKQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLLGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPSLAAPTPGARGPDPSSPDKAKLAVEKGRKARKLRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAAPAPVSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDPRKKKKGKEAGPGAGLPPPRAPALPSEARAPHASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAVERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHQGQHWDQKSSRSLPAALRVSSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RDFGPQRSVHGPPPP CCCCCCCCCCCCCCC	17.14	24043423
21	Phosphorylation	GPPPPLLSGLAMDSH CCCCCCCCCCCCCCC	39.17	24043423
27	Phosphorylation	LSGLAMDSHRVGAAT CCCCCCCCCCCCCCC	10.50	24043423
41	Phosphorylation	TAGRLPASGLPGPLP CCCCCCCCCCCCCCC	38.63	-
78	Phosphorylation	VASGMGPSASSHGSP HHCCCCCCHHHCCCC	34.75	25850435
80	Phosphorylation	SGMGPSASSHGSPVP CCCCCCHHHCCCCCC	27.49	25850435
81	Phosphorylation	GMGPSASSHGSPVPL CCCCCHHHCCCCCCC	31.42	25850435
84	Phosphorylation	PSASSHGSPVPLPSD CCHHHCCCCCCCCCC	19.80	25850435
166	Phosphorylation	GPGGDGFYLPTAGAP CCCCCCCEECCCCCC	19.80	-
185	Phosphorylation	SHAPSARTPGGGHSS CCCCCCCCCCCCCCC	26.46	20068231
191	Phosphorylation	RTPGGGHSSGAPAKG CCCCCCCCCCCCCCC	33.47	20068231
192	Phosphorylation	TPGGGHSSGAPAKGS CCCCCCCCCCCCCCC	33.04	20068231
199	Phosphorylation	SGAPAKGSSSRDGPA CCCCCCCCCCCCCCH	25.16	29083192
200	Phosphorylation	GAPAKGSSSRDGPAK CCCCCCCCCCCCCHH	37.75	29083192
201	Phosphorylation	APAKGSSSRDGPAKE CCCCCCCCCCCCHHH	35.77	29083192
212	Methylation	PAKERAGRGGEPPPL CHHHCCCCCCCCCCC	49.29	115918693
263	Phosphorylation	PRLAERLSPFLAESK HHHHHHHHHHHHCCC	21.59	23401153
269	Phosphorylation	LSPFLAESKTKNAAL HHHHHHCCCCCCCCC	39.76	23403867
321	Phosphorylation	GARLLRRTETLLPGP HHHHHHHHHHCCCCC	27.21	29978859
323	Phosphorylation	RLLRRTETLLPGPRP HHHHHHHHCCCCCCC	32.74	29978859
333	Phosphorylation	PGPRPCPSPLPPPPA CCCCCCCCCCCCCCC	45.87	25849741
416	Phosphorylation	VLQAPPGSPRPLDRP CCCCCCCCCCCCCCC	24.41	30576142
453	Phosphorylation	TVRATRASPDPRAYV CHHCCCCCCCHHHCC	26.92	29414761
467	Sumoylation	VPAKELLKPEADPRP CCHHHHCCCCCCCCC	54.13	-
467	Sumoylation	VPAKELLKPEADPRP CCHHHHCCCCCCCCC	54.13	-
492	Ubiquitination	PAAQQAAKLFGLEPG HHHHHHHHHHCCCCC	47.57	-
548	Ubiquitination	VVAASSSKKAYLDPG HHHHCCCCCCCCCCC	43.29	18655026
548 (in isoform 1)	Ubiquitination	-	43.29	21906983
549	Ubiquitination	VAASSSKKAYLDPGA HHHCCCCCCCCCCCC	44.18	-
587	Phosphorylation	GEASAMQSLIKYSGS HHHHHHHHHHHHCCC	20.98	24719451
609	Acetylation	VRPGGCGKKSPFGGL ECCCCCCCCCCCCCC	54.90	25953088
611	Phosphorylation	PGGCGKKSPFGGLGT CCCCCCCCCCCCCCC	29.02	23401153
618	Phosphorylation	SPFGGLGTMKPEPAP CCCCCCCCCCCCCCC	27.37	23927012
620	Sumoylation	FGGLGTMKPEPAPTS CCCCCCCCCCCCCCC	46.17	-
620	Acetylation	FGGLGTMKPEPAPTS CCCCCCCCCCCCCCC	46.17	26051181
620	Sumoylation	FGGLGTMKPEPAPTS CCCCCCCCCCCCCCC	46.17	28112733
620	Ubiquitination	FGGLGTMKPEPAPTS CCCCCCCCCCCCCCC	46.17	-
626	Phosphorylation	MKPEPAPTSAGASRA CCCCCCCCCCCCCCH	33.06	23927012
627	Phosphorylation	KPEPAPTSAGASRAQ CCCCCCCCCCCCCHH	24.52	23927012
631	Phosphorylation	APTSAGASRAQARLP CCCCCCCCCHHHCCC	27.51	23927012
660	Phosphorylation	RDPERPESAKAFGRE CCCCCCHHHHHHCCC	37.44	25850435
662	Ubiquitination	PERPESAKAFGREGS CCCCHHHHHHCCCCC	54.23	-
712	Phosphorylation	VDQERSLSLSNVKGH CCCCCEECCCCCCCC	30.88	25159151
714	Phosphorylation	QERSLSLSNVKGHGR CCCEECCCCCCCCCC	35.88	27251275
717	Ubiquitination	SLSLSNVKGHGRADE EECCCCCCCCCCCCC	49.82	-
749	Ubiquitination	RLDRDQEKLLRESKE HCCHHHHHHHHHHHH	47.38	-
755	Ubiquitination	EKLLRESKELADLAR HHHHHHHHHHHHHHH	52.58	-
767	O-linked_Glycosylation	LARLHPTSCAPNGLN HHHHCCCCCCCCCCC	16.84	30059200
807	Methylation	ATHPWLPRSGNASMW HCCCCCCCCCCCCCH	55.84	54560247
847	Phosphorylation	GGSLPSAYQFVRDPQ CCCCCCHHHHHCCCC	13.56	23532336
929	Phosphorylation	QALELQRSAQLVQER HHHHHHHHHHHHHHH	13.86	28387310
960	Ubiquitination	RGLEAAGKAGLATAG HHHHHHHHHCCCCCC	34.26	-
974	Ubiquitination	GPGLLPRKPPGLAAG CCCCCCCCCCCCCCC	54.33	-
991	Phosphorylation	GTYGKAVSPPPSPRA CCCCCCCCCCCCCCC	36.23	29255136
995	Phosphorylation	KAVSPPPSPRASPVA CCCCCCCCCCCCHHH	32.56	29255136
999	Phosphorylation	PPPSPRASPVAALKA CCCCCCCCHHHHHHH	22.61	22167270
1016	Phosphorylation	IQKLEDVSKPPAYAY HHHHHHCCCCCCCCC	52.33	29255136
1021	Phosphorylation	DVSKPPAYAYPATPS HCCCCCCCCCCCCCC	16.67	29255136
1023	Phosphorylation	SKPPAYAYPATPSSH CCCCCCCCCCCCCCC	4.82	29255136
1026	Phosphorylation	PAYAYPATPSSHPTS CCCCCCCCCCCCCCC	21.14	29255136
1028	Phosphorylation	YAYPATPSSHPTSPP CCCCCCCCCCCCCCC	36.60	29255136
1029	Phosphorylation	AYPATPSSHPTSPPP CCCCCCCCCCCCCCC	34.39	29255136
1032	Phosphorylation	ATPSSHPTSPPPASP CCCCCCCCCCCCCCC	48.74	29255136
1033	Phosphorylation	TPSSHPTSPPPASPP CCCCCCCCCCCCCCC	39.60	23401153
1038	Phosphorylation	PTSPPPASPPPTPGI CCCCCCCCCCCCCCC	43.65	23401153
1042	Phosphorylation	PPASPPPTPGITRKE CCCCCCCCCCCCCCC	39.66	29255136
1046	Phosphorylation	PPPTPGITRKEEAPE CCCCCCCCCCCCCCC	41.42	23663014
1069	Phosphorylation	ELEKEAPSPFQALFS HHHHHCCCHHHHHHC	45.45	29255136
1127	Phosphorylation	GPERLALSPEDKPIR CCCCCCCCCCCCCCC	22.19	29255136
1136	Phosphorylation	EDKPIRLSPSKITEP CCCCCCCCHHHCCCC	19.78	29255136
1138	Phosphorylation	KPIRLSPSKITEPLR CCCCCCHHHCCCCCC	33.06	30266825
1141	Phosphorylation	RLSPSKITEPLREGP CCCHHHCCCCCCCCC	34.97	24719451
1177	Phosphorylation	TELPPLESPLPLPAA CCCCCCCCCCCCCHH	39.14	26074081
1232	Phosphorylation	GPEPRVDSPGRTEPC CCCCCCCCCCCCCCC	26.79	30266825
1236	Phosphorylation	RVDSPGRTEPCTAAL CCCCCCCCCCCCCHH	50.63	30266825
1240	Phosphorylation	PGRTEPCTAALDLGV CCCCCCCCCHHHHCC	26.19	30266825
1250	Phosphorylation	LDLGVQLTPETLVEA HHHCCCCCHHHHHCC	11.29	29507054
1253	Phosphorylation	GVQLTPETLVEAKEE CCCCCHHHHHCCCCC	36.99	27732954
1258	Sumoylation	PETLVEAKEEPVEVP HHHHHCCCCCCCCCC	49.45	-
1359	Phosphorylation	PQARPLPSPGAAGAQ CCCCCCCCCCHHHHH	43.58	23401153
1402	Phosphorylation	ELELERRSQEMGGAE HHHHHHHHHHCCHHH	36.39	20363803
1442	Ubiquitination	GPVVDPLKNLRLPRE CCCCCHHHCCCCCCC	60.36	-
1451	Acetylation	LRLPRELKPNKKYSW CCCCCCCCCCCCCCH	41.62	7431957
1454	Acetylation	PRELKPNKKYSWMRK CCCCCCCCCCCHHHH	62.71	7987625
1467	Phosphorylation	RKKEERMYAMKSSLE HHHHHHHHHHHHCHH	15.12	28348404
1471	Phosphorylation	ERMYAMKSSLEDMDA HHHHHHHHCHHHHHH	27.37	28270605
1472	Phosphorylation	RMYAMKSSLEDMDAL HHHHHHHCHHHHHHH	30.20	28270605
1503	Ubiquitination	EKQRELVKLQRRRDS HHHHHHHHHHHHCCC	52.07	-
1510	Phosphorylation	KLQRRRDSEDRREEP HHHHHCCCHHHHHCH	39.32	28258704
1520	Phosphorylation	RREEPHRSLARRGPG HHHCHHHHHHHHCCC	24.28	20873877
1533	Phosphorylation	PGRPRKRTHAPSALS CCCCCCCCCCCCCCC	25.98	23927012
1537	Phosphorylation	RKRTHAPSALSPPRK CCCCCCCCCCCCCCC	42.50	30266825
1540	Phosphorylation	THAPSALSPPRKRGK CCCCCCCCCCCCCCC	32.35	30266825
1559	Phosphorylation	SGKLSSKSLLTSDDY CCCCCCCCCCCCCCH	30.47	27251275
1562	Phosphorylation	LSSKSLLTSDDYELG CCCCCCCCCCCHHCC	35.09	28348404
1563	Phosphorylation	SSKSLLTSDDYELGA CCCCCCCCCCHHCCC	28.58	28348404
1579	Phosphorylation	IRKRHKGSEEEHDAL HCCCCCCCHHHHHHH	46.79	25159151
1591	Acetylation	DALIGMGKARGRNQT HHHHCCCCCCCCCCC	26.47	25953088
1591	Ubiquitination	DALIGMGKARGRNQT HHHHCCCCCCCCCCC	26.47	-
1605	Phosphorylation	TWDEHEASSDFISQL CCCCCHHCHHHHHHH	27.70	25849741
1610	Phosphorylation	EASSDFISQLKIKKK HHCHHHHHHHHHCHH	29.47	24719451
1613	Ubiquitination	SDFISQLKIKKKKMA HHHHHHHHHCHHHCC	44.86	-
1621	Phosphorylation	IKKKKMASDQEQLAS HCHHHCCCCHHHHHH	36.01	-
1628	Phosphorylation	SDQEQLASKLDKALS CCHHHHHHHHHHHHH	42.20	22210691
1635	Phosphorylation	SKLDKALSLTKQDKL HHHHHHHHCCCHHHC	38.56	24719451
1644	Phosphorylation	TKQDKLKSPFKFSDS CCHHHCCCCCCCCCC	46.11	25599653
1649	Phosphorylation	LKSPFKFSDSAGGKS CCCCCCCCCCCCCCC	31.11	23312004
1651	Phosphorylation	SPFKFSDSAGGKSKT CCCCCCCCCCCCCCC	27.84	23312004
1665	Phosphorylation	TSGGCGRYLTPYDSL CCCCCCCCCCHHHHH	10.54	24961811
1667	Phosphorylation	GGCGRYLTPYDSLLG CCCCCCCCHHHHHCC	15.74	24961811
1671	Phosphorylation	RYLTPYDSLLGKNRK CCCCHHHHHCCCCHH	21.46	24961811
1687	Phosphorylation	LAKGLGLSLKSSREG HHHHHCCCHHHCCCC	31.77	27251275
1717	Phosphorylation	KARGQPKSAHSPFAS CCCCCCCCCCCCCHH	37.59	-
1730	Phosphorylation	ASEVSSYSYNTDSEE HHHHHCCCCCCCCHH	17.54	24275748
1733	Phosphorylation	VSSYSYNTDSEEDEE HHCCCCCCCCHHHHH	32.44	22617229
1735	Phosphorylation	SYSYNTDSEEDEEFL CCCCCCCCHHHHHHH	40.63	22617229
1757	Phosphorylation	GPSSSKLTPSLLCSM CCCCCCCCHHHHHHH	17.99	25627689
1759	Phosphorylation	SSSKLTPSLLCSMVA CCCCCCHHHHHHHHH	28.83	28555341
1763	Phosphorylation	LTPSLLCSMVAKNSK CCHHHHHHHHHHCCC	19.09	-
1769	Phosphorylation	CSMVAKNSKAAGGPK HHHHHHCCCCCCCCC	23.98	15570572
1779	Methylation	AGGPKLTKRGLAAPR CCCCCCCHHCCCCCC	55.71	116251853
1794	Phosphorylation	TLKPKPATSRKQPFC CCCCCCCCCCCCCEE	37.28	-
1857	Phosphorylation	GARERALSPGLEESG CHHHCCCCCCCCHHH	18.88	29255136
1863	Phosphorylation	LSPGLEESGLGLLAR CCCCCCHHHHHHHHH	29.91	23927012
1874	Phosphorylation	LLARFAASALPSPTV HHHHHHHHCCCCCCC	27.23	24732914
1878	Phosphorylation	FAASALPSPTVGPSL HHHHCCCCCCCCCCC	33.77	24732914
1880	Phosphorylation	ASALPSPTVGPSLSV HHCCCCCCCCCCCEE	42.29	24732914
1884	Phosphorylation	PSPTVGPSLSVVQLE CCCCCCCCCEEEHHH	27.61	24732914
1886	Phosphorylation	PTVGPSLSVVQLEAK CCCCCCCEEEHHHHH	25.28	24732914
1893	Acetylation	SVVQLEAKQKARKKE EEEHHHHHHHHHHHH	42.85	25953088
1904	Phosphorylation	RKKEERQSLLGTEFE HHHHHHHHHHCCEEE	31.61	22115753
1908	Phosphorylation	ERQSLLGTEFEYTDS HHHHHHCCEEEECCC	37.15	23090842
1912	Phosphorylation	LLGTEFEYTDSESEV HHCCEEEECCCCCCE	22.59	22199227
1913	Phosphorylation	LGTEFEYTDSESEVK HCCEEEECCCCCCEE	26.33	25159151
1915	Phosphorylation	TEFEYTDSESEVKVR CEEEECCCCCCEEEE	34.91	25159151
1917	Phosphorylation	FEYTDSESEVKVRKR EEECCCCCCEEEEEC	52.20	22199227
1925	Phosphorylation	EVKVRKRSPAGLLRP CEEEEECCCCCCCCC	23.33	23898821
1947	Phosphorylation	GPSLAAPTPGARGPD CCCCCCCCCCCCCCC	29.63	23090842
1956	Phosphorylation	GARGPDPSSPDKAKL CCCCCCCCCHHHHHH	62.98	29255136
1957	Phosphorylation	ARGPDPSSPDKAKLA CCCCCCCCHHHHHHH	42.37	29255136
1989	Phosphorylation	FEAGPEASDDDLWTR CCCCCCCCCCCHHHH	39.65	30266825
1995	Phosphorylation	ASDDDLWTRRRSERI CCCCCHHHHHHHCCE	22.92	30266825
1999	Phosphorylation	DLWTRRRSERIFLHD CHHHHHHHCCEEEEC	29.43	27273156
2016	Phosphorylation	AAAPAPVSTAPATKT HCCCCCCCCCCCCCC	20.14	26074081
2017	Phosphorylation	AAPAPVSTAPATKTS CCCCCCCCCCCCCCC	36.57	26074081
2021	Phosphorylation	PVSTAPATKTSRCAK CCCCCCCCCCCCCCC	33.52	26074081
2023	Phosphorylation	STAPATKTSRCAKGG CCCCCCCCCCCCCCC	19.63	26074081
2024	Phosphorylation	TAPATKTSRCAKGGP CCCCCCCCCCCCCCC	27.24	26074081
2033	Phosphorylation	CAKGGPLSPRKDAGR CCCCCCCCCCCCCCC	26.28	23401153
2086	Acetylation	ASSLTAAKRSKAKAK HHHHHHHHHHHHHHC	55.53	25953088
2127	Phosphorylation	DFEPNQDSSFSEDEH CCCCCCCCCCCCCCC	24.42	28348404
2128	Phosphorylation	FEPNQDSSFSEDEHL CCCCCCCCCCCCCCC	40.87	28348404
2130	Phosphorylation	PNQDSSFSEDEHLPR CCCCCCCCCCCCCCC	46.19	25159151
2139 (in isoform 2)	Phosphorylation	-	27.94	26270265
2146	Phosphorylation	GAVERPLTPAPRSCI CCCCCCCCCCCCCCE	21.78	29255136
2175	Phosphorylation	PMDDKLLYAGHVQTV ECCCCEEEEEECEEE	22.45	23312004
2181	Phosphorylation	LYAGHVQTVHSPDIY EEEEECEEECCCCEE	21.06	28348404
2184	Phosphorylation	GHVQTVHSPDIYRVV EECEEECCCCEEEEE	21.67	28555341
2188	Phosphorylation	TVHSPDIYRVVVEGE EECCCCEEEEEEECC	12.53	28122231
2231 (in isoform 2)	Phosphorylation	-	7.39	20068231
2235 (in isoform 2)	Phosphorylation	-	8.50	20068231
2238 (in isoform 2)	Phosphorylation	-	8.82	20068231
2243 (in isoform 2)	Phosphorylation	-	21.02	20068231
2244 (in isoform 2)	Phosphorylation	-	20.00	20068231
2246 (in isoform 2)	Phosphorylation	-	3.24	20068231
2248 (in isoform 2)	Phosphorylation	-	26.21	20068231
2250 (in isoform 2)	Phosphorylation	-	2.05	20068231
2278	Methylation	RIPLSHIRLLPPDYK EEEHHHEEECCCCCC	25.42	115918697
2292	Phosphorylation	KIQCAEPSPALLVPS CCEECCCCCCEECCC	17.82	25159151
2299	Phosphorylation	SPALLVPSAKRRSRK CCCEECCCHHHCCCC	38.65	25159151
2301	Acetylation	ALLVPSAKRRSRKTS CEECCCHHHCCCCCC	53.32	20167786
2307	Phosphorylation	AKRRSRKTSKDTGEG HHHCCCCCCCCCCCC	39.64	-
2308	Phosphorylation	KRRSRKTSKDTGEGK HHCCCCCCCCCCCCC	31.41	24719451
2319	Phosphorylation	GEGKDGGTAGSEEPG CCCCCCCCCCCCCCC	33.12	-
2322	Phosphorylation	KDGGTAGSEEPGAKA CCCCCCCCCCCCCCC	36.00	-
2328	Ubiquitination	GSEEPGAKARGRGRK CCCCCCCCCCCCCCC	44.52	18655026
2337	Phosphorylation	RGRGRKPSAKAKGDR CCCCCCCCHHHCCCH	45.49	-
2354	Phosphorylation	TLEEGNPTDEVPSTP CCCCCCCCCCCCCCC	49.11	24275569
2359	Phosphorylation	NPTDEVPSTPLALEP CCCCCCCCCCCCCCC	48.08	26074081
2360	Phosphorylation	PTDEVPSTPLALEPS CCCCCCCCCCCCCCC	19.09	26074081
2367	Phosphorylation	TPLALEPSSTPGSKK CCCCCCCCCCCCCCC	37.15	25159151
2368	Phosphorylation	PLALEPSSTPGSKKS CCCCCCCCCCCCCCC	49.70	25159151
2369	Phosphorylation	LALEPSSTPGSKKSP CCCCCCCCCCCCCCC	35.69	25159151
2372	Phosphorylation	EPSSTPGSKKSPPEP CCCCCCCCCCCCCCC	37.81	25159151
2375	Phosphorylation	STPGSKKSPPEPVDK CCCCCCCCCCCCCCH	49.80	25849741
2446	Phosphorylation	KARAAEESGAKGPRR HHHHHHHHCCCCCCC	35.24	-
2470	Phosphorylation	KLDHEGVTSPKSKKA ECCCCCCCCCCCHHH	50.60	30266825
2471	Phosphorylation	LDHEGVTSPKSKKAK CCCCCCCCCCCHHHH	28.11	23401153
2500	Phosphorylation	QEPKSLLSLGSYPPA CCCCHHHCCCCCCCC	35.66	-
2503	Phosphorylation	KSLLSLGSYPPAAGS CHHHCCCCCCCCCCC	39.50	-
2504	Phosphorylation	SLLSLGSYPPAAGSS HHHCCCCCCCCCCCC	16.07	-
2511	Phosphorylation	YPPAAGSSEPKAPWP CCCCCCCCCCCCCCC	57.93	-
2521	Phosphorylation	KAPWPKATDGDLAQE CCCCCCCCCCCCCCC	46.79	23403867
2534	Phosphorylation	QEPGPGLTFEDSGNP CCCCCCCCCCCCCCC	30.78	23663014
2538	Phosphorylation	PGLTFEDSGNPKSPD CCCCCCCCCCCCCCC	33.02	21955146
2543	Phosphorylation	EDSGNPKSPDKAQAE CCCCCCCCCCHHHHH	39.32	23401153
2559	Phosphorylation	DGAEESESSSSSSSG CCCCCCCCCCCCCCC	44.81	-
2560	Phosphorylation	GAEESESSSSSSSGS CCCCCCCCCCCCCCC	30.13	-
2561	Phosphorylation	AEESESSSSSSSGSS CCCCCCCCCCCCCCC	43.44	-
2569	Phosphorylation	SSSSGSSSSSSSSSS CCCCCCCCCCCCCCC	35.62	-
2570	Phosphorylation	SSSGSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2571	Phosphorylation	SSGSSSSSSSSSSSG CCCCCCCCCCCCCCC	35.87	-
2572	Phosphorylation	SGSSSSSSSSSSSGS CCCCCCCCCCCCCCC	35.87	-
2573	Phosphorylation	GSSSSSSSSSSSGSE CCCCCCCCCCCCCCC	35.87	-
2616	Phosphorylation	AASPASSSSSSSSSS CCCCCCCCCCCCCCC	31.57	-
2617	Phosphorylation	ASPASSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2618	Phosphorylation	SPASSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2619	Phosphorylation	PASSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2620	Phosphorylation	ASSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2621	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2622	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2623	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2624	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2625	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2626	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2627	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2628	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2629	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2630	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2631	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2632	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2633	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2634	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2635	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2636	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2637	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2638	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2639	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2640	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2641	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2642	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2643	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2644	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2645	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2646	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2647	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2648	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2649	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2650	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2651	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2652	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2653	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2654	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2655	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2656	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2657	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2658	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2659	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2660	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2661	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
2662	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2663	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2664	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2665	Phosphorylation	SSSSSSSSSSSSSST CCCCCCCCCCCCCCC	35.87	-
2666	Phosphorylation	SSSSSSSSSSSSSTT CCCCCCCCCCCCCCC	35.87	-
2667	Phosphorylation	SSSSSSSSSSSSTTD CCCCCCCCCCCCCCC	35.87	-
2671	Phosphorylation	SSSSSSSSTTDEDSS CCCCCCCCCCCCCCC	36.96	-
2672	Phosphorylation	SSSSSSSTTDEDSSC CCCCCCCCCCCCCCC	39.97	-
2713	Phosphorylation	QAGKARPSAHSPGKK HCCCCCCCCCCCCCC	32.82	27174698
2716	Phosphorylation	KARPSAHSPGKKTPA CCCCCCCCCCCCCCC	34.76	25849741
2721	Phosphorylation	AHSPGKKTPAPQPQA CCCCCCCCCCCCCCC	28.33	25159151
2771	Phosphorylation	AKRQRLPSVENRPKI HHHCCCCCCCCCHHH	46.81	23401153
2809	Phosphorylation	GKARKLFYKAIVRGK HHHHHHHHHHHHCCC	15.22	24505115
2860	Phosphorylation	VVRVKWFYHPEETSP EEEEEEEECCCCCCC	18.49	23312004
2865	Phosphorylation	WFYHPEETSPGKQFH EEECCCCCCCCCCCC	38.26	28348404
2866	Phosphorylation	FYHPEETSPGKQFHQ EECCCCCCCCCCCCC	34.63	25159151
2869	Ubiquitination	PEETSPGKQFHQGQH CCCCCCCCCCCCCCC	53.85	-
2884	Phosphorylation	WDQKSSRSLPAALRV CCHHCCCCCCHHHHH	40.42	20068231
2892	Phosphorylation	LPAALRVSSQRKDFM CCHHHHHHHHCHHHH	17.83	20068231
2893	Phosphorylation	PAALRVSSQRKDFME CHHHHHHHHCHHHHH	31.02	20068231
2896	Methylation	LRVSSQRKDFMERAL HHHHHHCHHHHHHHH	47.91	23644510
2904	Phosphorylation	DFMERALYQSSHVDE HHHHHHHHHCCCCCH	12.83	-
2929	Phosphorylation	LVVGLEQYEQMLKTK EEECHHHHHHHHHHC	9.96	-
2938	Phosphorylation	QMLKTKKYQDSEGLY HHHHHCCCCCCCCCE	21.07	30576142
2945	Phosphorylation	YQDSEGLYYLAGTYE CCCCCCCEEEEEEEE	13.80	30576142
2951	Phosphorylation	LYYLAGTYEPTTGMI CEEEEEEEECCCCEE	20.99	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TNC18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNC18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNC18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TNC18_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNC18_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-991; SER-995AND SER-999, AND MASS SPECTROMETRY.	18669648 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2328, AND MASSSPECTROMETRY.	17370265 [Abstract]