TGBR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGBR3_HUMAN
• UniProt AC: Q03167
• Protein Name: Transforming growth factor beta receptor type 3
• Gene Name: TGFBR3
• Organism: Homo sapiens (Human).
• Sequence Length: 851
• Subcellular Localization: Secreted. Secreted, extracellular space. Cell membrane ; Single-pass type I membrane protein . Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
• Protein Description: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors..
• Protein Sequence: MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	GQLQREVTLHLNPIS CCEEEEEEEEECCCC	12.05	22496350
92	Phosphorylation	LHLNPISSVHIHHKS EEECCCCEEEEEECE	20.59	22496350
141	N-linked_Glycosylation	VVQFSSANFSLTAET EEEEECCCEEEEEEE	29.05	UniProtKB CARBOHYD
168	Phosphorylation	LNWARKEYGAVTSFT HHHHHHHHCCCCCCC	17.27	26074081
172	Phosphorylation	RKEYGAVTSFTELKI HHHHCCCCCCCEEEE	20.00	26074081
173	Phosphorylation	KEYGAVTSFTELKIA HHHCCCCCCCEEEEE	24.46	26074081
175	Phosphorylation	YGAVTSFTELKIARN HCCCCCCCEEEEEEE	39.93	26074081
184	Phosphorylation	LKIARNIYIKVGEDQ EEEEEEEEEEECCCC	9.76	26074081
315	Phosphorylation	RSMTMTKSIRDDIPS HCEECCHHHHCCCCC	17.43	22912867
322	Phosphorylation	SIRDDIPSTQGNLVK HHHCCCCCCCCCHHH	33.43	22912867
369	O-linked_Glycosylation	MGDEEVHTIPPELRI HCCCCCCCCCHHHEE	40.11	55834739
473	Phosphorylation	EKDSFQASGYSGMDV EECCEECCCCCCCCE	27.72	30576142
476	Phosphorylation	SFQASGYSGMDVTLL CEECCCCCCCCEEEE	31.03	30576142
486	Phosphorylation	DVTLLDPTCKAKMNG CEEEECCCCCCEECC	26.72	30576142
492	N-linked_Glycosylation	PTCKAKMNGTHFVLE CCCCCEECCCEEEEE	52.05	UniProtKB CARBOHYD
534	O-linked_Glycosylation	VPALGDSSGWPDGYE ECCCCCCCCCCCCCC	50.01	-
545	O-linked_Glycosylation	DGYEDLESGDNGFPG CCCCCCCCCCCCCCC	59.76	-
571	N-linked_Glycosylation	RPEIVVFNCSLQQVR CCEEEEEECCCCCCC	11.67	UniProtKB CARBOHYD
590	N-linked_Glycosylation	FQEQPHGNITFNMEL CCCCCCCCEEEEEEE	27.39	UniProtKB CARBOHYD
651	Phosphorylation	YSNPDRMSHYTIIEN CCCCCCCCCEEEEEC	17.78	23532336
653	Phosphorylation	NPDRMSHYTIIENIC CCCCCCCEEEEECCC	7.73	23532336
667	Ubiquitination	CPKDESVKFYSPKRV CCCCCCCCEECCCEE	48.11	-
697	N-linked_Glycosylation	FVFKPVFNTSLLFLQ EEEECCCCHHHHHHH	29.06	UniProtKB CARBOHYD
761	O-linked_Glycosylation	VIHHEAESKEKGPSM EEEEHHHHHCCCCCC	53.84	OGP
831	Phosphorylation	SPPASENSSAAHSIG CCCCCCCCCCCCCCC	19.80	22427868
843	Phosphorylation	SIGSTQSTPCSSSST CCCCCCCCCCCCCCC	20.63	12958365

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
831	S	Phosphorylation	Kinase	TGFBR1	P36897	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGBR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGBR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGFB1_HUMAN	TGFB1	physical	8106553

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.