TCOF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCOF_HUMAN
• UniProt AC: Q13428
• Protein Name: Treacle protein
• Gene Name: TCOF1
• Organism: Homo sapiens (Human).
• Sequence Length: 1488
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. [PubMed: 12777385]
• Protein Sequence: MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RELLPLIYHHLLRAG HHHHHHHHHHHHHHH	7.29	28152594
64	Acetylation	SELGRKRKAEEDAAL HHHHHHHHHHHHHHH	64.28	26051181
74	2-Hydroxyisobutyrylation	EDAALQAKKTRVSDP HHHHHHHHHHCCCCC	41.54	-
74	Acetylation	EDAALQAKKTRVSDP HHHHHHHHHHCCCCC	41.54	25953088
76	Phosphorylation	AALQAKKTRVSDPIS HHHHHHHHCCCCCCC	35.28	21406692
79	Phosphorylation	QAKKTRVSDPISTSE HHHHHCCCCCCCCCC	34.09	23663014
83	Phosphorylation	TRVSDPISTSESSEE HCCCCCCCCCCCCHH	31.13	21082442
84	Phosphorylation	RVSDPISTSESSEEE CCCCCCCCCCCCHHH	36.91	21082442
85	Phosphorylation	VSDPISTSESSEEEE CCCCCCCCCCCHHHH	28.79	21082442
87	Phosphorylation	DPISTSESSEEEEEA CCCCCCCCCHHHHHH	42.70	25159151
88	Phosphorylation	PISTSESSEEEEEAE CCCCCCCCHHHHHHH	45.00	25159151
102	Phosphorylation	EAETAKATPRLASTN HHHHHHCCCCHHCCC	14.29	27174698
107	Phosphorylation	KATPRLASTNSSVLG HCCCCHHCCCCCCCC	32.48	27273156
108	Phosphorylation	ATPRLASTNSSVLGA CCCCHHCCCCCCCCC	33.25	25159151
110	Phosphorylation	PRLASTNSSVLGADL CCHHCCCCCCCCCCC	23.16	25159151
111	Phosphorylation	RLASTNSSVLGADLP CHHCCCCCCCCCCCC	24.35	25159151
119	Phosphorylation	VLGADLPSSMKEKAK CCCCCCCHHHHHHHH	50.81	25159151
120	Phosphorylation	LGADLPSSMKEKAKA CCCCCCHHHHHHHHH	31.75	25159151
121	Sulfoxidation	GADLPSSMKEKAKAE CCCCCHHHHHHHHHH	8.35	21406390
122	Acetylation	ADLPSSMKEKAKAET CCCCHHHHHHHHHHH	58.99	26051181
122	Ubiquitination	ADLPSSMKEKAKAET CCCCHHHHHHHHHHH	58.99	-
124	Acetylation	LPSSMKEKAKAETEK CCHHHHHHHHHHHHH	50.06	19814631
124	Methylation	LPSSMKEKAKAETEK CCHHHHHHHHHHHHH	50.06	19814631
126	Acetylation	SSMKEKAKAETEKAG HHHHHHHHHHHHHCC	58.80	19814643
126	Sumoylation	SSMKEKAKAETEKAG HHHHHHHHHHHHHCC	58.80	25772364
134	Acetylation	AETEKAGKTGNSMPH HHHHHCCCCCCCCCC	59.11	-
138	Phosphorylation	KAGKTGNSMPHPATG HCCCCCCCCCCCCCC	34.73	19060867
144	Phosphorylation	NSMPHPATGKTVANL CCCCCCCCCHHHHHH	43.60	22817900
146	Acetylation	MPHPATGKTVANLLS CCCCCCCHHHHHHHC	35.16	23954790
147	O-linked_Glycosylation	PHPATGKTVANLLSG CCCCCCHHHHHHHCC	26.62	23301498
147	Phosphorylation	PHPATGKTVANLLSG CCCCCCHHHHHHHCC	26.62	23927012
153	Phosphorylation	KTVANLLSGKSPRKS HHHHHHHCCCCCCCC	47.55	22167270
155	Acetylation	VANLLSGKSPRKSAE HHHHHCCCCCCCCCC	54.64	19608861
156	Phosphorylation	ANLLSGKSPRKSAEP HHHHCCCCCCCCCCC	33.20	22167270
160	Phosphorylation	SGKSPRKSAEPSANT CCCCCCCCCCCCCCC	38.86	30266825
164	Phosphorylation	PRKSAEPSANTTLVS CCCCCCCCCCCEEEE	26.17	30266825
167	Phosphorylation	SAEPSANTTLVSETE CCCCCCCCEEEECCC	22.63	26503892
168	Phosphorylation	AEPSANTTLVSETEE CCCCCCCEEEECCCC	25.60	30266825
171	Phosphorylation	SANTTLVSETEEEGS CCCCEEEECCCCCCC	41.74	22167270
173	Phosphorylation	NTTLVSETEEEGSVP CCEEEECCCCCCCCC	40.99	22167270
178	Phosphorylation	SETEEEGSVPAFGAA ECCCCCCCCCCCCCC	28.36	30266825
192	Phosphorylation	AAKPGMVSAGQADSS CCCCCCEECCCCCCC	20.14	17081983
198	Phosphorylation	VSAGQADSSSEDTSS EECCCCCCCCCCCCC	38.49	25137130
199	Phosphorylation	SAGQADSSSEDTSSS ECCCCCCCCCCCCCC	37.99	17081983
200	Phosphorylation	AGQADSSSEDTSSSS CCCCCCCCCCCCCCC	43.36	25137130
203	Phosphorylation	ADSSSEDTSSSSDET CCCCCCCCCCCCCCC	26.85	30576142
204	Phosphorylation	DSSSEDTSSSSDETD CCCCCCCCCCCCCCC	40.31	25137130
205	Phosphorylation	SSSEDTSSSSDETDV CCCCCCCCCCCCCCC	35.63	25137130
206	Phosphorylation	SSEDTSSSSDETDVE CCCCCCCCCCCCCCC	41.39	30576142
207	Phosphorylation	SEDTSSSSDETDVEG CCCCCCCCCCCCCCC	41.22	25137130
210	Phosphorylation	TSSSSDETDVEGKPS CCCCCCCCCCCCCCC	50.78	30576142
219	Acetylation	VEGKPSVKPAQVKAS CCCCCCCCHHHCCCC	38.69	19608861
226	Phosphorylation	KPAQVKASSVSTKES CHHHCCCCCCCCCCC	26.09	23403867
227	Phosphorylation	PAQVKASSVSTKESP HHHCCCCCCCCCCCC	25.58	23927012
229	Phosphorylation	QVKASSVSTKESPAR HCCCCCCCCCCCCCH	35.39	23401153
230	Phosphorylation	VKASSVSTKESPARK CCCCCCCCCCCCCHH	36.35	30266825
231	Acetylation	KASSVSTKESPARKA CCCCCCCCCCCCHHC	49.00	26051181
233	Phosphorylation	SSVSTKESPARKAAP CCCCCCCCCCHHCCC	25.97	22167270
244	Acetylation	KAAPAPGKVGDVTPQ HCCCCCCCCCCCCCC	41.82	25953088
249	Phosphorylation	PGKVGDVTPQVKGGA CCCCCCCCCCCCCCC	16.85	19664994
253	Acetylation	GDVTPQVKGGALPPA CCCCCCCCCCCCCHH	46.51	25953088
261	Acetylation	GGALPPAKRAKKPEE CCCCCHHHCCCCHHH	59.67	25953088
270	Phosphorylation	AKKPEEESESSEEGS CCCHHHHCCCCCCCC	46.16	23927012
272	Phosphorylation	KPEEESESSEEGSES CHHHHCCCCCCCCCC	52.94	23927012
273	Phosphorylation	PEEESESSEEGSESE HHHHCCCCCCCCCCH	35.30	23927012
277	Phosphorylation	SESSEEGSESEEEAP CCCCCCCCCCHHHCC	41.03	23927012
279	Phosphorylation	SSEEGSESEEEAPAG CCCCCCCCHHHCCCC	52.59	28355574
287	Phosphorylation	EEEAPAGTRSQVKAS HHHCCCCCHHHHHHH	29.29	26552605
289	Phosphorylation	EAPAGTRSQVKASEK HCCCCCHHHHHHHHH	38.88	21406692
296	Acetylation	SQVKASEKILQVRAA HHHHHHHHHHHHHHC	46.34	19608861
304	Phosphorylation	ILQVRAASAPAKGTP HHHHHHCCCCCCCCC	33.53	23927012
308	Acetylation	RAASAPAKGTPGKGA HHCCCCCCCCCCCCC	63.36	25953088
310	Phosphorylation	ASAPAKGTPGKGATP CCCCCCCCCCCCCCC	28.32	23927012
313	Acetylation	PAKGTPGKGATPAPP CCCCCCCCCCCCCCC	46.72	26051181
316	Phosphorylation	GTPGKGATPAPPGKA CCCCCCCCCCCCCCH	28.75	25159151
322	Acetylation	ATPAPPGKAGAVASQ CCCCCCCCHHCCCCC	49.79	25953088
328	Phosphorylation	GKAGAVASQTKAGKP CCHHCCCCCCCCCCC	31.61	25849741
330	Phosphorylation	AGAVASQTKAGKPEE HHCCCCCCCCCCCCC	21.99	28985074
339	Phosphorylation	AGKPEEDSESSSEES CCCCCCCCCCCCCCC	42.53	23927012
341	Phosphorylation	KPEEDSESSSEESSD CCCCCCCCCCCCCCC	43.02	23927012
342	Phosphorylation	PEEDSESSSEESSDS CCCCCCCCCCCCCCC	37.40	20873877
343	Phosphorylation	EEDSESSSEESSDSE CCCCCCCCCCCCCCH	55.45	20873877
346	Phosphorylation	SESSSEESSDSEEET CCCCCCCCCCCHHCC	35.08	30108239
347	Phosphorylation	ESSSEESSDSEEETP CCCCCCCCCCHHCCH	48.73	23927012
349	Phosphorylation	SSEESSDSEEETPAA CCCCCCCCHHCCHHH	49.18	23401153
353	Phosphorylation	SSDSEEETPAAKALL CCCCHHCCHHHHHHH	22.85	30108239
363	Acetylation	AKALLQAKASGKTSQ HHHHHHHHHCCCCCC	30.08	25953088
365	Phosphorylation	ALLQAKASGKTSQVG HHHHHHHCCCCCCCC	39.87	23927012
368	Phosphorylation	QAKASGKTSQVGAAS HHHHCCCCCCCCCCC	28.10	23927012
369	Phosphorylation	AKASGKTSQVGAASA HHHCCCCCCCCCCCC	26.76	25159151
375	Phosphorylation	TSQVGAASAPAKESP CCCCCCCCCCCCCCC	33.96	23927012
379	Acetylation	GAASAPAKESPRKGA CCCCCCCCCCCCCCC	58.63	26051181
381	Phosphorylation	ASAPAKESPRKGAAP CCCCCCCCCCCCCCC	29.33	29255136
384	Methylation	PAKESPRKGAAPAPP CCCCCCCCCCCCCCC	57.18	-
393	Acetylation	AAPAPPGKTGPAVAK CCCCCCCCCCHHHHH	56.96	25953088
394	Phosphorylation	APAPPGKTGPAVAKA CCCCCCCCCHHHHHH	55.07	22817900
400	Acetylation	KTGPAVAKAQAGKRE CCCHHHHHHHCCCCC	34.14	25953088
410	Phosphorylation	AGKREEDSQSSSEES CCCCCCCCCCCCCCC	34.93	23927012
412	Phosphorylation	KREEDSQSSSEESDS CCCCCCCCCCCCCCC	39.52	23927012
413	Phosphorylation	REEDSQSSSEESDSE CCCCCCCCCCCCCCH	33.85	23927012
414	Phosphorylation	EEDSQSSSEESDSEE CCCCCCCCCCCCCHH	51.10	23927012
417	Phosphorylation	SQSSSEESDSEEEAP CCCCCCCCCCHHCCC	42.24	23927012
419	Phosphorylation	SSSEESDSEEEAPAQ CCCCCCCCHHCCCCC	57.07	28355574
430	Phosphorylation	APAQAKPSGKAPQVR CCCCCCCCCCCCCCC	52.82	23927012
432	Acetylation	AQAKPSGKAPQVRAA CCCCCCCCCCCCCCC	62.32	25953088
440	Phosphorylation	APQVRAASAPAKESP CCCCCCCCCCCCCCC	33.53	23927012
444	Acetylation	RAASAPAKESPRKGA CCCCCCCCCCCCCCC	58.63	26051181
446	Phosphorylation	ASAPAKESPRKGAAP CCCCCCCCCCCCCCC	29.33	29255136
449	Methylation	PAKESPRKGAAPAPP CCCCCCCCCCCCCCC	57.18	116252639
459	Phosphorylation	APAPPRKTGPAAAQV CCCCCCCCCCCCCEE	50.07	28555341
475	Phosphorylation	VGKQEEDSRSSSEES CCCCCCCCCCCCCCC	37.02	23927012
477	Phosphorylation	KQEEDSRSSSEESDS CCCCCCCCCCCCCHH	42.01	23927012
478	Phosphorylation	QEEDSRSSSEESDSD CCCCCCCCCCCCHHH	40.43	23927012
479	Phosphorylation	EEDSRSSSEESDSDR CCCCCCCCCCCHHHH	46.78	23927012
482	Phosphorylation	SRSSSEESDSDREAL CCCCCCCCHHHHHHH	38.06	23401153
484	Phosphorylation	SSSEESDSDREALAA CCCCCCHHHHHHHHH	48.09	23927012
503	Phosphorylation	QVKPLGKSPQVKPAS HCCCCCCCCCCCCCC	20.83	22167270
507	Acetylation	LGKSPQVKPASTMGM CCCCCCCCCCCCCCC	29.62	25953088
507	Sumoylation	LGKSPQVKPASTMGM CCCCCCCCCCCCCCC	29.62	28112733
510	O-linked_Glycosylation	SPQVKPASTMGMGPL CCCCCCCCCCCCCCC	27.70	23301498
510	Phosphorylation	SPQVKPASTMGMGPL CCCCCCCCCCCCCCC	27.70	22167270
511	Phosphorylation	PQVKPASTMGMGPLG CCCCCCCCCCCCCCC	21.61	22167270
519	Acetylation	MGMGPLGKGAGPVPP CCCCCCCCCCCCCCC	53.95	26051181
523	Acetylation	PLGKGAGPVPPGKVG CCCCCCCCCCCCCCC	34.60	19608861
528	Acetylation	AGPVPPGKVGPATPS CCCCCCCCCCCCCCC	50.20	25953088
533	O-linked_Glycosylation	PGKVGPATPSAQVGK CCCCCCCCCCCCCCC	22.40	23301498
533	Phosphorylation	PGKVGPATPSAQVGK CCCCCCCCCCCCCCC	22.40	19664994
535	Phosphorylation	KVGPATPSAQVGKWE CCCCCCCCCCCCCCC	27.29	30266825
545	Phosphorylation	VGKWEEDSESSSEES CCCCCCCCCCCCCCC	42.53	25137130
547	Phosphorylation	KWEEDSESSSEESSD CCCCCCCCCCCCCCC	43.02	25137130
548	Phosphorylation	WEEDSESSSEESSDS CCCCCCCCCCCCCCC	37.40	25137130
549	Phosphorylation	EEDSESSSEESSDSS CCCCCCCCCCCCCCC	55.45	25137130
552	Phosphorylation	SESSSEESSDSSDGE CCCCCCCCCCCCCCC	35.08	25137130
553	Phosphorylation	ESSSEESSDSSDGEV CCCCCCCCCCCCCCC	44.80	25137130
555	Phosphorylation	SSEESSDSSDGEVPT CCCCCCCCCCCCCCC	32.07	25137130
556	Phosphorylation	SEESSDSSDGEVPTA CCCCCCCCCCCCCCC	55.41	25137130
562	Phosphorylation	SSDGEVPTAVAPAQE CCCCCCCCCCCCCCH	38.65	28787133
571	Phosphorylation	VAPAQEKSLGNILQA CCCCCHHCHHHHHHC	40.53	25159151
579	Acetylation	LGNILQAKPTSSPAK HHHHHHCCCCCCCCC	35.55	25953088
579	Malonylation	LGNILQAKPTSSPAK HHHHHHCCCCCCCCC	35.55	26320211
581	Phosphorylation	NILQAKPTSSPAKGP HHHHCCCCCCCCCCC	40.92	29255136
582	Phosphorylation	ILQAKPTSSPAKGPP HHHCCCCCCCCCCCC	42.74	29255136
583	Phosphorylation	LQAKPTSSPAKGPPQ HHCCCCCCCCCCCCC	31.21	29255136
586	Acetylation	KPTSSPAKGPPQKAG CCCCCCCCCCCCCCC	75.28	25953088
591	Ubiquitination	PAKGPPQKAGPVAVQ CCCCCCCCCCCEEEE	62.17	-
600	Sumoylation	GPVAVQVKAEKPMDN CCEEEEEEEECCCCC	33.46	-
600	Acetylation	GPVAVQVKAEKPMDN CCEEEEEEEECCCCC	33.46	19608861
600	Sumoylation	GPVAVQVKAEKPMDN CCEEEEEEEECCCCC	33.46	28112733
608	Phosphorylation	AEKPMDNSESSEESS EECCCCCCCCCCCCC	34.29	20363803
610	Phosphorylation	KPMDNSESSEESSDS CCCCCCCCCCCCCCC	42.76	20363803
611	Phosphorylation	PMDNSESSEESSDSA CCCCCCCCCCCCCCC	41.13	20363803
614	Phosphorylation	NSESSEESSDSADSE CCCCCCCCCCCCCHH	35.08	20363803
615	Phosphorylation	SESSEESSDSADSEE CCCCCCCCCCCCHHH	38.57	20363803
617	Phosphorylation	SSEESSDSADSEEAP CCCCCCCCCCHHHHH	35.60	20363803
620	Phosphorylation	ESSDSADSEEAPAAM CCCCCCCHHHHHHHH	36.73	20363803
637	Acetylation	AQAKPALKIPQTKAC HHHCCCCCCCCCCCC	55.22	25953088
637	Malonylation	AQAKPALKIPQTKAC HHHCCCCCCCCCCCC	55.22	26320211
637	Sumoylation	AQAKPALKIPQTKAC HHHCCCCCCCCCCCC	55.22	28112733
642	Acetylation	ALKIPQTKACPKKTN CCCCCCCCCCCCCCC	42.62	25953088
655	Acetylation	TNTTASAKVAPVRVG CCCCCCCEEECEEEE	36.11	25953088
663	Phosphorylation	VAPVRVGTQAPRKAG EECEEEECCCCCCCC	20.78	18212344
671	Phosphorylation	QAPRKAGTATSPAGS CCCCCCCCCCCCCCC	31.46	29255136
673	Phosphorylation	PRKAGTATSPAGSSP CCCCCCCCCCCCCCC	34.77	29255136
674	Phosphorylation	RKAGTATSPAGSSPA CCCCCCCCCCCCCCC	15.41	29255136
678	Acetylation	TATSPAGSSPAVAGG CCCCCCCCCCCCCCC	34.94	19608861
678	Phosphorylation	TATSPAGSSPAVAGG CCCCCCCCCCCCCCC	34.94	29255136
679	Phosphorylation	ATSPAGSSPAVAGGT CCCCCCCCCCCCCCC	18.89	29255136
686	Phosphorylation	SPAVAGGTQRPAEDS CCCCCCCCCCCCCCC	22.08	29255136
693	Phosphorylation	TQRPAEDSSSSEESD CCCCCCCCCCCCCCC	24.51	21955146
694	Phosphorylation	QRPAEDSSSSEESDS CCCCCCCCCCCCCCC	50.64	21955146
695	Phosphorylation	RPAEDSSSSEESDSE CCCCCCCCCCCCCCH	45.80	21955146
696	Phosphorylation	PAEDSSSSEESDSEE CCCCCCCCCCCCCHH	47.53	21955146
699	Phosphorylation	DSSSSEESDSEEEKT CCCCCCCCCCHHHHH	42.24	21955146
701	Phosphorylation	SSSEESDSEEEKTGL CCCCCCCCHHHHHCE	57.07	21955146
706	Phosphorylation	SDSEEEKTGLAVTVG CCCHHHHHCEEEEHH	40.48	25022875
711	Phosphorylation	EKTGLAVTVGQAKSV HHHCEEEEHHHCCCC	17.20	25022875
716	Acetylation	AVTVGQAKSVGKGLQ EEEHHHCCCCCCCCE	37.47	-
720	Acetylation	GQAKSVGKGLQVKAA HHCCCCCCCCEEEEE	55.05	26051181
725	Acetylation	VGKGLQVKAASVPVK CCCCCEEEEEECCCC	25.85	25953088
725	Sumoylation	VGKGLQVKAASVPVK CCCCCEEEEEECCCC	25.85	28112733
728	Phosphorylation	GLQVKAASVPVKGSL CCEEEEEECCCCCCC	31.64	30266825
732	Sumoylation	KAASVPVKGSLGQGT EEEECCCCCCCCCCC	36.39	-
732	Acetylation	KAASVPVKGSLGQGT EEEECCCCCCCCCCC	36.39	25953088
732	Methylation	KAASVPVKGSLGQGT EEEECCCCCCCCCCC	36.39	66724785
732	Sumoylation	KAASVPVKGSLGQGT EEEECCCCCCCCCCC	36.39	28112733
734	Phosphorylation	ASVPVKGSLGQGTAP EECCCCCCCCCCCCC	24.49	29743597
739	Phosphorylation	KGSLGQGTAPVLPGK CCCCCCCCCCCCCCC	21.65	23312004
746	Acetylation	TAPVLPGKTGPTVTQ CCCCCCCCCCCCCCE	48.66	23954790
755	Sumoylation	GPTVTQVKAEKQEDS CCCCCEEEEEHHCCC	40.80	-
755	Acetylation	GPTVTQVKAEKQEDS CCCCCEEEEEHHCCC	40.80	19608861
755	Sumoylation	GPTVTQVKAEKQEDS CCCCCEEEEEHHCCC	40.80	25114211
762	Phosphorylation	KAEKQEDSESSEEES EEEHHCCCCCCCCCC	38.33	23927012
764	Phosphorylation	EKQEDSESSEEESDS EHHCCCCCCCCCCCH	47.18	23927012
765	Phosphorylation	KQEDSESSEEESDSE HHCCCCCCCCCCCHH	45.00	23927012
769	Phosphorylation	SESSEEESDSEEAAA CCCCCCCCCHHHHHC	50.11	23927012
771	Phosphorylation	SSEEESDSEEAAASP CCCCCCCHHHHHCCH	46.76	23927012
777	Phosphorylation	DSEEAAASPAQVKTS CHHHHHCCHHHHHHH	18.95	23927012
784	Phosphorylation	SPAQVKTSVKKTQAK CHHHHHHHHHHHHHH	26.65	22817900
788	Phosphorylation	VKTSVKKTQAKANPA HHHHHHHHHHHCCHH	28.21	23532336
791	Acetylation	SVKKTQAKANPAAAR HHHHHHHHCCHHHHH	38.59	25953088
801	Phosphorylation	PAAARAPSAKGTISA HHHHHCCCCCCCCCC	41.44	25056879
803	Acetylation	AARAPSAKGTISAPG HHHCCCCCCCCCCCC	62.01	26051181
805	Phosphorylation	RAPSAKGTISAPGKV HCCCCCCCCCCCCHH	15.85	27362937
807	O-linked_Glycosylation	PSAKGTISAPGKVVT CCCCCCCCCCCHHHH	28.40	23301498
811	Acetylation	GTISAPGKVVTAAAQ CCCCCCCHHHHHHHH	32.26	23954790
814	O-linked_Glycosylation	SAPGKVVTAAAQAKQ CCCCHHHHHHHHHHH	17.36	23301498
814	Phosphorylation	SAPGKVVTAAAQAKQ CCCCHHHHHHHHHHH	17.36	27362937
820	Acetylation	VTAAAQAKQRSPSKV HHHHHHHHHCCCCCC	33.88	25953088
823	Phosphorylation	AAQAKQRSPSKVKPP HHHHHHCCCCCCCCC	30.91	28464451
825	Phosphorylation	QAKQRSPSKVKPPVR HHHHCCCCCCCCCCC	51.86	29496963
837	Phosphorylation	PVRNPQNSTVLARGP CCCCCCCCCEEEECC	18.04	28555341
838	Phosphorylation	VRNPQNSTVLARGPA CCCCCCCCEEEECCC	27.39	21712546
846	Phosphorylation	VLARGPASVPSVGKA EEEECCCCCCHHHHH	37.38	28348404
849	Phosphorylation	RGPASVPSVGKAVAT ECCCCCCHHHHHHHH	41.15	25159151
856	Phosphorylation	SVGKAVATAAQAQTG HHHHHHHHHHHHHHC	18.87	21406692
862	Phosphorylation	ATAAQAQTGPEEDSG HHHHHHHHCCCCCCC	58.69	20873877
868	Phosphorylation	QTGPEEDSGSSEEES HHCCCCCCCCCCCCC	43.80	25022875
870	Phosphorylation	GPEEDSGSSEEESDS CCCCCCCCCCCCCCC	38.23	25022875
871	Phosphorylation	PEEDSGSSEEESDSE CCCCCCCCCCCCCCH	53.18	25022875
875	Phosphorylation	SGSSEEESDSEEEAE CCCCCCCCCCHHHHH	50.11	25022875
877	Phosphorylation	SSEEESDSEEEAETL CCCCCCCCHHHHHHH	57.07	25022875
883	Phosphorylation	DSEEEAETLAQVKPS CCHHHHHHHHHHCCC	34.15	20873877
890	Phosphorylation	TLAQVKPSGKTHQIR HHHHHCCCCCCHHHH	47.40	19664994
904	Acetylation	RAALAPAKESPRKGA HEECCCCCCCCCCCC	58.63	23236377
904	Malonylation	RAALAPAKESPRKGA HEECCCCCCCCCCCC	58.63	26320211
906	Phosphorylation	ALAPAKESPRKGAAP ECCCCCCCCCCCCCC	29.33	29255136
914	Phosphorylation	PRKGAAPTPPGKTGP CCCCCCCCCCCCCCC	37.07	22167270
918	Acetylation	AAPTPPGKTGPSAAQ CCCCCCCCCCCCHHH	56.96	25953088
922	Phosphorylation	PPGKTGPSAAQAGKQ CCCCCCCCHHHCCCC	37.27	20068231
932	Phosphorylation	QAGKQDDSGSSSEES HCCCCCCCCCCCCCC	49.19	20068231
932 (in isoform 5)	Phosphorylation	-	49.19	24043423
934	Phosphorylation	GKQDDSGSSSEESDS CCCCCCCCCCCCCCC	34.34	25022875
934 (in isoform 5)	Phosphorylation	-	34.34	24043423
935	Phosphorylation	KQDDSGSSSEESDSD CCCCCCCCCCCCCCC	45.34	25022875
935 (in isoform 5)	Phosphorylation	-	45.34	24043423
936	Phosphorylation	QDDSGSSSEESDSDG CCCCCCCCCCCCCCC	47.26	25022875
936 (in isoform 5)	Phosphorylation	-	47.26	24043423
939	Phosphorylation	SGSSSEESDSDGEAP CCCCCCCCCCCCCCC	38.06	25022875
939 (in isoform 5)	Phosphorylation	-	38.06	24043423
941	Phosphorylation	SSSEESDSDGEAPAA CCCCCCCCCCCCCCC	57.71	25022875
941 (in isoform 5)	Phosphorylation	-	57.71	24043423
950	Phosphorylation	GEAPAAVTSAQVIKP CCCCCCCCCCEECCC	17.39	20068231
950 (in isoform 5)	Phosphorylation	-	17.39	24043423
951	Phosphorylation	EAPAAVTSAQVIKPP CCCCCCCCCEECCCC	15.31	28290473
951 (in isoform 5)	Phosphorylation	-	15.31	24043423
957 (in isoform 5)	Phosphorylation	-	20.15	24043423
958 (in isoform 5)	Phosphorylation	-	32.84	24043423
962 (in isoform 4)	Phosphorylation	-	10.69	23684312
964 (in isoform 4)	Phosphorylation	-	32.60	23684312
967	Phosphorylation	IFVDPNRSPAGPAAT EEECCCCCCCCCCCC	26.24	19664994
974	Phosphorylation	SPAGPAATPAQAQAA CCCCCCCCHHHHHHH	22.66	23927012
974 (in isoform 4)	Phosphorylation	-	22.66	20873877
977 (in isoform 4)	Phosphorylation	-	34.90	20873877
978 (in isoform 4)	Phosphorylation	-	11.77	20873877
980 (in isoform 4)	Phosphorylation	-	13.34	20873877
981 (in isoform 4)	Phosphorylation	-	11.23	20873877
982	Phosphorylation	PAQAQAASTPRKARA HHHHHHHCCCHHHHH	41.79	29255136
983	Phosphorylation	AQAQAASTPRKARAS HHHHHHCCCHHHHHC	23.53	29255136
988 (in isoform 4)	Phosphorylation	-	41.50	20873877
990	Phosphorylation	TPRKARASESTARSS CCHHHHHCHHCCCCC	26.90	26503892
992	Phosphorylation	RKARASESTARSSSS HHHHHCHHCCCCCCC	25.52	26503892
993	Phosphorylation	KARASESTARSSSSE HHHHCHHCCCCCCCC	23.26	26503892
996	Phosphorylation	ASESTARSSSSESED HCHHCCCCCCCCCCC	31.91	26503892
997	Phosphorylation	SESTARSSSSESEDE CHHCCCCCCCCCCCC	32.12	26503892
998	Phosphorylation	ESTARSSSSESEDED HHCCCCCCCCCCCCC	39.10	25159151
999	Phosphorylation	STARSSSSESEDEDV HCCCCCCCCCCCCCC	47.27	25159151
1001	Phosphorylation	ARSSSSESEDEDVIP CCCCCCCCCCCCCCC	52.90	25159151
1003 (in isoform 4)	Phosphorylation	-	67.67	25849741
1010	Phosphorylation	DEDVIPATQCLTPGI CCCCCCHHHCCCCCC	17.92	20363803
1014	Phosphorylation	IPATQCLTPGIRTNV CCHHHCCCCCCCCCC	27.39	20068231
1019	Phosphorylation	CLTPGIRTNVVTMPT CCCCCCCCCCEECCC	30.37	20860994
1024	Sulfoxidation	IRTNVVTMPTAHPRI CCCCCEECCCCCCCC	1.55	21406390
1026	Phosphorylation	TNVVTMPTAHPRIAP CCCEECCCCCCCCCC	27.12	20860994
1036	Phosphorylation	PRIAPKASMAGASSS CCCCCCHHHCCCCCC	18.45	29396449
1041	Phosphorylation	KASMAGASSSKESSR CHHHCCCCCCCCCCC	33.94	28985074
1042	Phosphorylation	ASMAGASSSKESSRI HHHCCCCCCCCCCCC	44.91	28348404
1043	Phosphorylation	SMAGASSSKESSRIS HHCCCCCCCCCCCCC	37.64	23312004
1046	Phosphorylation	GASSSKESSRISDGK CCCCCCCCCCCCCCC	28.75	24732914
1047	Phosphorylation	ASSSKESSRISDGKK CCCCCCCCCCCCCCC	34.42	24732914
1050	Phosphorylation	SKESSRISDGKKQEG CCCCCCCCCCCCCCC	38.92	24732914
1050 (in isoform 6)	Phosphorylation	-	38.92	21712546
1050 (in isoform 7)	Phosphorylation	-	38.92	21712546
1060	Phosphorylation	KKQEGPATQVSKKNP CCCCCCCCCCCCCCC	32.41	20363803
1060 (in isoform 6)	Phosphorylation	-	32.41	22167270
1060 (in isoform 7)	Phosphorylation	-	32.41	22167270
1063	Phosphorylation	EGPATQVSKKNPASL CCCCCCCCCCCCCCC	28.26	21601212
1064	Acetylation	GPATQVSKKNPASLP CCCCCCCCCCCCCCH	58.68	25953088
1064 (in isoform 6)	Phosphorylation	-	58.68	22167270
1064 (in isoform 7)	Phosphorylation	-	58.68	22167270
1068 (in isoform 6)	Phosphorylation	-	32.85	22167270
1068 (in isoform 7)	Phosphorylation	-	32.85	22167270
1069	Phosphorylation	VSKKNPASLPLTQAA CCCCCCCCCHHHHHH	31.60	25159151
1072 (in isoform 6)	Phosphorylation	-	7.22	22167270
1072 (in isoform 7)	Phosphorylation	-	7.22	22167270
1073	Phosphorylation	NPASLPLTQAALKVL CCCCCHHHHHHHHHH	17.77	18212344
1073 (in isoform 6)	Phosphorylation	-	17.77	22167270
1073 (in isoform 7)	Phosphorylation	-	17.77	22167270
1076 (in isoform 6)	Phosphorylation	-	9.71	26503892
1076 (in isoform 7)	Phosphorylation	-	9.71	26503892
1077 (in isoform 6)	Phosphorylation	-	4.40	22167270
1077 (in isoform 7)	Phosphorylation	-	4.40	22167270
1078	Acetylation	PLTQAALKVLAQKAS HHHHHHHHHHHHHHH	30.40	25953088
1078 (in isoform 6)	Phosphorylation	-	30.40	22167270
1078 (in isoform 7)	Phosphorylation	-	30.40	22167270
1085	O-linked_Glycosylation	KVLAQKASEAQPPVA HHHHHHHHHCCCCCC	40.27	23301498
1091 (in isoform 8)	Phosphorylation	-	7.77	20873877
1094	Phosphorylation	AQPPVARTQPSSGVD CCCCCCCCCCCCCCC	34.78	23927012
1094 (in isoform 8)	Phosphorylation	-	34.78	20873877
1097	Phosphorylation	PVARTQPSSGVDSAV CCCCCCCCCCCCCCC	29.88	23927012
1098	Phosphorylation	VARTQPSSGVDSAVG CCCCCCCCCCCCCCE	49.90	23927012
1099 (in isoform 8)	Phosphorylation	-	31.43	25159151
1101 (in isoform 8)	Phosphorylation	-	34.11	20873877
1102	Phosphorylation	QPSSGVDSAVGTLPA CCCCCCCCCCEECCC	23.58	23927012
1105 (in isoform 8)	Phosphorylation	-	22.66	-
1106	Phosphorylation	GVDSAVGTLPATSPQ CCCCCCEECCCCCCC	23.99	30266825
1110	Phosphorylation	AVGTLPATSPQSTSV CCEECCCCCCCCCCC	38.71	23927012
1111	Phosphorylation	VGTLPATSPQSTSVQ CEECCCCCCCCCCCC	24.05	23927012
1114	Phosphorylation	LPATSPQSTSVQAKG CCCCCCCCCCCCCCC	26.49	25159151
1114 (in isoform 8)	Phosphorylation	-	26.49	25921289
1115	Phosphorylation	PATSPQSTSVQAKGT CCCCCCCCCCCCCCC	27.89	30266825
1115 (in isoform 8)	Phosphorylation	-	27.89	25921289
1116	Phosphorylation	ATSPQSTSVQAKGTN CCCCCCCCCCCCCCC	19.92	25463755
1120	Acetylation	QSTSVQAKGTNKLRK CCCCCCCCCCCCCCC	49.53	26051181
1130 (in isoform 7)	Phosphorylation	-	6.24	20873877
1133 (in isoform 7)	Phosphorylation	-	4.89	20873877
1138 (in isoform 7)	Phosphorylation	-	66.03	25159151
1140 (in isoform 7)	Phosphorylation	-	43.49	20873877
1142	Phosphorylation	QATKAPESSDDSEDS HHHCCCCCCCCCCCC	37.70	25137130
1143	Phosphorylation	ATKAPESSDDSEDSS HHCCCCCCCCCCCCC	43.72	25137130
1144 (in isoform 7)	Phosphorylation	-	73.13	-
1146	Phosphorylation	APESSDDSEDSSDSS CCCCCCCCCCCCCCC	48.58	25137130
1149	Phosphorylation	SSDDSEDSSDSSSGS CCCCCCCCCCCCCCC	31.80	25137130
1150	Phosphorylation	SDDSEDSSDSSSGSE CCCCCCCCCCCCCCC	54.56	19664995
1152	Phosphorylation	DSEDSSDSSSGSEED CCCCCCCCCCCCCCC	28.49	30576142
1153	Phosphorylation	SEDSSDSSSGSEEDG CCCCCCCCCCCCCCC	43.65	25137130
1153 (in isoform 7)	Phosphorylation	-	43.65	25921289
1154	Phosphorylation	EDSSDSSSGSEEDGE CCCCCCCCCCCCCCC	50.74	25137130
1154 (in isoform 7)	Phosphorylation	-	50.74	25921289
1156	Phosphorylation	SSDSSSGSEEDGEGP CCCCCCCCCCCCCCC	39.50	30576142
1168	Phosphorylation	EGPQGAKSAHTLGPT CCCCCCCCCCCCCCC	25.42	23911959
1168 (in isoform 3)	Phosphorylation	-	25.42	20873877
1171	Phosphorylation	QGAKSAHTLGPTPSR CCCCCCCCCCCCCCC	32.88	30576142
1171 (in isoform 3)	Phosphorylation	-	32.88	20873877
1175	Phosphorylation	SAHTLGPTPSRTETL CCCCCCCCCCCHHHH	31.90	29496963
1176 (in isoform 3)	Phosphorylation	-	25.58	25159151
1177	Phosphorylation	HTLGPTPSRTETLVE CCCCCCCCCHHHHHH	55.07	29396449
1178 (in isoform 3)	Phosphorylation	-	37.47	20873877
1179	Phosphorylation	LGPTPSRTETLVEET CCCCCCCHHHHHHHH	37.35	23898821
1181	Phosphorylation	PTPSRTETLVEETAA CCCCCHHHHHHHHHH	35.18	23898821
1182 (in isoform 3)	Phosphorylation	-	3.57	-
1186	Phosphorylation	TETLVEETAAESSED HHHHHHHHHHHCCCC	20.05	21955146
1190	Phosphorylation	VEETAAESSEDDVVA HHHHHHHCCCCCCCC	34.01	19664994
1191	Phosphorylation	EETAAESSEDDVVAP HHHHHHCCCCCCCCC	36.23	26503892
1191 (in isoform 3)	Phosphorylation	-	36.23	25921289
1192 (in isoform 3)	Phosphorylation	-	68.46	25921289
1199	Phosphorylation	EDDVVAPSQSLLSGY CCCCCCCCHHHHCCC	23.75	23898821
1201	Phosphorylation	DVVAPSQSLLSGYMT CCCCCCHHHHCCCCC	35.30	23898821
1204	Phosphorylation	APSQSLLSGYMTPGL CCCHHHHCCCCCCCC	32.92	23663014
1206	Phosphorylation	SQSLLSGYMTPGLTP CHHHHCCCCCCCCCC	8.40	23663014
1208	Phosphorylation	SLLSGYMTPGLTPAN HHHCCCCCCCCCCCC	13.01	29116813
1212	Phosphorylation	GYMTPGLTPANSQAS CCCCCCCCCCCCCCC	26.69	20873877
1216	Phosphorylation	PGLTPANSQASKATP CCCCCCCCCCCCCCC	29.27	20873877
1219	Phosphorylation	TPANSQASKATPKLD CCCCCCCCCCCCCCC	18.39	19664994
1222	Phosphorylation	NSQASKATPKLDSSP CCCCCCCCCCCCCCC	25.37	25159151
1224	Sumoylation	QASKATPKLDSSPSV CCCCCCCCCCCCCCH	61.65	28112733
1227	Phosphorylation	KATPKLDSSPSVSST CCCCCCCCCCCHHHH	55.36	29255136
1228	Phosphorylation	ATPKLDSSPSVSSTL CCCCCCCCCCHHHHH	22.36	19664994
1230	Phosphorylation	PKLDSSPSVSSTLAA CCCCCCCCHHHHHEE	36.26	29255136
1232	Phosphorylation	LDSSPSVSSTLAAKD CCCCCCHHHHHEECC	23.18	30266825
1233	Phosphorylation	DSSPSVSSTLAAKDD CCCCCHHHHHEECCC	25.86	30266825
1234	Phosphorylation	SSPSVSSTLAAKDDP CCCCHHHHHEECCCC	16.95	30266825
1238	Sumoylation	VSSTLAAKDDPDGKQ HHHHHEECCCCCCCC	57.99	28112733
1248	Sumoylation	PDGKQEAKPQQAAGM CCCCCCCCHHHHCCC	42.48	28112733
1257	Phosphorylation	QQAAGMLSPKTGGKE HHHCCCCCCCCCCCC	18.56	19664994
1260	Phosphorylation	AGMLSPKTGGKEAAS CCCCCCCCCCCCCCC	55.33	23403867
1263	Acetylation	LSPKTGGKEAASGTT CCCCCCCCCCCCCCC	45.59	26051181
1267	Phosphorylation	TGGKEAASGTTPQKS CCCCCCCCCCCCCCC	43.66	30266825
1269	Phosphorylation	GKEAASGTTPQKSRK CCCCCCCCCCCCCCC	32.57	30266825
1270	Phosphorylation	KEAASGTTPQKSRKP CCCCCCCCCCCCCCC	27.52	30266825
1273	Acetylation	ASGTTPQKSRKPKKG CCCCCCCCCCCCCCC	54.13	25953088
1274	Phosphorylation	SGTTPQKSRKPKKGA CCCCCCCCCCCCCCC	40.05	23403867
1287	Phosphorylation	GAGNPQASTLALQSN CCCCCCHHHHHHHCC	20.78	-
1288	Phosphorylation	AGNPQASTLALQSNI CCCCCHHHHHHHCCC	21.04	-
1296	Phosphorylation	LALQSNITQCLLGQP HHHHCCCHHHHHCCC	19.92	-
1320	Phosphorylation	ASVVKVLTELLEQER HHHHHHHHHHHHHHH	27.81	20068231
1335	2-Hydroxyisobutyrylation	KKVVDTTKESSRKGW HHHHCCHHHHHHHHH	58.66	-
1335	Ubiquitination	KKVVDTTKESSRKGW HHHHCCHHHHHHHHH	58.66	-
1337	Acetylation	VVDTTKESSRKGWES HHCCHHHHHHHHHHH	36.68	19608861
1338	Phosphorylation	VDTTKESSRKGWESR HCCHHHHHHHHHHHH	38.82	19664995
1346	Acetylation	RKGWESRKRKLSGDQ HHHHHHHHHHHCCCC	64.26	20167786
1346	Ubiquitination	RKGWESRKRKLSGDQ HHHHHHHHHHHCCCC	64.26	-
1350	Phosphorylation	ESRKRKLSGDQPAAR HHHHHHHCCCCCCCC	43.27	22167270
1358	Phosphorylation	GDQPAARTPRSKKKK CCCCCCCCCCCCCCC	20.51	22167270
1361	Phosphorylation	PAARTPRSKKKKKLG CCCCCCCCCCCCCCC	50.45	25159151
1362	Acetylation	AARTPRSKKKKKLGA CCCCCCCCCCCCCCC	70.64	20167786
1376	Acetylation	AGEGGEASVSPEKTS CCCCCCCCCCCCCCC	20.87	19608861
1376	Phosphorylation	AGEGGEASVSPEKTS CCCCCCCCCCCCCCC	20.87	22167270
1377	Acetylation	GEGGEASVSPEKTST CCCCCCCCCCCCCCC	16.63	19608861
1378	Phosphorylation	EGGEASVSPEKTSTT CCCCCCCCCCCCCCC	25.50	19664994
1382	Phosphorylation	ASVSPEKTSTTSKGK CCCCCCCCCCCCCCC	29.64	22167270
1383	Phosphorylation	SVSPEKTSTTSKGKA CCCCCCCCCCCCCCH	40.53	22167270
1384	Phosphorylation	VSPEKTSTTSKGKAK CCCCCCCCCCCCCHH	40.08	22167270
1385	Phosphorylation	SPEKTSTTSKGKAKR CCCCCCCCCCCCHHC	28.36	22167270
1386	Phosphorylation	PEKTSTTSKGKAKRD CCCCCCCCCCCHHCC	39.23	23927012
1396	Phosphorylation	KAKRDKASGDVKEKK CHHCCCCCCCCCCCC	41.07	18691976
1403	Acetylation	SGDVKEKKGKGSLGS CCCCCCCCCCCCCCC	67.93	21339330
1405	Acetylation	DVKEKKGKGSLGSQG CCCCCCCCCCCCCCC	54.96	21339330
1407	Phosphorylation	KEKKGKGSLGSQGAK CCCCCCCCCCCCCCC	32.80	22167270
1410	Phosphorylation	KGKGSLGSQGAKDEP CCCCCCCCCCCCCCC	30.63	22167270
1414	Sumoylation	SLGSQGAKDEPEEEL CCCCCCCCCCCHHHH	70.24	-
1414	Acetylation	SLGSQGAKDEPEEEL CCCCCCCCCCCHHHH	70.24	19608861
1414	Sumoylation	SLGSQGAKDEPEEEL CCCCCCCCCCCHHHH	70.24	28112733
1427	Phosphorylation	ELQKGMGTVEGGDQS HHHHCCCCCCCCCCC	13.39	29632367
1434	Phosphorylation	TVEGGDQSNPKSKKE CCCCCCCCCCCCHHH	60.89	21815630
1437	Acetylation	GGDQSNPKSKKEKKK CCCCCCCCCHHHHHH	78.23	26051181
1469	Phosphorylation	KKASTKDSESPSQKK HHHHCCCCCCHHHHH	41.34	30266825
1471	Phosphorylation	ASTKDSESPSQKKKK HHCCCCCCHHHHHHH	33.53	30266825
1473	Phosphorylation	TKDSESPSQKKKKKK CCCCCCHHHHHHHHH	65.00	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
156	S	Phosphorylation	Kinase	CDK1	P06493	PSP
210	T	Phosphorylation	Kinase	CK2A1	P68400	PSP
583	S	Phosphorylation	Kinase	CDK1	P06493	PSP
983	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCOF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCOF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM9S1_HUMAN	TM9SF1	physical	21988832
KBTB8_HUMAN	KBTBD8	physical	26399832
NOLC1_HUMAN	NOLC1	physical	26399832
ARRB1_HUMAN	ARRB1	physical	26399832
ARRB2_HUMAN	ARRB2	physical	26399832
RPA1_HUMAN	POLR1A	physical	26399832
RPA2_HUMAN	POLR1B	physical	26399832
DKC1_HUMAN	DKC1	physical	26399832
NHP2_HUMAN	NHP2	physical	26399832
NOP58_HUMAN	NOP58	physical	26399832
NOP56_HUMAN	NOP56	physical	26399832
CSK21_HUMAN	CSNK2A1	physical	26399832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 154500: Treacher Collins syndrome 1 (TCS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-155; LYS-296; LYS-600;LYS-755 AND LYS-1414, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; THR-249; SER-381;SER-583; THR-983; SER-1111; SER-1228; SER-1350; SER-1376 AND SER-1378,AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-168; SER-171; THR-173;THR-249; THR-310; THR-316; SER-381; THR-533; SER-906; THR-983;SER-1111; THR-1222; SER-1227; SER-1228; SER-1230; SER-1257; SER-1350;SER-1376 AND SER-1378, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; THR-84; SER-85;SER-87; SER-88; SER-153; SER-156; THR-249; THR-310; THR-316; SER-381;SER-503; THR-581; SER-583; SER-762; SER-764; SER-765; SER-769;SER-771; SER-777; SER-868; SER-870; SER-871; SER-875; SER-877;SER-906; SER-996; SER-997; SER-998; SER-999; SER-1001; SER-1111;SER-1190; SER-1191; SER-1228; THR-1234; SER-1257; SER-1350; THR-1358;SER-1376; SER-1378; SER-1407 AND SER-1410, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-906; SER-1350 ANDSER-1378, AND MASS SPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-906; SER-967 ANDTHR-983, AND MASS SPECTROMETRY.
PubMed: 18220336

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153; SER-156; SER-381;SER-582; SER-583; SER-1228 AND SER-1378, AND MASS SPECTROMETRY.
PubMed: 18187866

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375; SER-381; SER-906;THR-914; SER-1350 AND SER-1378, AND MASS SPECTROMETRY.
PubMed: 19007248

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1410, AND MASSSPECTROMETRY.
PubMed: 17525332

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; THR-144; SER-153;SER-160; SER-381; THR-394; SER-446; SER-583; SER-764; SER-784;SER-801; THR-805; SER-906; SER-1257; SER-1350; THR-1358; SER-1361;SER-1376 AND SER-1378, AND MASS SPECTROMETRY.
PubMed: 17287340

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-304; THR-310;THR-316; SER-381; SER-446; SER-582; SER-583; SER-906; THR-914 ANDSER-1350, AND MASS SPECTROMETRY.
PubMed: 17924679

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-249; SER-1111; SER-1228AND SER-1378, AND MASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; THR-84; SER-85;SER-87; SER-88; SER-164; SER-171; SER-233; SER-446; SER-475; SER-477;SER-478; SER-479; SER-482; SER-484; SER-608; SER-610; SER-611;SER-614; SER-615; SER-617; SER-620; SER-868; SER-870; SER-871;SER-875; SER-877 AND SER-906; SER-932; SER-934; SER-935; SER-936;SER-939; SER-941; SER-996; SER-997; SER-998; SER-999; SER-1001;SER-1257; SER-1350; SER-1378 AND SER-1471, AND MASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-967; SER-1111; SER-1228;SER-1376; SER-1378 AND SER-1471, AND MASS SPECTROMETRY.
PubMed: 15302935